改良早期预警评分与校正改良预警评分在外科术后患者中的应用对比研究

目的:探讨改良早期预警评分(MEWS)与校正MEWS在外科病房手术后患者的应用价值对比。方法:回顾性分析外科病房收治的171例外科手术后患者的临床资料。手术后入病房时即刻作为观察起点,通过查阅病例记录对每一例患者分别进行MEWS和校正MEWS评分,以转出病房为观察终点,资料收集完后进行统计分析。结果:MEWS与校正MEWS评分分值段越高,患者自动出院/死亡、转入ICU比例明显增加,与低分段比较具有统计学意义(P0.01);以收入ICU为预测指标时,MEWS界值是4,敏感度是54.5%,特异度是90.6%,其ROC曲线下面积(0.878±0.030)(95%:0.848~0.908,P=0.000);校正MEWS界值是5,敏感度是59.1%,特异度是89.3%,其ROC曲线下面积(0.907±0.023)(95%:0.884~0.930,P=0.000)。结论:校正MEWS比MEWS评分更能反映外科术后患者病情危重程度,是提高监护级别的扳机点;观察数据护士易于获得,值得在外科病房中推广应用。     

雄黄诱导K562细胞凋亡的研究

ObjectiveTo investigate the apoplosis of K₅₆₂ cells induced by realgar.MethodsApoptosis was detected by morphological observation DNA gel electrophoresis and flow cytometric cell cycle analysis.APO_2.7 expression was detected by flow cytometery.Results Realgar induced K₅₆₂ cells into sub-G₁ cells and significantly decreased S phase cells.ConclusionRealgar can induce apoptosis in K₅₆₂ cells.