奥拉西坦联合天智颗粒治疗血管性痴呆的疗效观察

目的 探讨奥拉西坦胶囊联合天智颗粒治疗血管性痴呆( VD)的临床疗效。方法 将2012年2月～2016年8月本院收治的240例血管性痴呆患者随机分为3组,每组各80例,分别给予奥拉西坦治疗、天智颗粒治疗、奥拉西坦联合天智颗粒治疗,疗程均为16周; 治疗前和治疗后所有患者均采用简易智能精神状态量表(MMSE)和日常生活活动能力量表(ADL)测评,并以MMSE 评分为依据判断治疗总有效率。结果 和治疗前比较,3组患者治疗后 MMSE评分均有显著提高,ADL评分均有明显减低(P<0.05),且治疗后联合治疗组评分较其他2组治疗后变化更明显(P<0.05)。奥拉西坦治疗组、天智颗粒治疗组、奥拉西坦联合天智颗粒治疗组的总有效率分别为83.75%、80.0%、92.5%,联合治疗组均高于单独治疗组(P<0.05)。结论 天智颗粒联合奥拉西坦能有效治疗血管性痴呆,明显提高患者认知功能、日常生活能力。     

天智颗粒联合奥拉西坦治疗轻中度血管性痴呆临床观察

目的研究天智颗粒联合奥拉西坦治疗轻中度血管性痴呆的临床疗效和安全性。方法将80例轻中度血管性痴呆患者随机分为2组,治疗组40例用天智颗粒联合奥拉西坦治疗;对照组40例用同等量奥拉西坦治疗,疗程60 d。治疗前后进行简易智力状态量表(MMSE)和日常生活能力量表(ADL)评定。结果 2组患者治疗后的MMSE和ADL评分较治疗前差异均有统计学意义(P<0.05);组间比较,治疗组评分改善明显优于对照组,无明显不良反应。结论天智颗粒联合奥拉西坦治疗轻中度血管性痴呆安全有效。     

奥拉西坦联合尼莫地平治疗血管性痴呆的临床观察

目的：探讨奥拉西坦联合尼莫地平治疗血管性痴呆的临床疗效。方法选择我院2011-05-2013-06收治的120例血管性痴呆患者的临床资料，观察组60例采用奥拉西坦联合尼莫地平进行治疗，对照组60例采用常规治疗措施，比较2组患者的临床疗效。结果观察组总有效率为93·3％，明显高于对照组，差异有统计学意义（P＜0·05）；观察组MMSE评分和Barthel评分均较对照组明显增加，差异均有统计学意义（P＜0·05）。结论奥拉西坦联合尼莫地平治疗血管性痴呆具有十分显著的作用，可明显改善患者的临床症状，促进脑记忆功能的恢复，从而大大提高患者的生活质量，值得临床应用。     

丁苯酚软胶囊联合奥拉西坦注射液对血管性痴呆病人认知功能的影响及安全性分析

目的探讨丁苯酚软胶囊联合奥拉西坦注射液对血管性痴呆患者认知功能的影响及安全性。方法选取血管性痴呆患者80例,随机分为2组,每组40例,对照组采用奥拉西坦注射液治疗,研究组在使用奥拉西坦注射液治疗的基础上联合丁苯酚软胶囊治疗,2组均连续治疗1个月,治疗前后采用简易智能状态量表(MMSE)和日常生活能力量表(ADL)评价临床疗效,并观察不良反应发生情况。结果研究组治疗后MMSE评分明显增加,ADL总分显著下降,治疗前后比较差异具有统计学意义(P0.05),且研究组治疗后的MMSE评分明显高于对照组,ADL总分明显低于对照组(P0.05);2组在治疗过程均未出现明显不良反应。结论丁苯酚软胶囊联合奥拉西坦注射液治疗血管性痴呆的疗效确切,无明显不良反应,能明显提高病人的认知功能和生活质量,值得应用。     

奥拉西坦联合尼莫地平治疗血管性痴呆的疗效及安全性评价

目的 探究奥拉西坦联合尼莫地平治疗血管性痴呆患者的疗效及安全性.方法 抽取2014-03—2016-02符合研究选取标准的92例血管性痴呆患者,根据用药方案不同分为对照组(n=46)与研究组(n=46).对照组仅采用尼莫地平治疗,研究组联合采用尼莫地平与奥拉西坦治疗.统计2组临床疗效、不良反应发生情况,并对比治疗前后2组认知功能(MMSE)及日常生活活动能力(ADL)评分变化情况.结果 研究组治疗有效率(91.30%)明显高于对照组(71.74%),差异有统计学意义(P<0.05);治疗前2组MMSE及ADL评分对比差异无统计学意义(P>0.05);经治疗,2组各指标评分均较治疗前显著改善,且研究组MMSE评分(24.53±3.44)分、ADL评分(56.14±10.48)分明显优于对照组[(19.07±3.40)分、(44.26±9.18)分],差异有统计学意义(P<0.05);研究组不良反应发生率(6.51%)与对照组(4.34%)对比,差异无统计学意义(P>0.05).结论 联合采用奥拉西坦及尼莫地平治疗血管性痴呆患者疗效确切,可有效改善患者痴呆状况,提高其认知功能及日常生活活动能力,且不会增加不良反应发生率,具有安全性.     

奥拉西坦联合乐脉颗粒辨证治疗血管性痴呆临床研究

目的探讨奥拉西坦联合乐脉颗粒辨证治疗血管性痴呆的临床效果,以期提高临床治疗水平。方法选取2010-04—2013-04 105例血管性痴呆患者为研究对象,分成2组,对照组予以奥拉西坦治疗,观察组在对照组基础上加乐脉颗粒治疗,比较2组治疗效果。结果对照组总有效率72.55%,观察组为88.89%,2组比较差异有统计学意义(P<0.05);2组治疗6周和12周MMSE、ADL评分以及双侧ICA、VA比较差异有统计学意义(P<0.05)。结论奥拉西坦联合乐脉颗粒辨治血管性痴呆临床效果显著。     

奥拉西坦联合重复经颅磁刺激治疗血管性痴呆的疗效观察

目的分析奥拉西坦联合重复经颅磁刺激治疗血管性痴呆的疗效。方法随机抽取78例血管性痴呆者,根据随机数字表法按照1∶1∶1比例分为观察组和对照Ⅰ组、对照Ⅱ组,每组26例;3组患者均按照《中国脑血管病防治指南》给予基本治疗,观察组加用奥拉西坦联合重复经颅磁刺激治疗,对照Ⅰ组单纯给予奥拉西坦胶囊,对照Ⅱ组仅作为阴性对照;同时对3组治疗前后简易精神状态(MMSE)评分、日常生活能力(ADL)评分及疗效进行对比分析。结果治疗后观察组MMSE、ADL评分及疗效与对照Ⅰ组、对照Ⅱ组相比存在明显差异(P0.05)。结论奥拉西坦联合重复经颅磁刺激治疗血管性痴呆效果显著,能有效改善患者精神症状和认知障碍,使其顺利回归社会,具有重要临床价值,值得推广。     

奥拉西坦治疗血管性认知功能障碍的疗效观察

目的观察奥拉西坦治疗血管性认知功能障碍的临床疗效。方法将43例血管性认知功能障碍患者随机分为治疗组和对照组,治疗组在对照组基础性治疗的基础上给予奥拉西坦口服,3个月后运用简易智力状态检查量表(MMSE)积分法进行评价。结果2组MMSE积分治疗后比治疗前均有提高(P<0.01),治疗组总有效率明显优于对照组(P<0.05)。结论奥拉西坦是治疗血管性认知功能障碍的有效药物之一。     

奥拉西坦联合银杏达莫注射液治疗血管性痴呆临床研究

目的探讨奥拉西坦联合银杏达莫注射液治疗血管性痴呆的临床效果。方法选择我院2008-09—2010-09血管性痴呆患者80例,随机分观察组和对照组。2组患者均给予常规治疗。观察组同时给予银杏达莫注射液和奥拉西坦。采用简易智力状态量表(MMSE)、画钟试验和日常生活活动能力量表(ADL)对2组患者治疗前后进行评定。结果观察组治疗后MMSE和画钟试验评分与对照组治疗后比较,差异有统计学意义(P<0.05);观察组治疗后ADL评分与对照组治疗后比较,差异有统计学意义(P<0.05);2组总有效率比较,差异有统计学意义(P<0.05)。结论奥拉西坦联合银杏达莫注射液能够显著改善血管性痴呆患者的认知障碍,提高患者日常生活活动能力,临床效果显著。     

丁苯酞软胶囊联合奥拉西坦注射液治疗血管性痴呆的疗效观察

目的探讨丁苯酞软胶囊联合奥拉西坦注射液对血管性痴呆病人认知功能的影响及应用的安全性。方法选择血管性痴呆病人120例,随机分为3组,丁苯酞软胶囊联合奥拉西坦注射液治疗组40例;奥拉西坦注射液治疗组40例;对照组40例,对照组只用胞磷胆碱钠注射液。以1个月为1疗程,3组病人治疗前及治疗1个月后均采用简易智能状态量表(MMSE)和日常生活能力量表(ADL)评价临床疗效。结果治疗后丁苯酞软胶囊联合奥拉西坦注射液治疗组MMSE和ADL评分优于奥拉西坦注射液治疗组(P<0.05),显著优于对照组(P<0.01)。结论丁苯酞软胶囊联合奥拉西坦注射液治疗血管性痴呆有效、安全,能显著改善病人的认知功能,提高生活质量。     

Mechanism of action of tubocurarine on nicotinic cholinoreceptors of neurons of the sympathetic ganglia of rats

Tubocurarine (Tc) effect on membrane currents elicited by acetylcholine (ACh) was studied in isolated superior cervical ganglion neurons of rat using patch-clamp method in the whole-cell recording mode. The "use-dependent" block of ACh current by Tc was revealed in the experiments with ACh applications, indicating that Tc blocked the channels opened by ACh. Mean lifetime of Tc-open channel complex, tau, was found to be 9.8 +/- 0.5 s (n = 7) at -50 mV and 20-24 degrees C. tau exponentially increased with membrane hyperpolarization (e-fold change in tau corresponded to the membrane potential shift by 61 mV). Inhibition of the ACh-induced current by Tc (3-30 microM/1) was completely abolished by membrane depolarization to the level of 80-100 mV. Inhibition of ACh-induced current was augmented at increased ACh doses. It is concluded that the open channel block produced by Tc is likely to be the only mechanism for Tc action on nicotinic acetylcholine receptors in superior cervical ganglion neurons of rat.     

The effect of age of onset of PD on risk of dementia

Background Dementia occurs in the majority of patients with Parkinson’s disease (PD). Late onset of PD has been reported to be associated with a higher risk for dementia. However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age. Methods Two community-based studies of PD in New York (n = 281) and Rogaland county, Norway (n = 227) and two population-based groups of healthy elderly from New York (n = 180) and Odense, Denmark (n = 2414) were followed prospectively for 3–4 years and assessed for dementia according to DSM-IIIR. All PD and control cases underwent neurological examination and were followed with neurological and neuropsychological assessments. We used Cox proportional hazards regression based on three different time scales to explore the effect of AAO of PD on risk of dementia, adjusting for age at baseline and other demographic and clinical variables. Findings In both PD groups and in the pooled analyses, there was a significant effect of age at baseline assessment on the time to develop dementia, but there was no effect of AAO independent of age itself. Consistent with these results, there was no increased relative effect of age on the time to develop dementia in PD cases compared with controls. Interpretation This study shows that it is the general effect of age, rather than AAO that is associated with incident dementia in subjects with PD. Received in revised form: 22 December 2005     

Limits of deinstitutionalization--perspectives of relatives of psychiatric patients

After a hopeful beginning, the social process of the reintegration of those with severe mental illness has come to a standstill. I am led to wonder whether "the community" really wants to live together with people suffering from severe mental illness, and if so, how closely? As long as the medical treatment of mental illness provided by the general practitioners is fundamentally deficient, as they are not able to prescribe the necessary interventions--such as out-patient psychiatric nursing, and service providers in the out-patient sector are content with offering increasingly intensive forms of care for the less seriously ill at the cost of the Social Welfare System--the reintegration of those with serious mental illness remains an illusion--which is mainly to the benefit of providers of residential care in homes and hostels.     

Sense of coherence as a predictor of subjective state of health: results of 4 years of follow-up of adults

A number of cross-sectional population studies have shown that a strong sense of coherence (SOC) is associated with various aspects of good perceived health. The association does not seem to be entirely attributable to underlying associations of SOC with other variables, such as age or level of education. OBJECTIVE: The aim of the study reported here was to determine whether SOC predicted subjective state of health. METHODS: The study was carried out as a two-way panel mail survey of 1976 individuals with 4 years interval for two collections of data. The statistical method used was multivariate cumulative logistic modeling. Age, initial subjective state of health, initial occupational training level, and initial degree of social integration were included as potential explanatory variables. RESULTS: A strong SOC predicted good health in women and men. CONCLUSIONS: SOC can be interpreted as an autonomous internal resource contributing to a favorable development of subjective state of health. SOC data should, however, be regarded as complementary to and not a substitute for information already known to be associated with increased risk of future ill health.     

Bibliography of officers of department of mental hygiene

Psychiatric Quarterly -