脑蛋白水解物注射液结合康复训练治疗痉挛型脑瘫疗效分析

目的观察脑蛋白水解物注射液结合康复训练治疗痉挛型脑瘫的临床效果。方法选取我院2009-06—2014-08收治的痉挛型脑瘫患儿100例,随机分为观察组与对照组,对照组实施基础康复训练治疗,观察组在此基础上结合脑蛋白水解物注射液治疗,观察2组临床疗效。结果观察组显效率与总有效率均明显高于对照组;治疗后2组发育商(DQ)均明显提高,且观察组提高程度更为显著,差异均有统计学意义(P0.05)。结论脑蛋白水解物注射液结合康复训练治疗痉挛型脑瘫患儿,可显著提高临床疗效,促进患儿DQ发育,改善患儿智力、感知觉障碍及行为症状,具有进一步推广应用价值。     

GM1联合中频电疗对脑瘫患儿神经功能康复的影响

目的分析GM1联合中频电疗对脑瘫患儿神经功能康复的影响。方法选择2010-06—2014-06在我院接受治疗的脑瘫患儿64例,根据数字随机表法分成观察组及对照组各32例,2组患儿均进行物理疗法、作业疗法、语言疗法及引导式教育等康复治疗措施,观察组在此基础上另给予GM1联合中频电疗等措施。2组均治疗3个月,对比2组治疗前后的粗大运动功能评定表(GMFM评分),发育诊断量表(GESELL评分)及疗效。结果 2组治疗后的GMFM各项目评分均较治疗前显著升高,但观察组的GMFM各项目评分均显著高于对照组,差异有统计学意义(P0.05)。2组治疗后的GESELL各项目评分均较治疗前显著升高,但观察组的GESELL各项目评分均显著高于对照组,差异有统计学意义(P0.05)。观察组总有效率93.75%,显著高于对照组的71.88%,差异有统计学意义(P0.05)。结论 GM1联合中频电疗对脑瘫患儿的神经功能康复具有较好的促进作用,效果明显,值得临床推广。     

免疫调节疗法对脑瘫儿童神经运动发育影响的临床研究

目的评价免疫调节疗法对脑瘫儿童神经运动发育的影响。方法将120例脑瘫患儿随机分为治疗组60例与对照组60例,治疗组在对照组的基础上给予免疫调节疗法,2组治疗均20 d一疗程,疗程间间隔10 d,连续治疗3个疗程,分别于治疗前、治疗3个疗程后采用Gesell发育测试、GMFM测试、体液免疫指标测定进行疗效评定。结果对照组治疗前后IgA、IgG、IgM、C3、C4水平差异无统计学意义(P0.05);治疗组治疗前后IgA、IgG、C4水平差异有统计学意义(P0.05);治疗后2组IgA、IgG水平比较差异有统计学意义(P0.05)。2组治疗前后Gesell各能区发育商差异有统计学意义(P0.05);治疗后2组Gesell各能区发育商比较差异有统计学意义(P0.05)。2组感染例次比较差异有统计学意义(P0.05)。2组治疗前后GMFM总分差异有统计学意义(P0.05);2组治疗后GMFM总分比较差异有统计学意义(P0.05)。结论配合使用免疫调节疗法可有效改善脑瘫患儿的免疫状态,更有利于提高脑瘫患儿粗大运动功能、Gesell测试发育商。     

综合康复疗法联合神经节苷脂治疗小儿痉挛型脑瘫的效果评价

目的分析综合康复疗法联合神经节苷脂治疗小儿痉挛型脑瘫的效果。方法选取我院儿童康复科2015-01—2016-06收治的痉挛型脑瘫患儿66例,按照随机数字表分为对照组与试验组各33例,2组均给予综合康复训练,包括运动疗法、作业疗法、按摩、引导式教育、理疗等,试验组在上述基础上给予神经节苷脂穴位注射,1次/d,每次4~6个穴位,10d一疗程,停药5d后进入下一疗程,连续治疗6个疗程。观察2组临床治疗效果,比较综合痉挛量表(CSS)、粗大运动功能量表(GMFM)、日常生活活动能力量表(ADL)评分。结果试验组临床总有效率为87.88%,明显高于对照组的66.67%,差异有统计学意义(χ~2=4.23,P0.05)。治疗前2组CSS评分、GMFM评分、ADL评分比较,差异均无统计学意义(P0.05),治疗后2组CSS评分明显降低,GMFM评分、ADL评分明显增加,且试验组CSS评分显著低于对照组,GMFM评分、ADL评分显著高于对照组,差异均有统计学意义(P0.05)。结论综合康复疗法联合神经节苷脂治疗痉挛型脑瘫患儿,可明显缓解肢体痉挛,提高患儿的运动功能与日常生活活动能力,改善预后。     

预防性治疗新生儿窒息心脑损伤101例临床分析

目的 探讨果糖二磷酸钠在新生儿窒息心脑损伤的预防性治疗中的效果,为改善该类患儿的治疗质量提供依据.方法 选择我院收治的102例窒息新生儿,按照随机数字表法分成观察组与对照组各51例,对照组行常规预防性治疗,观察组在常规预防性治疗基础上应用果糖二磷酸钠治疗,比较2组临床疗效.结果 观察组心肌损伤发生率、脑损伤发生率均显著低于对照组,差异有统计学意义(P＜0.05);治疗第4天,观察组轻度窒息、重度窒息患儿的血清肌酸激酶同工酶(CK-MB)、肌钙蛋白Ⅰ(CTn Ⅰ)均显著低于对照组,治疗第7天,观察组轻度窒息、重度窒息患儿的神经评分分别与对照组相比,差异均有统计学意义(P＜0.05).结论 果糖二磷酸钠预防性治疗窒息新生儿,可降低发生心脑损伤的风险,有效缓解心脑损伤,具有较高的临床应用价值.     

康复机器人对痉挛型脑性瘫痪患儿的康复效果

目的分析康复机器人训练对痉挛型脑性瘫痪患儿康复治疗的效果。方法选择2014-10—2016-10我院收治的痉挛型脑性瘫痪患儿94例,按随机数字表法分为对照组和观察组各47例,对照组采用常规康复训练,观察组在对照组基础上增加康复机器人辅助的减重步行训练,治疗前和治疗后3个月分别采用粗大运动功能测量表(GMFM)和日常生活能力评分(ADL)评定2组患儿的运动功能和生活能力。结果治疗后3个月,对照组E区GMFM评分及ADL评分均高于治疗前(P0.05),D区GMFM评分与治疗前比较差异无统计学意义(P0.05),观察组D区、E区GMFM评分及ADL评分均高于治疗前(P0.05),且观察组D区、E区GMFM评分及ADL评分均显著高于对照组(P0.05)。结论康复机器人训练能够有效改善痉挛型脑性瘫痪患儿的下肢运动功能,显著提高患儿的日常行动能力。     

“痉挛三针”对痉挛型脑瘫儿童运动功能的影响

目的观察"痉挛三针"对痉挛型脑瘫儿童运动功能的影响。方法选择我院治疗的86例痉挛型脑瘫患儿,依据随机数字表法分为观察组与对照组各43例。对照组采用头针针灸结合康复训练治疗,观察组在对照组的治疗基础上加用"痉挛三针"。比较2组治疗前后的改良Ashworth评分、GMFM-88中D区与E区评分及治疗效果。结果治疗后2组改良Ashworth评分均不同程度降低,GMFM-88中D区与E区评分均有所提高,观察组显著优于对照组;观察组总有效率(90.7%)显著优于对照组(81.4%),差异有统计学意义(P0.05)。结论 "痉挛三针"可有效降低痉挛型脑瘫儿童内收肌肌张力,使患儿获得更好的独立行走及跑跳等运动功能。     

早期综合护理干预模式在脑损伤患儿神经智力发育及脑瘫中的影响

目的探讨早期综合护理干预模式在脑损伤患儿神经智力发育及脑瘫中的影响。方法选取常规护理的46例患儿为对照组,行综合护理干预的55例患儿为观察组,观察组除接受常规护理指导外,还采取视听触觉刺激。随访1a,评价2组脑瘫发生率及智力发育水平指数(mental development index,MDI)、运动发育指数(phychomoter development index,PDI)。结果观察组脑瘫发生率显著低于对照组,差异有统计学意义(P0.05);观察组MDI和PDI与对照组相比差异有统计学意义(P0.05)。结论早期综合护理干预模式可降低脑损伤患儿脑瘫发生率,有助于其MDI和PDI的提高。     

综合干预疗法治疗小儿脑损伤综合征的疗效观察

目的探讨综合干预疗法治疗脑损伤综合征患儿的效果。方法选取我院小儿康复门诊收治的脑损伤综合征患儿120例为研究对象,采用数字随机对照表分为对照组和观察组,对照组予以脑活素穴位注射,观察组在对照组基础上行综合干预疗法,治疗前和治疗3个月后行Gesell法测定发育商,行粗大神经运动功能(GMFM)评分评估各区水平,均于1a后复查。结果观察组治疗3个月、12个月后社会适应、精细运动、大运动、个人社交、语言发育商均高于对照组,差异有统计学意义(P0.05);观察组治疗3个月、12个月后A卧位和翻身、B坐位、C爬和跪水平均较对照组高,差异有统计学意义(P0.05)。结论综合干预疗法能够促使脑损伤综合征患儿神经运动发育,疗效确切。     

康复训练与A型肉毒毒素对痉挛性脑瘫患儿肌张力恢复及日常生活能力的影响

目的探讨康复训练联合A型肉毒毒素注射液治疗痉挛性脑瘫对患儿肌张力恢复及日常生活能力影响。方法选取驻马店市中心医院2014-08—2016-09痉挛性脑瘫患儿93例,采用随机数字表法分组,对照组46例予以A型肉毒毒素注射液治疗,研究组47例予以A型肉毒毒素注射液与康复训练联合治疗,2组均持续治疗20 d,分析2组治疗前后运动功能(Fugl-Meyer)、痉挛状态(CSS)、日常生活能力(Barthel)、肌张力(MAS)评分变化情况。结果 2组治疗前Fugl-Meyer、Barthel评分对比差异无统计学意义(P0.05),研究组治疗后Fugl-Meyer、Barthel评分与对照组比较明显提高,差异有统计学意义(P0.05);2组治疗前CSS、MAS评分对比差异无统计学意义(P0.05),研究组治疗后CSS、MAS评分与对照组比较明显降低,差异有统计学意义(P0.05)。结论 A型肉毒毒素注射液与康复训练联合治疗痉挛性脑瘫,可显著改善患儿肌张力及日常生活能力。     

Factors associated with satisfaction with care among patients with epilepsy

OBJECTIVE: The purpose of the work described here was to determine those variables associated with satisfaction with care among patients with epilepsy. METHODS: We interviewed patients followed at a tertiary epilepsy center. Predictor variables included age, gender, race, education, income, insurance, seizure frequency, and Quality of Life in Epilepsy-10 inventory (QOLIE-10) results. Target variables were the subscales of the Short Form Patient Satisfaction Questionnaire (PSQ-18). We used univariate analysis to identify those variables significantly associated with the subscales and multiple linear regression to determine those independently significant. RESULTS: The study population comprised 193 patients. Lower education and better QOLIE-10 scores were independently associated with general satisfaction with care. The mental health scale was associated with general satisfaction with care. Lower educational level was the only variable independently associated with patient satisfaction with communication, the financial aspect of care, and time spent with physician. CONCLUSION: Lower educational level and better quality of life are the main variables associated with higher general satisfaction with care among patients with epilepsy.     

Treatment with rituximab in patients with polyneuropathy with anti-MAG antibodies

Journal of Neurology -     

Surgical Outcome in Patients with Epilepsy with Occult Vascular Malformations Treated with Lesionectomy

Summary: Purpose: This retrospective study reports the long-term surgical outcome of patients with medically refractory epilepsy and vascular malformations who were treated with lesionectomy. A detailed analysis of surgical failures had been performed in an attempt to define predictors of surgical success and failure.
Methods: Fifteen patients with medically intractable epilepsy and angiographically occult vascular malformations (AOVMs) were treated surgically with lesionectomy at Duke University Medical Center. Lesionectomy consisted of removal of the AOVM and surrounding hemosiderin-stained brain only, without the use of electrocorticography (ECoG) to guide resection.
Results: Eleven (73%) patients are seizure free after lesionectomy. Three showed no significant improvement, and one patient died, presumably after a seizure. Age of onset, duration of seizures, age at resection, and gender did not affect outcome. All patients with neocortical AOVMs in whom EEG findings correlated with the site of the lesion were seizure free after lesional resection. Treatment failures were associated with the presence of multiple intracranial lesions, poorly localized or diffuse EEG findings, discordant positron emission tomography (PET) imaging, or with a lesion in close proximity to the limbic system.
Conclusions: Lesionectomy, with removal of surrounding hemosiderin-stained brain, can be considered the procedure of choice in carefully selected patients with epilepsy with occult vascular malformations.     

Children with ADHD and motor dysfunction compared with children with ADHD only

The purpose of this study was to identify group differences in children with attention-deficit-hyperactivity disorder and motor dysfunction (ADHD-MD) and ADHD only, and to evaluate the medication responsiveness of ADHD-MD. Sixty-three children (49 males and 14 females; mean age 9 years 10 months, SD 2 years 10 months) underwent a triple blind, placebo-controlled crossover study evaluating two dose levels of methylphenidate (0.3 mg/kg and 0.5 mg/kg [corrected], twice daily) and placebo. Forty-nine trials were completed. Nineteen were children with ADHD-MD, 44 had ADHD only. Behavior and functioning were assessed at home and at school. Treatment effects were assessed using the Abbreviated Symptom Questionnaire for Parents and Teachers. Children with ADHD-MD were more likely to have severe ADHD-combined type and other neurodevelopmental and behavioral problems. Both groups of children had a linear dose response to medication (placebo, low, high) and there was no evidence of a group by dose interaction or an overall group effect at home or school. The lack of group effect suggests that these children responded to medication like the other subgroups.     

Chronic headache with vasospasm treated with nimodipine

Journal of Neurology -