Individuals with Prader-Willi Syndrome (PWS) are at risk for autism spectrum disorder (ASD), including socialization problems. The PWS chromosome 15q11-13 maternal uniparental disomy (mUPD) subtype displays greater ASD symptoms than the paternal deletion (DEL) subtype. Since interpreting faces leads to successful socialization, we compared face discrimination in PWS with ASD to explore the socialization characteristics of these disorders. Although face processing impairment in ASD is well documented, PWS face processing research is limited. Forty-four PWS participants (14 DEL and 19 mUPD) and 17 participants with ASD were measured on face discrimination. PWS and ASD participants scored in the impaired functioning range. For primary findings, DEL and mUPD PWS genetic subtype groups did not differ. These findings suggest PWS individuals, regardless of subtype, show impaired face processing similar to ASD. This research highlights the need for additional research on social cognitive functioning in PWS to understand the role of 15q11-13 in ASD. 相似文献
Introduction Difficulties imitating gestures have been found in several studies in children and adolescents with Autism Spectrum Disorders
(ASD). It has been hypothesized that imitation abilities might be precursors of language abilities in young children with
autism. No study on imitation and language abilities in adolescents with ASD has been performed to date.
Methods Fifteen male adolescents with ASD, 16 male and 13 female controls were compared regarding imitation abilities of upper and
lower facial movements, and language skills as assessed by the pragmatic rating scale and the Aachen Aphasia test (AAT).
Results Autism Spectrum Disorder subjects showed reduced imitation abilities of facial movements and non-meaningful combined hand-and-finger
gestures. Regarding language, ASD subjects showed difficulties in AAT spontaneous speech measures and reduced pragmatic language
abilities. Correlations of imitation and language measures differed between ASD, male and female controls.
Conclusion The weak and differential correlations of imitation and language measures in the three comparison groups might imply a differential
organization of language and imitation networks in the three comparison groups. Pragmatic abilities, which are a central feature
in ASD, were not related to imitation abilities. Therefore, imitation and language abilities in ASD might not be as closely
correlated as previously expected.
An erratum to this article is available at . 相似文献
Introduction: autism spectrum disorder (ASD) and intellectual disability (ID) seem to influence the risk of and vulnerability to exposure to trauma and adverse events. While assessment of a psychiatric disorder in ASD and ID generally is challenging, identification of post-traumatic stress disorder (PTSD) seems particularly so, and knowledge does not seem easily accessible. Methods: This article provides a systematic review of studies describing trauma reactions in individuals with both ASD and ID, including studies involving any single case with the combination of ASD, ID, and PTSD. To systematically explore PTSD symptom presentation in the group, all reported symptoms from studies were assigned by DSM-5 criteria. Results: Eighteen studies met the inclusion criteria, eight group studies and 10 case studies. Assessment methodology in studies varied, as did the format of symptom report. DSM-5 criteria provided a useful framework for integrating findings across studies, indicating that PTSD may be identified in individuals with ASD and ID. However, symptoms involving alterations in arousal and negative alterations in thought and behavior seem more easily identified than symptoms of reexperiencing and avoidance. Conclusions: There is an urgent need to identify behavioral equivalents to PTSD symptoms in this group, making it possible to identify warning signs of trauma and abuse even if such incidents are not known to family or professional carers. 相似文献
Purpose: Parents/caregivers of children with autism spectrum disorder (ASD) have varying types of initial concerns regarding their child’s development, which may be culturally bound to parents’ perceptions of their child’s development. This study investigated differences in the types of initial developmental concerns reported by parents or caregivers of different racial/ethnic groups with children in an early intervention program.
Method: This study examined the frequency of endorsement of different types of concerns in African American, Caucasian, and Hispanic families.
Results: No significant differences between racial/ethnic groups were found in the endorsement of concerns related to communication, language/speech, motor, problem behavior, sensory, feeding, prematurity, attention, adaptive functioning, and medical conditions. Racial/ethnic groups differed significantly in their endorsement for social concerns.
Conclusion: Racial/ethnic group differences were confirmed regarding initial developmental concerns related to social behavior, which may be due to cultural beliefs. The implications of these findings on early identification are discussed. 相似文献
Recent reports suggest that individuals with autism spectrum disorders (ASD) may experience depression at a high frequency, yet few published studies address this issue, especially among adults. In the current investigation, we reviewed features of depression and comorbid traits among depressed inpatients with intellectual disabilities (ID) as a function of ASD. A retrospective chart review was performed for 53 inpatients meeting criteria for depression (13 individuals with ASD and ID and 40 matched individuals with ID but without ASD), all of whom had received a diagnosis of depression at the time of discharge from a specialty psychiatric unit for adults with ID. The depression diagnoses were based on a comprehensive clinical assessment; specific mood and anxiety symptoms were reported by informants at the time of intake using the Mood and Anxiety Semi-Structured (MASS) Interview for Patients with Intellectual Disabilities (Charlot, Deutsch, Hunt, Fletcher, & McIlvane, 2007Charlot, L., Deutsch, C., Hunt, A., Fletcher, K. and McIlvane, W.2007. Validation of the Mood and Anxiety Semi-Structured (MASS) Interview for Patients with Intellectual Disabilities. Journal of Intellectual Disabilities Research, 51: 821–834. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]). Overall, few qualitative differences were detected between the 2 groups. Both depressed inpatient groups had high rates of comorbid anxiety disorders as well as externalizing behaviors. Inpatients with ASD had a total of 2 more symptoms (out of 29 possible symptom items) than their depressed peers without an ASD diagnosis (mean scores of 12.23 and 9.85, respectively). Anxiety disorders were reported in 62% of individuals with ASD and 38% of those without ASD. Antipsychotic medication was prevalent among the patients with ASD and depression. Over 80% of the inpatients with ASD and depression, compared with 49% of the non-ASD group, were treated with these medications. 相似文献
This study aimed to investigate temporally extended self-awareness (awareness of one’s place in and continued existence through
time) in autism spectrum disorder (ASD), using the delayed self-recognition (DSR) paradigm (Povinelli et al., Child Development
67:1540–1554, 1996). Relative to age and verbal ability matched comparison children, children with ASD showed unattenuated performance on the
DSR task, despite showing significant impairments in theory-of-mind task performance, and a reduced propensity to use personal
pronouns to refer to themselves. The results may indicate intact temporally extended self-awareness in ASD. However, it may
be that the DSR task is not an unambiguous measure of temporally extended self-awareness and it can be passed through strategies
which do not require the possession of a temporally extended self-concept.