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1.

Background

Persons with schizophrenia are thought to be at increased risk of committing violent crime – 4 to 6 times the level of general population individuals without this disorder. The relationship between schizophrenia and homicide is complex and cannot be reduced to a simple causal link.

Objectives

The objectives of this study were to describe the characteristics of homicide in Moroccan patients suffering from schizophrenia and to determine the correlated sociodemographic, clinical and toxic variables.

Methods

The study included two groups of patients with a DSM IV diagnosis of schizophrenia who attended the “Ibn Nafis” university psychiatric hospital of Marrakech in Morocco. The first group was composed of 30 patients hospitalized for homicide in the forensic unit between 1 January 2005 and 31 August 2015. The second group included 90 patients without any criminal record. These two groups have been matched according to age and gender. Demographic, clinical and therapeutic variables were analyzed and compared between the two groups.

Results

Data analysis has objectified the following results: the mean of age in the first group was 37.03 (± 9.09) and in the second group was 31.4 (± 8.76). No significant differences were found between the two groups regarding the different sociodemographic variables and the age of onset of disease. Significant differences were found between the two groups regarding: personal antecedents of attempt of homicide (P = 0.003), personal antecedents of attempt of suicide (P < 0.001), a history of previous violence (P = 0.005), untreated psychosis before the act (P < 0.001), poor medication compliance and a low familial support (P < 0.001), antisocial behavior (P < 0.001) and addictive behavior (P = 0.005).

Discussion

Several studies identified some possible predictor factors for violent behavior: poor compliance, lack of insight impulsivity and paranoid–hallucinatory symptoms, systematized delusions and addictive behavior seem to considerably increase the risk of turning to violence. Demographic variables as suggested by other studies are less valuable predictors of homicide in patients with schizophrenia.

Conclusion

Awareness of these factors will allow us to provide improved prevention of violence within schizophrenic subjects. Interventions for reducing such behavior should focus on clinical variables and integrate an early diagnosis of the disease and an improvement of medication compliance.  相似文献   

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Background

Schizophrenia is a chronic, relapsing, mental disorder, and lack of adherence is a common and severe problem in such patients leadingto global and heavy consequences for patients (relapses, hospitalizations, impaired quality of life…), for the family and for society. Improved understanding of the underlying reasons will help to form intervention strategies relevant to the context.

Objectives

We aimed to assess medication adherence among stable patients suffering from schizophrenia and to identify factors associated with non-adherence.

Methods

This is a retrospective cohort study of outpatients with schizophrenia at the psychiatric hospital Ar-razi of Salé (Maroc). The patients were aged over 18, clinically stabilized under the same treatment during the three months prior to inclusion. Data (demographic, clinical and therapeutic) was collected by a questionnaire developed for this purpose. Assessment of adherence and awareness of the disorder (insight) were performed respectively by two validated scales: Medication Adherence Rating Scale the (MARS) and scale Q8.

Results

Fourty percent of schizophrenic patients included in our study were not compliant to treatment. Compared to adherent patients, non-adherent patients had history of substance use (57.6 % vs. 42.4 %, P < 0.05), were less aware of their disorder (77.8 % vs. 22.2 %, P < 0.01), had significantly more drug intake per day (2.4 vs. 1.9, P < 0.01), took significantly more tablets per day (2.8 vs. 2.2; P < 0.05) and complained of significantly more side effects (43.2 vs. 56.8, P < 0.05). A logistic regression model had shown that only side effects, lack of insight, and a history of substances use are significant predictors of poor adherence in patients with schizophrenia.

Conclusion

The results of this work should guide our efforts to improve adherence in patients with schizophrenia. Waiting for new drugs with fewer side effects and better benefit/risk, some strategies would help to improve adherence to treatment. For example: implementation of strategies to manage psychoactive substance use, structured psycho-educational strategies to improve insight, and training therapists to improve the therapeutic alliance should be established.  相似文献   

4.
In 1997, an expert group from WHO Europe made a report and international recommendations for training and practice in therapeutic education of the patient. The French version of the text was published the following year. In France, it is the law of 21 July 2009, called “Patient Health Territory Hospital”, which formalizes this practice and inscribes it in the course of care of patients suffering from chronic diseases. The TPE is regulated by official texts and must respect the recommendations of the High health authority. That is the French peculiarity. Thus, any TPE program must be authorized by the Regional Health Agency (ARS) on which the establishment is dependent. Practices that would not be authorized by these ARS are not entitled to be called TPE, even if they meet all of the criteria. Although included in the law in 2009, this practice of TPE remains long unknown in France to most hospital practitioners. Thus, concerning our psychiatric hospital, located 50 km south of Paris, it is a certification visit that requires us in 2011 to register the TPE in our program of establishment. A small group of professionals of varied training (psychiatrist, addictologist, general practitioner, pharmacist, psychologist, nurse, social worker, educator, legal agent, dietician, caregiver) is working on this task in the course of the year 2012. We decide to build a program for people suffering from schizophrenia. We form a partnership with an association of Patient families, the UNAFAM. We choose to do only group support, more effective in the pathology we have retained. When the practitioners involved present their project in front of their peers, they have not yet received the mandatory 40 hours training required by the HAS for any therapeutic education workshop facilitator. This may explain that our project is being received with so little enthusiasm. We are faced with many reproaches. However, we are pursuing the construction of the workshops, which will be disturbed by the compulsory training of 40 hours that only be in 2013. We realize that the support of our hierarchy is essentially moral, since no dedicated time will be assigned to this program, which we have to carry out with the same means. We start our first workshops in September 2014, with ARS funding as an experimental project. Our program includes the following eight workshops: “Living with your illness”, “understanding and managing your treatment”, “social skills”, “lifestyle”, “addicts”, “Libido”, “do”, “do with”, “do together”, “caregivers”. The nurse coordinator carries out the educational diagnosis and the participant decides which workshops he wants to participate in. This nurse coordinator participates in all the workshops in addition to the specific animators. The workshops follow each other and two programs are closed over the year. There is no mandatory order and participants can integrate a program at any time. Often, they ask to participate in other workshops than those initially chosen after having experienced the group. The approach of the workshop animators is based on the motivational approach. After four years of operation, the effectiveness of this program is being evaluated. The feedback from participants is in any case very favorable, and they all underline their pleasure in having interlocutors who are no longer in the usual caregiving posture. But we also measure the fragility of this program, depending on a very small number of people.  相似文献   

5.

Objective

The starting-point of this article consists in considering what is contemporary as being post-contemporary. Like the present, what is contemporary is something that cannot be pinned down. It requires hindsight in order to analyse it. Our first objective is to approach our post-contemporary age as being characterised by radicality. This takes the form of a search for origins, which shows up in a return of the religious, alongside the emergence of an anguish reducing things to nothingness. Solitude is a characteristic of this radical position, raising the issue of an otherness that turns anguish into hatred, whether of oneself or of the other. Indeed, the post-contemporary subject acts-out when faced with social ties and a culture that can no longer uphold him. Our second objective is to demonstrate that the effect of this radical position leads the subject to use his body as the only way out. Having become an external organism, the body comes to represent that which is intolerable for the subject. In order to escape anguish turned into hatred, the subject excludes himself from his own body. Finally, the third objective is to show how the free radical subject is a product of ‘liberal’ society, seeking to create his freedom at every moment.

Method

Our method uses clinical practice. We work from two contrasting clinical fields; on the one hand acting out in the form of acts of murder or suicide, on the other hand acts of passage from one gender to another.

Results

Acting out and acts of passage both relate to these free radical subjects who shape their own body, or who shape the body of the other as though it were their own.

Discussion

We will discuss the points of convergence and divergence between these two situations.

Conclusion

Our conclusion demonstrates that acts on the body of the other and acts on one's own body coincide. Acting out in the form of murder or suicide masks the wish for an act of passage, which is however impossible. The act of passage from one gender to the other requires an acting out that sometimes cannot be countenanced. With those whose aim is an act of passage, it is an acting out that must be sought. Similarly, with those who act-out, the need is to try to restore, in the aftermath, the possibility of an act of passage.  相似文献   

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Introduction

In schizophrenic disorders, supportive psychosocial therapies have been used as adjuncts to pharmacotherapy to help alleviate residual symptoms and to improve social functioning and quality of life. Among these therapies, psychoeducational therapies showed a significant efficacy on improving drug adherence and on reducing relapses. However, according to the French Health Agency, fewer than 10% of psychiatric structures in France offer registered psychoeducation programs. Caregiver apprehension of patients’ depressive reactions to the awareness of the disease could underlie the underuse of psychoeducation therapies. Indeed, the psychoeducation programs’ impact on objective and subjective quality of life is discussed among the literature. In this context, we conducted a retrospective, monocentric, open-labelled and non-controlled pilot study to measure the impact of a registered psychoeducation program on objective and subjective quality of life of patients suffering from schizophrenia. Secondary objectives included measures of the effects on drug observance and awareness of the disease.

Methods

We included stabilized patients over the age of eighteen suffering from schizophrenia. Referent psychiatrics were asked to inform the patient of the diagnosis and to prescribe psychoeducation therapy. From 2011 to 2014, we offered three ambulatory programs, each program including fifteen two-hour group sessions. The groups were opened for three to six patients and managed by two caregivers. Themes discussed during the sessions included: schizophrenic disease, treatments, relationships to family, diet, social issues, toxics, relaxation. Objective and subjective quality of life were evaluated one month before and one month after the program using respectively the global assessment functioning (GAF) and the subjective quality of life (SQoL) scales. The Medical Adherence Rating Scale (MARS) and the French IQ8 scale evaluated respectively drug adherence and awareness of the disease. All patients gave their written consent for the study. Based on medical records and scales, we compared data before and after the program using the Wilcoxon test, adapted for small samples.

Results

Fourteen patients, with a mean age of 37.6 years, were included. All patients had a chronic antipsychotic treatment and four benefitted from a bitherapy with a mood stabilizer. The mean length of disease was 15.3 years, with a mean number of 3.4 hospitalizations before inclusion. The participation rate was nearly twelve sessions out of fifteen. Mean GAF score before the program was 48/100. After the program, mean GAF score was significantly increased to 54/100 (P = 0.008). As to SQoL score, we found a significant difference of the sub item psychological well-being from 3.2/5 before the program to 3.8/5 after the program (P = 0.03). Global SQoL score and other sub items (self-esteem, resilience, and physical well-being) showed a slight but not significant improvement. The sub items family relationships and sentimental life were diminished, non-significantly. Concerning the drug adherence, the mean MARS score was significantly increased from 6.1 to 6.4/8 (P = 0.03). Comparison of the insight IQ8 scale showed a slight but non-significant increase. When asked to note the program, patients were globally very satisfied, with a mean rate of 8.6/10. Of fourteen patients, one needed to be hospitalized three years after program.

Discussion

This retrospective study on a small sample of patients suffering from schizophrenic disorder pointed out a significant improvement on drug adherence, objective quality of life and psychological well-being, after an eight-month registered program of psychoeducational therapy. These results are in line with a recent report from the Cochrane group who reported a significant raise of GAF associated with psychoeducational therapies. The literature data for subjective quality of life are more contradictory. Despite the small sample and evaluation means that need to be corrected in further studies, we reproduced the results described in the literature regarding the improvement on drug adherence. However, the stability of these effects should be checked in the medium and long term.

Conclusion

Adjunctive psychoeducation therapy has a positive impact on reducing relapses in schizophrenia. In this study, we showed a significant benefit on drug adherence, objective quality of life and psychological well-being on a small sample of patients and provide arguments for the development of psychoeducation programs which are currently underrepresented in France. Our results encourage conducting a further prospective multicenter controlled study on a larger sample to clarify the benefit of psychoeducational therapy on objective and subjective quality of life in schizophrenia.  相似文献   

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Objectives

Video games and virtual reality have recently become used by clinicians for training or information media or as therapeutic tools. The purpose is to review the use of these technologies for therapy destined for schizophrenia patients.

Methods

We conducted a review in October 2016 using Pubmed, Scopus and PsychInfo using the following Medical Subject Headings (MESH): “video games”, “virtual reality” and “therapy, computer-assisted/methods”, each associated with “schizophrenia”. Papers were included in the review if: (a) they were published in an English, Spanish or French-language peer-reviewed journal, (b) the study enrolled patients with schizophrenia or schizo-affective disorder, (c) the patients used a therapeutic video game or therapeutic virtual reality device.

Results

Eighteen publications were included. The devices studied are mainly therapeutic software developed specifically for therapeutic care. They can be classified according to their therapeutic objectives. These targets corresponded to objectives of psychosocial rehabilitation: improvement of residual symptomatology, cognitive remediation, remediation of cognition and social skills, improvement of everyday life activities, support for occupational integration. Very different devices were proposed. Some researchers analysed programs developed specifically for patients with schizophrenia, while others were interested in the impact of commercial games. Most of the studies were recent, preliminary and European. The impact of these devices was globally positive, particularly concerning cognitive functions.

Conclusions

Computer-assisted therapy, video games and virtual reality cannot replace usual care but could be used as adjunctive therapy. However, recommending their use seems premature because of the recent and preliminary character of most studies. Moreover, a link is still lacking between this field of research in psychiatry and other fields of research, particularly game studies. Finally, it might be interesting to analyse more precisely the neuropsychological impact of existing commercial games which could potentially be useful for psychosocial rehabilitation.  相似文献   

11.
IntroductionSocial autonomy concerns specific areas that people with chronic psychiatric disorders, such as schizophrenia, face daily when they live in the community. The degree of social autonomy is one of the principal determinants of success of the therapeutic project for patients suffering from schizophrenia. However, the domains of social autonomy would depend on the socio-cultural context and the familial and professional environment of the country.ObjectivesThe objectives of this study were to evaluate the social autonomy level and to research its associated factors in a sample of Tunisian out-patients with schizophrenia.MethodsIt was a cross-sectional study of 115 out-patients (mean age: 37.6 ± 10.2 years, 75.7% male), followed for schizophrenia according DSM-IV diagnostic criteria and treated with long-term antipsychotics, mainly first generation (81%), with a mean daily dosage of 1130 ± 875 mg in chlorpromazine equivalent. Data were collected during interviews with patients and their family members and supplemented by the review of medical records. Degree of social Autonomy was assessed by the Leguay's 17-items Social Autonomy Scale (EAS), exploring five dimensions: personal care, management of daily life, resource management, relationship with outside and affective and social relations. Global functioning level was assessed by the Global Assessment of Functioning (GAF) scale.ResultsThe total EAS score ranged from 14 to 90 with a mean score of 56.6 ± 16.8. Higher sub-scores indicating a poor social autonomy concerned the dimensions of “relationship with the outside world”, “resource management” and “management of daily life”. A negative correlation was found between the EAS total score and the GAF score (r = −0.78, P < 0.0001). Thus, the lower GAF score suggesting impaired global functioning was associated to the higher EAS score in favor of altered social autonomy. Altered social autonomy was associated with low school level (P = 0.02), lack of regular professional activity (P = 0.001), disorganized subtype (P = 0.002), negative symptoms at the last hospitalization (P = 0.03), continuous course (P < 0.0001) and daily dosage of antipsychotic medication (P = 0.02). However, age or gender of the patients, psychiatric family history, age of onset, duration of untreated psychosis, number and duration of previous hospitalizations, antipsychotic treatment generation were not associated with social autonomy in our sample.ConclusionsDespite therapeutic advances in recent decades, the social autonomy of our patients with schizophrenia remains precarious. Several socioeconomic and clinical factors seem to be involved. Further interventions will be needed to enable our patients to function more actively and autonomously in society.  相似文献   

12.
ObjectiveThrough the study of a social and health care program supporting the recovery of people living with schizophrenia (PASSVers), this article aims to show the interest of using the Alceste lexical analysis method to evaluate health-promoting activities.MethodSemi-structured interviews were conducted with users supported for 12 to 20 months (n = 21), nurses and social workers (n = 11), and family caregivers (n = 6). The corpus was analyzed using Alceste software.ResultsEach population used a specific vocabulary to evaluate the program, reflecting different viewpoints towards it. The contextualization of the vocabulary significantly present in the discourse classes highlighted the program's effects on each of the three groups. We noticed a shift in posture among professionals with a detachment from purely medical concerns, as well as the impact of the support on the health of the users and on the well-being of their relatives.DiscussionLexical analysis appeared particularly relevant for evaluating a health promotion program such as PASSVers. Indeed, this tool for interpreting a corpus is based on the distribution of vocabulary, excluding any judgment by the analyst. Thus, this method ensures a rigorous methodological basis for determining the classes of discourse to be interpreted.ConclusionThe Alceste method enables the rigorous study of a corpus through a detailed analysis of the vocabulary. In the evaluation of the PASSVers program, it allowed us to highlight the specific points of view of each group, and to identify the benefits of the program for each of them.  相似文献   

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《Revue neurologique》2014,170(8-9):497-507
Epilepsy is a chronic disease with a wide range of presentations occurring at any age. It affects the patient's quality of life, implying a need for numerous healthcare services. Therapeutic education programs (TEPs) are designed to match patient age, disease course, and individual learning abilities. In France, these programs are proposed by the national health authorities (Superior Health Authority), and authorized by the Regional Health Agencies. Two years ago, a Therapeutic Education Programs Commission (TEPC), supported by the French League against Epilepsy (FLAE), was created. The goal was to bring together representative healthcare professionals in a working group in order to standardize practices. This led to the creation of a national reference of healthcare skills specific for children and adults with epilepsy. Five tables, for five “life periods”, outline the framework of this professional reference tool. Program personalization, an essential part of TEPs, is necessary to develop a creative atmosphere. This slow process is specific to the various stages of life and can be influenced by the occurrence of various handicaps. Family and caregivers make key contributions to the process. The national framework for therapeutic education in epilepsy serves as a central crossroad where professions can find essential information to create or adapt their own TEPs. In the near future, regional experiences will be documented and collected for regular updates. This professional therapeutic education network will help promote therapeutic education programs and facilitate standard practices. Finally, several TEP files and tools will be shared on the FLAE website available for professional access. Today, the group's goal is to achieve national deployment of this “referential” framework.  相似文献   

15.

Objectives

The studies of comorbidities, risk factors of organic pathologies, or declining life expectancy of patients with mental disorders, particularly psychotic disorders, are the subject of many publications. The cares, including palliative care, for these patients, but also the patients and caregivers experience in these situations are rarely described in the literature. From the story of Peter, we evoke the palliative support and the management of these patients in a psychiatric hospital.

Patient

Pierre was monitored for paranoid schizophrenia. He was hospitalized in a psychiatric hospital after a suicidal attempt. Before that event, he spent a large part of his life in the psychiatric hospital, with more than 50 hospitalisations. After 1 month of hospitalisation, a diagnosis of a lung cancer with lethal prognosis was done. Pierre was very anxious, especially about the medical exams, and also the chemotherapy. He did not eat and sleep anymore. He told every doctor and nurse that he did not want any treatment, especially not chemotherapy. After discussions with Pierre, his family, specialized doctors in pneumology and palliative care, we decided to respect his will, and Pierre was informed about that decision. After that, he felt relieved, ate and slept again, and kept his normal activities in the hospital. Pierre died 4 months after the diagnosis was done.

Results

We present a brief introduction on palliative care history in France, and discuss the specificities of this kind of monitoring, especially about the management of the medical teams, but also the assessments of the behavior or the pain. It is sometime really difficult to assess behavior and pain for patients suffering from schizophrenia. These patients cannot talk about their pain as well as other patients because of the language impairment and lack of capacity of expressing their feelings. Also, it seems, in recent research, that schizophrenic patients do not feel the pain as other patients. These specificities increasingly complex the evaluation, at the limit of normal and pathologic event. Beyond these practical aspects, we initiate a reflection on the challenges of this unusual support. In fact, we discuss the end of life and the specific follow-up of this patient, and the legal aspects in this situation of patients suffering from severe psychiatric illness. We also talk about the impact of this kind of management on the patient and the medical team. We question and discuss the possibility of patients suffering from severe schizophrenia to take some decisions about their health. Finally, we question ethical aspects in this specific context, dealing with unreasonable obstinacy, refusal of treatment. In fact, it is an ethical question to know if we have to consider the will of a patient suffering from judgment trouble because of his psychiatric disease if he do not want a medical treatment. Do we have to respect that choice? Do we have to try to convince him, even if he will have some psychotic anxiety?

Conclusions

We discuss in this publication the care for patient suffering from psychosis disorders, concerning the patient's right, but also our responsibility as doctors in medical decision. In the situation described, limiting curative care was adapted to the gravity of the disease, and did not compromised the patient's integrity. The patient's right and responsibility needs to be treated for each situation, without any theorical previous rules, except the Leonetti law. We argue that caregivers in psychiatric hospital have to accompany these patients, also at the end of their lives. Some teams in psychiatric hospital works for the prevention and treatment for the physical pain, and we probably need to extend their abilities to healthcare at the end of life, promoting medical education.  相似文献   

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《L'Encéphale》2019,45(2):127-132
IntroductionBipolar disorder is a mental illness that is associated with a long-term impairment in psychosocial functioning and quality of life. The objective of this study was to evaluate the influence of a therapeutic education program on the quality of life of patients with bipolar disorder (type 1 or 2).MethodThis study included 18 patients with bipolar disorder (type 1 or 2) following the therapeutic education program on bipolar disorder which includes 8 sessions of 2 hours each. The assessment of quality of life and mood, self-esteem, insight and global functioning was performed before and after the program using the following tools: World Health Organization Quality Of Life questionnaire in short version (WHOQOL-Bref), Hamilton Depression Rating Scale, Young Mania Rating Scale, Rosenberg Self-Esteem Scale, Birchwood Insight Scale and Global Assessment of Functioning Scale. The total score of WHOQOL-Bref constitutes the primary study outcome. The under-scores of WHOQOL-Bref as insight, self-esteem, functioning, depression and mania scores constitute secondary outcomes.ResultsOur results show an improvement in quality of life, regarding global and main dimension scores of WHOQOL-Bref. The mean total scores for quality of life at the beginning and the end of the program were respectively 55.47/100 (standard deviation = 14.11) and 60.03/100 (standard deviation = 12.62). However, the difference was still not significant even after statistical adjustment with depression, mania and functioning scores. Self-esteem was significantly improved (P = 0.0469). Quality of life and self-esteem evolutions were strongly related (correlation coefficient = 0.80, P = 0.0006). At the end of the program, the less depressed the patients were, the better their quality of life was (correlation coefficient = 0.67, P = 0.0090). We did not find any correlation between quality of life and mania intensity or global functioning level at the end of the program.ConclusionThis study suggests a need to focus on self-esteem perception in order to understand and ameliorate the quality of life of patients with bipolar disorders. Going further, the use of bipolar disorder specific scales to assess quality of life would be more relevant.  相似文献   

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Since the Carter judgment in 2015, voluntary euthanasia and assisted suicide are legal in Canada. The purpose of this article is to analyze the relevance of making people with mental disorders eligible for medical aid in dying (MAD). The text consists of three parts. The first part presents the history of the legalization of the MAD in Canada. In the second part, we discuss the extension of the MAD to individuals suffering from mental disorders. We then insist on five aspects: the MAD and suicide in Quebec, suicide's place in the values of Quebec society, a reflection on rational suicide and the impact of mental health on the ability to make decisions, the respect of the laws and their application as well as assisted suicide of people with mental disorders in Belgium and the Netherlands. In the third part, we suggest four recommendations: to extend the requests to cases with mental disorders whose suffering is refractory to all care, to increase the minimum delay for the treatment of these requests, to systematically include a mental health specialist and to involve the loved ones throughout the process.  相似文献   

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