抑郁症患者事件相关电位P300亚成分的研究

近年对事件相关电位Ｐ30 0 的研究证实 ,Ｐ30 0 可分出Ｐ3ａ、Ｐ3ｂ、Ｐ3ｅ和ＳＷ等亚成分[1 ] 。为验证此结论 ,我们做了以下工作。对象和方法　对象为上海市精神卫生中心患者 ,共 43例 (由于伪迹最后Ｆｚ脑区只有 35例 ,Ｃｚ脑区为 36例 )。均符合中国精神疾病分类方案与诊断标准第 2版修订本中情感性精神障碍抑郁发作标准 ;汉密尔顿抑郁量表 (ＨＡＭＤ)为(2 2 1± 3 8)分。 43例中男 2 2例 ,女 2 1例 ;平均年龄 (43±1 2 )岁。以上海市精神卫生中心职工为正常对照组 (ＮＣ组 ) ,共 39名。其中男 2 0名 ,女 1 9名 ;平均年龄 (39± 1 1 )…     

焦虑症和抑郁症患者认知电位P300对照研究

目的探讨焦虑症(AD)和抑郁症(CD)在事件相关电位(ERP)P300检测中的不同表现。方法收集符合CCMD-3诊断标准的37例焦虑症患者和32例抑郁症患者以及36例健康成人对照组(NC),使用美国仪器以及“听觉靶-非靶刺激序列”为诱发事件,完成P300检测。结果(1)AD组、CD组和NC组在靶潜伏期Pz脑区P3以及在靶波幅Pz脑区P2、P3和非靶波幅Pz脑区P2上均有显著差异(P<0.01)。(2)AD组主要成分P3表现为延迟,与NC组和CD组有极显著性差异(P<0.01)。(3)AD组和CD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P<0.05)。结论P300有可能作为AD组和CD组辅助诊断的一个脑电生理学标志。     

事件相关电位P300在抑郁症的应用意义

本文阐述了事件相关电位P300对抑郁症的评定作用，从而说明事件相关电位P300在抑郁症临床及科研中具有重要意义。     

焦虑症和抑郁症患者认知电位P300的比较

目的 探讨焦虑症(AD)和抑郁症(CD)在事件相关电位(ERP)P300检测中的不同表现.方法 收集37例AD患者和32例CD患者以及36例健康成人对照组(NC).使用美国仪器以及"听觉靶-非靶刺激序列"为诱发事件,完成P300检测.结果 (1)AD组、CD组和NC组在靶潜伏期Pz脑区P3以及在靶波幅Pz脑区P2、P3和非靶波幅Pz脑区P2上均有显著差异(P＜0.01).(2)AD主成分P3表现为延迟,与NC组和CD组有极显著性差异(P＜0.01).(3)AD组和CD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P＜0.05～＜0.01).结论 提示作为反映AD和CD认知功能障碍的客观生理指标,P300有可能作为AD和CD辅助诊断的一个脑电生理学标志.P300检查可作为成人精神科的必查项目.     

老年期抑郁症患者事件相关电位P300特征

目的：探讨有无自杀行为的老年期抑郁症患者认知功能的事件相关电位P300特征。方法：对60例老年期抑郁症患者（有自杀行为者20例,无自杀行为者40例）及60例性别、年龄匹配的正常老年人为对照,进行听觉诱发的事件相关电位P300检测。同时应用汉密尔顿抑郁量表（HAND）及老年认知功能量表（SECF）分别评价抑郁症组抑郁情绪及认知功能。结果：抑郁症组与对照组相比,P2、N2、P3潜伏期明显延长,P2、P3波幅明显降低;有自杀行为组N2、P3波幅比无自杀行为组明显降低。抑郁症组HAMD总分与P300各指标无相关,SECF总分与N2、P2、P3潜伏期显著负相关。结论：P300对老年期抑郁症患者早期认知功能损害评定具有一定价值,有、无自杀行为的老年期抑郁症患者认知功能损害不同。     

抑郁症的事件相关脑电位P300实验研究

目的探讨抑郁症听觉事件相关电位P300的变化特点。方法对35例抑郁症患者和31名健康成年人,应用美国NieoletBravo脑诱发电位仪进行P300检测。结果与正常组相比,抑郁症组Oz点P3潜伏期延迟[正常组（315±29）ms,抑郁症组（341±31）ms,t=3．50,P〈0．01],P2潜伏期延迟[正常组（165±19）ms,抑郁症组（175±21）ms,t=2．02,P〈0．05],P3波幅降低[正常组（9．5±6．1）μV,抑郁症组（4．5±3．1）μV,t=4．27,P〈0．01],非靶P2波幅降低[正常组（4．2±1．2）μV,抑郁症组（2．3±1．3）μV,t=6．14,P〈0．01]。结论P300是评定抑郁症患者大脑综合功能的有效工具,在临床上值得进一步推广应用。     

事件相关电位P300在抑郁症的应用意义

本文阐述了事件相关电位 P30 0对抑郁症的评定作用 ,从而说明事件相关电位 P30 0在抑郁症临床及科研中具有重要意义。     

老年抑郁症和阿尔茨海默症的听觉P300比较研究

目的比较老年抑郁症(SD)患者和阿尔茨海默症(AD)患者的听觉P300的特点。方法对36例SD患者、32例AD患者以及40名健康老人对照(NC组)进行P300检测。结果 SD组、AD组和NC组在靶潜伏期Cz脑区N2以及在靶波幅Cz脑区P3和非靶波幅Cz脑区P2上均有显著统计学差异(P<0.01)。AD主成份N2表现为延迟,与NC组和SD组有极显著统计学差异(P<0.01)。SD组和AD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著统计学差异(P<0.05或P<0.01)。结论作为反映SD和AD患者认知功能障碍的客观生理指标,P300有可能作为SD和AD辅助诊断的一个脑电波标志。     

男性首发抑郁症与精神分裂症患者事件相关电位P300的研究

目的:探讨男性首发抑郁症和首发精神分裂症患者事件相关电位P300的特征及差异。方法:入组首次发作且未经治疗的男性抑郁症患者50例(抑郁症组)、精神分裂症患者48例(精神分裂症组)与健康对照者45名(对照组)。使用听觉Oddball诱发模式测量P300电位的潜伏期和波幅;采用24项汉密尔顿抑郁量表(HAMD-24)评估抑郁症组患者的临床症状,并使用简明精神病评定量表(BPRS)评估精神分裂症组患者的临床症状。结果:与对照组相比,抑郁症组与精神分裂症组的P300电位均表现为N2、P3潜伏期延长(P0.01),P3波幅减低(P0.01),但两病例组间N2、P3潜伏期及P3波幅的比较差异无统计学意义(P0.05)。抑郁症组HAMD评分、精神分裂症组BPRS评分与P300各项指标均无显著相关(P均0.05)。结论:首发男性抑郁症和精神分裂症患者均存在认知功能受损,但尚未发现两种疾病之间存在认知功能的差异。     

强迫症患者听觉事件相关电位P300的研究

目的 探讨听觉事件相关电位（ERP） P300与强迫症患者各项指标的相关性.方法 将63例强迫症患者作为研究组,选取63名身心健康正常人为对照组,采用自制的一般状况调查表了解两组人员的基本情况,对两组人员分别进行事件相关电位P300的检测,对强迫症患者采用耶鲁布朗强迫症量表评估其病情.结果 研究组ERP各项指标中N2、P3潜伏期长于对照组（t分别为-1.568,-2.602;P＜0.05）,N1、P2、N2、P3波幅均小于对照组（t分别为2.505,2.646,3.029,4.904;P＜0.05）.强迫思维组N2、P3潜伏期长于强迫行为组（t分别为3.301,2.580;P＜0.05）,P3波幅低于强迫行为组（t=-5.240,P＜0.01）.经相关分析显示事件相关电位P300的P3波幅与强迫思维分及强迫行为分呈负相关（r分别为-0.384,-0.512;P＜0.05）,N2和P3潜伏期均与强迫思维分呈正相关（r分别为0.448,0.405;P＜0.05）.结论 听觉事件相关电位P300可以客观反映强迫症的认知功能.     

焦虑症的事件相关电位P300研究

目的观察焦虑症患者事件相关电位P300的变化特点.方法对22例焦虑症患者和22例健康成年人,应用Nicolet Bravo脑诱发电位做事件相关电位P300检测.结果与正常组相比,焦虑症组靶N2潜伏期延长(P<0.05),靶P2波幅低(P<0.01),靶P3潜伏期长且波幅低(P<0.01),非靶P2波幅低(P<0.01).P300各指标在男女性别之间的差异无统计学意义(P>0.05).结论焦虑症患者P300有多项指标变化,值得进一步随访.     

焦虑障碍的认知性电位P300研究

目的 探讨焦虑障碍听觉认知性电位P300的特点.方法 对32例焦虑障碍患者(AN组)和30名健康成年人(NC组),应用美国脑诱发电位仪进行P300检测.结果 与NC组相比,AN组Oz点P3潜伏期后移[NC组(328±16)ms,AN组(340±18)ms,t=2.801,P<0.01],P3波幅降低[NC组(6.1±2.0)μV,AN组(4.6±2.2)μV,t=2.84,P<0.05],非靶P2波幅降低[NC组(3.1±0.8)μV,AN组 (1.9±0.9)μV,t=5.61,P<0.01].结论 焦虑障碍认知性电位P300变化诸特点值得进一步随访.     

血管性痴呆的事件相关电位P300研究

目的探讨血管性痴呆(Vascular dementia,VD)的事件相关电位(Event-related potentials,ERP)P300的变化特点.方法应用Nicolet Bravo脑诱发电位仪对18例VD患者和20例正常老年人进行P300检测.结果与正常老年组相比,VD组的P300表现为靶N2、P3潜伏期延长,靶P3、非靶P2波幅下降,有显著性差异(P＜0.05-0.01).结论P300可反映VD认知功能的变化,尤其是靶P3的潜伏期和波幅,有助于评估VD的认知功能状态.     

正常儿童与孤独症患儿事件相关电位P300 对照研究

目的探讨孤独症患儿的事件相关电位P300的特点.方法使用美国Nicolet Spirit脑电生理仪记录37例孤独症患儿和30名正常健康儿童的P300特点.结果(1)与正常儿童比较,孤独症患儿P300波形变异较大.(2)在靶潜伏期P3上,孤独症患儿延迟于正常儿童,差异有极显著性(P＜0.01).(3)在靶波幅P3和非靶波幅P2上,孤独症患儿波幅又降低于正常儿童(P＜0.01和P＜0.05).结论P300对临床辅助诊断孤独症有参考价值.     

血管性痴呆患者治疗前后P300的变化

目的探讨事件相关电位(Event-related potentials,ERP)P300在评估血管性痴呆(vascular dementia,VaD)患者认知功能中的价值.方法应用Nicolet Bravo脑诱发电位仪对30例VaD患者分别在治疗前和治疗后6周进行ERP P300检测,同期间使用简易精神状况检查(MMSE)来评估患者的认知功能.结果治疗前,VaD组有明显的认知功能缺损,其MMSE[(17.52±3.57)分]分值低于NC组[(26.57±1.43)分,(P＜0.01)].其P300表现为P2、N2、P3潜伏期长,P2、P3波幅低,非靶P2波幅低(P＜0.05～0.01);治疗后,随着VaD患者的认知功能的恢复,其P300主要表现为P3潜伏期缩短,P3波幅的增高(P＜0.05).结论动态检测P300有助于反映VaD患者认知功能的变化,尤其是P3潜伏期的变化较为敏感.     

Alzheimer病的事件相关电位P300异常变化

目的探讨Alzheimer病（AD）患者与正常老年人在事件相关电位（Event-relatedpotentim,ERP）P300检测中的不同特点。方法应用国产WOND2000C脑诱发电位仪对32例AD患者和39例正常老年人进行P300检测。结果与正常老年组相比,AD组的P300表现为靶N2、P3潜伏期延长,靶P3、非靶P2波幅下降,有显著性差异（P〈0．05-0．01）。结论P300可反映AD认知功能的变化,靶P3的潜伏期和波幅,有助于评估AD的认知功能状态。     

Event-related potential P300 in cerebral infarction

N1, P2 and P300 potentials were studied in 20 cases of cerebral infarction and 47 healthy controls with standard technique of auditory event-related potentials. Healthy controls of both sexes, different ages, education levels and cognitive capacity did not show apparent differences in the latency of p300 (P greater than 0.05, respectively). The patient group, however, revealed significant (P less than 0.001) prolongation of latency of P300 (mean = 409.6 +/- 50 ms) as compared with 28 well matched healthy subjects (mean = 337.7 +/- 24 ms). Although there was some decline of amplitude of P300 in the patient group, the difference between the control and patient groups was not significant (P greater than 0.05). There was significant difference in the Cognitive Capacity Screening Examination findings between the control and patient groups (P less than 0.01), but it seemed that the evaluation of latency of cognition-related p300 might be more objective and sensitive (P less than 0.001).     

Event-related potential (P300) in epilepsy

The P300 component of auditory event-related potential was studied in 39 patients with temporal lobe epilepsy (TLE), 26 with idiopathic generalized epilepsy (IGE) and 28 controls. The age-corrected P300 latencies were significantly longer in TLE patients compared with those in IGE patients and controls. Neither the duration of epilepsy nor clinical manifestation was related to the P300 component in the same epileptic syndrome. The age-corrected P300 latencies recorded from Cz were significantly prolonged in TLE patients with bilateral temporal EEG foci compared with those with unilateral focus. The effects of anti-epileptic drugs on the P300 component were not significant. Our findings imply that prolonged P300 latency in TLE patients, especially in those with bilateral EEG foci is due to damage of the hippocampus, which is potentially an epileptogenic focus.     

Event-related evoked potential P300 in frontotemporal dementia.

There are no studies on event-related cognitive potentials in frontotemporal dementia (FTD). In order to evaluate the aptitude and usefulness of the event-related P300 potential in this disease, we prospectively examined 60 cases: 11 patients with FTD diagnosed according to the Lund and Manchester criteria and Neary consensus criteria, 33 patients with a probable Alzheimer's disease diagnosis following NINCDS-ADRDA criteria, and 16 normal controls. P300 latency, amplitude and reaction time were recorded using an auditory oddball paradigm. In this sample, P300 potential could be reliably performed by 10/11 FTD patients, notwithstanding their language or executive function deficiencies. The FTD group P300 mean latency was midway between the normal controls and the Alzheimer's disease group (ANOVA F(2, 74199) = 16.5; p = 0.00003). The latency range of the FTD patients were within normal values (average plus 1.96 standard deviation of the values of the control group), except for one case with a latency of 448 ms. Post hoc Newman-Keuls analysis showed that the P300 latencies of the control and FTD groups did not differ significantly (p = 0.15) and that the Alzheimer's disease group had a delayed P300 latency that differed significantly from that of the FTD (p = 0.002) and control group (p = 0.0002). However, there was overlapping in P300 latency values of the three groups. Despite these differences in latencies, the reaction time was significantly increased in the FTD and the Alzheimer's disease groups. These findings indicate that the P300 potential is less affected in patients with FTD than those with Alzheimer's disease. This fact could aid in FTD diagnosis, differential diagnosis with Alzheimer's disease and possibly its clinical management.