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1.
目的研究中文版心境障碍问卷(MDQ)在双相Ⅱ型障碍患者中的信度、效度等方面的应用效果。方法使用中文版MDQ对56例双相Ⅱ型障碍患者测评,其中22例患者(39.28%)在8~14d重测。结果经相关分析及Kruskal--Wallis检验,双相Ⅱ型障碍患者在接受测评时的心境状态对MDQ得分的影响无显著性意义(P值分别为0.31、0.49)。因子分析显示特征值〉1的因子有4个,特征值分别为2.85、1.82、1.63、1.58,4个因子对总方差的累积贡献率为60.6%。内部因子一致性分析MDQ全量表的Cronbach’s alpha值为0.72。MDQ重测相关系数为0.66,有显著性意义。两次测评中,MDQ中13项条目应答一致率为47.1%~88.2%。患者的MDQ得分范围为0~12分,有27例患者的MDQ得分≥7分(48.21%)。13项条目阳性回答率为23.5%~74.5%。结论中文版MDQ经在双相Ⅱ型患者中初步测试,其信度、效度基本满足心理测量学要求,可在中国患者中应用。  相似文献   

2.
目的 评估中文版心境障碍问卷(MDQ)在双相障碍(BP)患者中的信度和效度以及与重性抑郁障碍(单相抑郁障碍,UP)患者区分的最佳划界分及相应的敏感性和特异性等结果.方法 对根据美国精神障碍诊断与统计手册第4版为诊断标准确诊的284例双相障碍患者(BP组)和134例单相抑郁障碍患者(UP组),使用中文版MDQ进行测评,其中147例双相障碍患者(51.8%)在8~14 d重测.结果 中文版MDQ对BP组评定结果的因子分析显示,选取2因子的方法最佳(因子Ⅰ、因子Ⅱ的特征根值分别为2.98、2.14),2个因子对总方差的累积贡献率为39.4%;中文版MDQ内部因子一致性分析克隆巴赫系数(Cronbach's alpha)为0.77,MDQ重测相关系数为0.63(P<0.01);13项条目的 阳性回答率为32.4%~78.2%;经ROC曲线法评价,MDQ区分BP组与UP组的最佳划界分为7分,相应敏感性、特异性为0.64、0.80.结论 中文版MDQ的信效度指标满足心理测量学要求,并且对于临床上的心境障碍患者,可以选择7分作为区分BP与UP的最佳划界分.  相似文献   

3.
目的:研究中文版32项轻躁狂症状清单(32-item hypomania checklist,HCL-32)在双相Ⅱ型障碍患者中应用的效度、信度。方法:对69例双相Ⅱ型障碍患者应用HCL-32进行测评,其中有26例(37.7%)患者在8~14d后重测。结果:经相关分析及Kruskal-Wallis检验,双相Ⅱ型障碍患者在接受测评时的心境状态对HCL-32得分的影响无统计学意义(P分别为0.48、0.23)。因子分析显示前2个因子的特征值较佳,分别为6.19和3.57,前2个因子对总方差的累积贡献率为30.5%。内部一致性信度分析HCL-32全量表Cronbach'salpha值为0.84,因子Ⅰ和因子Ⅱ分别为0.85和0.66。全量表重测相关系数为0.51(P=0.007)。前后两次测评中,32项条目重测一致率为53.8%~96.2%。患者的HCL-32得分范围为3~26分,HCL-32总分≥14的患者有46例(66.7%)。量表分均值为(15.26±5.91)分。32项条目阳性回答率为7.2%~82.6%。结论:HCL-32中文版在双相Ⅱ型障碍患者中初步试用,其效度、内部一致性信度尚满意,但重测信度偏低。  相似文献   

4.
目的评价中文版偏头痛患者药物依赖性问卷的信度和效度。方法选取115例合并药物依赖综合征的偏头痛患者,收集其临床资料并进行中文版偏头痛患者药物依赖性问卷的测试。采用重测信度、内部一致性信度评价分析问卷信度,采用内容效度和结构效度评价分析问卷效度。结果量表的重测信度除条目11和条目16为0.558和0.443以外,其余条目的重测信度均大于0.7。总量表的Cronbach’α系数为0.820,各个维度的Cronbach’α系数均0.7。量表的各条目得分和相应维度总分之间的相关系数在0.595~0.962之间。因子分析共提取7个特征根大于1的因子,可解释总变异的76.3%,在相应项目上均有较强的因子载荷。结论中文版偏头痛患者药物依赖性问卷具有较好的信度和效度,适合临床推广应用。  相似文献   

5.
目的:评价自我护理能力实施量表(ESCA)中文版在精神分裂症患者中的信度和效度。方法:抽取150例精神分裂症患者进行ESCA初测,进行初步的项目分析;正式施测阶段抽取300例精神分裂症患者,7 d后对其中30例进行重测,计算克朗巴赫α系数、重测信度评价量表内部一致性;采用探索性因子分析方法考评量表结构效度;相关分析来评价量表的效标效度。结果:条目一总分相关法及决断值法对条目的区分度进行分析后,组成35个条目的新量表,经最大方差旋转法旋转后提取4个因子,4个因子累计解释的方差为42.38%;ESCA与日常生活能力评定量表、护士用住院病人观察量表相关系数分别为0.59,0.63;Cranach'sα系数为0.88,重测信度为0.65。结论:ESCA中文版具有较好的信度和效度,用于精神分裂症患者自我护理能力的研究需要反复修订。  相似文献   

6.
目的 比较心境障碍问卷(MDQ)和 32 项轻躁狂症状清单(HCL-32)在单相抑郁障碍和双相 障碍患者中的应用效果。方法 纳入 2014 年 9 月至 2015 年 12 月于首都医科大学附属北京安定医院就 诊的 212 例心境障碍患者,其中单相抑郁障碍组患者 107 例,双相障碍组患者 105 例。采用主成分分析 法对 2 个量表进行因子分析。采用 Cronbach''s α 系数评估 2 个量表的内部一致性信度,采用 Spearman 相 关分析 2 个量表各条目得分与总分的相关性,比较两组患者 2 个量表的阳性应答率及得分。采用受试者 工作特征(ROC)曲线分析 2 个量表的筛查性能并比较 ROC 曲线下面积。结果 MDQ 为两因子结构,特 征值分别为 5.39、1.47,对总方差的累积贡献率为 52.81%;HCL-32 为三因子结构,特征值分别为 12.61、 2.87、1.84,对总方差的累积贡献率为 54.11%。MDQ 和 HCL-32 的 Cronbach''s α 系数分别为 0.88(95%CI: 0.85~0.90)、0.95(95%CI:0.94~0.96)。MDQ、HCL-32 各条目与总分之间的相关系数分别为 0.50~0.72 (P< 0.01)、0.16~0.78(P< 0.05)。双相障碍组 MDQ 所有条目的阳性应答率均高于单相抑郁障碍组;除 条目 32 外,双相障碍组 HCL-32 各条目的阳性应答率均高于单相抑郁障碍组。单相抑郁障碍组的 MDQ 总分为 3.00(0,5.00)分,HCL-32 总分为 9.00(1.00,17.00)分,低于双相障碍组的 5.00(1.50,9.00)、17.00 (12.00,23.50)分,差异有统计学意义(Z=-4.03、-5.02;P< 0.01)。MDQ 区分单相抑郁障碍和双相障碍的 ROC 曲线下面积为 0.66(95%CI:0.59~0.73,P< 0.001),与 HCL-32 的 0.70(95%CI:0.63~0.77,P< 0.001) 比较,差异无统计学意义(Z=1.07,P=0.28)。MDQ 的最佳划界分为 6 分,灵敏度为 0.48,特异度为 0.82; HCL-32 的最佳划界分为 8 分,灵敏度为 0.85,特异度为 0.47。结论 MDQ 和 HCL-32 在单相抑郁障碍 和双相障碍患者中应用的信度较好,均可适用于专科医院鉴别双相障碍和单相抑郁障碍。HCL-32 较 MDQ 灵敏度高,但特异度低。  相似文献   

7.
目的评估中文版Bell-Lysaker情绪识别任务(Bell-Lysaker emotion recognition task,BLERT)在中国成年重性抑郁障碍(major depressive disorder,MDD)患者中的信度和效度。方法招募MDD患者125例,稳定期双相障碍(bipolar disorder,BD)患者69例,健康对照(healthy controls, HC)66名,使用中文版BLERT、中国面部表情图片系统(Chinese affective facial picture system,CAFPS)进行测评,其中83例MDD患者(66.4%)2周后完成重测。结果中文版BLERT的内部一致性信度Cronbach'sα为0.78,重测信度组内相关系数为0.72(P0.01);关联效度r为0.55(P0.01),BLERT在MDD组与HC组间区分效度较高,最佳划界分为15分(此时敏感性为0.79,特异性为0.60);验证性因子分析显示7种基本情绪拟合良好(RMSEA=0.03,IFI=0.95,TLI=0.93,CFI=0.94)。结论中文版BLERT在中国成年MDD患者中具有可接受的信度和效度。  相似文献   

8.
目的 应用心境障碍问卷(MDQ)对诊断为抑郁障碍的精神专科住院患者进行双相障碍的筛查,评估MDQ的应用价值.方法 应用MDQ对48例抑郁障碍住院患者进行评定,以美国精神障碍诊断与统计手册第4版轴Ⅰ障碍定式检查-病人研究版( SCID- Ⅰ/P)为标准对患者进行重新诊断,并与MDQ筛查结果进行比较.结果 48例患者中,以MDQ得分≥7分判断为双相障碍者13例(27.1%);SCID- Ⅰ/P诊断为双相障碍者17例(35.4%),其中MDQ得分≥7分者11例.操作特征曲线分析显示,MDQ筛查双相障碍的敏感性为0.647,特异性为0.935.结论 住院诊断为抑郁障碍的患者中未被识别的双相障碍比例较高,采用MDQ有助于从抑郁障碍中筛查出双相障碍.  相似文献   

9.
目的:评价Morisky问卷对精神分裂症患者服药依从性的信度和效度。方法:采用便利取样法选取125例精神分裂症恢复期患者进行Morisky问卷调查,7 d后对其中30例患者进行Morisky问卷重测,计算Cronbach'sα系数及重测信度,评价量表的信度;采用探索性因子分析方法考评量表结构效度。结果:采用条目-总分相关法及决断值法对条目的区分度进行分析,问卷的4个条目皆达显著水平,符合选题标准,可以保留。问卷总Cronbach'sα系数为0.78,7 d后重测信度为0.84。经最大方差旋转法旋转后提取1个因子,累计解释的方差为52.25%,4个条目的因子负荷0.65~0.78之间。结论:Morisky问卷在精神分裂症恢复期患者服药依从性中有较好的信度及效度。  相似文献   

10.
目的:探讨对住院精神障碍患者分离体验量表第二版(DES-II)中文版评定的信度和效度。方法:404例住院精神障碍患者进行分离体验量表的评定。6周后在初筛病例中随机抽取样本数20%进行量表重测。将DES-II量表初筛评定结果按得分高低随机排序并分组抽样:0~10分第一组抽取样本数的10%;10~20分第二组抽取30%;20~40分第三组抽取50%;40分以上第四组抽取100%。抽取99例样本进行DDIS量表评定,其中完成量表并符合分析要求量表80例,验证DES-II中文版和DDIS分量表的相关效度。结果:DES量表各项目与总分间的相关系数在0.566~0.728之间;DES-II中文版评定量表的Cronbach’s的α系数为0.957;量表奇偶分半系数分别是0.843、0.883。6周后重测量表相关系数为0.617;DES得分分组的一致性Kappa值为0.549。DES量表因子分析结果表明,量表为单一因子的一维量表。对DDIS量表除外躯体性主诉和物质滥用之外所有的13个分量表和DES量表进行关联效度分析,DDIS分量表和DES得分相关系数在0.306~0.720之间,DDIS分量表得分相加的和DES因子分的相关系数为0.994。结论:分离体验量表DES-II中文版信度和效度较好,DES和DDIS各分量表的相关性较高。DES量表可以作为临床筛查的有效工具,具有临床和科研应用价值。  相似文献   

11.
Aims:  The aim of the present study was to determine the validity of a Chinese version of the Mood Disorder Questionnaire (MDQ) as a screening instrument for bipolar disorder in a psychiatric outpatient population in Hong Kong.
Methods:  A total of 185 patients primarily being treated for mood disorders were asked to fill in the Chinese MDQ and supply other personal data during their scheduled clinic visit. The mean age was 43.0 years and 65.9% were female. A subsample of 102 randomly selected subjects, stratified by the MDQ symptom score, received a telephone-based Structured Clinical Interview for DSM-IV (SCID). Sixty-two patients (60.8%) were suffering from bipolar disorder (bipolar I, n  = 48; bipolar II, n  = 9; bipolar disorder not otherwise specified, n  = 5), 35 (34.3%) from depressive disorder, and one (1.0%) from substance dependence, while four (3.9%) were unaffected by either mood or alcohol/substance use disorder. The internal consistency, factor structure and operating characteristics of the Chinese MDQ were analyzed.
Results:  The internal consistency of the Chinese MDQ, evaluated using Cronbach alpha, was 0.82. Principal component analysis with varimax rotation indicated an 'energized-activity' factor and an 'irritability-racing thoughts' factor, which explained 47.2% of the rotated variance. The optimal cut-off was seven or more manic symptoms occurring within the same time period, which yielded a sensitivity of 0.73 and a specificity of 0.88 for detecting bipolar disorder. An additional criterion that the symptoms cause impairment resulted in significant loss of sensitivity.
Conclusion:  The Chinese MDQ is a valid screening instrument for bipolar disorder in a psychiatric outpatient population.  相似文献   

12.
OBJECTIVE: This study assessed the operating characteristics of the mood disorder questionnaire (MDQ) among offenders arrested and detained at a county jail. METHOD: The MDQ, a brief self-report instrument designed to screen for all subtypes of bipolar disorder (BP I, II and NOS) was voluntarily administered to adult detainees at the Ottawa County Jail in Port Clinton, Ohio. A confirmatory diagnostic evaluation was also performed using the mini-international neuropsychiatric interview (MINI). The MDQ was scored using a standard algorithm requiring endorsement of 7/13 mood items as well as two items that assess whether manic or hypomanic symptoms co-occur and cause moderate to severe functional impairment. In addition to the standard algorithm for scoring the MDQ, modifications were also tested in an attempt to improve overall sensitivity. RESULTS: Among 526 jail detainees who completed the MDQ, 37 (7%) screened positive for bipolar disorder. Of 164 detainees who agreed to a research diagnostic evaluation, 32 (19.5%) screened positive on the MDQ, while 55 (33.5%) met criteria for bipolar disorder according to the MINI. When administered to the sample of 164 adult jail detainees, the sensitivity of the MDQ was 0.47 and the specificity was 0.94. The MDQ was significantly better at detecting BP I (0.59) than BP II/NOS (0.19; p=0.008). Modification of scoring the MDQ improved the sensitivity for detection of BP II from 0.23 to 0.54 with minimal decrease in specificity (0.84). The optimum sensitivity and specificity of the MDQ was achieved by decreasing the item threshold to 3/13 and eliminating the symptom co-occurrence and functional impairment items. CONCLUSION: The MDQ was found to have limited utility as a screening tool for bipolar disorder in a correctional setting, particularly for the BP II subtype.  相似文献   

13.
Bipolar disorder is prone to being overlooked because its diagnosis is more often based on retrospective report than cross-sectional assessment. Recommendations for improving the detection of bipolar disorder include the use of screening questionnaires. The Mood Disorder Questionnaire (MDQ) is the most widely studied self-report screening scale that has been developed to improve the detection of bipolar disorder. Although developed as a screening scale, the MDQ has also been used as a case-finding measure. However, studies of the MDQ in psychiatric patients have found high false positive rates, though no study has determined the psychiatric diagnoses associated with false positive results on the MDQ. The goal of the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project was to identify the psychiatric disorders associated with increased false positive rates on the MDQ. Four hundred eighty psychiatric outpatients were interviewed with the Structured Clinical Interview for DSM-IV (SCID) and completed the MDQ. After excluding the 52 patients diagnosed with a lifetime history of bipolar disorder we compared diagnostic frequencies in patients who did and did not screen positive on the MDQ. Based on the Hirschfeld et al. scoring guidelines of the MDQ, 15.2% (n = 65) of the 428 nonbipolar patients screened positive on MDQ. Compared to patients who screened negative, the patients who screened positive were significantly more likely have a current and lifetime diagnosis of specific phobia, posttraumatic stress disorder, alcohol and drug use disorders, any eating disorder, any impulse control disorder, and attention deficit disorder. Results were similar using a less restrictive threshold to identify MDQ cases. That is, MDQ caseness was associated with significantly elevated rates of anxiety, impulse control, substance use, and attention deficit disorders. Studies using the MDQ as a stand-alone proxy for the diagnosis of bipolar disorder should consider whether the presence of these other forms of psychopathology could be responsible for differences between individuals who screen positive and negative on the scale.  相似文献   

14.

Objectives

Studies report high comorbidity of lifetime anxiety disorders with bipolar disorders in Western patients, but it is unclear in Taiwan. The authors explored the comorbidity of anxiety disorders in different bipolar disorder subtypes in Han Chinese in Taiwan.

Methods

Three hundred twenty-five patients with bipolar disorder (bipolar I: 120; bipolar II: 205) disorder were recruited from two general medical outpatient services. They were evaluated and their diagnoses confirmed by a psychiatrist using the Chinese version of the Modified Schedule of Affective Disorder and Schizophrenia-Lifetime. The exclusion criteria were: any DSM-IV-TR Axis I diagnosis, other than bipolar disorder, being outside the 18-65-year-old age range, any other major and minor mental illnesses except anxiety disorder, any neurological disorders or organic mental disorders.

Results

Thirty-two (26.7%) of patients were comorbid with lifetime anxiety disorder and bipolar I, 80 (39.0%) with lifetime anxiety disorder and bipolar II, 7 (5.8%) were comorbid with two or more anxiety disorders and bipolar I, and 27 (13.2%) with two or more anxiety disorders and bipolar II.

Conclusion

That more than twice as many bipolar II than bipolar I patients reported two or more anxiety disorders implies that the complication is more prevalent in bipolar II patients.  相似文献   

15.
Wilke WS, Gota CE, Muzina DJ. Fibromyalgia and bipolar disorder: a potential problem?
Bipolar Disord 2010: 12: 514–520. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objective: To screen patients with fibromyalgia for bipolar disorder and to determine if there were any clinical clues, other than the Mood Disorders Questionnaire (MDQ), which might suggest a diagnosis of comorbid bipolar disorder. Methods: A total of 128 consecutive new fibromyalgia patients referred to a tertiary care center rheumatology practice were enrolled and assessed using a standard clinical protocol that included the completion of four screening questionnaires: (i) MDQ for bipolar disorder, (ii) Beck Depression Inventory (BDI) for depression, (iii) Epworth Sleepiness Scale (ESS) for daytime sleepiness, and (iv) Fibromyalgia Impact Questionnaire Disability Index (FIQ‐DI) to assess for functional capacity. Results: A quarter of the fibromyalgia subjects, 25.19%, had a positive screen for bipolar disorder (MDQ ≥ 7); 78.12% were clinically depressed (BDI ≥ 10); and 52.13% reported daytime sleepiness (ESS ≥ 10). Fibromyalgia subjects who screened positive for bipolar disorder had more severe depression than those with a negative screen [median BDI: 26.0 (19.0, 32.0) versus 15.0 (9.0, 24.0), p < 0.001]. Conclusions: We report a high prevalence of positive testing for bipolar disorder in this fibromyalgia cohort. Clinical data and questionnaire instruments other than nonspecific high depression severity failed to identify these patients. Since the norepinephrine serotonin reuptake inhibitors duloxetine and milnacipran have been recently approved by the U.S. Food and Drug Administration for the treatment of fibromyalgia, and because patients with bipolar disorder may experience destabilization of mood when treated with such agents, patients with fibromyalgia should be systematically screened for bipolar disorder prior to treatment.  相似文献   

16.
Objective: The Mood Disorder Questionnaire (MDQ) is an instrument for the detection of patients with bipolar disorder (BD). The original English version is validated in both the psychiatric and the general population, but a validated Spanish version is not yet available. Psychometric properties of the Spanish adaptation of the MDQ in psychiatry are described. Methods: The MDQ is a self‐administered questionnaire comprising a list of 13 hypomanic symptoms and two questions about concurrence of symptoms and functional impairment caused by the symptoms. We selected patients from 15 psychiatric outpatient departments, diagnosed with BD type I and II (BDI and BDII) and major depression (MD) according to DSM‐IV‐TR criteria (concurrent validity instrument). A control group of healthy subjects (HS) was selected. The patient‐selection criteria included stability of the disorder and pharmacological treatment. The MDQ was administered to 236 subjects, distributed among the four groups, on two occasions, four weeks apart. We analysed the internal consistency, test–retest reliability, and discriminative capacity of the MDQ for the detection of patients with BD. Results: Concurrent validity based on diagnosis according to DSM‐IV‐TR was 0.83. The internal consistency, evaluated by Cronbach’s α, was 0.90. The mean (SD) number of affirmative responses by group was: 9.8 (2.4) for BDI, 8.5 (2.8) for BDII, 2.7 (2.2) for MD, and 1.02 (1.9) for HS. Statistically significant differences between all the groups were found (Kruskal–Wallis test, p < 0.001). Concurrent validity using the diagnostic variable was 0.83. Test–retest reliability was 0.92. We analysed the scale’s discriminative capacity, revealing a sensitivity value of 0.60 [95% confidence interval (CI) = 0.51–0.69] and a specificity value of 0.98 (95% CI = 0.94–0.99) in the detection of BD. The positive and negative probability ratios were 35.5 and 2.4, respectively. If we consider only seven positive responses as the discriminative criterion, sensitivity increases to 0.81 (95% CI = 0.73–0.88), the specificity value is 0.95 (95% CI = 0.89–0.98) and the positive and negative probability quotients are 16 and 5.3. Conclusions: The psychometric characteristics of the Spanish version are similar to those of the original version. In the Spanish adaptation of the MDQ, seven positive responses to hypomanic symptoms show a good discriminative capacity for BD in patients attending psychiatric outpatient facilities; therefore, this cut‐off score is proposed for the detection of BD in psychiatric outpatients.  相似文献   

17.
PURPOSE: Different authors suggested the occurrence of a pleomorphic affective syndrome in patients with epilepsy named interictal dysphoric disorder (IDD). We sought to investigate whether IDD occurs only in patients with epilepsy and to validate IDD features against DSM-IV criteria. METHODS: Consecutive patients with a diagnosis of epilepsy (E) or migraine (M) have been assessed using the BDI, MDQ, and the Interictal Dysphoric Disorder Inventory (IDDI), a questionnaire specifically created to evaluate IDD symptoms. Diagnosis of current and lifetime DSM-IV Axis I disorders was established using the MINI Plus version 5.0.0. RESULTS: A total of 229 patients (E = 117; M = 112) were evaluated. Females were significantly more represented in the migraine group (E = 46.5% vs. M = 73.3% p = 0.009), but there was no difference in age, duration of the disease, or education level. Patients with epilepsy were more likely to screen positively at MDQ (E = 17% vs. M = 5.3% p = 0.006) and to have a diagnosis of bipolar disorder (E = 14.5% vs. M = 4.5% p = 0.013) as compared to migraine patients. There was no between-groups difference in IDD prevalence (E = 17%; M = 18.7%) and IDDI total scores (E = 4.1 +/- 2.0 vs. M = 3.8 +/- 2.0). Validation of IDD against DSM-IV categories showed current major depression being the foremost diagnostic category correlated with IDD in both epilepsy (OR = 0.32-0.12-0.88, p = 0.028) and migraine (OR = 0.10, 95% CI = 0.02-0.49, p = 0.004) samples. Current anxiety disorder correlated with IDD only in migraine patients (OR = 0.19, 95% CI = 0.05-0.77, p = 0.02). CONCLUSION: IDD represents a homogenous construct that can be diagnosed in a relevant proportion of patients but it is not typical only of epilepsy, occurring in other central nervous system disorders such as migraine.  相似文献   

18.
OBJECTIVE: Patients suffering from both bipolar I disorder and borderline personality disorder (BPD) pose unique treatment challenges. The purpose of this matched case-control study was to compare acute treatment outcomes of a sample of patients who met standardized diagnostic criteria for both bipolar I disorder and BPD (n = 12) to those who met criteria for bipolar I disorder only (n = 58). METHOD: Subjects meeting criteria for an acute affective episode were treated with a combination of algorithm-driven pharmacotherapy and weekly psychotherapy until stabilization (defined as four consecutive weeks with a calculated average of the 17-item version of the Hamilton Rating Scale for Depression and Bech-Rafaelsen Mania scale totaling < or = 7). RESULTS: Only three of 12 (25%) bipolar-BPD patients achieved stabilization, compared with 43 of 58 (74%) bipolar-only patients. Two of the three bipolar-BPD patients who did stabilize took over 95 weeks to do so, compared with a median time-to-stabilization of 35 weeks in the bipolar-only group. The bipolar-BPD group received significantly more atypical mood-stabilizing medications per year than the bipolar-only group (Z = 4.3, p < 0.0001). Dropout rates in the comorbid group were high. CONCLUSIONS: This quasi-experimental study suggests that treatment course may be longer in patients suffering from both bipolar I disorder and BPD. Some patients improved substantially with pharmacotherapy and psychotherapy, suggesting that this approach is worthy of further investigation.  相似文献   

19.
ObjectiveTo evaluate the performance of the French version of the Mood Disorder Questionnaire (MDQ) in patients attending a general psychiatric outpatient service as well as whether MDQ scores are independent of patient mood state at time of completion.Method183 patients completed the MDQ and were assessed with the MADRS and YMRS scales, before being interviewed with the SCID (time 1). MDQ, MADRS and YMRS assessment was repeated four to six weeks later (time 2).ResultsAccording to the SCID, 44 patients were suffering from bipolar spectrum disorder and 102 from unipolar disorder (37 patients dropped out). The MDQ provided high specificity (83.3%). Sensitivity was 63.6%, with better identification of bipolar I (85.0%) than bipolar II patients (45.8%). In the whole sample, test-retest reliability was satisfactory (kappa = 0.64). Modest correlations were observed between the number of endorsed MDQ items and YMRS scores at time 1 (Spearman r = 0.19; p = 0.021) and time 2 (r = 0.26; p = 0.002).ConclusionsDespite some fluctuations over time and a discrete influence of symptom severity, the screening algorithm can be used reliably, whether in the acute or remission phase of a depressive episode.  相似文献   

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