成年癫痫患者生活质量的研究

目的　评价成年癫痫患者的生活质量。方法　对符合入选标准的 33例成年癫痫患者和正常对照者 17名 ,进行癫痫患者生活质量量表 31(QOLIE 31)、Zung氏抑郁自评表 (SDS)的评估。结果　SDS评分水平与QOL的多个方面呈独立负相关 ,病程是总体健康水平、药物影响的独立危险因素。全身强直 阵挛发作 (GTC ,17例 )、复杂部分性发作 (CPS ,16例 )两组患者在药物影响 (分别为 6 1 0± 2 3 8和 5 6 6± 19 4,对照组为 10 0± 0 0 )、对发作的担忧两方面均与对照组有显著性差异 (P <0 .0 0 1)。GTC组从事脑力劳动的人数大大低于学历背景相似的对照组 (P =0 0 1) ,而CPS组从事脑力劳动的人数与对照组相比差异无显著性意义 (P =0 .479) ,GTC组与CPS组相比未见显著性差异 (P =0 .0 97)。男性癫痫患者在婚育方面受到的影响有大于女性患者的趋势。结论　成年癫痫患者生活质量低于健康对照组。     

焦虑、抑郁情绪对癫患者生活质量的影响

目的探讨焦虑、抑郁情绪对癫患者生活质量的关系。方法应用生活质量综合评定问卷(GQOLI)、Zung焦虑自评量表(SAS)及Zung抑郁自评量表(SDS)对60例癫患者(癫组)及60名健康自愿者(对照组)进行评定,并对生活质量与焦虑、抑郁作相关分析。结果癫患者的生活质量总分及躯体功能、心理功能、社会功能、物质生活4个维度分均明显低于对照组(P<0.01),而SAS及SDS评分则均明显高于对照组(P<0.01);生活质量总分及躯体功能、心理功能、社会功能、物质生活4个维度分均与SAS及SDS评分呈显著性负相关。结论癫患者的生活质量较差,焦虑、抑郁情绪明显;其生活质量与焦虑、抑郁情绪密切相关。     

癫痫患者伴发焦虑和抑郁的临床研究

我们对231例癫痫患者中伴有焦虑、抑郁的患者进行分析，探讨癫痫患者焦虑、抑郁的发病率、临床特点，以及抗焦虑、抑郁治疗的效果。现报告如下。     

焦虑、抑郁情绪对癫患者生活质量的影响

目的 探讨焦虑、抑郁情绪对癫(癎)患者生活质量的关系.方法 应用生活质量综合评定问卷(GQOLI)、Zung焦虑自评量表 (SAS)及Zung抑郁自评量表 (SDS)对60例癫(癎)患者(癫(癎)组)及60名健康自愿者(对照组)进行评定,并对生活质量与焦虑、抑郁作相关分析.结果 癫(癎)患者的生活质量总分及躯体功能、心理功能、社会功能、物质生活4个维度分均明显低于对照组(P＜0.01),而SAS及SDS评分则均明显高于对照组(P＜0.01);生活质量总分及躯体功能、心理功能、社会功能、物质生活4个维度分均与SAS及SDS评分呈显著性负相关.结论 癫(癎)患者的生活质量较差,焦虑、抑郁情绪明显;其生活质量与焦虑、抑郁情绪密切相关.     

脑梗死患者的生活质量与其焦虑、抑郁情绪的相关性研究

目的 探讨脑梗死患者的生活质量与其焦虑、抑郁情绪的关系。方法 采用Zung焦虑自评量表（SAS）、Zung抑郁自评量表（SDS）及生活质量综合评定问卷（GQOLI）对80例脑梗死患者（脑梗死组）及80名健康人（对照组）进行问卷调查,并对生活质量与其焦虑、抑郁情绪作相关分析。结果 脑梗死患者的生活质量总分及躯体功能、心理功能、社会功能3个维度评分均明显低于对照组（P〈0．01）,而SAS及SDS评分均明显高于对照组（P〈0．01）。脑梗死患者的生活质量总分及躯体功能、心理功能、社会功能3个维度评分均与SAS及SDS评分呈显著性负相关。结论 脑梗死患者的生活质量较差,焦虑、抑郁情绪明显;其生活质量与焦虑、抑郁情绪密切相关。     

伴抑郁症状的焦虑障碍患者生活质量的研究

目的 探讨伴有抑郁症状的焦虑障碍患者的生活质量.方法 纳入符合美国精神障碍诊断与统计手册第4版焦虑障碍诊断标准的患者163例和162名正常对照,患者按是否伴有抑郁症状分为单纯焦虑组以及焦虑-抑郁共存组,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数表(PSQI)和世界卫生组织生命质量测定量表简表(WHOQOL-BREF)等分别评定受试者的情绪症状、睡眠和生活质量,采用SPSS18.0对两组进行比较.结果 46.6%(76/163)的焦虑障碍患者伴有抑郁症状.焦虑-抑郁共存组的SAS标准分、PSQI总分均高于单纯焦虑组(P<0.01),WHOQOL-BREF总分及生理、心理、社会关系及环境领域得分分别为[ (47.92±8.52 )、(10.17±2.64)、(11.12±2.55)、(11.29±2.27)、(10.69±2.65)],而单纯焦虑组和健康对照组相应得分分别为[(57.88±9.43)、(13.02±2.61)、(13.08±2.29)、(13.44±2.41)、(12.47±2.63)和(65.14±9.42)、(14.99±2.41)、(11.12±2.55)、(11.29±2.27)、(10.69±2.65)],前者各得分均分别高于后两者(P均小于0.01).结论 焦虑障碍患者常伴发抑郁症状,伴有抑郁症状的焦虑障碍患者生活质量更低.     

心理剧治疗对强迫症患者焦虑、抑郁及生活质量的影响

目的探讨心理剧治疗对强迫症患者焦虑、抑郁及生活质量的影响。方法将100例强迫症患者随机均分为研究组和对照组，在两组均给予足量足疗程的药物治疗及接受一般健康教育的基础上，仅对研究组辅以心理剧治疗，4周为一个疗程。生活质量测评工具SF-36量表、Yale—Brown强迫症量表（Y—BOCS）、17项汉密顿抑郁量表（HAMD17）、汉密顿焦虑量表（HAMA）对两组患者进行治疗前后效果评定。结果干预后研究组患者的Y—BOCS总分和HAMD17HAMA总分值均显著低于对照组（P〈0．01），而疗效显著高于对照组（P〈0．01），研究组患者的显效率显著高于对照组（P〈0．01），研究组患者的SF-36量表各维度分值显著高于对照组（P〈0．01）。结论心理剧治疗可巩固患者的疗效，并改善其焦虑、抑郁情绪，能显著提高患者的心理健康水平及生活质量，可作为一种有效的心理治疗手段应用于临床。     

心理干预对恶性肿瘤患者焦虑、抑郁状态及生活质量的影响

目的 探讨心理干预对恶性肿瘤患者焦虑抑郁状态及生活质量的影响.方法 将205例恶性肿瘤患者随机分为对照组和心理干预组,对照组采用常规放疗、化疗及最佳支持治疗,心理干预组在常规治疗基础上对患者进行心理干预,治疗前后采用焦虑自评量表(SAS),抑郁自评量表(SDS)和EORTC-QLQ-C30量表对患者进行焦虑抑郁状态及生活质量的测定.结果 两组患者入院时SDS及SAS评分比较无统计学差异(P＞0.05),心理干预组第6周SDS及SAS评分均明显低于对照组,差异有统计学意义(P＜0.05),心理干预后可改善癌症患者生活质量,较干预前差异有统计学意义(P＜0.05).结论 心理干预能够改善恶性肿瘤患者焦虑抑郁情绪,提高生活质量,有利于患者的康复.     

成年癫痫患者生活质量的研究

目的运用QOLIE-31量表中文版调查评估广东地区成年癫痫患者的生活质量。方法对398例患者采用简单随机抽样,信函调查等调查方法进行调查,用SPSS 10.0软件进行统计学处理。结果198例不同性别间P>0.05.不同性别之间生活质量无显著性差异;婚姻在发作担忧、总的生活质量、感情幸福、精力和疲劳以及中国文化调适等方面有显著性差异P<0.05,不同经济状况之间在发作担忧和药物作用方面存在显著差异P<0.05;不同学历在社会功能一项P<0.05.表示不同学历在社会功能方面有显著性意义。结论在不同性别之间成年癫痫患者的生活质量无明显不同;婚姻、学历和经济状况对患者的生活质量有不同的影响。     

成年癫痫患者生活质量的有关问题

癫痫是神经科常见的慢性疾病。如果坚持正规治疗 ,80 %的患者可以完全控制发作[1] ,但仍有 2 0 %患者发作难以控制。反复的癫痫发作不仅对患者的身心健康造成损害 ,长期服药、社会歧视等因素也同样给患者及其家属乃至社会带来了巨大的心理压力和沉重的经济负担。随着医学模式从单纯的生物医学模式转变为生物、心理及社会医学模式 ,以往沿用的反映健康的指标如死亡率、患病率等已不适用 ,而生活质量 (ｑｕａｌｉｔｙｏｆｌｉｆｅ ,ＱＯＬ)这一反映健康的新指标日益受到重视。一、生活质量的定义生活质量 ,又称生命质量或生存质量 ,在医学研究…     

Depression,anxiety and quality of life in parents of children with epilepsy

0bjectives – To assess the impact of childhood epilepsy on parental quality of life (QOL) and psychological health, and to investigate possible correlations between parental QOL and background variables as well as parental anxiety and depression. Subjects and methods – Parents having an epileptic child (n = 263) and parents having a healthy child (n = 270) were enrolled. Groups were in balance for background variables. Short‐Form Health Survey (SF‐36) Questionnaire, Zung Depression Scale (ZDS) and Zung Anxiety Scale (ZAS) were applied to all parents. Patients were divided into the first visit group (newly diagnosed epilepsy) and follow‐up visit group. Results – The parents of children with epilepsy had significantly lower QOL scores in SF‐36 for all subscales and higher levels of depression and anxiety by using ZDS and ZAS. The factors correlated with parental QOL were seizure control, visit status, anxiety, depression, employment, cost of epilepsy, status epilepticus, drug side effect and age of parents. Conclusions – Childhood epilepsy has a severe impact on parental QOL and psychological health, and recognition of possible correlations between parental QOL and background variables will be helpful to improve parental QOL.     

Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea

OBJECTIVES: The level of, and factors affecting the quality of life (QOL) in patients with epilepsy may be different in Korea where social prejudice toward them is still pronounced. However, these issues have not yet been addressed properly. METHODS: We consecutively identified 154 epilepsy patients who visited the outpatient clinic at the Seoul National University Hospital. An interview was performed by two research nurses with the use of a standardized questionnaire, which included data pertaining to seizure characteristics, symptoms of depression/anxiety, social support, family life/social life satisfaction, and the activities of daily living (ADLs). The QOL was assessed with the use of QOL in Epilepsy Inventory (QOLIE-31). RESULTS: Factors affecting the QOL were: age (P<0.01), education in years (P<0.01), employment status (P<0.05), employment type (P<0.05), current economic status (P<0.05), seizure frequency (P<0.01), the number of antiepileptic drugs (P<0.01), family life/social life dissatisfaction (P<0.01, respectively), social support (P<0.01), the symptoms of anxiety and depression (P<0.01, respectively) and ADL dysfunction (P<0.01). In multiple regression analysis, the symptom of anxiety was the most important factor in explaining lower QOL in patients with epilepsy, while depression (P<0.01), social life dissatisfaction (P<0.01), ADL dysfunction (P<0.05) and seizure frequency (P<0.05) were also significant factors. CONCLUSION: Psycho-social factors outweighed the physical factors in determining QOL in Korean epilepsy patients. Recognition of these factors will lead health professionals to develop different strategies to improve the QOL of these patients.     

心理干预对癫患者焦虑抑郁情绪的影响

目的:探讨心理干预对癫患者焦虑抑郁情绪的影响。方法:对163例成人癫患者在抗癫治疗的同时实施为期3个月的心理干预;采用中文版Zung焦虑自评量表(SAS)及抑郁自评量表(SDS)分别于干预前、干预后1个月和3个月进行评定。结果:163例癫患者实施心理干预后焦虑和抑郁情绪改善显著,并随干预时间延长而显著下降。与干预前比较,干预1周,SAS及SDS评分与干预前差异无统计学意义(P=0.469、0.272);干预1个月和3个月,SAS及SDS评分与干预前比较差异有显著统计学意义(F=15.196、16.207,P均<0.001)。结论:癫患者焦虑抑郁情绪明显;心理干预能够显著改善患者焦虑抑郁情绪;干预时间越长,效果越好。     

Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners

OBJECTIVES: Studies demonstrating reduced quality of life and psychological well-being in multiple sclerosis (MS) have typically investigated patients within more advanced stages of disease. The aim of the present paper was to evaluate the emotional burden and quality of life of recently diagnosed MS patients and their partners. METHODS: Data on health-related quality of life (SF-36), anxiety and depression (Hospital Anxiety and Depression Scale) and disease-related distress (Impact of Event Scale) were obtained in 101 patients and their partners (n=78). RESULTS: On average 8 months after diagnosis (range 0-24 months), 34% of the patients and 40% of the partners had clinically high levels of anxiety, and 36% of the patients and 24% of the partners had levels of severe distress. Scores of anxiety, depression and distress were higher in patients with more functional limitations (Expanded Disability Status Scale=3.0). Quality of life was significantly poorer in patients compared with controls, particularly among those with higher disability. CONCLUSIONS: Both patients and their partners demonstrated high levels of anxiety and distress in the early period after the diagnosis. These findings indicate careful attention by health care professionals to identify those who may benefit from further psychological support.     

难治性癫患者的社会质量和生活质量调查

目的评估难治性癫(IE)患者的社会质量和生活质量。方法对60例IE患者及其家属进行访谈,调查其社会质量和生活质量。结果 IE患者的社会质量和生活质量普遍较低,在康复指导、日常生活、心理关怀等方面有很多的需求。结论应该全面关心以改善IE患者的社会和生活质量。     

癫(疒间)患者焦虑抑郁情绪研究

目的:探讨癫(疒间)患者焦虑抑郁情绪的有关因素. 方法:80例成年癫疒间患者,前期诊疗不规范,采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评估. 结果:癫疒间合并焦虑情绪者25%,合并抑郁情绪者45%.多因素回归分析结果显示,病程越长,发作程度越严重,男性患者更易产生焦虑情绪,而居住在农村的癫疒间患者更易产生抑郁情绪. 结论:癫疒间患者焦虑抑郁情绪明显高于正常人群,性别、病程、发作严重程度和生活居住地是影响癫疒间患者焦虑抑郁情绪的独立危险因素.     

癫患者焦虑抑郁情绪研究

目的：探讨癫癎患者焦虑抑郁情绪的有关因素。方法：80例成年癫癎患者，前期诊疗不规范，采用焦虑自评量表（SAS）和抑郁自评量表（SDS）评估。结果：癫癎合并焦虑情绪者25％，合并抑郁情绪者45％。多因素回归分析结果显示，病程越长，发作程度越严重，男性患者更易产生焦虑情绪，而居住在农村的癫癎患者更易产生抑郁情绪。结论：癫癎患者焦虑抑郁情绪明显高于正常人群，性别、病程、发作严重程度和生活居住地是影响癫癎患者焦虑抑郁情绪的独立危险因素。     

The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy

PURPOSE: To determine the independent effects of depression and anxiety on health-related quality of life (HRQOL) in epilepsy as well as the relative explanatory power of psychiatric comorbidity compared with demographic and clinical epilepsy variables (e.g., seizure frequency, severity, and chronicity). METHODS: Subjects (n = 87) with temporal lobe epilepsy completed self-report measures of depression, anxiety, HRQOL, and seizure severity. Information was derived regarding subjects' seizure frequency, duration, and treatment. HRQOL status (QOLIE-89) was examined in relation to self-reported symptoms of anxiety and depression, clinical seizure features, and demographic characteristics. RESULTS: Depression and anxiety were independently associated with reduced HRQOL. Psychiatric comorbidity explained more variance in HRQOL than did combined groups of clinical seizure or demographic variables. Although weaker in explanatory power than psychiatric comorbidity, several epilepsy factors were nonetheless significantly related to HRQOL, including seizure frequency, severity, and chronicity. CONCLUSIONS: Interictal anxiety and depression exert independent adverse effects on HRQOL. In addition, frequent, severe, and chronic seizures reduce HRQOL, but appear less powerful predictors of HRQOL than interictal psychiatric symptoms. Recognition and treatment of comorbid depression and anxiety is an important consideration in improving quality of life in epilepsy.