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1.
背景:间接测热法为临床上测定静息能量消耗的“金标准”,由于缺乏设备,常常需要选择预测公式计算静息能量消耗,哪个预测公式的计算值最接近间接测热法尚无定论。而在使用预测公式的时候,到底用标准体质量还是实际体质量一直是营养学界争论的热点。 目的:探讨预测公式计算的静息能量消耗的准确性和间接测热法的意义及标准体质量的应用是否可以增加预测公式的准确性。 方法:选择27名健康成人(男13名,女14名)为研究对象,于早晨8:30~11:00之间,用ultima PFX代谢车测定其静息能量消耗。用Broca公式和Broca改良公式分别计算男女受试者的标准体质量,并将标准体质量和实际体质量带入Harris-Benedict(H-B),Schofield,WHO,Owen,Mifflin和Liu氏等能量消耗预测公式,计算静息能量消耗。比较预测静息能量消耗与测定静息能量消耗之间的差异。 结果与结论:在男性受试者中,所有公式(标准体质量和实际体质量)计算的静息能量消耗和测定静息能量消耗间的差异均无显著性意义(P > 0.05)。而女性受试者中,用Liu氏和Owen公式计算的静息能量消耗低于测定静息能量消耗(P < 0.05);同时用标准体质量计算的静息能量消耗较用实际体质量计算的高(P < 0.05或P < 0.01),但相对于测定静息能量消耗,两种方法的准确率差异无显著性意义(P > 0.05);各种预测公式中H-B、WHO和Schofield的准确率较高,可达62.96%。所以不建议使用预测公式计算个体静息能量消耗,但在不能使用间接测热法时,应用H-B、WHO和Schofield公式较准确。 关键词:静息能量消耗;间接测热法;能量预测公式;标准体质量;健康人  相似文献   

2.
背景:肥胖是由多基因决定的复杂性疾病,体质量指数是研究肥胖的常用表型。有研究显示一些候选基因与体质量指数变异相关,然而它们之间的相互关系却仍未阐明。 目的:探讨雌激素受体α基因(ER-α)PvuII多态性是否与体质量指数的变异相关联。 方法:征集了绝经前女性390例,均来自南昌地区江西省人民医院的体检人员,测量其身高和体质量,计算体质量指数。用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法对所有被试者的雌激素受体α基因PvuII位点进行基因分型。 结果与结论:雌激素受体α基因PP,Pp和pp基因型频率分别为0.133,0.485和0.382。雌激素受体α基因型分布符合哈迪-温伯格平衡(P > 0.05)。雌激素受体α基因PvuII与体质量指数没有显著的关联性(P= 0.338)。证实雌激素受体α基因PvuII多态性对南昌地区绝经前妇女体质量指数没有重要的影响。  相似文献   

3.
背景: 体质量指数(BMI)是研究肥胖的常用表型,它是由多基因决定的复杂性状。 目的:验证骨钙素基因Hind Ⅲ多态性是否与体质量指数的变异相关联。 方法:征集南昌当地绝经前女性390例,并测量身高和体质量。用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法对所有个体的骨钙素基因Hind Ⅲ位点进行基因分型。 结果与结论:骨钙素HH,Hh和hh基因型频率分别为0.077,0.408和0.515。骨钙素基因型分布符合哈的温格尔平衡(P > 0.05)。骨钙素基因Hind Ⅲ与体质量指数存在显著的关联(P=0.002),它可以解释大约5.47%体质量指数的变异。HH基因型个体的体质量指数最高[(22.81±0.73)kg/m2],Hh基因型个体的体质量指数居中[(21.50±0.53) kg/m2],而hh基因型个体的体质量指数最低[(20.23± 0.63) kg/m2]。因此,HH和Hh基因型个体的体质量指数比hh基因型个体的体质量指数分别高大约12.75%和6.28%。文章首次在健康绝经前女性中报道骨钙素基因HindⅢ多态性与体质量指数的变异相关联。  相似文献   

4.
背景:测量体力活动能量消耗的方法有很多,但测量上肢活动能量消耗方面的研究较少。 目的:以间接热量测定法测量几种常见的上肢运动形式能量消耗,分析上肢运动能量消耗的特征以及年龄、性别等因素的影响。 设计、时间及地点:对比观察,实验于2009-01/03在江苏省体育科学研究所完成。 对象:无代谢性疾病的健康成年人108名,男47名,女61名,其中20~39岁65名,40~59岁43名。 方法:受试者以坐姿做摆臂(60次/min)、屈肘(40次/min)、肩水平屈伸(60次/min)、直臂侧上举(30次/min)4种动作,每个动作间隔休息3 min。 主要观察指标:采用德国CORTEX系列MetaMax 3B心肺功能测试仪受试者静息及不同运动形式下耗氧量值。 结果:静息耗氧量男性高于女性(P < 0.05),20~39岁高于40~59岁(P < 0.05)。摆臂的耗氧量最高男性(550.9±90.6) mL/min,女性(425.8±75.7) mL/min;屈肘最低男性(440.4±82.7) mL/min,女性(367.0±60.1) mL/min。4种运动形式的净耗氧量都低于250 mL/min(1代谢当量)。 结论:①4种常见上肢活动形式的耗氧量增加较少,一般不会超过1代谢当量。②年龄和体质量对静息状态能量消耗影响较大,性别的影响较小。③年轻人群的上肢运动效率更高,在运动中的能量更加节省。  相似文献   

5.
背景:骨密度及骨矿物含量是诊断骨质疏松及评价骨质量的重要指标,肥胖是否影响骨质疏松的发生尚无定论。 目的:调查分析287例汉族健康志愿者全身骨密度、骨矿物含量与肥胖的关系。 设计、时间及地点:调查分析,于2006-01/12在济南市妇幼保健院完成。 对象:选择健康志愿者287人,年龄(37±17)岁。 方法:测量287例汉族健康志愿者的身高、体质量、全身各部位的骨密度及骨矿物含量。以体质量指数对样本进行分组:体质量指数≥28 kg/m2为肥胖;体质量指数 ≥24 kg/m2,< 28 kg/m2为超重;体质量指数≥ 18.5 kg/m2,< 24 kg/m2为正常体质量。 主要观察指标:采用协方差分析比较不同体质量指数调查对象的骨密度及骨矿物含量;采用偏相关分析法分析体质量指数与全身各部位骨密度及骨矿物含量的关系。 结果:协方差分析显示,在排除性别和年龄的影响后,肥胖组全身、头部、上肢、下肢、躯干、脊柱部位的骨密度及骨矿物含量均高于超重组和正常体质量组(P < 0.05~0.01)。偏相关分析显示,在排除性别和年龄的影响后,体质量指数与全身总骨密度、全身总矿物含量、头骨密度、头骨矿物含量、上肢密度、上肢矿物含量、下肢密度、下肢矿物含量、躯干密度、躯干矿物含量、脊柱密度、脊柱矿物含量均呈显著正相关(P均=0.000)。 结论:全身骨密度及骨矿物含量与肥胖呈正相关。  相似文献   

6.
高辉 《中国神经再生研究》2010,14(26):4924-4928
背景:目前有一些研究考虑到了体质量指数对全膝人工关节表面置换后功能的影响,但是大部分病例数较少,随访时间较短。 目的:观察体质量指数对全膝人工关节表面置换后功能的影响。 方法:选择北京大学人民医院骨关节科收治的骨关节炎患者320例,均接受初次膝关节髌骨置换,其中双膝置换200例,共520个膝关节,左膝置换219个,右膝置换301个。由同一组医生采用同一种假体(均为Scorpio后稳定型膝关节假体)对320例患者行全膝人工关节表面置换治疗。按体质量指数分为4组(超重组:体质量指数25.1~27.0 kg/m2,肥胖组:体质量指数27.1~30.0 kg/m2,病理性肥胖组:体质量指数> 30 kg/m2,对照组:体质量指数< 25 kg/m2)。按1989年美国纽约特种外科医院评分标准(HSS),记录置换前及随访时膝关节评分和功能评分,以及膝关节最大屈曲度、伸直度数和并发症。 结果与结论:320例患者均通过门诊复查进行随访,随访时间12~46个月,平均28.3个月。置换前超重组、肥胖组、病理性肥胖组功能评分较对照组低(P < 0.05),但关节评分无显著性差异。在最后的随访中发现,无论膝评分和功能评分各组置换后均明显提高,各组提高的幅度无显著性差异(P > 0.05)。肥胖组和病理性肥胖组围置换期并发症明显增高(P < 0.05),181膝中有14膝(9.2%)合并伤口并发症,1膝(0.5%)感染,2膝(1.3%)内侧副韧带损伤,感染发生于置换后10周内并与伤口并发症有关;而超重组258膝中有6膝(2.3%)合并伤口并发症;对照组81膝中有1膝(1%)合并伤口并发症。围置换期无死亡和肺栓塞病例。提示体质量指数对全膝人工关节表面置换后早期的功能恢复无明显影响。  相似文献   

7.
目的:探讨二甲双胍对抗精神病药所致肥胖患者胰岛素抵抗及血清白介素-18(IL-18)水平的影响。方法:对44例抗精神病药所致肥胖患者(肥胖组)给予二甲双胍治疗12周,监测治疗前后的体质量、体质量指数(BMI)、胰岛素抵抗指数(HOMA-IR)及血清IL-18水平;以27例非肥胖患者(非肥胖组)和47名正常人(正常对照组)作为对照。结果:治疗前肥胖组HOMA-IR、血清IL-18水平高于非肥胖组(Z=-5.05,P0.001;Z=-2.78,P0.01)及正常对照组(Z=5.98,Z=6.68;P均0.001);非肥胖组血清IL-18水平高于正常对照组(Z=4.58,P0.001)。治疗后肥胖组体质量及BMI均有明显下降(Z=2.07,Z=2.13;P均0.05);HOMA-IR虽有明显下降(Z=2.74,P0.01)但仍高于非肥胖组及正常对照组(Z=-4.01,Z=4.73;P均0.001);IL-18水平显著下降(Z=5.48,P0.001)并低于非肥胖组(Z=3.42,P0.01),但仍高于正常对照组(Z=3.59,P0.01)。HOMA-IR与IL-18水平治疗前后均无相关(r=0.108,r=0.034;P均0.05);HOMA-IR变化值与IL-18水平变化值也无相关(r=0.122,P0.05)。结论:二甲双胍能改善抗精神病药所致肥胖患者的胰岛素抵抗,降低血清IL-18水平。  相似文献   

8.
目的:调查肥胖患者人工全膝关节置换的特点及疗效,并与非肥胖患者进行对比。 方法:选择2004-09/2007-03在北京协和医院骨科接受初次单侧全膝关节置换的膝骨关节炎患者共80例(80膝),均使用后稳定型固定平台假体。其中体质量指数< 25.0 kg/m2者入非肥胖组,体质量指数≥27.1 kg/m2者入肥胖组,非肥胖组和肥胖组各40例。对患者进行定期随访,记录置换前和末次随访时的膝关节最大伸屈度数、HSS评分结果及并发症发生情况。 结果:所有入组病例均获得随访,随访时间25~54个月,平均36.7个月。2组末次随访的膝关节最大屈曲度及HSS评分均高于置换前(P < 0.05),最大伸直度低于置换前(P<0.05)。肥胖组置换前及末次随访时的膝关节最大伸屈度数和HSS评分与非肥胖组差异无显著性意义(P > 0.05)。非肥胖组只有1例出现伤口并发症,发生率为2.5%;而肥胖组中有4例出现伤口并发症,其中1例合并症状性下肢深静脉血栓,2例合并关节僵硬,并发症发生率为10%,二者比较差异有显著性意义(P < 0.05)。 结论:人工全膝关节置换是终末期膝骨关节炎的有效治疗方法,肥胖患者可以获得同非肥胖患者相似的近期临床效果,但围手术期应重视伤口处理和下肢深静脉血栓等并发症的预防。  相似文献   

9.
背景:针灸与药物均是治疗单纯性肥胖病的有效方法,电针与常用减肥药西布曲明影响肥胖机体脂肪细胞产物是否存在差异? 目的:观察电针与常用减肥药西布曲明影响肥胖大鼠脂肪细胞产物的差异,以探讨针灸减肥的机制。 设计:分层随机对照设计。 单位:南京中医药大学针药结合实验室。 材料:选用120只生后45 d雄性SD大鼠,由上海实验动物中心提供,实验过程中对动物的处置符合动物伦理学标准。盐酸西布曲明胶囊由太极集团涪陵制药厂生产,批号为国药准字X20010279;电针仪为韩氏LH402A穴位神经电刺激仪,由北京华卫产业开发公司生产。 方法:实验于2004-10/2006-11在南京中医药大学针药结合实验室和南京中医药大学实验动物中心完成。①高脂高能量饲料喂养100只SD雄性大鼠,选择食源性肥胖大鼠54只,分为电针组、药物组、肥胖组,每组18只,并以18只正常饲料大鼠为正常组。② 电针组大鼠均以2/15 Hz,4 mA的电针治疗,针刺穴位为同侧的“后三里”、“内庭”,每次针一侧2个穴位,隔日交替。以自制的束缚装置固定,治疗时大鼠处于清醒而不剧烈挣扎状态,治疗时间15 min/d,每6天休息1 d,共观察49 d,治疗42次;药物组采用0.2 g/L盐酸西布曲明溶液2.0 mg/(kg·d)灌胃;正常组及肥胖组与针刺组同样束缚而不针刺。 主要观察指标:①肥胖指标:检测各组大鼠体质量、体长、减重率及脂体比,生化比色法测定血清总胆固醇、高密度脂蛋白胆固醇及三酰甘油。②胰岛素敏感性指标:酶联免疫法测定空腹血清葡萄糖、胰岛素及胰岛素敏感指数。③脂肪细胞分泌调节物质水平:酶联免疫法测定血清抵抗素、瘦素、脂联素、肿瘤坏死因子α、白介素-6及其可溶性受体水平。 结果:纳入大鼠120只,食源性肥胖大鼠模型成功54只及正常组18只均进入结果分析。①肥胖组大鼠体质量、体脂量、胆固醇、三酰甘油明显高于正常组,差异有统计学意义(P < 0.01)。电针组大鼠体质量、体脂量、脂体比、胆固醇、三酰甘油低于肥胖组,差异有统计学意义(P < 0.01)。药物组大鼠三酰甘油低于肥胖组,差异有统计学意义(P < 0.01)。电针组减重率高于药物组,脂体比低于药物组,差异有显著性意义(P < 0.01)。②肥胖组大鼠血糖、血清胰岛素明显高于正常组,胰岛素敏感指数低于正常组,差异均有统计学意义(P < 0.01)。电针组及药物组血糖和胰岛素水平低于肥胖组,胰岛素敏感指数高于肥胖组,差异有统计学意义(P < 0.01)。③电针组大鼠脂联素水平高于肥胖组,差异有统计学意义(P < 0.01)。抵抗素、肿瘤坏死因子α水平均低于肥胖组,差异有统计学意义(P < 0.01)。药物组大鼠抵抗素水平低于肥胖组,差异有统计学意义(P < 0.01)。 结论:电针在改变肥胖大鼠脂肪组织异常分泌的产物方面的作用较西布曲明更为明显,这可能是针灸减肥和防治肥胖相关疾病的重要机制之一。  相似文献   

10.
目的探讨癫痫发作对成年女性患者体质量及血清瘦素水平的影响。方法检测35例新诊断的成年女性原发性癫痫患者(癫痫组)和35名健康对照者(正常对照组)入组时及6个月后的体质量、身高及血清瘦素水平,并进行比较。观察癫痫患者的发作频率,对癫痫患者体质量与年龄、BMI和血清瘦素水平的关系进行相关性分析。结果 6个月后,癫痫组BMI及血清瘦素水平显著高于正常对照组(均P<0.05),并且体质量、BMI及血清瘦素水平显著高于入组时(均P<0.05)。6个月中,癫痫患者癫痫发作(2.57±3.73)次/月。癫痫患者的体质量与癫痫发作频率、血清瘦素水平呈正相关(r=0.42,P=0.013;r=0.54,P=0.001)。结论女性癫痫患者的体质量和血清瘦素水平明显增高,并且其体质量增加与癫痫发作频率、血清瘦素水平高有关。  相似文献   

11.
OBJECTIVE: The authors studied weight gain mechanisms and energy balance in patients treated with olanzapine. METHOD: The body mass index of male schizophrenic adolescent inpatients treated with olanzapine (N=10) and of 10 matched patients treated with haloperidol (N=10) were measured at baseline and after 4 weeks of treatment. For the patients treated with olanzapine, caloric intake, resting energy expenditure, and physical activity (determined through accelerometry and heart rate monitoring) were assessed at baseline and after 4 weeks of treatment. RESULTS: Body mass index significantly increased in those treated with olanzapine but not in those given haloperidol. The increase in body mass index was due to an increase in caloric intake without change in diet composition. Olanzapine had no significant effect on resting energy expenditure. Daily energy expenditure was very low before and after treatment. CONCLUSIONS: Olanzapine-induced weight gain is associated with a general increase in caloric intake.  相似文献   

12.
The objective of this cross-sectional, observational study was to compare the dietary history and the 7-day record method to assess dietary habits in obese women. The second goal was to investigate whether eating behavior characteristics influence self-reported dietary intake. The study took place at the Obesity Outpatient Clinic, University Hospital Gasthuisberg, Leuven, Belgium. Subjects were 137 obese women with a mean age of 40 ± 12 years and a mean body mass index of 38.2 ± 6.0 kg/m2.

Dietary intake was assessed both by the dietary history and by the 7-day record method. Resting energy expenditure was measured by continuous indirect calorimetry. Physical activity level was estimated using the Baecke questionnaire. To study different aspects of eating behaviour, the “Dutch Eating Behaviour Questionnaire” was used.

Absolute energy intake, as assessed by the 7-day record, was consistently lower than with the dietary history method. Sixteen percent of the obese women were overreporters while 66% clearly underreported energy intake, using dietary history as standard method. Restrained eating was associated with underreporting, while all aspects of emotional and external eating behavior were significantly higher in the group of overreporters. No relationship could be observed between the degree of underreporting and age, body weight or body mass index.

Energy intake, as assessed by the dietary history method, correlated better with measured energy expenditure in obese subjects than the 7-day record. Eating behavior characteristics influence the accuracy of self-reported dietary intake in obese women.  相似文献   

13.

The objective of this cross-sectional, observational study was to compare the dietary history and the 7-day record method to assess dietary habits in obese women. The second goal was to investigate whether eating behavior characteristics influence self-reported dietary intake. The study took place at the Obesity Outpatient Clinic, University Hospital Gasthuisberg, Leuven, Belgium. Subjects were 137 obese women with a mean age of 40 ± 12 years and a mean body mass index of 38.2 ± 6.0 kg/m2.

Dietary intake was assessed both by the dietary history and by the 7-day record method. Resting energy expenditure was measured by continuous indirect calorimetry. Physical activity level was estimated using the Baecke questionnaire. To study different aspects of eating behaviour, the “Dutch Eating Behaviour Questionnaire” was used.

Absolute energy intake, as assessed by the 7-day record, was consistently lower than with the dietary history method. Sixteen percent of the obese women were overreporters while 66% clearly underreported energy intake, using dietary history as standard method. Restrained eating was associated with underreporting, while all aspects of emotional and external eating behavior were significantly higher in the group of overreporters. No relationship could be observed between the degree of underreporting and age, body weight or body mass index.

Energy intake, as assessed by the dietary history method, correlated better with measured energy expenditure in obese subjects than the 7-day record. Eating behavior characteristics influence the accuracy of self-reported dietary intake in obese women.  相似文献   

14.
Background and purposeA strikingly increasing number of obese patients causes a great interest in potential medical problems resulting from abnormal body weight. Many conditions are associated with obesity. The severity and risk of migraine may be connected with a body weight. We would like to assess a correlation between body mass index (BMI) and frequency and duration of migraine.Materials and methodsWe collected data of 53 female patients with migraine and 36 healthy persons (25 women) as a control group. Mean duration of migraine attacks and their mean frequency were based on patients’ diaries. The patients reported their height. Weight was measured by the authors. We consequently calculated BMI and performed statistics on SAS 9.2.ResultsThe mean BMI of the migraine group was 24.27 ± 4.47. Forty-nine percent of patients had normal BMI (18.5–25), 30% patients were overweight (>25) and 13% were obese (>30). The mean BMI among controls was 22.69 ± 2.96. Eighty-four percent of the control group had normal BMI, 12% was overweight and 5% was obese. An association of BMI in women with frequency of migraine episodes per month occurred remarkable when adjusted for age. Difference of a mean BMI value between the migraine and the control group was nearly statistically significant. Body mass index and duration of the episodes revealed similarly strong correlation.ConclusionsIncreased BMI correlates with frequency of migraine. Its influence on a risk of the headaches and their duration remains to be specified.  相似文献   

15.
OBJECTIVE: Patients with schizophrenia treated with clozapine often gain weight. This study evaluated the effects of dietary control and physical activity among obese inpatients with schizophrenia being treated with clozapine. METHODS: Fifty-three clozapine-treated obese patients with schizophrenia in a veterans hospital in eastern Taiwan who had a body mass index greater than 27 (weight divided by height in meters squared) and who were taking clozapine were randomly assigned to a study group of 28 or a control group of 25. The study group was placed on a diet that reduced calorie intake by 200 to 300 kcal per day (to 1,300 to 1,500 kcal per day for women and to 1,600 to 1,800 kcal per day for men) and a six-month regimen of regular physical activity in which participants used approximately 600 to 750 kcal per week (level walking and walking on stairs for 60 minutes three days per week). Anthropometric, metabolic, and hormonal parameters were measured after three and six months by using anthropometry, an enzyme autoanalyzer, immunoassay, and enzyme-linked immunosorbent assay. RESULTS: Compared with the control group, the study group showed a significant decrease in body weight, body mass index (5.4% reduction), waist circumference (3.3 cm), and hip circumference (3.3 cm) after three months and after six months. Triglyceride and insulin-like growth factor-binding protein-3 (IGFBP-3) decreased significantly only after six months. CONCLUSIONS: A program of dietary control and regular physical activity can significantly reduce body weight and improve metabolic profiles of insulin, triglyceride, and IGFBP-3 among obese inpatients taking clozapine for the treatment of schizophrenia.  相似文献   

16.
Autosomal dominant spinocerebellar ataxia type 1 (SCA1) is a genetic movement disorder with neuronal loss in the cerebellum, brainstem, and other cerebral regions. The course of SCA1 is accompanied with progressive weight loss and amyotrophia—the causes for that remain, however, unclear. We tested the hypothesis that an imbalance between energy intake and expenditure contributes to weight loss in SCA1 patients. Anthropometric measures, energy intake (food records), and resting (calorimetry) and free-living (accelerometry) energy expenditure were determined in 10 patients with genetically proven SCA1 and 10 healthy controls closely matched for age, sex, and body composition. At rest, energy expenditure per kilogram fat-free mass was 22 % and fat oxidation rate 28 % higher in patients vs. controls indicating an increased catabolic state. Under free-living conditions, total energy expenditure and daily step counts were significantly lower in patients vs. controls. However, most patients were able to maintain energy intake and expenditure in a balanced state. Resting energy expenditure, fat oxidation, and activity energy expenditure per step count are higher, whereas 24-h total energy expenditure is lower in SCA1 patients vs. healthy controls. An altered autonomic nervous system activity, gait ataxia, and a decreased physical activity might contribute to this outcome.  相似文献   

17.
The aim of this study was to determine the body composition and resting metabolic rate (RMR) of girls with Rett syndrome (RS) (n=15) and to compare them with an equally handicapped group of girls with developmental disabilities (DD) (n=13). Body composition was measured by bioelectrical impedance analysis and RMR - the amount of energy expended while at rest - by indirect calorimetry. Weight, height, body mass index (BMI), BMI percentiles and food intake were all measured and calculated by standardized procedures. Feeding time, ambulatory status and ability to self-feed were also assessed. Due to the sampling, there were no significant differences in age, height, weight, BMI, BMI percentiles and ambulatory status. Significant differences between groups were found for lower percentage lean body mass (LBM) (64.2±14.6 vs. 84.4±24.6) and higher absolute and relative fat mass (FM) in RS. RMR values adjusted for LBM were significantly higher in the group of girls with RS (approximately 160?kcal/day), indicating that higher energy expenditure is a component of increased risk of severely low body weight.  相似文献   

18.
The resting energy expenditure and the adaptation of the autonomic nervous system induced by sport activities in sedentary women and in female professional basketball players have been studied. Resting energy expenditure, body composition and the level of activity of the autonomic nervous system were measured before and after a period of six months. The physical activity induced an increase in resting energy expenditure and free fat mass without variations in body weight. Basketball players showed a significant increase in the parasympathetic activity, measured by the power spectral analysis of the heart rate variability. These findings demonstrate that resting energy expenditure is higher in the athletes than in sedentary women, despite the augmented parasympathetic activity that is usually related to lower energy expenditure.  相似文献   

19.
OBJECTIVES: Patients with bipolar disorder (BD) on long-term maintenance treatment represent a clinical population with peculiar characteristics, for which available equations to estimate resting energy expenditure (REE) are not suitable. The aim of this study was to measure REE by means of indirect calorimetry in bipolar patients on maintenance treatment and in controls, and to estimate the agreement between measured and predicted REE in both groups. METHODS: Patients diagnosed with BD I and healthy controls were assessed for height, weight and body mass index (BMI). Predicted REE was calculated using Harris-Benedict, Schofield, Recommended Nutrients Assumption Levels (LARN), and OUR equations; measurements of REE were performed using a portable indirect calorimeter. RESULTS: Results for our sample show the most commonly used formulas give a systematic overestimation of REE with respect to measured basal metabolic rate in the patient group. The mean bias was considerably greater for bipolar subjects than for controls. CONCLUSIONS: These results suggest that patients with severe mental illness on long-term psychopharmacologic treatment may have reduced basal energy expenditure that may be a cause of weight gain.  相似文献   

20.
Purpose:  Levodopa dose per kilogram body weight is reported to be a significant factor for dyskinesia in Parkinson's disease. We have investigated this hypothesis in data from the studies comparing ropinirole versus levodopa as the initial therapy.
Methods:  Data from the ropinirole versus levodopa studies 056 and REAL-PET in early Parkinson's disease were pooled and manipulated to calculate levodopa dose per kilogram body weight. Logistic regression analysis was performed to investigate significant variables for the development of dyskinesia. Only the patients on levodopa monotherapy or with ropinirole were analyzed.
Results:  Analysis of levodopa therapy patients revealed that dyskinetic patients had received significantly higher absolute levodopa dose and levodopa dose per kilogram body weight. Logistic regression revealed that the most significant factor was the higher levodopa dose per kilogram body weight, P  = 0.005, odds ratio 1.078, 95% CI 1.023–1.135; younger age was the second factor – P  = 0.026. Variables of gender, absolute levodopa dose, weight, disease duration and initial motor Unified Parkinson's disease rating score were not significant.
Conclusion:  Higher levodopa dose per kilogram body weight is an independently significant factor for developing dyskinesia. This relationship should be considered in treatment of Parkinson's disease patients aiming to prevent and manage dyskinesia.  相似文献   

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