共查询到20条相似文献，搜索用时 187 毫秒
1.
Naoum P. Issa Shasha Wu Sandra Rose Vernon L. Towle Peter C. Warnke James X. Tao 《Clinical neurophysiology》2018,129(9):1796-1803
Objective
Mesial temporal lobe epilepsy (mTLE) is the most common type of focal epilepsy, but often lacks scalp EEG correlates. We ask if hippocampal epileptiform discharges that are characteristic of mTLE are associated with small sharp spikes (SSS) recorded on scalp EEG. SSS are considered benign waveforms, so are not currently used as markers of epilepsy.Methods
To determine if there is a relationship between SSS and hippocampal discharges, simultaneous scalp and hippocampal depth electrode EEGs were recorded from 27 patients being evaluated for possible mTLE. Scalp EEG waveforms were assessed at the time of hippocampal discharges identified on intracranial hippocampal depth electrodes.Results
15 of 27 patients had SSS on scalp EEG that were time locked to hippocampal epileptiform discharges measured intracranially. These hippocampal spikes tended to have overlying high frequency oscillations and to co-localize with a seizure onset zone, suggesting that they were pathological discharges.Conclusions
There is a tight coupling between a subset of pathological hippocampal discharges and SSS.Significance
SSS can be scalp EEG markers of mTLE rather than normal EEG variants. 相似文献2.
Alice D. Lam Douglas Maus Sahar F. Zafar Andrew J. Cole Sydney S. Cash 《Clinical neurophysiology》2017,128(9):1647-1655
Objective
In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG.Methods
Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern.Results
Using SCOPE-mTL, 73% of seizures with occult mTL onset were identified as such, and no seizures that lacked an occult mTL onset were identified as having one. Predicted mTL seizure onset times were highly correlated with actual mTL seizure onset times (r = 0.69). 50% of seizures with early mTL onset were lateralizable prior to scalp ictal onset, with 94% accuracy.Conclusions
SCOPE-mTL can identify and lateralize mTL seizures prior to scalp EEG ictal onset, with high sensitivity, specificity, and accuracy.Significance
Quantitative analysis of scalp EEG can provide important information about mTL seizures, even in the absence of a visible scalp EEG ictal correlate. 相似文献3.
Hong Li Caihong Ji Lujia Zhu Peiyu Huang Biao Jiang Xiaojun Xu Jianzhong Sun Zhong Chen Meiping Ding Minming Zhang Shuang Wang 《Clinical neurophysiology》2017,128(5):830-838
Objective
To investigate the pattern of functional demarcation of hippocampal network and its relationship with memory performance in mesial temporal lobe epilepsy (mTLE) with unilateral hippocampal sclerosis.Methods
Resting state fMRI data were acquired from fifteen left mTLE patients, fourteen right mTLE patients and twenty healthy subjects. We explore the hippocampal-cortical alterations and corresponding inter-hemispheric functional connectivity (FC) across anterior and posterior hippocampal networks. The association between FC and memory performance was assessed.Results
Left mTLE showed increased intra-hemispheric FC in anterior hippocampal networks, including left anterior hippocampal-entorhinal cortex and right anterior hippocampal-orbitofrontal cortex, and decreased inter-hemispheric FC between anterior hippocampus, entorhinal cortex and posterior cingulate cortex. Right mTLE was associated with extensive reduction in inter-hemispheric FC along the areas of anterior and posterior hippocampal networks. Intra-hemispheric FC between left anterior hippocampus and entorhinal cortex was positively correlated with verbal memory in left mTLE. Inter-hemispheric FC between posterior parahippocampal gyrus was negatively correlated with verbal memory in right mTLE.Conclusions
Our findings suggested that left and right mTLE exhibit different neural reorganization patterns of anterior and posterior hippocampal networks associated with verbal memory.Significance
The findings may facilitate the characterization of mTLE associated with memory deficit. 相似文献4.
Michael B.H. Hall Ida A. Nissen Elisabeth C.W. van Straaten Paul L. Furlong Caroline Witton Elaine Foley Stefano Seri Arjan Hillebrand 《Clinical neurophysiology》2018,129(6):1221-1229
Objective
Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.Methods
We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.Results
The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).Conclusions
Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.Significance
Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone. 相似文献5.
Sumiya Shibata Masao Matsuhashi Takeharu Kunieda Yukihiro Yamao Rika Inano Takayuki Kikuchi Hisaji Imamura Shigetoshi Takaya Riki Matsumoto Akio Ikeda Ryosuke Takahashi Tatsuya Mima Hidenao Fukuyama Nobuhiro Mikuni Susumu Miyamoto 《Clinical neurophysiology》2017,128(5):734-743
Objective
We describe temporal spread imaging (TSI) that can identify the spatiotemporal pattern of epileptic activity using Magnetoencephalography (MEG).Methods
A three-dimensional grid of voxels covering the brain is created. The array-gain minimum-variance spatial filter is applied to an interictal spike to estimate the magnitude of the source and the time (Ta) when the magnitude exceeds a predefined threshold at each voxel. This calculation is performed through all spikes. Each voxel has the mean Ta (<Ta>) and spike number (Nsp), which is the number of spikes whose source exceeds the threshold. Then, a random resampling method is used to determine the cutoff value of Nsp for the statistically reproducible pattern of the activity. Finally, all the voxels where the source exceeds the threshold reproducibly shown on the MRI with a color scale representing <Ta>.Results
Four patients with intractable mesial temporal lobe epilepsy (MTLE) were analyzed. In three patients, the common pattern of the overlap between the propagation and the hypometabolism shown by fluorodeoxyglucose-positron emission tomography (FDG-PET) was identified.Conclusions
TSI can visualize statistically reproducible patterns of the temporal and spatial spread of epileptic activity.Significance
TSI can assess the statistical significance of the spatiotemporal pattern based on its reproducibility. 相似文献6.
Martin Pail Pavel Řehulka Jan Cimbálník Irena Doležalová Jan Chrastina Milan Brázdil 《Clinical neurophysiology》2017,128(1):106-114
Objective
The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions.Methods
We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ).Results
In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes.Conclusions
FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ.Significance
Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity. 相似文献7.
Satsuki Watanabe François Dubeau Natalja Zazubovits Jean Gotman 《Clinical neurophysiology》2017,128(6):986-991
Objective
It has been reported that interictal epileptic discharges (IEDs) recorded in temporal regions on scalp EEG are unlikely to originate from mesial temporal structures. However, EEG-fMRI sometimes show mesial temporal activation. We hypothesized that BOLD activation in the temporal neocortex is weaker than in the mesial structures, reflecting the fact that propagated activity has less metabolic demand than the original discharge.Methods
Twelve patients with epilepsy who have BOLD response in mesial temporal structures were selected from our EEG-fMRI database. We searched the temporal lobe ipsilateral to IEDs and checked whether there is positive BOLD response in the neocortex.Results
All IED types showed a BOLD response in the temporal neocortex ipsilateral to the mesial temporal BOLD response. T-values were higher in mesial temporal structures than in neocortex in 13/16 cases.Conclusions
Hemodynamic changes were observed in the mesial temporal lobe at the time of IEDs recorded from the temporal region on the scalp. The finding of smaller BOLD changes in the ipsilateral neocortex is in agreement with our hypothesis.Significance
Our study indicates that scalp-recorded temporal lobe spikes are likely to result from mesial temporal spikes propagating neuronally to the neocortex. 相似文献8.
I.C. Zibrandtsen P. Kidmose C.B. Christensen T.W. Kjaer 《Clinical neurophysiology》2017,128(12):2454-2461
Objective
Ear-EEG is recording of electroencephalography from a small device in the ear. This is the first study to compare ictal and interictal abnormalities recorded with ear-EEG and simultaneous scalp-EEG in an epilepsy monitoring unit.Methods
We recorded and compared simultaneous ear-EEG and scalp-EEG from 15 patients with suspected temporal lobe epilepsy. EEGs were compared visually by independent neurophysiologists. Correlation and time-frequency analysis was used to quantify the similarity between ear and scalp electrodes. Spike-averages were used to assess similarity of interictal spikes.Results
There were no differences in sensitivity or specificity for seizure detection. Mean correlation coefficient between ear-EEG and nearest scalp electrode was above 0.6 with a statistically significant decreasing trend with increasing distance away from the ear. Ictal morphology and frequency dynamics can be observed from visual inspection and time-frequency analysis. Spike averages derived from ear-EEG electrodes yield a recognizable spike appearance.Conclusions
Our results suggest that ear-EEG can reliably detect electroencephalographic patterns associated with focal temporal lobe seizures. Interictal spike morphology from sufficiently large temporal spike sources can be sampled using ear-EEG.Significance
Ear-EEG is likely to become an important tool in clinical epilepsy monitoring and diagnosis. 相似文献9.
Betweenness centrality of intracranial electroencephalography networks and surgical epilepsy outcome
Bartosz T. Grobelny Dennis London Travis C. Hill Emily North Patricia Dugan Werner K. Doyle 《Clinical neurophysiology》2018,129(9):1804-1812
Objective
We sought to determine whether the presence or surgical removal of certain nodes in a connectivity network constructed from intracranial electroencephalography recordings determines postoperative seizure freedom in surgical epilepsy patients.Methods
We analyzed connectivity networks constructed from peri-ictal intracranial electroencephalography of surgical epilepsy patients before a tailored resection. Thirty-six patients and 123 seizures were analyzed. Their Engel class postsurgical seizure outcome was determined at least one year after surgery. Betweenness centrality, a measure of a node’s importance as a hub in the network, was used to compare nodes.Results
The presence of larger quantities of high-betweenness nodes in interictal and postictal networks was associated with failure to achieve seizure freedom from the surgery (p?<?0.001), as was resection of high-betweenness nodes in three successive frequency groups in mid-seizure networks (p?<?0.001).Conclusions
Betweenness centrality is a biomarker for postsurgical seizure outcomes. The presence of high-betweenness nodes in interictal and postictal networks can predict patient outcome independent of resection. Additionally, since their resection is associated with worse seizure outcomes, the mid-seizure network high-betweenness centrality nodes may represent hubs in self-regulatory networks that inhibit or help terminate seizures.Significance
This is the first study to identify network nodes that are possibly protective in epilepsy. 相似文献10.
Tyler S. Davis John D. Rolston Robert J. Bollo Paul A. House 《Clinical neurophysiology》2018,129(11):2466-2474
Objective
Single-pulse electrical stimulation (SPES) of intracranial electrodes evokes responses that may help identify the seizure onset zone (SOZ); however, lack of automation and response variability has limited clinical adoption of this technique. We evaluated whether automated delivery of low-current SPES could evoke delayed high-frequency suppression (DHFS) of ongoing electrocorticography (ECoG) signals that, when combined with objective analytic techniques, may provide a reliable marker of this zone.Methods
Low-current SPES (1-ms, 3.5-mA biphasic pulses) was delivered to 652 electrodes across 10 patients undergoing ECoG for seizure focus localization. DHFS was measured by calculating the normalized trial-averaged time-frequency power (70–250?Hz) 0.4–1?sec post-stimulation. Electrodes that evoked suppression when stimulated or recorded suppression when stimulation was nearby were used to estimate the SOZ.Results
The estimated SOZ significantly identified the clinical SOZ in 6 of 10 patients (5 of 7 temporal foci) with a false-positive rate of 0–0.06. Stimulation required <2?h, was undetectable by patients, and did not induce seizures or after-discharges.Conclusions
We show that DHFS provides accurate estimates of the clinical SOZ in patients with refractory epilepsy.Significance
This approach may increase the safety, speed, and reproducibility of SOZ identification while reducing cost, subjectivity, and patient discomfort. 相似文献11.
Amir G. Baroumand Pieter van Mierlo Gregor Strobbe Lars H. Pinborg Martin Fabricius Guido Rubboli Anne-Mette Leffers Peter Uldall Bo Jespersen Jannick Brennum Otto Mølby Henriksen Sándor Beniczky 《Clinical neurophysiology》2018,129(11):2403-2410
Objective
To evaluate the accuracy of automated EEG source imaging (ESI) in localizing epileptogenic zone.Methods
Long-term EEG, recorded with the standard 25-electrode array of the IFCN, from 41 consecutive patients with focal epilepsy who underwent resective surgery, were analyzed blinded to the surgical outcome. The automated analysis comprised spike-detection, clustering and source imaging at the half-rising time and at the peak of each spike-cluster, using individual head-models with six tissue-layers and a distributed source model (sLORETA). The fully automated approach presented ESI of the cluster with the highest number of spikes, at the half-rising time. In addition, a physician involved in the presurgical evaluation of the patients, evaluated the automated ESI results (up to four clusters per patient) in clinical context and selected the dominant cluster and the analysis time-point (semi-automated approach). The reference standard was location of the resected area and outcome one year after operation.Results
Accuracy was 61% (95% CI: 45–76%) for the fully automated approach and 78% (95% CI: 62–89%) for the semi-automated approach.Conclusion
Automated ESI has an accuracy similar to previously reported neuroimaging methods.Significance
Automated ESI will contribute to increased utilization of source imaging in the presurgical evaluation of patients with epilepsy. 相似文献12.
Hiroshi Shirozu Akira Hashizume Hiroshi Masuda Yosuke Ito Yoko Nakayama Takefumi Higashijima Masafumi Fukuda Shigeki Kameyama 《Clinical neurophysiology》2017,128(8):1504-1512
Objective
We aimed to validate the usefulness of gradient magnetic-field topography (GMFT) for analysis of ictal magnetoencephalography (MEG) in patients with neocortical epilepsy.Methods
We identified 13 patients presenting with an ictal event during preoperative MEG. We applied equivalent current dipole (ECD) estimation and GMFT to detect and localize the ictal MEG onset, and compared these methods with the ictal onset zone (IOZ) derived from chronic intracranial electroencephalography. The surgical resection areas and outcomes were also evaluated.Results
GMFT detected and localized the ictal MEG onset in all patients, whereas ECD estimation showed localized ECDs in only 2. The delineation of GMFT was concordant with the IOZ at the gyral-unit level in 10 of 12 patients (83.3%). The detectability and precision of delineation of ictal MEG activity by GMFT were significantly superior to those of ECD (p < 0.05 and p < 0.01, respectively). Complete resection of the IOZ in the concordant group provided seizure freedom in 3 patients, whereas seizures remained in 9 patients who had incomplete resections.Conclusions
Because of its higher spatial resolution, GMFT of ictal MEG is superior to conventional ECD estimation in patients with neocortical epilepsy.Significance
Ictal MEG study is a useful tool to estimate the seizure onset in patients with neocortical epilepsy. 相似文献13.
F. Fürbass S. Kampusch E. Kaniusas J. Koren S. Pirker R. Hopfengärtner H. Stefan T. Kluge C. Baumgartner 《Clinical neurophysiology》2017,128(8):1466-1472
Objective
This study investigated sensitivity and false detection rate of a multimodal automatic seizure detection algorithm and the applicability to reduced electrode montages for long-term seizure documentation in epilepsy patients.Methods
An automatic seizure detection algorithm based on EEG, EMG, and ECG signals was developed. EEG/ECG recordings of 92 patients from two epilepsy monitoring units including 494 seizures were used to assess detection performance. EMG data were extracted by bandpass filtering of EEG signals. Sensitivity and false detection rate were evaluated for each signal modality and for reduced electrode montages.Results
All focal seizures evolving to bilateral tonic-clonic (BTCS, n = 50) and 89% of focal seizures (FS, n = 139) were detected. Average sensitivity in temporal lobe epilepsy (TLE) patients was 94% and 74% in extratemporal lobe epilepsy (XTLE) patients. Overall detection sensitivity was 86%. Average false detection rate was 12.8 false detections in 24 h (FD/24 h) for TLE and 22 FD/24 h in XTLE patients. Utilization of 8 frontal and temporal electrodes reduced average sensitivity from 86% to 81%.Conclusion
Our automatic multimodal seizure detection algorithm shows high sensitivity with full and reduced electrode montages.Significance
Evaluation of different signal modalities and electrode montages paces the way for semi-automatic seizure documentation systems. 相似文献14.
Gewalin Aungaroon Andrew Trout Rupa Radhakrishnan Paul S. Horn Ravindra Arya Jeffrey R. Tenney Todd M. Arthur Katherine D. Holland Francesco T. Mangano James L. Leach Leonid Rozhkov Hansel M. Greiner 《Clinical neurophysiology》2018,129(9):1842-1848
Objective
We evaluated the impact of radiotracer injection latency and post-injection seizure duration on subtraction ictal SPECT co-registered to MRI (SISCOM) test performance in identifying the epileptogenic zone (EZ) in children with drug-resistant epilepsy who had undergone a resective epilepsy surgery.Methods
SISCOM concordance with the EZ was retrospectively reviewed to evaluate its performance in 113 children. The impact of radiotracer injection latency and post-injection seizure duration was evaluated for their predictive value of SISCOM localization accuracy.Results
The overall sensitivity and specificity of SISCOM in identifying an EZ was 64.8% (95%CI?=?50.6–77.3) and 40.7% (95%CI?=?28.1–54.3). The positive likelihood ratio and diagnostic odd ratio was 1.09 (95%CI?=?0.80–1.48) and 1.26 (95%CI?=?0.59–2.71), respectively. Logistic regression showed that injection latency and post-injection seizure duration did not significantly predict the probability of true positive SISCOM (p-value?=?0.45 and 0.29, respectively).Conclusion
Radiotracer injection latency and post-injection seizure duration were not shown to have a statistical significant impact on SISCOM performance in identifying the EZ.Significance
This study demonstrates that further study of factors contributing to the performance of SISCOM in EZ identification in children is needed. 相似文献15.
Chaturbhuj Rathore Pandurang R. Wattamwar Neeraj Baheti Malcolm Jeyaraj Gopal K. Dash Sankara P. Sarma Kurupath Radhakrishnan 《Clinical neurophysiology》2018,129(9):1907-1912
Objective
To evaluate the prognostic value of postoperative EEGs to estimate post anterior temporal lobectomy (ATL) seizure outcome.Methods
We studied postoperative EEGs in 325 consecutive patients who had minimum five years of post-ATL followup. Interictal epileptiform discharges (IEDs) present only during sleep were classified as sleep IEDs. We defined favorable final-year outcome as no seizures during the final one year and favorable absolute-postoperative outcome as no seizures during the entire postoperative period.Results
At mean follow-up of 7.3?±?1.8?years, 281 (86.5%) patients had favorable final-year outcome while 161 (49.5%) had favorable absolute-postoperative outcome. IEDs on three months and one year EEG were associated with unfavorable outcomes while IEDs at 7th day had no association with outcomes. Sleep record increased the yield of IEDs by 30% at each time-point without compromising predictive value. EEG at one year predicted the risk of seizure recurrence on drug withdrawal.Conclusion
While EEG at three months and at one-year after ATL predicted seizure outcome, EEG at 7th day was not helpful. Sleep record increases the sensitivity of postoperative EEG without compromising specificity.Significance
Both awake and sleep EEG provide useful information in postoperative period following ATL. 相似文献16.
Objective
Relationship between electrographic seizures on hippocampal electrocorticography (IH-ECoG) and presence/type of hippocampal pathology remains unclear.Methods
IH-ECoG was recorded for 10–20?min from the ventricular surface of the hippocampus following removal of the temporal neocortex in 40 consecutive patients. Correlation between intraoperative hippocampal seizures and preoperative MRI, hippocampal histopathology, and EEG from invasive monitoring was determined.Results
IH-ECoG captured electrographic seizures in 15/40 patients (in 8/23 with abnormal hippocampal signal on MRI and 7/17 patients without MRI abnormality). Hippocampal neuronal loss was observed in 22/40 (Group 1), while 18/40 had no significant neuronal loss (Group 2). In Group 1, 4/22 had seizures on IH-ECoG, while 11/18 had electrographic seizures in Group 2. In 24/40 patients who underwent prolonged extraoperative intracranial EEG (IC-EEG) recording, hippocampal seizures were captured in 14. Of these, 7 also had seizures during IH-ECoG. In 10/24 IC-EEG patients without seizures, 3 had seizures on IH-ECoG.Conclusions
IH-ECoG frequently captures spontaneous electrographic seizures. These are more likely to occur in patients with pathologic processes that do not disrupt/infiltrate hippocampus compared to patients with intractable epilepsy associated with disrupted hippocampal architecture.Significance
Intraoperative hippocampal seizures may result from deafferentation from the temporal neocortex and disinhibition of the perforant pathway. 相似文献17.
Gopal Krishna Dash Chaturbhuj Rathore Malcolm K. Jeyaraj Pandurang Wattamwar Sankara P. Sarma Kurupath Radhakrishnan 《Clinical neurophysiology》2018,129(5):946-951
Objective
Interictal regional paroxysmal fast activity (RPFA) on scalp EEG is common in patients with focal cortical dysplasia (FCD). Little data exists regarding the presence of RPFA in other etiologies.Methods
We studied the association between RPFA and etiology on MRI in patients with drug resistant focal epilepsy undergoing presurgical evaluation in 2011. RPFA was defined as ≥3 consecutive spikes with a frequency of ≥10?Hz lasting ≥300?ms but <4?s.Results
626 patients fulfilled the inclusion criteria. Of these, 138 (22%) patients had RPFA while rest had other interictal epileptiform discharges (IEDs). RPFA was located at posterior head region in 52.2% patients, frontal regions in 24.6% patients and over temporal regions in 17.4% patients. Focal gliosis (61, 44%) and FCD (27, 19%) were common etiologies in patients with RPFA. Compared to patients with other IEDs, patients with RPFA were more likely to have focal gliosis (61/138 vs. 39/488; p?<?0.0001) or FCD (27/138 vs 37/488; p?<?0.001) as the etiology of epilepsy.Conclusion
In developing countries, focal gliosis is more common than FCD as the underlying etiology in patients with RPFA on scalp EEG.Significance
Focal gliosis should be considered as one of the common substrate for RPFA on scalp EEG. 相似文献18.
Giulia Varotto Silvana Franceschetti Davide Caputo Elisa Visani Laura Canafoglia Elena Freri Francesca Ragona Giuliano Avanzini Ferruccio Panzica 《Clinical neurophysiology》2018,129(11):2372-2379
Objective
To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS).Methods
We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality.Results
In comparison with the controls, the awake EEG recordings of the patients with lateralised BECTS showed a minimal increase in out-degrees on F4 and F3. The greater differences, found during sleep, included significant reductions in both in- and out-degrees and strength in all of the patient groups, but in T4 or T3 showing increased out-degrees and strength in Right and Left-BECTS. Betweenness centrality was significantly reduced on C3 and C4 in the patients with MF-BECTS.Conclusions
Our observations suggest that the main finding in BECTS patients is widely reduced local connectivity.Significance
The network changes in BECTS can be interpreted as a permissive condition occurring in a developmental window that predisposes to seizure generation during spindle-sleep. 相似文献19.
Shuang Wang Norman K. So Bo Jin Irene Z. Wang Juan C. Bulacio Rei Enatsu Shenyi Dai Zhong Chen Jorge Gonzalez-Martinez Imad M. Najm 《Clinical neurophysiology》2017,128(6):945-951
Objective
This study aimed to identify the subtype of interictal ripples that help delineate the epileptogenic zone in neocortical epilepsy.Methods
Totally 25 patients with focal neocortical epilepsy who had invasive electroencephalography (EEG) evaluation and subsequent surgery were included. They were followed up for at least 2 years. Interictal ripples (80–250 Hz) and fast ripples (250–500 Hz) during slow-wave sleep were identified. Neocortical ripples were defined as type I ripples when they were superimposed on epileptiform discharges, and as type II ripples when they occurred independently. Resection ratio was calculated to present the extent to which the cortical area showing an interictal event or the seizure onset zone (SOZ) was completely removed.Results
Fast ripples and types I and II ripples were found in 8, 19, and 21 patients, respectively. Only the higher resection ratio of interictal fast or type I ripples was correlated to the Engel 1a surgical outcome.Conclusions
Type I ripples could assist in localizing the epileptogenic zone in neocortical epilepsy.Significance
Type I and fast ripples both may be pathological high-frequency oscillations. 相似文献20.
Satoru Ikemoto Shin-ichiro Hamano Susumu Yokota Reiko Koichihara Yuko Hirata Ryuki Matsuura 《Clinical neurophysiology》2018,129(9):1920-1925