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1.
目的观察随访护理改善癫痫患者焦虑抑郁情绪及生活质量的作用。方法选取2013-04—2015-03我院收治的成年癫痫患者124例,随机分为观察组与对照组,对照组实施常规护理,观察组在此基础上开展随访护理,比较观察2组焦虑抑郁情绪(临床自评量表SAS/SDS)与生活质量(癫痫患者生活质量量表QOLIE-31)情况。结果观察组护理干预后SAS/SDS评分均显著降低,且明显低于对照组(P0.05);观察组QOLIE-31各项评分均明显升高,且高于对照组,差异均有统计学意义(P0.05)。结论随访护理够有效缓解成年癫痫患者焦虑、抑郁等负面情绪,同时明显提高患者的生活质量,具有理想的临床应用价值。  相似文献   

2.
目的调查研究外科手术治疗对成年难治性癫痫患者生活质量的影响.方法运用QOLIE-31量表对100例在我院接受癫痫灶切除术或阻断癫痫异常放电传播和减弱癫痫灶相互影响手术的癫痫患者手术前后生活质量进行调查,并与100例药物治疗对照进行比较,统计学分析用SPSS10.0软件.结果难治性癫痫患者生活质量明显低于对照组,表现在惧怕发作,对日常生活不满意,情绪差,精力不足,认知功能下降,对长期服用抗癫痫药物的顾虑较多,社交、工作受限等,经手术治疗癫痫患者的生活质量明显提高.结论成年难治性癫痫患者生活质量普遍较低,外科手术治疗可显著提高其生活质量.  相似文献   

3.
成年癫痫患者抑郁、焦虑状况及生活质量调查   总被引:7,自引:0,他引:7  
目的调查成年癫痫患者抑郁、焦虑的患病率及可能的危险因素;评价抑郁及焦虑对癫痫患者生活质量的影响。方法采用Beck抑郁问卷(BDI)、贝克焦虑量表(BAI)及癫痫患者生活质量量表-31(QO-LIE-31中文版),对200例成年癫痫患者的抑郁、焦虑情况及生活质量进行评估。结果在200例癫痫患者中43.5%伴发抑郁,28.5%伴发焦虑,23%伴发抑郁及焦虑。发作频繁、无有薪职业是癫痫患者伴发抑郁的重要危险因素,无有薪职业是癫痫患者伴发焦虑的危险因素。抑郁组及抑郁伴焦虑组的QOLIE-31总分及各项评分均低于非抑郁非焦虑组(P=0.000);焦虑组的QOLIE-31总分(P=0.004)及发作的担忧(P=0.019)、认知功能(P=0.009)方面的得分均低于非抑郁非焦虑组。结论抑郁和焦虑是癫痫患者常见的精神共病,严重影响了癫痫患者的生活质量。积极控制发作、为癫痫患者提供更多的就业机会是改善癫痫患者生活质量的重要因素。  相似文献   

4.
成年癫痫患者生活质量的研究   总被引:12,自引:0,他引:12  
目的运用QOLIE-31量表中文版调查评估广东地区成年癫痫患者的生活质量。方法对398例患者采用简单随机抽样,信函调查等调查方法进行调查,用SPSS 10.0软件进行统计学处理。结果198例不同性别间P>0.05.不同性别之间生活质量无显著性差异;婚姻在发作担忧、总的生活质量、感情幸福、精力和疲劳以及中国文化调适等方面有显著性差异P<0.05,不同经济状况之间在发作担忧和药物作用方面存在显著差异P<0.05;不同学历在社会功能一项P<0.05.表示不同学历在社会功能方面有显著性意义。结论在不同性别之间成年癫痫患者的生活质量无明显不同;婚姻、学历和经济状况对患者的生活质量有不同的影响。  相似文献   

5.
目的调查分析立体定向手术治疗对成年难治性癫痫患者生活质量的影响。方法对92例无明确致痫灶的成年难治性癫痫患者进行立体定向手术治疗,采用症状自评量表(SCL-90)、癫痫患者生活质量量表-31(QOLIE-31)在手术前及手术后半年、1年、2年、3年、4年、5年对患者进行连续评估。结果尽管部分患者术后癫痫症状不能完全控制,但患者总的生活质量在手术后各阶段均较术前明显提高。手术效果EngelⅠ级患者术后各时间段的生活质量优于Ⅱ~Ⅳ级患者的生活质量。术前具有明显精神症状患者术后各时间段的生活质量与术前无精神症状患者的术后生活质量比较无明显差异。结论对于经术前综合评估不能确定致痫灶,特别是伴有明显精神症状的难治性癫痫患者,立体定向手术治疗是一种有效的治疗手段,可显著改善这部分患者的生活质量。  相似文献   

6.
目的:评价拉莫三嗪对癫痫患者生活质量的影响。方法:采用多中心、前瞻性的研究方法,对新诊断癫痫患者应用拉莫三嗪治疗,并在基线期及用药6个月后,采用QOLIE-31、MOSSF-36量表、数字符号转换测验、HAMD抑郁量表和女性专用调查问卷对患者进行生活质量评价。结果:共纳入新诊断癫痂患者282例。MOSSF-36量表的8个项目得分在用药后均有显著提高(P〈0.01);QOLIE-31问卷中“对癫痫的担心”、“情绪”、“活力”、“认知”、“药物不良反应”、“社会功能”及“总体自身健康评价”项目得分在用药后均有显著提高(P〈0.01)。用药后,患者Hamilton抑郁量表平均3.65分,显著低于基线期6.42分(P〈0.01);数字符号转换测验得分在用药后与基线期比较有显著提高(P〈0.01)。结论:拉莫三嗪初始单药治疗能在一定程度上改善新诊断癫痫患者的生活质量。  相似文献   

7.
目的探讨拉莫三嗪(LTG)治疗新诊断成人原发性癫痫的临床疗效。方法选择符合标准的癫痫患者40例,采用LTG单药治疗,观察记录治疗前后癫痫发作次数及成人癫痫患者生活质量量表-31(QOLIE-31)评分。结果控制16例(40.0%),显效14例(35.00%),有效8例(20.00%),无效2例(5.00%)。治疗后患者QOLIE-31各维度评分较治疗前均提高,差异有统计学意义(P0.05)。癫痫发作频率减少百分率与QOLIE-31总评分呈显著正相关关系(r=0.350,P0.05)。结论 LTG治疗新诊断成人原发性癫痫具有较高的癫痫发作控制率,临床疗效显著,可以明显改善患者的生存状态和生活质量。  相似文献   

8.
目的检验卒中危险因素初筛表的信度、效度。方法对130例测试对象进行卒中危险因素初筛表、改良弗明汉卒中风险评估量表(Framingham Stroke Profile,FSP)进行调查,检验卒中危险因素初筛表的信度及效度。结果卒中危险因素初筛表的Cronbachα系数为0.701,分半信度为0.826,重测信度为0.94。因子分析法提取5个共性因子,公因子的累计方差贡献率为62.199%,量表的结构效度、内容效度、效标效度达到测量学要求。结论卒中危险因素初筛表具有较好的信度与效度,符合量表测量学的要求,可作为我国卒中风险评估的工具。  相似文献   

9.
目的:评价新型抗癫痫药物左乙拉西坦(Lev)作为添加治疗对难治性部分性癫痫患者生活质量的影响。方法:43例确诊有癫痫部分性发作的成年患者随机分为两组:Lev治疗组与安慰剂组,Lev治疗16周后比较两组的有效率和不良反应,并用QOLIE-31量表对两组癫痫患者进行生活质量评定,所有患者在转入Lev开放性治疗6个月后再次进行QOLIE评估。结果:16周治疗期末Lev组癫痫部分性发作的治疗有效率明显高于安慰剂组,两组不良反应的发生率相当;Lev组生活质量明显高于安慰剂组,两组患者转入开放性治疗6个月后,生活质量均显著改善。结论:Lev作为添加用药治疗成人难治性部分性癫痫发作,显著减少发作频率、安全耐受性较好,能够提高癫痫患者的生活质量。  相似文献   

10.
目的评估迷走神经刺激对癫痫患者生活质量的影响。方法 14例药物难治性全身性癫痫患者进行迷走神经刺激术治疗,比较其术前及术后癫痫患者生活质量量表-31(QOLIE-31)评分的变化。结果平均随访12月,患者发作频率平均减少61.0%,其中5例发作频率减少<50%,6例发作频率减少≥50%,3例发作停止。癫痫患者生活质量量表总分从术前的50.5上升至术后的57.1,平均增加6.6(P=0.0276)。各个分量表中得分均有一定程度增加,其中认知功能、情绪两项改善有统计学意义。癫痫患者生活质量量表总分及7个分量表得分改善与发作减少均无相关性。结论迷走神经刺激是一种治疗药物难治性癫痫安全、有效的方法。其作用不仅体现在癫痫发作的减少,对生活质量也有一定的改善作用。而且这两者之间无相关性,提示生活质量改善是迷走神经刺激独立的临床疗效评价指标之一。  相似文献   

11.
A psychometric evaluation of a French transcultural version of the quality of life in epilepsy inventory-31 (QOLIE-31) was carried out. QOLIE-31 was compared to a generic health-related quality of life questionnaire, the Nottingham health profile (NHP). The psychometric properties of QOLIE-31, assessed in 190 adults with epilepsy, included: acceptability, test-retest reliability and validity (multi-trait analysis including internal consistency and item-to-scale correlations, construct validity using factor analysis, discriminative validity using relationship with disease characteristics, treatment effects, divergent and convergent validity using correlations with NHP scores). Both acceptability and reproducibility were good and internal consistency was high (Cronbach's alpha coefficient = 0.86). Factor analysis with varimax rotation identified seven factors with eigenvalues > 1, with two factors, related to cognitive function and mood, accounting for 46.5% of the variance. However, goodness of fit indices revealed that a model with four factors best fitted the data. The first factor corresponds to a generic mental dimension, the second is equivalent to the cognitive functioning dimension, the third to medication effects including social functioning, and the fourth to seizure worry. Discriminative validity was good for seizure control and treatment tolerability. High correlations between QOLIE-31 and pertinent NHP scales (emotional reactions, energy and social isolation) were observed. The French version of QOLIE-31 thus meets established psychometric criteria for reliability and validity.  相似文献   

12.
OBJECTIVE: The aim of the work described here was to develop and validate a Chinese version of the Quality of Life in Epilepsy Inventory-89 (QOLIE-89). METHODS: The original English version of the QOLIE-89 was adapted to the Chinese language through a translation-retranslation procedure. The inventory was then completed by 293 adult patients with epilepsy. Forty patients also completed the Chinese version of the QOLIE-31. Test-retest and internal consistency reliabilities, criterion validity, and discriminative validity were assessed. RESULTS: Test-retest reliability (Pearson's correlation coefficient) for the Chinese version of the QOLIE-89 ranged from 0.70 to 0.98, and internal consistency reliability (Cronbach's alpha) ranged from 0.70 to 0.99. Spearman's rank correlation between the total scores on the Chinese versions of the QOLIE-89 and QOLIE-31 was 0.97, and domain scores ranged from 0.86 to 1.00. QOLIE-89 items could be used to discriminate between patients with respect to epileptic seizure severity and antiepileptic drug side effects. CONCLUSION: The psychometric properties of the Chinese version of the QOLIE-89 are good and similar to those of the American version and can be applied to assess quality of life in adult patients with epilepsy in China.  相似文献   

13.
PurposeTo evaluate the psychometric properties of the Serbian-language version of the Quality of Life in Epilepsy Inventory-31 (QOLIE-31).MethodsAfter undergoing a translation and cultural adaptation of its items in order to create a Serbian-language version of QOLIE-31, we assessed its psychometric properties—reliability, construct validity and criterion validity. The sample consisted of 203 adults with epilepsy. Reliability was tested both by assessing the internal consistency and by the test–retest method. Construct validity was assessed by factor analysis, multitrait-scaling analysis and method of known-groups validation. This was achieved by assessing the relationship between scales and external measures (socio-demographic characteristics, seizure severity and etiology of epilepsy). Criterion validity was assessed by correlation analysis between QOLIE-31 and Short form 36 health survey (SF-36) and Neurotoxicity scale-II.ResultsThe domains showed high internal consistency (Cronbach's α 0.94). Test–retest reliability for Overall test score was 0.83 (Pearson's coefficient) indicating temporal stability. Seizure severity and etiology of epilepsy significantly influenced all QOLIE-31 domains except the Medication effect domain, with lowest scores in high seizure severity and symptomatic etiology groups. Employment status significantly influenced Overall quality of life, Emotional well-being, Social function and Overall score. Educational level was related to the Emotional well-being domain, with highest scores for students. The QOLIE-31 was highly positively correlated with SF-36 (rho = 0.898) and strongly negatively correlated with Neurotoxicity scale-II (rho = ?0.783).ConclusionSerbian adaptation of the QOLIE-31 questionnaire is reliable and valid for assessing the quality of life in patients with epilepsy.  相似文献   

14.
PURPOSE: We report the cultural adaptation and psychometric properties of the Quality of Life in Epilepsy-31 Inventory (QOLIE-31) for the Portuguese language and Brazilian culture. METHODS: This study involved 150 outpatients: 50 presurgical patients with refractory temporal lobe epilepsy (TLE) related to mesial temporal sclerosis (MTS), 50 patients with juvenile myoclonic epilepsy (JME), and 50 seizure-free patients with TLE. They completed the QOLIE-31, Nottingham Health Profile (NHP), Beck Depression Inventory (BDI), and Adverse Events Profile (AEP) and underwent a neuropsychological evaluation (NE). Internal consistency reliability, interrater and test-retest reliability, and construct validity were assessed. RESULTS: QOLIE-31 mean scores were 33.1 (Social Function), 68.9 (Overall Quality of Life), 56.5 (Seizure Worry), 64.1 (Emotional Well-Being), 63.7 (Energy/Fatigue), 38.9 (Cognitive Function), and 49.7 (Medication Effects). Internal consistency was high (Cronbach's alpha), as were the associations between QOLIE-31 and the BDI, NHP, AEP, and NE. CONCLUSION: The Portuguese/Brazilian version of the QOLIE-31 inventory showed good reliability, validity, and construct validity.  相似文献   

15.
The purpose of this study is to weigh psychological state, patients' demographics, seizure-related factors, and medical comorbidity in older adults with epilepsy against the same parameters in younger adults in an attempt to identify best quality of life (QoL) predictors. The Quality of Life in Epilepsy Inventory for Adults (QOLIE-31) and the Beck Depression Inventory-II (BDI-II) were completed by 146 patients with localization-related epilepsy. There was no statistical difference in the QOLIE-31 total score between younger and older adults. Best QoL predictors were BDI-II and seizure frequency, with BDI-II providing more than 3 times the impact of seizure frequency. BDI-II also substantively predicted most QOLIE-31 domains. Additionally, epilepsy duration positively correlated with overall QoL only among older adults. In summary, in younger as well as older adult epilepsy patients, depressive symptoms emerge as the strongest predictor of QoL. However, older adults appear to adapt better to their chronic health problem.  相似文献   

16.
Improving quality of life is the most important goal for patients with epilepsy. To recognize the factors associated with quality of life in patients with epilepsy in Mexico, we performed a cross-sectional survey using the Quality of Life in Epilepsy 31 (QOLIE-31) inventory to assess the quality of life of 401 adult patients with epilepsy at the National Institute of Neurology and Neurosurgery of Mexico. Clinical and demographical data were collected. Multiple regression was used to determine which factors affected quality of life in our patients. The variables that most strongly predicted a lower QOLIE-31 total score after multiple regression were sleep disorders (P<0.001), socioeconomic status (P<0.001), female gender (P=0.002), and high seizure frequency (P=0.001). In our study, neither depression nor time of evolution of epilepsy had significant influence on QOLIE-31 scores.  相似文献   

17.
A psychometric evaluation of a French version of the side-effects and life satisfaction inventory (SEALS) was carried out. SEALS was compared to the quality of life in epilepsy-31 questionnaire (QOLIE-31) and a generic, health-related quality-of-life questionnaire, the Nottingham health profile (NHP). The psychometric properties of SEALS, assessed in 190 adult subjects with epilepsy, included: acceptability, test-retest reliability and validity, multitrait analysis including internal consistency and item-to-scale correlations, construct validity using factor analysis and discriminative validity using associations with disease characteristics and treatment effects, and, correlations with NHP and QOLIE-31 scores for convergent and divergent validity. Both acceptability and reproducibility were good and internal consistency was high (Cronbach's alpha coefficient = 0.92). Factor analysis with varimax rotation identified five factors: the first, related to cognitive function accounted for 26.0% of the variance. Discriminative validity was good for most treatment characteristics (tolerability, seizure control, compliance) and clinical features (epilepsy type, seizure frequency and severity, depressive symptoms). Correlations with the NHP and QOLIE-31 scores were consistently strong. It was concluded that the psychometric properties of the French translation of SEALS were similar to the original English version. In addition, SEALS provides information on quality of life that is complementary to that obtained with QOLIE-31. In particular, with respect to the QOLIE-31, the SEALS provides information on cognitive and neuropsychological aspects of impairment of quality of life, whereas the QOLIE-31 has a broader scope, taking into account multiple aspects of quality of life in epilepsy.  相似文献   

18.
Quality of life in epilepsy has not been documented in the English-speaking Caribbean. The aim of this study was to explore the quality of life of persons with epilepsy (PWE) living in Jamaica and determine the impact of socioeconomic factors by examining two socially distinct groups in semiprivate (Epilepsy Centre of Jamaica) and public (Kingston Public Hospital) outpatient clinics. One hundred nine consecutive patients were interviewed. Quality of life was assessed using the Quality of Life in Epilepsy-31 inventory (QOLIE-31). Both groups were matched for gender, epilepsy syndrome, epilepsy duration, and number of antiepileptic drugs. Predictors of quality of life included number of antiepileptic drugs (P=0.039), epilepsy duration (P<0.05), and functional status (P<0.001). Neither seizure frequency nor socioeconomic status predicted QOLIE-31 scores. Mean QOLIE-31 total score (61.57 vs 49.2, P<0.001) and QOLIE-31 subscale scores (with the exception of the Seizure Worry score [53.8 vs 48.2, P=0.08]) were significantly higher than the corresponding t scores. The QOLIE-31 can reliably be used in Jamaica. Our findings suggest Jamaicans living with epilepsy perceive themselves as having a better than expected quality of life.  相似文献   

19.
OBJECTIVE: The purpose of this study was to establish the prevalence rate of convulsive epilepsy and the treatment gap in some rural areas of Tibet Autonomous Region in China, to evaluate the quality of life (QOL) of patients with epilepsy and identify factors contributing to their QOL. METHODS: A door-to-door epidemiological survey using randomized cluster sampling was conducted in a rural population in Tibet. A screening questionnaire for convulsive epilepsy was used. Clinical and sociodemographic data were collected from patients confirmed as having convulsive epilepsy. QOL was measured with the Quality of Life in Epilepsy inventory (QOLIE-31). Factors associated with QOLIE-31 total and subcomponent scores were analyzed by multiple regression analysis. RESULTS: A total of 14,822 people were screened. Of these, 37 were confirmed to have convulsive epilepsy, which was active in 35. Lifetime prevalence was estimated to be 2.5 per 1000 in this population. Nearly 60% of patients received traditional Tibetan treatment; 97% of the patients with active epilepsy did not receive reasonable antiepileptic therapy in the week before the survey (treatment gap). The mean QOLIE-31 total score was 42.2 (SD 17.6), with the lowest subcomponent score 22.6 (SD 20.3) for Seizure Worry and the highest 85.8 (SD 18.6) for Medication Effects. High seizure frequency, low economic status, advanced age, late seizure onset, and high education level significantly correlated with low QOLIE-31 total and/or subcomponent scores. CONCLUSIONS: The prevalence rate for epilepsy was relatively lower than reported for other rural regions; however, the large treatment gap and poor QOL indicated the pressing needs for medical, financial, and social support in this population.  相似文献   

20.
PurposeThis study aimed at finding determinants of quality of life in people with epilepsy (PWE) living in Belgrade, Serbia.MethodIn this study, we recruited consecutive adults with epilepsy attending our outpatient department. Adult patients (age range: 18–65 years) of normal intelligence and without any progressive neurological disease or psychiatric disorder were included in the study. They completed the following questionnaires: QOLIE-31 Inventory (Serbian version), Beck's Depression Inventory-II, Beck's Anxiety Inventory, Symptom Check List-90, and Neurotoxicity Scale-II. Hierarchical multiple regression analysis was performed to assess the predictive effects of some factors on QOLIE-31 Inventory.ResultsThe mean QOLIE-31 score of 203 patients who completed the questionnaires was 70.64 ± 17.74. Sociodemographic factors (age, sex, education, and employment) did not significantly predict QOLIE-31 score. Significant determinants of quality of life were clinical characteristics – seizure severity and etiology of epilepsy – accounting for 30.9% of the variance, depressive and anxiety symptoms accounting for 42.8% of the variance, and cognitive effects of antiepileptic drugs, accounting for 1.5% above other variables.ConclusionsThe results suggest that seizure severity and etiology of epilepsy, depressive and anxiety symptoms, and cognitive adverse medication effects are main determinants of quality of life in this population of PWE.  相似文献   

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