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1.
目的:调查社区精神分裂症患者服药依从性及其相关因素。方法:对287例免费服药治疗的精神分裂症患者进行病程,一般情况调查表,自知力,服药依从性与简明精神病评定量表(BPRS),社会功能缺陷筛选量表(SDSS)及治疗中出现的症状量表(TESS)的评定与分析。结果:服药依从者70.7%;病程>5年者依从性比≤5年者差;文化程度初中及以下;服用经典抗精神病药组(包括氯氮平);自知力障碍重者依从性差;BPRS总分其思维障碍、敌对猜疑因子分越高者依从性越差;SDSS及TESS(严重度)评分越高者依从性越差。结论:提示患者文化程度高、社会支持系统好、药物不良反应小、有自知力者服药依从性好。  相似文献   

2.
目的:探讨社区免费服药对精神分裂症患者服药依从性及复发的影响. 方法:64例精神分裂症患者随机分成研究组和对照组各32例,均给予利培酮常规治疗.研究组给予社区定期免费给药及健康教育,对照组不给予社区免费给药及健康教育.两组于入组时、入组后6个月和12个月采用简明精神病评定量表(BPRS)、自知力与治疗态度问卷量表(I...  相似文献   

3.
认知治疗对精神分裂症患者服药依从性的影响   总被引:3,自引:0,他引:3  
目的:探讨认知治疗对精神分裂症患者服药依从性的影响. 方法:将100例精神分裂症患者随机平分为干预组和对照组.均接受系统的抗精神病药治疗,干预组在此基础上进行认知治疗,而对照组仅限于一般健康教育,出院后随访1年.采用简明精神病评定量表(BPRS)、自知力与治疗态度问卷(ITAQ)、自拟服药依从性调查表,于治疗前、出院时、出院后6个月及1年分别各评定1次. 结果:两组BPRS、ITAQ、服药依从性和再次住院次数差异有显著性,均以干预组显著较好. 结论:认知治疗能有效提高精神分裂症患者服药依从性,降低复发率.  相似文献   

4.
目的:探讨内观疗法对精神分裂症患者服药依从性和复发的影响。方法:将112例精神分裂症患者随机分为内观疗法组和对照组各56例,两组均进行系统的抗精神病药物治疗和常规护理,内观疗法组在此基础上进行内观疗法。分别于治疗前、治疗3个月时及治疗1年时用自知力与治疗态度问卷量表(ITAQ)进行评定,并比较其服药依从性。观察1年了解其复发情况。结果:两组患者治疗3个月时及1年时内观疗法组的服药依从性明显优于对照组(分别为P〈0.01,P〈0.05)。1年内复发率内观疗法组明显低于对照组(P〈0.05)。结论:内观疗法能够提高精神分裂症患者服药依从性,降低复发率。  相似文献   

5.
目的探讨居家护理在精神分裂症患者康复中的干预作用。方法选择痊愈精神分裂症120例,随机分为干预组60例和对照组60例,出院后两组均给予精神药物治疗。干预组实施出院后居家护理康复指导,包括定期电话和上门随访。对照组实施常规出院宣教,每个月门诊复查和电话咨询。在出院时及第6、12个月末两组分别采用日常生活能力(ADL)评定量表、简明精神病评定量表(BPRS)及康复状态量表(MRSS)、进行评定,并统计1年内复发情况。结果观察1年后,干预组的ADL总分、BPRS总分、MRSS总分低于对照组,差异有显著性意义(P〈0.01);干预组服药依从性高于对照组,差异有显著性意义(P〈0.01),干预组的复发率(21.67%)低于对照组(33.39%),差异有显著性意义(P〈0.05)。结论实施居家护理干预可巩固治疗效果,减少疾病复发,改善日常生活能力。  相似文献   

6.
目的探讨系统康复治疗对慢性精神分裂症患者的康复效果。方法将80例慢性精神分裂症患者按入院顺序分为康复组和对照组,每组40例。在常规住院治疗的基础上单独对康复组病人施以为期3个月的系统康复治疗,用BPRS、自知力与治疗态度问卷(ITAQ)和社会功能缺陷筛选量表(SDSS)于入组时、出院时和出院后1a对患者进行相关评定。结果出院时2组BPRS、SDSS、ITAQ总分均较入组时有明显改善,康复组较为明显(P〈0.05或P〈0.01);并维持至出院1a仍显著优于对照组(P〈0.05);且1a内的复发率和再住院率显著低于对照组(P〈0.05)。结论系统康复治疗可提高慢性精神分裂症患者的治疗依从性,改善患者的精神症状,降低复发率和再住院率,有益于患者社会功能恢复。  相似文献   

7.
团体心理治疗对女性精神分裂症患者康复影响研究   总被引:1,自引:0,他引:1  
目的 探讨团体心理治疗对女性慢性精神分裂症患者的康复效果的影响.方法 选取经抗精神病药治疗大部分阳性症状消失的120例女性慢性精神分裂症患者随机分成研究组和对照组各60例,研究组患者在药物治疗基础上进行团体心理治疗,对照且参加一般药物治疗,治疗前及治疗后第8周末用简明精神病量表(BPRS)、阴性症状量表(SANS)、社会功能缺陷筛选量表(SDSS)进行测评分析.结果 治疗后两组BPRS、SANS总分均较治疗前显著降低(P<0.05,P<0.01);治疗后SDSS 4项因子分研究组较治疗前显著减低(P<0.05).治疗后研究组BPRS、SANS总分及SDSS4项因子评分显著低于对照组(P<0.05).结论 团体心理治疗对女性慢性精神分裂症患者的康复有显著的效果.  相似文献   

8.
对社区慢性精神分裂症患者个体化康复治疗的近期效果   总被引:1,自引:0,他引:1  
目的探讨对慢性精神分裂症患者个体化康复治疗的近期效果。方法抽取上海市虹口区社区慢性精神分裂症患者,随机分为干预组和对照组;对干预组进行为期4月的个体化康复治疗;在基线收集一般资料,并在基线和干预结束后使用简明精神病量表(The Brief Psychiatric Rating Scale,BPRS)、副反应量表(Treatment Emergent Symptom Scale,TESS)、社会功能缺陷筛选量表(Social Disability Screening Schedule,SDSS)、日常生活能力量表(Activity of Daily Living Scale,ADL)、功能活动调查表(Functional Activites Questionaire,FAQ)、药物依从性以及不良反应报告(自制)等评定。结果人组的干预组20例和对照组14例,诊断均为精神分裂症,两组在年龄、性别、受教育程度、病程、住院次数、家族史均为统计学差异。基线两组的各个量表得分均无统计学差异,随访时两组在BPRS总分、BPRS缺乏活力因子两项存在统计学差异。干预组在个体化康复治疗后BPRS总分、BPRS缺乏活力因子、BPRS思维障碍因子、BPRS激活性、TESS、SDSS、FAQ共7项得分较治疗前分值降低。对照组在随访时仅有SDSS共1项得分较基线增高。结论个体化康复治疗能够改善慢性精神分裂症患者的精神症状和社会适应等社会功能,以及降低药物副反应。  相似文献   

9.
综合干预对康复期精神分裂症患者疗效的随访研究   总被引:10,自引:0,他引:10  
目的 探索生物-心理-社会综合干预对康复期精神分裂患者的疗效及在国内精神科领域率先尝试慢性病自我管理模式。方法 研究对象为我院3个治疗病房的患者,出院前1月对干预组患者和家属实施综合干预,对照组按正常治疗出院,评定两组患者出院时的阳性阴性症状量表(PAN-SS)和大体评定量表(GAS)。干预组出院后进行定期的电话和上门随访,对照组一般门诊随访,3个月、6个月、1年时再分别对两组患者做PANSS量表、GAS、MRSS康复状态评定量表、SDSS社会功能缺陷筛选量表的测定。结果 干预组经综合干预后PANSS量表、MRSS、SDSS分值逐步下降,GAS分值升高,与对照组比较差异显著;干预组服药依从性、自觉门诊随访率显著高于对照组,再住院率低于对照组(P〈0.01)。结论 对康复期精神分裂症患者进行综合干预可以提高临床疗效、改善阳性症状、提高社会功能并能增加服药依从性,减少复发。  相似文献   

10.
社区综合干预对慢性精神分裂症患者生活质量的影响   总被引:2,自引:0,他引:2  
目的:探讨社区综合干预对慢性精神分裂症患者生活质量和服药依从性的影响。方法:120例慢性精神分裂症患者,随机分成研究组和对照组,各60例。研究组进行社区综合干预,对照组只进行药物治疗。入组前后实施简明精神病评定量表(BPRS)、生活质量综合评定问卷74(GQOLI-74)以及自知力与治疗态度问卷(ITAQ)评定。结果:治疗12个月研究组BPRS评分显著低于对照组(P〈0.05);研究组GQOLI-74心理健康因子评分和社会功能因子评分显著高于对照组(P〈0.05);研究组ITAQ评分显著高于对照组(P〈0.05)。结论:社区综合干预能改善慢性精神分裂症患者的生活质量,提高服药依从性。  相似文献   

11.
Blood CuZn superoxide dismutase (CuZn-SOD) changes during neuroleptic drugs treatment were measured by means of double-antibody immunoradiometric assay, in 121 schizophrenics (77 cases with Type I and 44 cases with Type II), and 128 normal subjects as control group. The results revealed: (1) before treatment, the overall blood content of CuZn-SOD in patient group showed higher significantly than that of control group (t = 12.34, P less than 0.001); (2) the content of CuZn-SOD in Type I schizophrenics was higher than that of Type II (t = 13.93, P less than 0.001); (3) after treatment, the CuZn-SOD content decreased obviously in Type I (t = 7.715, P less than 0.001), while no significant change in Type II was encountered (t = 0.541, P less than 0.05). The pathophysiological mechanisms of dopamine-Oxygen free radicals relating to the Type I and Type II schizophrenics was discussed briefly.  相似文献   

12.
精神分裂症患者的攻击行为与甲状腺轴   总被引:14,自引:2,他引:12  
目的:探索甲状腺激素与精神分裂症患者冲动攻击行为的关系。方法:以既往史和外显攻击行为量表(MOAS)评分区分,有攻击行为者为研究组,无攻击行为者为对照组,比较两组的血清甲状腺激素水平,并对其与精神症状、攻击行为型之间的相关性进行检验。结果:研究组促甲状腺激素(TSH)水平较对照组升高,甲状腺素(T4)水平与言语攻击、对财产的攻击行为有显著性相关,三碘甲状腺原氨酸(T3)水平与焦虑抑郁症状有关。结论:甲状腺激素水平可能与精神分裂症患者的贡献行为有关。  相似文献   

13.
All patients who were first-admitted to Danish psychiatric institutions in the calendar years 1970, 1973, 1976, 1979, and 1982 and who were diagnosed as schizophrenics at least once within a 2-year period of observation from the first day of the first admission are followed up by means of the nation-wide Danish Psychiatric Register (totally 1,175 males and 665 females). Sex and age specific first-admission rates of schizophrenia show that the difference between male and female rates especially appears in the age group 15-24 years. In this age group the peak incidence is found for both sexes, also if the patients only diagnosed as schizophrenics at a later admission are included. The ratio of male to female incidence rates are not changed by inclusion of the latter patients. A higher frequency of married or formerly married patients is found among the schizophrenics who were diagnosed late in the course of treatment than among those who were so at first-admission. This might be a manifestation of a less severe symptomatology which could explain the tendency to hesitate in diagnosing patients as schizophrenics.  相似文献   

14.
精神分裂症患者及其一级亲属探究性眼球轨迹运动的研究   总被引:26,自引:0,他引:26  
目的 探讨精神分裂症患者及其一级亲属的眼球轨迹运动在生物遗传学上的意义。方法 应用眼球轨迹运动标记记录仪,对64例精神分裂症患者(症状显著26例,症状缓解38例)及其26例一级亲属、35名正常人进行测试。经判别式分析获正分者为精神分裂症性障碍,获负分者为非精神分裂症性障碍,并以眼球轨迹运动的有关参数作分析指标。结果 显著组患者判别式分析平均获2.076分,缓解组患者获2.571分,一级亲属且平均获  相似文献   

15.
TGFBR2 gene is a tumor suppressor gene located at chromosome 3p22, and the locus is reported to be linked with schizophrenia susceptibility. According to the previous studies, a reduced incidence of cancer is observed in schizophrenic patients compared with the general population and tumor suppressor genes may be associated with schizophrenia. We measured the mRNA expression of TGFBR2 gene in the peripheral leukocytes from 19 medication-free schizophrenics and 25 medication-free major depressive patients compared with age- and sex-matched control subjects using a quantitative real-time PCR method. We also followed up the TGFBR2 mRNA expression levels from 13 schizophrenics after several weeks - antipsychotic treatments. The TGFBR2 mRNA levels of medication free schizophrenics were significantly higher than those of control subjects and decreased to almost the same level as controls after antipsychotic treatment. On the other hand, the TGFBR2 mRNA levels of medication-free major depressive patients were not significantly different from controls. In genetic studies, we failed to find any association between the TGFBR2 gene and schizophrenia with 10 SNPs of TGFBR2 gene in Japanese subjects (279 subjects each) and there was no significant difference with haplotype analysis, either. Our results suggest that the TGFBR2 gene itself does not link to schizophrenia but that the TGFBR2 mRNA levels in the peripheral leukocytes may be a potential state marker for schizophrenia.  相似文献   

16.
Although, emotions play a crucial role in schizophrenia, the changes in emotional dimension still remain controversial. The aim of our work was: 1) to compare the disorders of emotional control between the examined groups: S--non-chronic schizophrenic patients (n = 50), CS--chronic schizophrenic patients (n = 50), N--healthy controls (n = 50), R--right brain-damaged patients (n = 30), and L--left brain-damaged patients (n = 30), 2) to assess a level of impairment of emotional control, its relation to lateralised hemisphere damage and chronicity of schizophrenic process. All psychiatric subjects were diagnosed as paranoid schizophrenics according to DSM-IV criteria and were scored on the PANSS scale after four weeks of neuroleptic treatment. Brain-damaged patients were included if they experienced single-episode cerebrovascular accidents causing right or left hemisphere damage (confirmed in CT scan reports). The neurological patients were examined at least 3 weeks after the onset of cerebrovascular episode. Emotional control was assessed using Brzeziński Questionnaire of Emotional Control aimed at the evaluation of: 1) control in perception and interpretation of emotive situation, 2) emotional arousal, 3) emotional-rational motivation, and 4) acting caused by emotions. Our results revealed significantly greater impairment of emotional control in schizophrenics (chronic schizophrenics, in particular) compared to healthy volunteers. Chronicity of the schizophrenic process seemed to intensify emotional control impairment. Interestingly, no significant qualitative and quantitative differences in emotional control mechanism between unilateral brain-damaged patients and the control group were found.  相似文献   

17.
目的:探讨伴有迟发性运动障碍(TD)的精神分裂症患者血清铁调素(Hep)、铁蛋白(Fn)水平,以及铁代谢状况与TD的关系。方法:采用酶免疫法及化学发光法测定30例伴TD的精神分裂症患者(TD组)、41例不伴TD的精神分裂症患者(非TD组)及41名正常人(正常对照组)血清Hep、Fn水平;用异常不自主运动量表(AIMS)评估患者TD的严重程度及其与血清Hep、Fn水平的相关性。结果:TD组血清Hep水平低于非TD组及正常对照组(Z=-2.99,Z=-3.62;P均0.01),非TD组与正常对照组之间Hep水平差异无统计学意义(Z=1.22,P0.05);TD组血清Fn水平高于非TD组及正常对照组(Z=2.00,Z=2.39;P均0.05),非TD组与正常对照组之间Fn水平差异无统计学意义(Z=-0.70,P0.05)。TD组血清Hep水平与Fn水平呈负相关(r=-0.396,P0.05),AIMS评分与血清Hep及Fn水平无相关性(r=-0.052,r=0.14;P均0.05)。结论:TD患者存在铁代谢蛋白异常,铁代谢障碍可能参与了TD的病理生理过程。  相似文献   

18.
Abstract: The visuo-motor reaction times of normal subjects and schizophrenics were measured to investigate adaptation of eye-hand coordination in schizophrenics under modified vision. Reaction time was measured in 32 normal subjects and 32 schizophrenics by using a rectangular board with 24 illuminated buttons. Subjects' task was to press an illuminated button as quickly as possible under normal and modified vision. Time elapsed from when the light was switched on to when the button was pressed was measured as the visuo-motor reaction time in msec. Three conditions were set up: control in normal vision; inverted using an inverting goggle; reversed using a reversing goggle. In general the visuo-motor reaction times of schizophrenics were slower than those of nonnal subjects. But in the reversed condition, there was no significant difference between normal subjects and schizophrenics. The visuo-motor reaction times of schizophrenics in the reversed Condition showed a large dispersion with the fastest being faster than that of any normal subjects. It is suggested that there may be a group among schizophrenics whose basic paradigm of visuo-motor association is different from that of normal subjects.  相似文献   

19.
目的:比较出院后精神分裂症患者以利培酮、氯氮平、低效价和高效价传统抗精神病药治疗者的再住院率。方法:对833例1999年内出院的精神分裂症患者调查,于2003年12月底前调查患者出院后至少48个月的情况。结果:601例完成调查,利培酮组81例,氯氮平组177例,低效价传统药组161例和高效价传统药组182例,4组的未再住院率,12个月(分别为59.3%、65.5%、65.2%和67.6%)、24个月(53.1%、52.0%、55.9%和51.1%)3、6个月(48.2%、36.7%、44.7%和36.8%)和48个月(42.0%、31.1%、39.1%和30.2%),差异均无显著性(P均>0.05)。利培酮的药物完全依从率高(60.5%)。结论:精神分裂症患者不同抗精神病药物治疗出院后的再住院率相当。  相似文献   

20.
衰退期精神分裂症血清甲状腺激素研究   总被引:1,自引:0,他引:1  
目的:探讨甲状腺激素与衰退期精神分裂症的关系。方法:将66例精神分裂症患者分为衰退期(研究组)和非衰退期(对照组),比较两组的血清甲状腺激素水平,并与有关因素进行相关性分析。结果:研究组促甲状腺激素(TSH)水平较对照组低。甲状腺素(T4)水平与总病程有关。三碘甲状腺原氨酸(T3)水平与疗程、总病程、焦虑抑郁因子、缺乏活力因子、敌对猜疑因子有关。TSH水平与疗程、缺乏活力因子有关。结论:精神分裂症的衰退症状与甲状腺功能异常有关。  相似文献   

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