百乐眠胶囊治疗功能性消化不良伴焦虑症状的疗效

目的：观察百乐眠胶囊治疗功能性消化不良（ FD ）伴焦虑症状患者的临床疗效。方法选取66例FD伴焦虑症状患者,随机分为研究组和对照组,每组各33例,研究组给予百乐眠胶囊治疗,对照组给予多塞平治疗,疗程为1个月,比较两组患者的汉密尔顿焦虑量表（HAMA）评分、FD症状评分、总有效率及不良反应发生率。结果两组患者治疗后HAMA评分和FD症状评分均较治疗前降低,差异有统计学意义（P＜0．05）,但两组间治疗后比较,差异无统计学意义（P＞0．05）。两组患者总有效率差异无统计学意义（ P＞0．05）,研究组不良反应发生率为6．06％,对照组为27．27％,差异有统计学意义（ P＝0．044＜0．05）。结论百乐眠胶囊可改善 FD伴焦虑症状患者的临床症状及焦虑水平。     

联合抗焦虑治疗持续性胸背痛伴焦虑症状患者的疗效观察

目的 探讨氟哌噻吨＋美利曲辛（商品名，黛力新）等药物联合治疗胸背痛伴焦虑症状患者的临床疗效。方法 将符合胸背痛伴焦虑症状的56例患者，随机分为A、B两组，每组28人．A组予以黛力新＋多虑平抗焦虑治疗，同时予以西乐葆止痛治疗；B组予以西乐葆单纯止痛治疗。观察治疗4周后患者胸背痛的疼痛程度的视觉类比评分（VAS）和汉密尔顿焦虑量表评分（HAMA）的变化。结果 A组患者治疗后VAS评分由（8．56±1．43）分下降到（3．42±1．71）分，HAMA焦虑量表评分由（29．48±8．75）分下降到（12．73±7．29）分；B组患者治疗后VAS评分由（8．61±1．24）分下降到（6．57±2．16）分，HAMA焦虑量表评分由（29．33±8．91）分下降到（20．36±5．77）分。2组治疗后VAS评分、HAMA焦虑量表评分的差值比较有显著性意义俨〈0．05）。结论 黛力新＋多虑平等联合治疗能显著改善患者的胸背痛伴焦虑症状，而单纯西乐葆止痛治疗效果不佳。     

黛力新联合心理干预对脑血管造影患者焦虑抑郁的疗效观察

目的 探讨黛力新联合心理干预对脑血管造影患者心理情绪的影响.方法 将80例行脑血管造影的患者随机分为黛力新联合心理干预组（药物治疗组）和心理干预组;分别采用汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）进行评定手术前后患者的焦虑、抑郁情况.结果 黛力新联合心理干预组的HAMA评分和 HAMD评分明显低于心理干预组.结论 黛力新联合心理干预可明显改善患者对脑血管造影术产生的焦虑和抑郁情绪,可作为辅助治疗措施.     

黛力新治疗老年期焦虑症临床分析

目的比较黛力新与多塞平治疗老年期焦虑症疗效及安全性。方法将门诊治疗的老年期焦虑症患者随机分入两组,分别用黛力新和多塞平治疗,疗程6个月。用汉密尔顿焦虑量表（HAMA）及副反应量表（TESS）于治疗前和治疗第1、2、3周末及治疗第6个月末分别评定疗效和不良反应。结果黛力新组有效率为90．3％,显效率为74．2％;多塞平组有效率为86．7％,显效率为56．6％,两组有效率及显效率均无显著差异（P均〉0．05）,但在治疗第1、2周末黛力新组HAMA总分较多塞平组显著减少（P〈0．01）。多塞平组抗胆碱能副反应较突出,黛力新组不良反应少而轻。结论黛力新治疗焦虑症疗效好,起效快,安全性高,依从性好,更适合老年期焦虑症患者的急性期治疗和长期维持治疗。     

百乐眠联合坦度螺酮治疗高血压病伴焦虑障碍的疗效及安全性

目的：评价百乐眠联合坦度螺酮治疗高血压病伴焦虑障碍的疗效及安全性。方法将128例高血压病伴焦虑障碍患者随机分为A、B、C、D 4组,均给予氨氯地平5 m g／d ,A组仅常规降压治疗,B组加用百乐眠（1．08g,2次／d）,C组加用坦度螺酮（10mg,3次／d）,D组加用百乐眠（1．08g,2次／d）和坦度螺酮（10 mg ,3次／d）,连续治疗12周。于治疗前及治疗后4,8,12周末监测血压,并采用HAMA及匹兹堡睡眠质量指数（PSQI）评定临床疗效,采用治疗不良反应量表（TESS）及实验室检查评价其安全性。结果从降压的有效率看,治疗后4周时,C、D组的有效率均高于A组,治疗后8周和12周时B、C、D组的有效率均高于A组;从HAMA的减分率看焦虑障碍改善的有效率,治疗后4周时B、C、D组的有效率均高于A组,治疗后8周和12周时B、C、D组有效率均高于A组,而且C、D组有效率均高于B组;从PSQI的减分率看睡眠障碍改善的有效率,治疗后4周、8周和12周时B、D组的有效率均高于A组,而且B、D组自身前后比较,发现治疗后12周时B、D组的有效率明显高于治疗后4周,治疗后8周和12周时C组有效率高于A组;治疗后12周时D组3项指标的有效率均高于A、B、C组,以上比较差异均有统计学意义（ P ＜0．05）。各组总的不良反应发生例数分别为A组15例、B组19例、C组16例、D组26例。结论百乐眠可以有效改善睡眠障碍,而且随着治疗时间的延长疗效更好;百乐眠可加强降压疗效并改善焦虑障碍;坦度螺酮可明显增强降压疗效并改善焦虑障碍;百乐眠联合坦度螺酮对高血压病伴焦虑障碍有很好的协同作用,联合使用比单用疗效高且起效快,而不良反应并无明显增加。     

黛力新联合西比灵治疗偏头痛伴抑郁和焦虑90例疗效观察

目的观察黛力新联合西比灵治疗偏头痛伴焦虑、抑郁情绪患者的疗效与不良反应。方法将90例伴抑郁和焦虑的偏头痛患者随机均分为2组,治疗组给予黛力新与西比灵口服,对照组单用西比灵,均以6周为1个疗程。根据治疗前后头痛发作次数、持续时间及头痛严重程度的变化进行疗效评定,并用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）进行评分,自制副反应量表记录不良反应。结果两种治疗方法均可显著减少偏头痛发作次数,缩短头痛发作时间,减轻头痛程度（P〈0.05）;治疗组还可明显减轻患者的抑郁、焦虑症状,治疗后2、4、6周HAMD和HAMA评分的改善优于对照组（P〈0.01）;治疗组头痛持续时间缩短也优于对照组（P〈0.05）。结论黛力新联合西比灵治疗伴情绪障碍的偏头痛疗效较好,不良反应不需作特殊处理。     

中西医结合治疗卒中后抑郁症82例疗效观察

目的观察中西医结合治疗卒中后抑郁症的临床疗效。方法164例卒中后抑郁症患者随机分为治疗组（黛力新＋安神解郁汤）和对照组（黛力新）,2组都服用5羟色胺再摄取抑郁制剂黛力新,治疗组加服中药安神解郁汤,治疗2周和6周后分别观察疗效。结果经汉密尔顿抑郁量表评分164例评分结果显示,治疗组均明显优于对照组（P〈0．01）。结论安神解郁汤具有安神解郁,行气活血的作用。     

老年反流性食管炎患者的心理状态及药物疗效分析

目的研究老年反流性食管炎患者焦虑和抑郁心理状态及黛力新的治疗效果。方法选取我院从2014年7月至2015年12月收治的老年反流性食管炎伴焦虑抑郁患者100例,按照随机数字表法将100例老年反流性食管炎伴焦虑抑郁患者分为观察组(50例)和对照组(50例);对照组采取常规治疗,观察组在对照组的基础上合并黛力新治疗。将两组患者的汉密尔顿焦虑量表(HAMA)评分与汉密尔顿抑郁量表(HAMD)评分、反流性食管炎症状程度积分(GERDQ)数值以及临床有效率进行对比分析。结果两组患者治疗前HAMA、HAMD和GERDQ评分,组间无明显差异(P0.05)。治疗后两组患者的HAMA、HAMD和GERDQ评分均降低(P0.05),且观察组上述量表评分低于对照组,两组比较差异具有统计学意义(P0.05);观察组的临床有效率(96.00%)显著高于对照组的临床有效率(82.00%),差异具有统计学意义(P0.05)。结论黛力新辅助治疗老年返流性食管炎伴焦虑抑郁症状的患者,可显著减轻患者的焦虑抑郁症状,改善患者的临床效果,因此值得在临床推广应用。     

黛力新对冠心病介入治疗手术围术期焦虑的影响

目的探讨黛力新对冠心病患者经介入治疗围术期焦虑和生活质量的影响。方法将我院2013年10月至2014年12月期间收治的186例冠心病介入治疗患者分成两组,对照组予以冠心病常规治疗,研究组在此基础上加用黛力新。采用心电图、HAMA量表和SF-36量表评估患者治疗前和治疗30 d的治疗效果。结果治疗30 d后,研究组患者心电图疗效明显优于对照组(P0.01),HAMA评分明显低于对照组(P0.01),SF-36量表各项评分均显著高于对照组(P0.01)。结论黛力新可以有效改善冠心病介入手术患者围术期的焦虑症状,提高心电图疗效和患者的生活质量。     

参松养心胶囊联合黛力新对卒中后抑郁及神经功能恢复的影响

目的观察参松养心胶囊联合黛力新治疗卒中后抑郁的疗效。方法64例卒中后抑郁患者随机分组后分剐接受参松养心胶囊和黛力新联合治疗（治疗组）及单纯黛力新治疗（对照组）,疗程为6周;采用汉密尔顿抑郁量表（HAMD）和Barthel指数（BI）及生活质量指数量表进行评定。结果在治疗6周后,治疗组的总有效率为87．5％,对照组为65．6％,两者相比有显著差异（P〈0．05）;两组分别于治疗前和治疗后2、4、6周末汉密顿抑郁量表（HAMD）和Barthel指数（BI）及生活质量指数量表评分均有显著差异（P〈0．05或P〈0．01）。结论参松齐心胶囊联合黛力新治疗可改善卒中后抑郁的症状,优于单用黛力新。     

Evaluation of the results of the treatment of patients with subacute sclerosing panencephalitis with TFX-Polfa

The authors report the results of a trial of treatment of patients with SSPE with the preparation TFX-POLFA given together with isoprinosine and amantadine to 13 children for 12 weeks, and to 7 for 6 weeks. The results of clinical and immunological treatment were compared with those in a group of 10 patients with SSPE receiving only isoprinosine and amantadine. In both groups a steady deterioration of the neurological status was observed in about half the cases. No significant effect of TFX was observed on the immune reactivity. During the treatment with TFX the per cent of lymphocytes forming early E rosettes rose.     

Understanding the experience of driving with a passenger with aphasia

Background: Drivers and passengers often spend a great deal of time conversing when riding in a personal automobile. Under most circumstances, drivers are easily able to maintain a conversation with their passengers while safely operating their vehicle. However, this task may be challenging when the passenger riding in the car has aphasia since many people with aphasia supplement their limited verbal output with other communication modalities, such as writing, gesturing, and using body language.

Aims: The aim of this paper is to describe the experience of driving a personal automobile when a passenger with aphasia is riding in the car.

Methods & Procedures: A phenomenological approach was used to gain an understanding of the lived experience of driving a car with a passenger with aphasia. Nine people who regularly serve as the primary drivers of a person with aphasia were interviewed twice using a semi-structured interview guide. Data were analysed using thematic analysis.

Outcomes & Results: Three main themes characterised the drivers’ experiences of riding with an aphasic passenger: (1) communicating, (2) helping, and (3) adapting. The theme of communicating was specified in terms of time constraints, topic avoidance, and communication strategies. The theme of helping was constructed from two subthemes: avoiding accidents and navigating. Drivers reported that passengers needed to adapt to the car environment due to stroke-induced cognitive and physical deficits.

Conclusions: The findings describe various problems that people who drive an automobile with a passenger with aphasia experience and the ways in which they seek to overcome these problems. Clinicians should collaborate with drivers and passengers with aphasia to enhance the safety and quality of their in-vehicle experience.     

Use of the BAT with a Cantonese-Putonghua speaker with aphasia

The aim of this article is to illustrate the use of the Bilingual Aphasia Test (BAT) with a Cantonese-Putonghua speaker. We describe G, who is a relatively young Chinese bilingual speaker with aphasia. G's communication abilities in his L2, Putonghua, were impaired following brain damage. This impairment caused specific difficulties in communication with his wife, a native Putonghua speaker, and was thus a priority for investigation. Given a paucity of standardised tests of aphasia in Putonghua, our goal was to use the BAT to assess G's impairments in his L2. Results showed that G's performance on the BAT subtests measuring word and sentence comprehension and production was impaired. His pattern of performance on the BAT allowed us to generate hypotheses about his higher-level language impairments in Putonghua, which were subsequently found to be impaired. We argue that the BAT is able to capture the primary language impairments in Chinese-speaking patients with aphasia when Putonghua is the second language. We also suggest some modifications to the BAT for testing Chinese-speaking patients with bilingual aphasia.     

Management of the child with weakness

With increased life expectancy associated with improved respiratory care and research advances in pediatric neuromuscular diseases leading to clinical trials involving potential curative treatments, the goal in the care of the child with weakness is to optimize survival and quality of life. The care of the child with weakness includes management of motor dysfunction because of weakness, orthopedic complications of contractures and scoliosis, and comorbid complications specific to each neuromuscular disease. Optimal holistic integrative care of the multisystemic problems of such patients is best provided by the collaborative efforts of health care providers of an interdisciplinary team.     

成年难治性癫痫患者生活质量手术前后对比分析

目的调查研究外科手术治疗对成年难治性癫痫患者生活质量的影响.方法运用QOLIE-31量表对100例在我院接受癫痫灶切除术或阻断癫痫异常放电传播和减弱癫痫灶相互影响手术的癫痫患者手术前后生活质量进行调查,并与100例药物治疗对照进行比较,统计学分析用SPSS10.0软件.结果难治性癫痫患者生活质量明显低于对照组,表现在惧怕发作,对日常生活不满意,情绪差,精力不足,认知功能下降,对长期服用抗癫痫药物的顾虑较多,社交、工作受限等,经手术治疗癫痫患者的生活质量明显提高.结论成年难治性癫痫患者生活质量普遍较低,外科手术治疗可显著提高其生活质量.     

佩带膝外翻支具膝骨关节炎患者膝关节的生物力学变化

背景：佩带膝关节外翻矫形器已被证明是一种可以有效减轻内侧间室膝骨关节炎患者疼痛的方法,但是佩带矫形器后的膝关节所产生的运动学以及动力学变化至今尚不明确。 目的：观察内侧间室膝骨关节炎患者佩带膝关节矫形器前后的膝关节运动学以及动力学参数变化,便于为将来设计新型膝关节矫形器提供依据。 方法：纳入20例内侧间室膝骨关节炎患者,分别通过三维步态分析系统和测力板对其在佩带膝外翻矫形器及不佩带膝外翻矫形器两种情况步行中的运动学及动力学参数进行采集,并进行对比。 结果与结论：相比未佩带膝关节外翻支具,佩带膝关节外翻支具后患者在步行过程中膝关节内收力矩明显减小,与此同时膝关节内翻角度明显减小,外翻角度明显增加(P均< 0.05),膝关节在步行过程中的最大屈曲角度以及时间空间参数差异无显著性意义。提示膝关节外翻矫形器可有效地通过增加内侧间室膝骨关节炎患者膝关节在步行过程中的外翻角度减小内翻角度从而降低膝内侧间室所承受的压力,与此同时纠正膝关节非正常对线。