经利培酮、氯氮平治疗的精神分裂症患者生活质量随访研究

目的 探讨利培酮、氯氮平对精神分裂症患生活质量的影响。方法 对符合CCMD－2－R诊断标准的精神分裂症患，在使用利培酮（24例）、氯氮平（26例）治疗期间进行6个月的随访，观察利培酮、氯氮平对精神分裂症患的精神症状、生活质量的影响。结果 发现：（1）利培酮组对精神分裂症阳性、阴性症状的改善和氯氮平组相似，对PANSS总分的改善明显优于氯氮平组。（2）6个月的治疗前后相比，利培酮对患的生活质量的影响，除精神支柱外均非常明显地提高；氯氮平可以部分提高患的生活质量，但对患的生理领域、心理领域、独立性领域没有明显改善。（3）6个月后，利培酮组与氯氮平组相比，药物对患生活质量的影响，利培酮组除对精神支柱外均非常明显优于氯氮平组。结论 利培酮比氯氮平更能改善精神分裂症患的生活质量，有利于患重返社会。     

利培酮对精神分裂症患者生活质量的影响

目的探讨利培酮与氯氮平对精神分裂症患生活质量的影响。方法将符合CCMD-3精神分裂症诊断标准的患，随机分为两组，应用利培酮与氯氮平治疗，疗程为12周。采用PANSS评定疗效，用ESRS评定锥体外系症状、TESS评定其他不良反应，以GQOLI评定生活质量。结果利培酮组的疗效明显优于氯氮平组，且无明显不良反应。利培酮组的躯体健康维度、心理健康维度及社会功能维度分均高于氯氮平组，有显性差异。结论利培酮对精神分裂症有显的疗效，患的依从性好，生活质量优于氯氮平。     

利培酮与氯氮平对精神分裂症患者生活质量影响的比较

目的 探讨利培酮与氯氮平治疗精神分裂症患者生活质量的影响.方法 对136例精神分裂症患者分别给予利培酮、氯氮平治疗,共8周.用阳性、阴性症状量表(PANSS)、不良反应量表(TESS)、生活质量综合评定问卷(GQOLI)分别评定患者的疗效及生活质量.结果 两组PANSS分值前后均有显著性差异,两组比较,无显著性差异.利培酮组的躯体健康维度、心理健康维度、社会功能维度得分高于氯氮平组,有显著差异(P＜0.01).结论 利培酮和氯氮平对精神分裂症均有显著疗效,利培酮治疗精神分裂症的生活质量优于氯氮平组.     

氯氮平与利培酮对精神分裂症病人生活质量影响的双盲对照研究

目的观察氯氮平与利培酮对精神分裂症病人生活质量的影响.方法采用双盲对照研究、生活质量综合评定问卷(GQOLI)分析病人生活质量.结果利培酮组的躯体健康维度、心理健康维度及社会功能维度得分明显高于氯氮平组,均有显著性差异(P＜0.01).结论利培酮对精神分裂症病人生活质量的影响优于氯氮平.     

利培酮对精神分裂症患者生活质量的影响

目的：比较利培酮与氯氮平对精神分裂症患者生活质量的影响。方法：对门诊72例服用利培酮及74例服用氯氮平的精神分裂症患者用自制精神分裂症患者生活质量调查表、阳性症状及阴性症状量表(PANSS)及不良反应症状量表(TESS)进行调查，并与某些因素进行多元逐步回归分析。结果：氯氮平组患者的客观及主观生活质量均较利培酮组差。结论：从消耗／效果分析，利培酮明显优于氯氮平，更有利于患者适应社会。     

利培酮与氯氮平治疗精神分裂症患者生活质量对照研究的meta分析

目的 比较利培酮与氯氮平治疗精神分裂症患者疗效及对生活质量的影响。方法对包括988例 精神分裂症患者的8篇中国文献进行meta分析,其中利培酮组共计501例,氯氮平组487例。结果2组治疗后的 有显著疗效,但组间比较疗效差异无显著性意义。对采用WHOQOF-100量表中文版的5个调查资料综合分析后 发现:与氯氮平组相比,利培酮组患者的生活质量除生理领域略差外,其他领域及生活质量总体状况均优于氯氮平 组;失效安全数在17．25～311．23之间,可靠性好。对采用生活质量综合评定问卷(GQOLI)的4个调查资料综合分 析后发现:2组患者在物质生活维度无显著性差异,利培酮组在其他3个维度较氯氮平组好;除物质生活维度外,失 效安全数在74．39～94．39之间,可靠性较好。结论氯氮平和利培酮对精神分裂症均有较好的疗效,利培酮的比 氯氮平更有利于改善精神分裂症患者的社区康复功能,有利于患者重返社会。     

利培酮、氯氮平维持治疗精神分裂症患者生活质量的对照观察

目的　比较利培酮与氯氮平治疗对精神分裂症患者生活质量的影响。方法　随机抽取 30例服用利培酮、30例服用氯氮平的精神分裂症患者 ,出院 3个月时用生活质量综合评定问卷 (GQOLI)评估患者的生活质量 ,用阳性症状和阴性症状量表 (PANSS)、不良反应量表 (TESS)评定疗效与副反应。结果　利培酮组GQOLI评分显著高于氯氮平组 (P <0 .0 1) ,TESS评分显著低于氯氮平组 (P <0 .0 1) ,PANSS评分两组差异无显著性 (P >0 .0 5 )。结论　利培酮和氯氮平相比 ,更能提高患者的生活质量 ,在维持治疗方面具有明显的优势     

利培酮与氯氮平治疗对精神分裂症患者认知功能影响的对照研究

目的比较利培酮与氯氮平对精神分裂症患者认知功能的影响。方法将58例精神分裂症患者随机分为两组,分别给予利培酮、氯氮平治疗8周。治疗前治疗8周末分别进行简明精神病评定量表（BPRS）、韦氏成人记忆量表修订本（WMS-RC）、威斯康星卡分类测验（WCST）和数字划销测验（CT）评定,比较利培酮与氯氮平对精神分裂症患者认知功能的影响。结果两组治疗8周后,各项检查项目均有显著改善。结论利培酮与氯氮平均能改善精神分裂症患者的认知功能。     

利培酮、氯氮平治疗对精神分裂症患者出院后生活质量的影响

为探讨新型抗精神病药对精神分裂症患者生活质量的影响 ,我们对经利培酮或氯氮平治疗后出院的精神分裂症患者的生活质量进行对照研究。对象　为 1997年 7月至 2 0 0 0年 6月在本院治疗后出院的精神分裂症患者。入组标准 :符合中国精神疾病分类方案与诊断标准第 2版修订本精神分裂症诊断标准、经利培酮或氯氮平治疗疗效达临床痊愈或显著进步、简明精神病评定量表 (ＢＰＲＳ)评分≤ 2 0分、出院后回归社会≥ 6个月者。共 2 19例符合标准。其中服用利培酮 110例 ,服用氯氮平 10 9例。两组共有 15例 (6 8%)脱落 (利培酮组有 8例因经济困难 ,氯…     

利培酮和氯氮平治疗伴抑郁症状的难治性精神分裂症对照研究

目的：比较利培酮和氯氮平对伴抑郁症状的难治性精神分裂症疗效。方法：共70例难治性精神分裂症患者随机服用利培酮和氯氮平治疗。利培酮组34例，氯氮平组36例；伴有抑郁症状者39例，利培酮组17例，氯氮平组22例。治疗12周。分别于治疗前、治疗4、8、12周末采用阳性与阴性症状量表（PANSS），汉密尔顿抑郁量表（HAMD）及功能大体评定量表（GAF）评定疗效。结果：两组PANSS、HAMD和GAF评分在治疗12周均有显著改善；两组间比较差异无显著性。有、无抑郁症状组在治疗4、8、12周末的HAMD总分与治疗前比较均显著减少。结论：抑郁症状不影响难治性精神分裂症的疗效；利培酮和氯氮平对伴抑郁症状的难治性精神分裂症均有效。     

Impact of chronic pain on the spouse: marital, emotional and physical consequences

The effects of chronic illness on marital relationships and the spouses' emotional and physical health were examined in chronic pain patients, their spouses, and a control sample of spouses of diabetic patients. Results indicated that pain patients and their spouses experienced considerable change in marital and sexual satisfaction. Patients with better marital adjustment also reported higher overall pain levels and had more solicitous and maritally satisfied spouses. Spouses' marital adjustment was positively associated with patients' marital satisfaction and spouses' own mood. Spouses' dysphoric mood was related to patients' negative appraisal of the pain experience, spouses' perceived lack of life control, and spouses' marital dissatisfaction. Although spouses of chronic pain patients showed no more physical symptoms than spouses of diabetics, they reported significantly more pain symptoms that were related to elevated levels of depressed mood. The results indicate that not only is chronic pain associated with problems in the marital relationship but heightened distress and physical symptoms in spouses as well. These effects are related less to the existence of a chronic pain problem per se but rather to patients' and spouses' manner of coping with the situation.     

Schizophrenic patients and their parents. A multimethod design and the findings from an illustrative empirical study of cognitive disorders and communication deviances

The research design and main findings from a multimethod research project, in which cognitive disorders in schizophrenic patients and communication deviances in their parents were examined, are presented. Non-paranoid schizophrenics manifested cognitive disturbances on a majority of the variables examined, while paranoid schizophrenics did not. Likewise, parents of non-paranoid schizophrenics revealed significantly more communication deviance than parents of paranoid schizophrenics as well as the control groups (normal and "neurotics"). Egocentrism appeared to be a prominent characteristic of the communication of non-paranoid schizophrenics' parents. Conspicuous among the cognitive deficits in their offspring were attentional disturbances. Support for the existence of a link between the parents' communication and the offsprings' cognitive functioning was found by correlation- and regression analyses.     

The effect of hypnotherapeutic ego strengthening with female spouses of South African coronary artery bypass surgery patients

In addition to exacerbating morbidity in male coronary artery bypass surgery (CABS) patients, their plight can also impose considerable strain on their female spouses' mood states, resulting in compromised quality of life. The current study was aimed at determining the impact of pre postoperative hypnotherapeutic ego strengthening (HES) on anxiety and depression in female spouses. It was conducted simultaneously with a recently published study of their CABS husbands' response to HES. Spouses whose husbands had been randomly assigned to an experimental group, were designated the experimental spouse group (n = 25) and spouses whose husbands constituted the control group, likewise comprised the control spouse group (n = 25). Assessment occurred preoperatively, on the day of discharge and at six week follow-up. Spouses in the experimental group (n = 25) were introduced to hypnotherapeutic ego strengthening (HES), pre and postoperatively. In the postoperative assessment experimental female spouses showed significantly reduced morbidity levels, which were maintained at follow-up. In contrast, females in the control group (n = 25) showed no change. The results supported the value of brief hypnotherapy as a means of psychologically empowering spouses whose husbands' were undergoing CABS.     

A study of doctors' and parents' attitudes to people with mental handicaps

ABSTRACT. The attitudes to people with mental handicaps held by a group of parents of children with mental handicaps and a group of doctors with some involvement in this area were compared using postal questionnaires. Doctors' estimates of how parents would respond were also compared with parents' responses and doctors' own responses. Four Likert-type scales were refined covering attitudes towards the effect on the family, the place in society of people with mental handicaps, their quality of life, and independence and autonomy. Results indicated that parents had more positive attitudes than doctors except with regard to independence and autonomy, to which doctors had the most positive attitudes. Doctors were aware that parents were likely to see the effect on the family in a more positive light, and independence less positively, than themselves. However, they underestimated the degree of positivity of parents about the place of people with mental handicaps in society, and their quality of life, to the extent that they expected parents to be significantly less positive about quality of life than they themselves were, whilst parents in fact proved significantly more positive. The differing perspectives and experiences of parents and doctors are discussed and some suggestions made of ways in which doctors' appreciation of the parental perspective could be developed in an attempt to facilitate sympathetic communication between them.     

癫癎患者生活质量及其影响因素的研究

目的研究癫痫间患者的生活质量及其影响因素。方法采用癫痫间患者生活质量量表-31(QO-LIE-31)对56例确诊的癫痫间患者和46例对照者进行评价。结果癫痫间组患者QOL各项得分均显著低于对照组(P<0.05);全身性强直-阵挛发作(GTCS)和复杂部分性发作(CPS)患者QOL各项得分无显著差异(P>0.05);伴有抑郁的癫痫间患者在对发作的担忧、情绪健康、精力/疲乏和总体健康水平方面低于不伴有抑郁的癫痫间患者(P<0.05);服用1种抗癫痫间药物(AED)的患者与服用1种以上的患者比较,在对发作的担忧、综合生活质量、情绪方面、药物的影响以及总体健康水平方面得分显著降低(P<0.05)。结论癫痫间患者生活质量显著降低,抑郁和服用多种AED对生活质量影响较大。     

Depression,anxiety and quality of life in parents of children with epilepsy

0bjectives – To assess the impact of childhood epilepsy on parental quality of life (QOL) and psychological health, and to investigate possible correlations between parental QOL and background variables as well as parental anxiety and depression. Subjects and methods – Parents having an epileptic child (n = 263) and parents having a healthy child (n = 270) were enrolled. Groups were in balance for background variables. Short‐Form Health Survey (SF‐36) Questionnaire, Zung Depression Scale (ZDS) and Zung Anxiety Scale (ZAS) were applied to all parents. Patients were divided into the first visit group (newly diagnosed epilepsy) and follow‐up visit group. Results – The parents of children with epilepsy had significantly lower QOL scores in SF‐36 for all subscales and higher levels of depression and anxiety by using ZDS and ZAS. The factors correlated with parental QOL were seizure control, visit status, anxiety, depression, employment, cost of epilepsy, status epilepticus, drug side effect and age of parents. Conclusions – Childhood epilepsy has a severe impact on parental QOL and psychological health, and recognition of possible correlations between parental QOL and background variables will be helpful to improve parental QOL.     

Quality of life of parents raising children with pervasive developmental disorders

ABSTRACT: BACKGROUND: It has been reported that parents of children with pervasive developmental disorders (PDDs) face higher levels of stress. The aims of the present study were; (i) to evaluate the quality of life (QOL) of parents caring for their children with PDDs, and (ii) to explore the correlates of their QOL. METHODS: A consecutive sample of parents of children with PDDs aged 6 to 15 were approached. The MOS 36-item Short-Form Health Survey (SF-36) was used to measure the QOL of the parents by eight subscales and two summary measures. Parents' personality and marital relationships were assessed with the NEO Five Factor Inventory and the Intimate Bond Measure, respectively. We characterized the parents' SF-36 profiles in comparison with the national normative scores and explored variables which correlated with their summary measures. RESULTS: Participants were 147 mothers and 122 fathers of 158 children with PDDs. Mothers had significantly lower scores in the areas of Role Physical (RP) Social functioning (SF), General health perceptions (GH), Vitality (VT), Role emotional (RE) and Mental Health (MH) than those among the general female population. The maternal mental component summary (MCS) was also significantly lower, but maternal physical component summary (PCS) and paternal PCS and MCS scores were not lower. Maternal PCS and MCS scores were both significantly associated with the high Care and the low Control scores, but regarding fathers only the paternal PCS scores were significantly associated with the low Control scores. Maternal PCS and MCS and paternal MCS scores were significantly associated with the high Agreeableness scores and the low Neuroticism scores. Multiple regressions have shown that Neuroticism was significantly related to the low MCS scores of mothers and fathers. Next, Care was related to maternal high PCS, and Control was related to maternal low MCS and paternal low PCS. CONCLUSIONS: The mothers of children with PDDs had lower QOL scores than those of the Japanese general population especially in mental domains. Impairment of the maternal QOL is significantly associated with the personality tendency of the parents and relationships with their partners.     

传统抗癫痫药物和妥泰对成年癫痫患者生活质量的影响

目的 评价传统抗癫痫药物和妥泰对成年癫痫患者生活质量的影响。方法 102例临床新确诊的成年癫痫患者被随机分为两组：一组予以传统抗癫痫药物单药系统治疗(AEDs组)，另一组予以妥泰单药治疗(TPM组)。1个月后比较两组的发作频率和不良反应。并用QOLIE-30表对这102例癫痫患者进行生活质量评定。结果 TPM组的发作频率和不良反应均明显低于AEDs组，而生活质量总分明显高于AEDs组，尤其在前五项的评分中更加明显。结论 TPM能提高癫痫患者的生活质量，其改善生活质量的作用主要是通过控制发作和减轻不良反应实现的。     

奎硫平与氯丙嗪对精神分裂症患者疗效及生活质量影响的对照研究

目的　探讨奎硫平、氯丙嗪对精神分裂症患者疗效及生活质量的影响。方法　对符合CCMD 2 R精神分裂症诊断标准的患者随机给予奎硫平 (4 0例 )、氯丙嗪 (37例 )治疗 6个月 ,采用阳性与阴性症状量表(PANSS)、副反应量表 (TESS)、世界卫生组织编制的生活质量量表 (WHOQOL 10 0 )观察疗效、副反应和生活质量的变化。结果　奎硫平组PANSS总分、阴性症状分低于氯丙嗪组 ,阳性症状分两组间差异无显著性 ,奎硫平组生活质量除精神支柱外均明显改善 ,在生活领域、心理领域、独立性领域、社会关系领域均较氯丙嗪组有显著改善。结论　奎硫平组生活质量优于氯丙嗪组。     

Association Between Resilience and Quality of life in Wenchuan Earthquake Shidu parents: The Mediating Role of Social Support

Of the Wenchuan earthquake victims, there was a special group who lost their only child, known as the Shidu parents. The purpose of this paper is to examine social support as a moderator between resilience and quality of life (QOL) in Shidu parents. A cross-sectional sample survey was conducted to collect data from 22 earthquake-stricken counties in Sichuan province. Of the Shidu parents from the Wenchuan earthquake, being of Han ethnicity, receiving a high monthly income, having a high education, having lost a younger child (18–27), and having lost a male child were all risk factors for a lower QOL (p?<?0.05). This study highlighted that different types of social support have different roles in building resilience and improving QOL. The results emphasized the importance of developing suitable social support strategies as mediators to improve resilience and the QOL in Shidu parents.