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1.
目的百乐眠胶囊联合双抗疗法治疗进展性脑梗死伴睡眠障碍患者的效果。方法随机将我院115例进展性脑梗死伴睡眠障碍患者分组,对照组57例予双抗治疗,观察组58例增加百乐眠胶囊,对比血清神经递质、炎症因子、睡眠质量、神经功能及负性情绪变化。结果观察组治疗后DA、BDNF、5-HT、EPH、TNF-α、IL-6、ET-1水平、夜间觉醒次数、睡眠潜伏期及PSQI、NIHSS、HAMA、HAMD评分均低于对照组,NO水平及总睡眠时间高于对照组(P0.05)。结论百乐眠胶囊联合双抗有效改善进展性脑梗死伴睡眠障碍患者睡眠质量及神经功能,其机制可能与抑制炎症反应,调节神经递质水平有关。  相似文献   

2.
目的:观察百乐眠胶囊治疗脑卒中急性期失眠的临床疗效。方法将144例缺血性脑卒中伴失眠患者按照服药情况分为观察组和对照组,两组患者均按照脑卒中临床路径规范治疗,观察组给予百乐眠胶囊治疗(4粒,2次/d),对照组给予阿普唑仑治疗(0.4 mg/d),治疗期间观察药物不良反应及患者症状改善情况,治疗前及治疗3周后分别通过匹兹堡睡眠质量指数(PSQI)量表进行睡眠质量评价,通过改良Rankin量表对患者的生活能力进行评价。结果治疗3周后两组患者睡眠质量、生活自理能力均明显改善,差异有统计学意义( P<0.05),且观察组的日间功能障碍评分和改良Rankin量表评分较对照组改善更佳,两组比较差异有统计学意义(P <0.05)。结论百乐眠胶囊对脑卒中急性期失眠患者的疗效显著,尤其是在日间功能障碍改善方面。  相似文献   

3.
目的百乐眠胶囊联合小重量持续牵引治疗神经根型颈椎病患者的疗效及患者的焦虑、抑郁情绪变化。方法采用随机数字表法将我院111例神经根型颈椎病患者分组,两组患者均给予小重量持续牵引治疗,对照组55例增加心理放松干预,观察组56例在对照组基础上增加百乐眠胶囊口服,观察两组患者治疗后焦虑(SAS)、抑郁情绪(SDS)、疼痛(VAS)、睡眠障碍(PSQI)、颈部残障指数(NDI)评分变化,并对比临床疗效。结果观察组治疗后SAS、SDS、VAS、PSQI及NDI评分均低于对照组,总有效率高于对照组(P0.05)。结论百乐眠胶囊联合小重量持续牵引能够有效改善神经根型颈椎病伴睡眠障碍患者睡眠质量,减轻疼痛,消除负性情绪及症状体征,促进颈部功能恢复。  相似文献   

4.
目的 研究脑电生物反馈疗法辅助治疗老年失眠症的效果.方法 将67例老年失眠症患者随机分为研究组(34例,使用右佐匹克隆合并脑电生物反馈治疗8周)和对照组(33例,单用右佐匹克隆治疗8周).采用多导睡眠(PSG)监测技术和匹兹堡睡眠质量指数量表(PSQI)评定疗效.结果 治疗后第8周末,两组多导睡眠脑电图中实际睡眠总时间、睡眠效率、睡眠维持率、睡眠潜伏期、REM(快速眼动)潜伏期、REM睡眠比例、夜间觉醒次数、觉醒总时间较治疗前显著改善(P<0.05);且研究组睡眠脑电图各项数据与对照组比较差异有统计学意义(P<0.05).两组PSQI评分均低于各自治疗前(P<0.05),研究组PSQI评分显著低于对照组(P<0.05).结论 脑电生物反馈疗法辅助治疗老年失眠症有较好的效果.  相似文献   

5.
目的探究放松训练用于脑卒中后焦虑抑郁合并失眠患者的改善效果。方法研究对象选取为2010年12月~2016年12月之间我院收治的150例脑卒中后焦虑抑郁合并失眠患者,采用数字表法随机分为治疗组和对照组,各75例。对照组单纯应用帕罗西汀治疗,治疗组则在对照组基础上加用放松训练,两组患者均连续治疗2个月,采用匹兹堡睡眠质量指数(PSQI)和睡眠脑电图对两组患者治疗前和治疗后的睡眠状况进行评价对比。并对比两组患者治疗前后汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)的评分结果。结果治疗前两组患者的HAMA、HAMD、PSQI评分对比无显著差异(P0.05),治疗后研究组的HAMA、HAMD、PSQI评分均显著低于对照组(P0.05);治疗前两组患者的各项脑电图参数对比无显著差异(P0.05),治疗1个月、治疗2个月时治疗组的睡眠潜伏期(SL)、睡眠总时间(TSA)、觉醒次数(AT)、觉醒时间(ASA)与对照组相比差异均具有统计学意义(P0.05)。结论放松训练联合帕罗西汀用于脑卒中后焦虑抑郁合并失眠症状患者能够更加有效的改善患者的睡眠状况和焦虑抑郁情绪,值得在临床上推广和应用。  相似文献   

6.
百乐眠胶囊治疗失眠症的临床研究   总被引:1,自引:0,他引:1  
目的评价百乐眠胶囊治疗失眠症的疗效。方法对40例失眠症患者进行开放性治疗,用睡眠评定量表(SDRS)进行疗效评价。结果治疗后1周和2周,患者SDRS评分中位数均较治疗前明显降低(P<0.01),2周时降低更明显(P<0.01)。1周时有效率为20%,2周时有效率为85%(P<0.01)。SDRS评定结果显示各临床表现均较治疗前明显好转(P<0.01)。结论百乐眠胶囊是治疗失眠症安全有效的药物。  相似文献   

7.
目的 观察右美托咪定睡眠诱导平衡治疗后顽固性原发性失眠患者脑内神经递质活动的变化.方法 对23例顽固性原发性失眠且内科治疗效果不佳的患者实施右美托咪定睡眠诱导平衡治疗,每日1h,持续3d,对照组23例患者采用常规方案治疗.采用阿森斯失眠量表及过度觉醒量袁评估患者治疗前后的主观症状变化,并采用脑电超慢涨落技术对治疗前后的脑内神经递质分别进行检测.结果 治疗后治疗组阿森斯失眠量表及过度觉醒量表指标分值明显改善,治疗前患者脑内5-羟色胺活动水平偏低,去甲肾上腺素活动水平偏高,经睡眠诱导平衡治疗后5-羟色胺活动水平升高,去甲肾上腺素活动水平降低,差异具有统计学意义(P<0.05),余神经递质活动水平无明显变化,差异无统计学意义(P>0.05),且无严重治疗不良反应.结论 顽固性原发性失眠患者脑内神经递质存在5-羟色胺活动水平偏低,去甲肾上腺素活动水平偏高,右美托咪定睡眠诱导平衡术治疗可以调节它们的活动水平,同时患者的失眠症状及过度觉醒表现也有所改善.  相似文献   

8.
目的探讨催眠疗法对老年失眠合并焦虑患者的睡眠质量及神经递质的影响。方法选取我院2017年8月至2018年8月期间收治的118例老年失眠合并焦虑患者作为研究对象。按随机数字表法将研究对象随机分为观察组和对照组,对照组(59例)采用常规治疗手段,观察组(59例)对照组基础上联合催眠疗法,持续干预5周。观察干预5周后两组患者的临床疗效,以及干预前后患者的匹茨堡睡眠质量指数量表(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分、睡眠进程参数指标和血清多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)等神经递质水平。结果 (1)观察组患者的总有效率为91.53%高于对照组的77.97%(P0.05);(2)观察组干预后患者的PSQI评分和HAMA评分低于对照组(P0.05);(3)观察组干预后患者的睡眠总时间、快速动眼期(REM)睡眠时间、睡眠效率高于对照组(P0.05),睡眠潜伏期、觉醒时间低于对照组(P0.05);(4)观察组干预后患者血清DA、5-HT、NE水平高于对照组(P0.05)。结论催眠疗法干预老年失眠合并焦虑患者效果显著,可改善患者的睡眠质量,缓解其焦虑情绪,促进机体神经递质水平恢复,值得临床推广应用。  相似文献   

9.
目的评价百乐眠治疗失眠障碍的疗效、安全性及与疗程的关系。方法检索中国知网(CNKI)、万方数据库、中国优秀硕士/博士学位论文数据库、维普中文科技期刊数据库(VIP)、Cochrane图书馆、Pubmed、EMBASE、中国学术会议论文数据库中截至到2016年12月的百乐眠治疗失眠的文献,用Jadad量表评价文献质量,用Stata 14软件进行Meta分析。结果纳入文献20篇,共计2235例(观察组1284例,对照组951例)。百乐眠组治疗失眠的总有效率显著高于对照组(RR=1.20,95%CI:1.10~1.31),百乐眠治疗失眠的有效率显著高于西药亚组(RR=1.24,95%CI:1.07~1.44)及其他中药亚组(RR=1.13,95%CI:1.03~1.23)。百乐眠组治疗失眠降低匹兹堡睡眠质量指数(PSQI)评分优于对照组[标准化均数差(SMD)=-0.53,95%CI:-0.81~-0.26]。随着用药疗程的增加(第2、3、4周),百乐眠治疗失眠降低PSQI评分较西药亚组的优势逐渐显现(SMD2=-0.50,95%CI:0.83~-0.16;SMD3=-0.60,95%CI:-0.97~-0.24;SMD4=-1.67,95%CI:-0.63~-0.05)。百乐眠组治疗失眠的不良反应事件发生率显著低于对照组(RR=0.25,95%CI:0.16~0.38)。百乐眠组不良反应事件发生率显著低于西药亚组(RR=0.23,95%CI:0.15~0.36)。随着用药疗程的增加(第2、3、4、8周),百乐眠组不良反应事件发生率逐渐低于西药亚组(RR2=0.45,95%CI:0.22~0.92;RR3=0.23,95%CI:0.04~1.33;RR4=0.16,95%CI:0.08~0.33;RR8=0.19,95%CI:0.06~0.59)。结论百乐眠胶囊治疗失眠障碍的总体有效率、降低PSQI评分均优于西药和其他中药,具有较高的安全性,值得在临床上进一步推广使用。但是否随着用药疗程的增加总体有效率及降低PSQI评分优势越显著仍有待进一步研究验证。  相似文献   

10.
目的探讨集束化护理干预应用于心内科住院失眠老年患者的临床效果。方法选择心内科住院且有明确失眠症的老年患者146例,随机分为观察组与对照组,每组73例,均服用一片阿普唑仑助眠。对照组实施常规护理,观察组则在此基础上实施集束化护理干预,对比两组护理前后睡眠进程参数、匹兹堡睡眠质量指数(PSQI)及汉密尔顿焦虑和抑郁量表(HAMA、HAMD)评分和临床疗效。结果观察组的总有效率为94.52%,显著高于对照组的80.82%(P0.05);干预后观察组的入睡潜伏时间、觉醒次数及觉醒时间均显著低于对照组,实际睡眠时间及睡眠维持率均显著高于对照组(P0.05);干预后观察组的PSQI量表各维度评分、HAMA及HAMD评分均显著低于对照组(P0.05)。结论集束化护理干预合并助眠药物能够改善心内科失眠老年患者的精神心理状态及失眠症状,提高其睡眠质量并促进病情康复。  相似文献   

11.
Background Dementia occurs in the majority of patients with Parkinson’s disease (PD). Late onset of PD has been reported to be associated with a higher risk for dementia. However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age. Methods Two community-based studies of PD in New York (n = 281) and Rogaland county, Norway (n = 227) and two population-based groups of healthy elderly from New York (n = 180) and Odense, Denmark (n = 2414) were followed prospectively for 3–4 years and assessed for dementia according to DSM-IIIR. All PD and control cases underwent neurological examination and were followed with neurological and neuropsychological assessments. We used Cox proportional hazards regression based on three different time scales to explore the effect of AAO of PD on risk of dementia, adjusting for age at baseline and other demographic and clinical variables. Findings In both PD groups and in the pooled analyses, there was a significant effect of age at baseline assessment on the time to develop dementia, but there was no effect of AAO independent of age itself. Consistent with these results, there was no increased relative effect of age on the time to develop dementia in PD cases compared with controls. Interpretation This study shows that it is the general effect of age, rather than AAO that is associated with incident dementia in subjects with PD. Received in revised form: 22 December 2005  相似文献   

12.
BONDY, S. C., M. E. HARRINGTON AND C. L. ANDERSON. Effects of prevention of afferentation on the developmentof the chick optic lobe. BRAIN RES. BULL. 3(5) 411–413, 1978.—The effects of unilateral extirpation of the right optic cup of the three-day incubated chick embryo upon the rate of synthesis and the stability of DNA in the non-innervated optic lobe, have been studied. This surgical procedure prevents innervation of the optic lobe contralateral to the removed eye, while the other optic lobe is normally innervated by retinal ganglion cells of the remaining eye. At the 20th day of incubation, the DNA content of the non-innervated lobe was below that of the paired lobe receiving normal innervation. This deficiency of cell number was caused by two events; death of an excess number of neurons formed early in embryogenesis and a reduced rate of glial proliferation in the later stages of incubation.  相似文献   

13.
2018年,国家卫生健康委员会等10部委联合发布《关于印发全国社会心理服务体系建设试点工作方案的通知》,四川省绵阳市被列为全国第一批试点地区。绵阳市人民政府依据《中华人民共和国精神卫生法》等相关法律法规和文件精神,结合前期调查研究和社会心理服务工作的试点实际,编制出台了《绵阳市社会心理服务工作管理办法》,并于2021年12月25日起施行。本文围绕社会心理服务的相关概念、办法总则、重点内容、保障措施等方面进行解读,以期为社会心理服务工作的规范、持续和有效开展提供参考。  相似文献   

14.
目的探讨腺垂体功能减退症患者的病因结构变化及临床表现。方法回顾性分析我院2013-01—2016-12住院及门诊78例腺垂体功能减退症患者的临床资料。结果男32例(41.03%),女46例(58.97%);诊断时年龄11~89岁,平均62.5岁;鞍区占位(包括术前及术后)52例(66.67%),席汉综合征8例(10.26%),空泡蝶鞍9例(11.65%),病因不明8例(10.26%),垂体-下丘脑发育不良1例(1.28%)。首次就诊科室:纳差厌食、恶心呕吐就诊于消化内科36例(46.15%)最常见。ACTH+TSH+Gn+G激素缺乏为19例最多,占24.36%,ACTH+TSH+Gn缺乏15例,占19.23%。结论腺垂体功能减退症病因结构发生变化,发病人群、首发症状及受累激素也不同,患者女性多于男性,发病年龄偏高,症状不典型,分布于临床多个科室,其中以低钠血症为首发临床表现就诊消化内科最多。  相似文献   

15.
《Clinical neurophysiology》2020,131(1):243-258
Standardization of Electromyography (EMG) instrumentation is of particular importance to ensure high quality recordings. This consensus report on “Standards of Instrumentation of EMG” is an update and extension of the earlier IFCN Guidelines published in 1999. First, a panel of experts in different fields from different geographical distributions was invited to submit a section on their particular interest and expertise. Then, the merged document was circulated for comments and edits until a consensus emerged.The first sections in this document cover technical aspects such as instrumentation, EMG hardware and software including amplifiers and filters, digital signal analysis and instrumentation settings. Other sections cover the topics such as temporary storage, trigger and delay line, averaging, electrode types, stimulation techniques for optimal and standardised EMG examinations, and the artefacts electromyographers may face and safety rules they should follow. Finally, storage of data and databases, report generators and external communication are summarized.  相似文献   

16.
目的分析帕金森病(PD)患者运动症状进展特点。方法采用PD统一评分量表(UPDRS)Ⅲ对912例PD患者进行评估。结果与病程1年的患者比较,除病程1~2年的患者外,其他病程患者的UPDRSⅢ评分、强直分、姿势或步态异常分、轴性症状总分、言语分、步态分显著升高(均P0.05),病程5~6年及14年患者的震颤分,病程5~6年、7~8年、9~13年、14年患者的运动迟缓分、姿势分显著升高(P0.05~0.01)。轴性症状进展速度高于UPDRSⅢ评分。结论 PD患者病程早期UPDRSⅢ评分进展快,震颤症状进展独立于其他症状,轴性症状评分较UPDRSⅢ更敏感地反映疾病加重趋势。  相似文献   

17.
18.
Summary The frequency of accumulation of 6-nm filaments in the adaxonal cytoplasm of Schwann cells in the 6th lumbar dorsal and ventral roots was evaluated in 4-, 8-, 26- and 45-week-old Sprague-Dawley rats. The frequency was higher in 4- and 8-week-old (growing) rats than in 26- and 45-week old (mature) rats, and also higher in ventral than in dorsal roots in 4-, 8- and 26-week old rats. There were no clusters on certain groups of myelinated fibers according to the size of transverse axonal area, in both the ventral and dorsal roots. Therefore, this accumulation may reflect certain functions of the adaxonal cytoplasm of Schwann cell during natural growth and maturation of the axon and myelin sheath.  相似文献   

19.
Introduction: An important consideration in treating acute mania is the promptness with which a chosen therapy can bring symptom amelioration. This article reviews the available published data from controlled, blinded studies regarding the latency of responses to antipsychotics in patients with acute mania.

Methods: Articles for this review were obtained from a search of the Medline database (1966–1999), using the following keywords and phrases: antipsychotic, atypical, bipolar disorder, mania, neuroleptic, typical. The bibliographic sections of articles gleaned from this search were used to direct further inquiries.

Results: Although information regarding the onset of action of antipsychotics is limited, we discovered data for four typical and three atypical antipsychotics. Drugs with the fastest onsets include haloperidol, risperidone, and olanzapine, with onsets appearing in 2–6 days. Chlorpromazine and thiothixene were at the slowest end of the continuum, with onsets of 2 weeks or longer. Data regarding pimozide are mixed, with some studies showing an onset equivalent to that of the 'fast' compounds and others showing one similar to that of the 'slow' compounds.

Conclusions: Choice of therapy should consider not only efficacy and safety, but also onset speed. Atypical antipsychotics appear to offer safer, faster, and more effective therapies.  相似文献   

20.
Nearly 400 years ago, Thomas Willis described the arterial ring at the base of the brain (the circle of Willis, CW) and recognized it as a compensatory system in the case of arterial occlusion. This theory is still accepted. We present several arguments that via negativa should discard the compensatory theory. (1) Current theory is anthropocentric; it ignores other species and their analog structures. (2) Arterial pathologies are diseases of old age, appearing after gene propagation. (3) According to the current theory, evolution has foresight. (4) Its commonness among animals indicates that it is probably a convergent evolutionary structure. (5) It was observed that communicating arteries are too small for effective blood flow, and (6) missing or hypoplastic in the majority of the population. We infer that CW, under physiologic conditions, serves as a passive pressure dissipating system; without considerable blood flow, pressure is transferred from the high to low pressure end, the latter being another arterial component of CW. Pressure gradient exists because pulse wave and blood flow arrive into the skull through different cerebral arteries asynchronously, due to arterial tree asymmetry. Therefore, CW and its communicating arteries protect cerebral artery and blood–brain barrier from hemodynamic stress.  相似文献   

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