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1.
A型肉毒毒素治疗特发性睑痉挛等的临床研究   总被引:4,自引:0,他引:4  
特发性睑痉挛(Blephrospasm,BS)和睑痉挛口颌肌张力障碍综合征或称Meige综合征,均系局限性或节段性肌张力不全范畴。从1994年3月始我们应用A型肉毒毒素局部注射治疗BS和Meige综合征,现将55例治疗和随访结果报道如下。临床资料:...  相似文献   

2.
肉毒毒素A治疗Meige综合征   总被引:2,自引:0,他引:2  
肉毒毒素A治疗Meige综合征黄新民Meige综合征又称睑痉挛、口下颌肌张力障碍综合征,1910年首先由Meige报道,是成年起病的一种变形性肌张力障碍,主要为睑痉挛和口面部异常运动。应用A型肉毒毒素(BTXA)治疗此病是80年代治疗学上的一个新进展...  相似文献   

3.
A型肉毒毒素治疗局限性肌张力障碍与面肌痉挛   总被引:104,自引:2,他引:102  
采用美国Alergan公司产A型肉毒毒素Botox局部注射治疗痉挛性斜颈10例,偏侧面肌痉挛19例,眼睑痉挛7例,Meige综合征3例,共39例局限性肌肉痉挛患者。在治疗后随访5~13个月。使用Tsui量表对治疗前后痉挛性斜颈病例进行病情评估,用Cohen和Albert量表对其余病例进行病情评估。结果表明治疗后病情的好转是显著的(P<0.001)。患者中症状明显改善者占82.1%,疗效持续6~26周,可在3至6个月后重复注射,重复取得疗效。其中12例出现轻微的并发症,包括2例眼睑下垂,7例面肌力弱,1例视力模糊,1例吞咽困难以及1例体重下降。以上12例除体重下降者外,均在数周内恢复。初步研究表明,局部注射A型肉毒毒素Botox,如在有经验医师的指导下,必要时在肌电图监视下进行,确为一种有效、安全、简便易行的治疗手段,能在一段时间内缓解甚至消除肌肉痉挛及相关症状。可望在局限性肌张力障碍和面肌痉挛或其它肌张力过高的疾病中,开辟一个新的治疗领域。  相似文献   

4.
目的探讨肌电引导对提高A型肉毒素局部注射治疗颈部肌张力障碍的有效性和安全性。方法对32例颈部肌张力障碍患者采用交叉对照设计,分成肌电引导和非肌电引导注射组。注射A型肉毒素的部位和剂量,根据受累肌肉、大小及痉挛、肥厚程度。按Tsui量表评价疗效。结果肌电引导组和非肌电引导组比较,治疗前后评分减少分别为11.53±3.41和10.84±3.25,t=2.64,P<0.05;明显和基本缓解率分别为84%和75%;颈肌无力和吞咽困难副作用分别为3例(9.36%)和9例(28.13%),χ2=4.17,P<0.05;2~7周完全恢复。结论该方法可明显提高颈部肌张力障碍的疗效及减少副作用。  相似文献   

5.
应用聚合酶链反应(PCR)技术研究了84例动脉硬化性血栓性脑梗塞(ATCI)患者和107例正常人的载脂蛋白B(apoB)基因的XbaI、EcoRI位点的多态性。结果ATCI组X-频率(0.827)低于对照组(0.916),ATCI组X+X-基因型频率增高,与对照组比较有显著性差异,而且X+X-基因型与血脂水平增高有相关性。提示,apoB基因的XbaI多态及连锁失衡可能作为动脉粥样硬化的遗传背景影响血脂质代谢,并参与ATCI的发病机制。  相似文献   

6.
肉毒杆菌毒素A对Meige综合征的治疗观察谭东,郭丽华,刘梅仕,韩丽70年代美国学者Scott首先将肉毒杆菌毒素A(BTXA)用于动物实验,以解除眼外肌的痉挛。80年代应用于临床以治疗紧张性或痉挛性肌肉运动障碍的疾病。本文介绍4例Meige综合征病人...  相似文献   

7.
偏侧面肌痉挛、眼睑痉挛、Meige综合征、痉挛性斜颈是局限性肌张力障碍性疾病,常表现为间断性或持续性局部肌肉不自主痉挛或抽动,特别是面部肌肉频繁痉挛及瞬目增多,直接影响面部美观,严重者妨碍工作与社交。治疗方法很多,如:安定、卡马西平、局部封闭疗法、针灸等,效果均欠佳,且疗效持续时间短,容易复发。我国应用A型肉毒素治疗局限性肌张力障碍性疾病不到10年,我省这方面的工作开展也较少,我们把近1年应用A型肉毒素治疗局限性肌张力障碍性疾病门诊患者15例,临床效果显著,现报道如下。  相似文献   

8.
A型内毒毒素治疗脑血管病后肌痉挛的疗效观察   总被引:6,自引:0,他引:6  
目的 观察A型肉毒毒素(BTX-A)治疗脑血管病(CVD)后肌痉挛的疗效和安全性。方法 使用国产BTA-X局部注射治疗42例CVD后肌痉挛患者。注射剂量、位点数根据受累肌肉大小、多少及痉挛程度采取个体化原则,注射部位按照解剖学体表标志定位。观察注射前后肢体肌力、肌张力(改良Ashworth评分)及功能等改变。结果 注射后患肢肌张力改良Ashworth评分、步速、步长,踝关节活动度均较治疗前明显改善(P<0.01、P<0.01、P<0.05、P<0.01);注射后12.12%(4/33)患者出现轻度下肢无力,持续4-6周后自行好转。结论 BTX-A局部注射是治疗CVD后肌痉挛的一种安全、简便的有效方法,副作用少。  相似文献   

9.
脑卒中患者血浆血栓素、前列环素与脑血流量的关系   总被引:2,自引:0,他引:2  
为进一步研究血栓素A2(TXA2)、前列环素(PGI2)与脑血管病的关系,我们测定了64例脑卒中患者TXA2和PGI2的代谢产物TXB2和6-酮-前列腺素F1α(6-K-PGF1α)血浆浓度,并同步观察了它们与局部脑血流量(rCBF)的关系。1资料1...  相似文献   

10.
肉毒毒素A治疗的浓度与位点距离探讨   总被引:2,自引:0,他引:2  
肉毒毒素(Botox)局部注射已成为各种肌张力障碍的首选治疗。我们用BotoxA治疗肌张力障碍性疾病262例,有效率99.23%。本组男性89例,女性173例。年龄10~71岁,平均51.2岁;病程2月~38年,平均3.6年;随访2~36月,平均21.6月。BotoxA分别稀释成25U/ml、27.5U/ml和30.5U/ml三种浓度,随机分别给病人注射,观察疗效与浓度的关系。注射前后检查EMG,以探讨2点间最佳距离。结果表明:小块肌肉和大块肌肉的最佳浓度分别是27.5U/ml和30.5U/ml;最佳距离分别是1.5cm和2cm~3cm。  相似文献   

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For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.  相似文献   

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Decades of intervention research have produced a rich body of evidence on the effects of psychotherapies and pharmacotherapies with children and adolescents. Here we summarize and critique that evidence. We review findings bearing on the efficacy of psychosocial treatments and medications under controlled experimental conditions. We also report evidence, where available, on the effectiveness of both classes of treatment with clinically referred youth treated in real-world clinical contexts. In general, the large body of evidence on efficacy contrasts sharply with the small base of evidence on effectiveness. Addressing this gap through an enriched research agenda could contribute importantly to linking scientific inquiry and clinical practice—to the benefit of both ventures. This is one element of a multifaceted agenda for future research and for synthesis of research, which will require the interplay of multiple disciplines related to child and adolescent mental health.  相似文献   

16.
Abstract

For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.  相似文献   

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OBJECTIVE: The population of Oman is a heterogeneous mix of nationalities providing a natural setting for studying the cross-cultural differences in the presence and severity of eating disorders as well as an opportunity for evaluating the performance of measurement instruments for these disorders. METHOD: Disordered eating screening instruments (the Eating Attitude Test and the Bulimic Investigatory Test) were administered to Omani teenagers, non-Omani teenagers, and Omani adults. RESULTS: On the Eating Attitude Test, 33% of Omani teenagers (29.4% females and 36.4% males) and 9% of non-Omani teenagers (7.5% of males and 10.6% females) showed a propensity for anorexic-like behavior. On the Bulimic Investigatory Test, 12.3% of Omani teenagers showed a propensity for binge eating or bulimia (13.7% females and 10.9% males). Among the non-Omani teenagers, 18.4% showed a tendency toward bulimia, with females showing a slightly greater tendency than males. In contrast, barely 2% of Omani adults showed either a presence of or a severity of disorderly behavior with food. CONCLUSION: Omani teenagers scored significantly higher than other ethnic groups and Omani adults. This finding is discussed in the light of emerging evidence from many parts of the world suggesting that cultural transition, compounded by demographic constraints, plays a significant role in abnormal eating attitudes.  相似文献   

19.
A current controversy exists about the relationship between spatial attention and conscious perception. While some authors propose that these phenomena are intimately related (Bartolomeo, 2008, Chun and Marois, 2002, O’Regan and Noë, 2001, Posner, 1994), others report dissociations between them (Kentridge et al., 1999, Koch and Tsuchiya, 2007, Wyart and Tallon-Baudry, 2008). However, spatial attention is not a unitary mechanism, and it is possible that not all forms of attention dissociate from conscious perception. In the present study we used a paradigm in which endogenous and exogenous forms of attention are orthogonally manipulated in order to investigate their relation with conscious perception within the same design. By analyzing two different cue-related components, our results demonstrated that while endogenous attention was electrophysiologically dissociated from conscious perception, exogenous attention was not, consistent with the hypothesis that exogenous attention is an important antecedent of our conscious experience. Our results support previous claims of dissociations between some forms of spatial attention and conscious perception, but also highlight the importance of exogenous orienting on the selection of information for conscious access.  相似文献   

20.
OBJECTIVE: To compare prevalence of serious emotional and behavioral problems and mental health contacts for these problems among American and British children and adolescents. METHOD: Data on children and adolescents ages 5 to 16 years were drawn from the 2004 U.S. National Health Interview Survey (response rate = 79.4%) and the 2004 survey of Mental Health of Children and Young People in Great Britain (response rate = 76.0%). Emotional problems, hyperactivity/inattention, and conduct problems were assessed using the parent version of the Strengths and Difficulties Questionnaire (SDQ). Psychometric properties of SDQ scales were compared across countries. RESULTS: The SDQ has similar psychometric properties across countries. More British than American children met the criteria for emotional and conduct problems, but not hyperactivity/inattention. Prevalence was higher for all problems in 5- to 8-year-old British boys and for emotional problems in 13- to 16-year-old British girls. American children with serious emotional and behavioral problems had a higher prevalence of mental health contacts overall and with mental health providers but not with general medical providers. CONCLUSIONS: British children have a higher prevalence of parent-reported serious emotional and behavioral problems than American children. However, British children with these problems are less likely than American children to receive mental health care.  相似文献   

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