双源CTA在颅内动脉瘤中的应用价值

目的:探讨双源CT血管造影(DSCTA)在颅内动脉瘤中的临床应用价值.方法:22例颅内动脉瘤患者行双源CTA检查,分别对双能量去骨法与常规法获得的重建图像按0～5级进行质量评分并记录后处理时间,进行配对样本t检验.以DSA为标准,,评估DSCTA的敏感性、特异性.结果:共检出动脉瘤30个.双能量法平均后处理时间明显少于常规法(6.85±1.38min vs 13.20±2.02min,P<0.01).图像质量评分分别为4.35±0.50和3.23±0,36,有统计学显著性差异(P<0.05).与DSA对照,双能量法和常规法检出率分别为100%和85.7%.按动脉瘤个数计算,DSCTA的敏感性为93.4%,特异性为100%.结论:双源CT的双能量CTA与DSA有高度一致性,可替代DSA而成为颅内动脉瘤筛选及术后随访的首选检查方法.     

三维时间飞跃法MR血管成像检出颅内动脉瘤的研究

目的分析三维时间飞跃法MR血管成像(3D TOF MRA)检出颅内动脉瘤的价值。资料与方法 36例进行了3D TOF MRA且有数字减影血管造影(DSA)和/或手术结果为对照的患者纳入本研究。以DSA和/或手术结果为参照标准,以患者为分析单位评价3D TOF MRA检出颅内动脉瘤的能力。对3D TOF MRA均检出动脉瘤者,分别测量动脉瘤的长径、短径和瘤颈,进行相关性分析。结果 36例患者中DSA和/或手术检出28例患者有28个动脉瘤,8例患者无动脉瘤;3D TOF MRA检出31例患者31个动脉瘤,5例患者无动脉瘤。以DSA和/或手术结果为参照,以患者为分析单位,3D TOF MRA检出颅内动脉瘤的敏感性、特异性和准确性分别为89.3%、75.0%、75.0%。3D TOF MRA和DSA在显示颅内动脉瘤长径、短径和瘤颈的差别无统计学意义,并且有很好的正相关性。结论 3D TOF MRA在诊断颅内动脉瘤方面具有高的敏感性和中等的特异性,高的假阳性率提示在作出小动脉瘤的诊断时需谨慎。     

颅内动脉瘤 3D DCE-MRA与DSA对照研究

目的 探讨三维动态增强MR血管造影(3D DCE-MRA)在颅内动脉瘤诊断中的价值. 资料与方法 对39例临床拟诊动脉瘤和常规MRA可疑动脉瘤的患者行3D DCE-MRA,随后行DSA,比较两种方法 对颅内动脉瘤的显示情况. 结果 34例动脉瘤患者中共有动脉瘤41个,3D DCE-MRA对动脉瘤诊断的敏感性为95%,特异性为80%,准确性为85%,3D DCE-MRA与DSA比较,差异无统计学意义(P>0.05). 结论 3D DCE-MRA是一项无创、安全、简便和可靠的诊断颅内动脉瘤的方法,对于颅内较大血管的动脉瘤的显示,可以取代DSA.     

科旋转采集三维数字减影血管造影对脑血管疾病的临床应用

目的评价旋转采集三维数字减影血管造影(3D DSA)的临床应用价值.方法回顾了53例分别施行过常规二维(2D DSA)和旋转采集3D DSA 脑血管造影检查的患者,其中男32例,女21例, 年龄19～72岁,平均46.3岁.常规2D DSA 为正位及侧位影像.三维影像重建方法采用遮盖表面显示(shaded surface display, SSD).结果本组53例脑血管造影患者中5例为动静脉畸形,2D DSA 及3D DSA 均能正确地做出诊断;其余48例患者中41例确诊为颅内动脉瘤,另7例常规2D DSA 疑为动脉瘤,经3D DSA 检查确定是血管扭曲.在确诊的41例颅内动脉瘤患者中36例2D DSA 及3D DSA 均能正确地做出诊断,5例患者因蛛网膜下腔出血临床疑为颅内动脉瘤破裂,常规正、侧位2D DSA 未显示确切异常,经3D DSA 进一步检查,确诊为颅内动脉瘤.经介入放射学治疗的29例颅内动脉瘤中26例常规正、侧位2D DSA 不能使瘤颈部得到最佳显示,3D DSA 使其显示最佳.统计学分析表明3D DSA 与2D DSA 对颅内动脉瘤诊断的总符合率为77.4%(41/53),一致性检验,χ2=5.267,P<0.05.结论旋转采集3D DSA 对血管病变的误诊和漏诊率低于常规2D DSA,能够形象、直观、精确地显示被检查区域的解剖结构.     

64层螺旋CT数字减影术对颅内动脉瘤诊断价值研究

目的 评价64层螺旋CT数字减影技术对颅内动脉瘤的诊断价值.方法 对36例蛛网膜下腔出血患者行64层螺旋CT平扫及增强扫描,每例患者均行常规CTA及减影CTA(digital subtraction CTA,DSCTA)重建,以DSA检查结果为标准,对比研究2种重建技术的图像质量、诊断准确性.结果 36例患者共计40个动脉瘤,经DSCTA检出动脉瘤40个,灵敏度、特异度分别为100%,经常规CTA检出动脉瘤37个,灵敏度、特异度分别为92.5%和100%.2组后处理图像质量单项有序行乘列表秩和检验有显著性差异(P＜0.01),DSCTA图像质量优于常规CTA.结论 64层螺旋CT DSCTA可作为筛查及诊断动脉瘤的首选方法.     

单次对比增强双能量去骨CTA诊断颅内动脉瘤的价值

目的 利用三维旋转数字减影血管造影(3D-DSA)为对照,评价双能量CT血管成像(DE-CTA)诊断颅内动脉瘤的价值.资料与方法 46例临床怀疑颅内动脉瘤的患者同时行3D-DSA.以3D-DSA为对照,以患者和以部位为分析单位计算DE-CTA的诊断准确性.以相似的方法在3D-DSA和DE-CTA上测量动脉瘤长轴、短轴及瘤颈大小.结果 3D-DSA证实11例无动脉瘤,35例有40个动脉瘤,动脉瘤平均长轴、短轴及瘤颈大小分别为(5.76±3.39)mm、(4.79±3.27)mm和(3.37±1.72)mm.DE-CTA正确检测了34例患者38个动脉瘤,漏诊2个动脉瘤.以3D-DSA为诊断标准,以患者和动脉瘤部位为分析单位,DE-CTA诊断动脉瘤的敏感性和特异性分别为97.1%、100%和95.0%、100%;诊断≤3 mm动脉瘤的敏感性和特异性分别为80%和100%.DE-CTA检测动脉瘤平均长轴、短轴及瘤颈大小分别为(5.54±3.48)mm、(4.50±3.31)mm和(3.11±1.67)mm;两种技术之间有很好的相关性(r=0.969、0.957、0.870;P=0.000).结论 与3D-DSA相比,单次对比增强DE-CTA在诊断颅内动脉瘤方面有很高的敏感性和特异性,是诊断颅内动脉瘤的有效方法.     

数字减影CT血管成像对颅内小动脉瘤的诊断价值

目的：评价数字减影 CT 血管成像(DSCTA)在颅内小动脉瘤诊断中的价值。方法回顾性分析92例经数字减影血管造影(DSA)或手术确诊为颅内动脉瘤患者的临床及 CT 影像资料,比较 DSCTA 和常规 CT 血管成像(CTA)2种技术对颅内动脉瘤检测的准确性。结果92例患者经证实共有102个动脉瘤,DSCTA 检出其中100个,常规 CTA 检出其中89个(χ2=8.707,P =0.003)。DSCTA 漏诊海绵窦段和床突下段动脉瘤各1例,而常规 CTA 漏诊13例床突下段及海绵窦段与颅骨紧贴<5.0 mm 的小动脉瘤。进一步将<3.0 mm 和3.0~5.0 mm 的动脉瘤合并计算,DSCTA 对检出5.0 mm 以下动脉瘤的敏感性显著高于常规CTA 技术(χ2=8.393,P =0.004)。结论DSCTA 对颅内动脉瘤诊断优于常规 CTA,尤其对颅底毗邻小动脉瘤的诊断有明显的优势,可作为筛查和诊断颅内动脉瘤的首选检查技术。     

多层CT血管成像与数字减影血管造影诊断颅内微小动脉瘤的比较

目的 探讨MSCTA对最大径≤3 mm颅内微小动脉瘤(IMA)的诊断价值.方法 回顾性分析连续826例可疑颅内动脉瘤患者的临床和影像资料.全部患者住院前(发病后2 h～4 d)均采用16层螺旋CT行MSCTA,全部颅内动脉瘤均经DSA、三维旋转数字减影血管造影(3DRA)或手术证实.MSCTA、DSA及3DRA等影像资料由2名放射科医师独立进行分析.以DSA或3DRA为标准,计算MSCTA诊断IMA的敏感性、特异性及准确度,采用Kappa分析,评价DSA或3DRA与MSCTA两种检查方法诊断颅内IMA的一致性.采用X~2检验分析IMA与非IMA患者多发动脉瘤的患病率.结果 826例可疑颅内动脉瘤患者中,788例为颅内动脉瘤患者,单发706例,多发82例,共发现889个动脉瘤,38例MSCTA、DSA或3DRA检查结果均为阴性.经DSA或3DRA检查证实,212例患者(271个动脉瘤)共有232个IMA.MSCTA检出229个IMA,假阳性1例,漏诊4个.以DSA或3DRA为标准,MSCTA诊断IMA的敏感性、特异性、准确度分别为98.3%(228/232)、97.4%(38/39)、98.2%(266/271).两种检查方法有较强的一致性(Kappa值为0.927,P<0.05).IMA与非IMA患者多发动脉瘤患病率分别为21.2%(45/212)、6.4%(37/576),差异有统计学意义(X~2=36.421,P<0.01).结论 MSCTA诊断IMA具有较高价值,鉴于MSCTA对IMA的检出达到≤3 mm水准,提出将颅内IMA影像大小界定从4～5 mm调整为≤3 mm.     

三维CT血管造影与平板DSA对颅内动脉瘤诊断价值的对比分析

目的 对比分析多层螺旋CT三维血管造影(3D-CTA)与平板DSA对颅内动脉瘤的诊断价值.方法 对44例自发性蛛网膜下腔出血(SAH)患者同时行3D-CTA及平板DSA(包括2D-DSA、3D-DSA)检查,评价不同检查方法对动脉瘤的诊断效能、3D-CTA容积再现(VR)与3D-DSA容积再现(VR)对共同检出的动脉瘤之瘤体长径差异、瘤颈及载瘤动脉清晰度.结果 44例自发性SAH患者经外科手术或血管内介入证实36例为动脉瘤患者,共46个动脉瘤(其中26例单发,10例多发).3D-CTA共检出40例48个动脉瘤(灵敏度83.33%,特异度75%,阳性预测值75%,阴性预测值66.67%).2D-DSA检出38例患者中44个动脉瘤(灵敏度77.78%,特异度75%,阳性预测值73.68%,阴性预测值75%).3D-DSA最大密度投影(MIP)检出34例动脉瘤患者共44个动脉瘤(灵敏度94.44%.特异度100%,阳性预测值100%,阴性预测值100%).3D-DSA(VR)检出36例动脉瘤患者共46个动脉瘤,无漏诊及误诊.就颅内动脉瘤的检出率方面,3D-CTA与2D-DSA、3D-DSA(MIP)的检出率差异无统计学意义(P>0.05),但3D-CTA(VR)与3D-DSA(VR)的检出率差异有统计学意义(P<0.05).无论是≥3 mm的动脉瘤还是<3 mm的动脉瘤,3D-CTA(VR)与3D-DSA(VR)对瘤体长径的测量差异均无统计学意义(P>0.1).在瘤颈及载瘤动脉清晰度显示方面,3D-CTA(VR)与2D-DSA和3D-DSA(VR)差异均有统计学意义(P<0.05),但3D-CTA(VR)与3D-DSA(MIP)差异无统计学意义(P>0.05).结论 3D-CTA对瘤体长径≥3 mm的颅内动脉瘤有很高的诊断效能,可作为一种微创的常规筛查方法,但对长径<3 mm的颅内动脉瘤有较高的漏诊及误诊率,对其未发现颅内动脉瘤的SSAH患者应进一步行3D-DSA检查.     

三维旋转血管造影技术在颅内动脉瘤诊疗中的应用

目的：探讨平板DSA三维旋转血管造影（3D-RA）在颅内动脉瘤的诊断和介入治疗中的应用技术。方法：72例患者利用平板DSA行常规全脑血管造影,再行3D-RA,并利用其Integris 3D-RA工作站行三维重组,分析其2D与3DRA对颅内动脉瘤显示的差异。结果：平板DSA常规全脑血管造影检出颅内动脉瘤56个,利用其3D-RA检出动脉瘤76个。结论：3D-RA可显著提高颅内动脉瘤的检出率,应用好3D-RA技术是指导临床诊断和治疗颅内动脉瘤的重要手段。     

多层螺旋CT 三维血管造影容积重建成像在颅内动脉瘤中的诊断价值

目的探讨多层面螺旋CT三维血管造影(MS 3D-CTA)容积重建(VR)技术在颅内动脉瘤中的诊断价值.方法对109例临床怀疑颅内动脉瘤的病人行MS 3D-CTA和DSA检查.使用GE Lightspeed pro 16层螺旋CT扫描仪获得原始图像,所有病例均采用VR技术对图像进行三维重建,20例同时有最大密度投影(MIP)辅助检查.VR和MIP后处理图像以及DSA图像由3位放射科医生用双盲法进行分析.结果DSA和手术证实83例共94个动脉瘤,其中单发74例,多发9例(7例2个动脉瘤,2例3个动脉瘤).VR图像上所测动脉瘤大小为1.3～32 mm,与DSA比较无显著性差异(t=1.548,P＞0.05).VR对颅内动脉瘤的敏感度为96.8%,特异度为92.9%,准确度为95.9%,阳性预测值为97.8%,阴性预测值为89.7%;DSA敏感度为97.9%,特异度为96.3%,准确度为97.5%,阳性预测值为98.9%,阴性预测值为92.9%.94个动脉瘤中,89个(94.7%)动脉瘤在VR图像上能清晰显示瘤体、瘤颈与载瘤动脉的三维空间关系,DSA为57个(60.6%).结论MS 3D-CTA VR的敏感度、特异度和准确度均较高,是一种快捷、经济和有效的检查技术.     

Sixty-four-row multisection CT angiography for detection and evaluation of ruptured intracranial aneurysms: interobserver and intertechnique reproducibility

BACKGROUND AND PURPOSE: The purpose of this work was to assess intertechnique and interobserver reproducibility of 64-row multisection CT angiography (CTA) used to detect and evaluate intracranial aneurysms. MATERIALS AND METHODS: From October 2005 to November 2006, 54 consecutive patients with nontraumatic subarachnoid hemorrhage (SAH) underwent both CTA and digital substraction angiography (DSA). Four radiologists independently reviewed CT images, and 2 other radiologists reviewed DSA images. Aneurysm diameter (D), neck width (N), and the presence of a branch arising from the sac were assessed. RESULTS: DSA revealed 67 aneurysms in 48 patients and no aneurysm in 6 patients. Mean sensitivity and specificity of CTA for the detection of intracranial aneurysms were, respectively, 94% and 90.2%. For aneurysms less than 3 mm, CTA had a mean sensitivity of 70.4%. Intertechnique and interobserver agreements were good for the detection of aneurysms (mean kappa = 0.673 and 0.732, respectively) and for the measurement of their necks (mean kappa = 0.753 and 0.779, respectively). Intertechnique and interobserver agreements were excellent for the measurement of aneurysm diameters (mean kappa = 0.847 and 0.876, respectively). In addition, CTA was accurate in determining the N/D ratio of aneurysms and adjacent arterial branches. However, the N/D ratio was overestimated by all of the readers at CTA. CONCLUSION: Sixty-four-row multisection CTA is an imaging method with a good interobserver reproducibility and a high sensitivity and specificity for the detection and the morphologic evaluation of ruptured intracranial aneurysms. It may be used as an alternative to DSA as a first-intention imaging technique in patients with SAH.     

多层螺旋CT三维血管成像对颅内动脉瘤诊断价值的研究

目的评估多层螺旋CT三维血管成像（MSCTA）在诊断颅内动脉瘤的价值。资料与方法对临床怀疑为颅内动脉瘤的73例患者的影像资料进行回顾性分析，其中23例行MSCTA检查，36例行DSA检查，12例同时行MSCTA和DSA检查，2例行MSCTA检查的同时与外科手术对照。结果MSCTA和DSA的可信度平均得分分别为7．87分和8．50分（P〈0．05）；MSCTA对颅内动脉瘤诊断的敏感性、特异性和准确性分别为92％、80％和91％。结论尽管MSCTA在颅内动脉瘤的诊断中可信度略低于DSA，但其敏感性、特异性和准确性较高，而且MSCTA通过三维后处理方法能很好地显示颅内动脉瘤的特征和周围的解剖结构，对颅内动脉瘤的诊断、外科手术有着重要的意义。     

Detection and characterization of intracranial aneurysms with 16-channel multidetector row CT angiography: a prospective comparison of volume-rendered images and digital subtraction angiography

BACKGROUND AND PURPOSE: The aim of our study was to compare multidetector row CT angiography (MDCTA) with digital subtraction angiography (DSA) in the detection and characterization of intracranial aneurysms. MATERIALS AND METHODS: In our blinded prospective study, 85 patients with suspected intracranial aneurysm (47 women, 38 men; age range, 19-83 years) underwent both 16-channel MDCTA and DSA. The MDCT angiograms were interpreted for the presence, location, size, ratio of the neck to the dome (N/D ratio), and lobularity of the aneurysms and relationship of the aneurysm with the adjacent arterial branches, by using volume-rendering techniques. MDCTA and DSA images (reference standard) were interpreted by 2 independent readers, and the results were compared. RESULTS: A total of 93 aneurysms were detected at DSA in 71 patients, whereas no aneurysms were detected in 14 patients. Compared with DSA, the overall sensitivity, specificity, and accuracy of MDCTA on a per-aneurysm basis were 92.5%, 93.3%, and 92.6%, respectively, for both independent readers. For aneurysms of <3 mm, however, MDCTA had a sensitivity of 74.1% for reader 1 and 77.8% for reader 2. There was excellent agreement between readers in the detection of aneurysms (kappa = 0.822). In addition, MDCTA was also accurate in determining N/D ratio of aneurysms, aneurysm lobularity, and adjacent arterial branches. CONCLUSION: MDCTA is accurate in the detection and characterization of intracranial aneurysms and can be used as a reliable alternative imaging technique to DSA in selected cases.     

Comparison of 16-row multislice CT angiography with conventional angiography for detection and evaluation of intracranial aneurysms

Purpose

The aim of this study is to compare the diagnostic performance of 16-row computed tomographic angiography (MDCTA) with digital subtraction angiography (DSA) for the detection and characterization of intracranial aneurysms in patients with nontraumatic subarachnoid hemorrhages (SAH).

Materials and methods

One-hundred and twelve consecutive patients with suspected intracranial aneurysm underwent both 16-row MDCTA and DSA. The MDCT angiograms were interpreted in a blinded fashion by using combination with VRI, MIP and MPR techniques. Sensitivity specificity and accuracy were calculated for the CTA and DSA. The results were compared with each other. The DSA reader's interpretation was accepted as the reference standard.

Results

A total of 164 aneurysms were detected at DSA in 112 patients, no aneurysms were detected by DSA and MDCTA in 16 patients. Eight aneurysms were missed by MDCTA. The overall sensitivity, specificity, and accuracy of MDCTA on a per-aneurysm basis were 95.1%, 94.1%, and 95%, respectively. According to the size of the aneurysm less than 3 mm; sensitivity, specificity and diagnostic accuracy of MDCTA were 86.1%, 94.1%, 88.6%, respectively.

Conclusion

This study suggests that MDCTA is equally as sensitive as DSA in the detection of intracranial aneurysms of greater than 3 mm, and it also reveals 100% detection rate for ruptured aneurysms.     

Detection and characterization of very small cerebral aneurysms by using 2D and 3D helical CT angiography

BACKGROUND AND PURPOSE: Many cases of subarachnoid hemorrhage are due to rupture of small cerebral aneurysms. Our purpose was to evaluate the usefulness of helical CT angiography (CTA) in the detection and characterization of very small (<5 mm) intracranial aneurysms. METHODS: One hundred eighty consecutive patients underwent CTA for suspected intracranial aneurysms. All aneurysms prospectively detected by CTA were confirmed by digital subtraction angiography (DSA) or at surgery. CT angiograms and digital subtraction angiograms were reviewed by two independent blinded radiologists who performed aneurysm detection, quantitation, and characterization using 2D multiplanar reformatted and 3D volume-rendering techniques. RESULTS: Fifty-one patients harboring 41 very small intracranial aneurysms were included in this series. Eighty-one percent (33 of 41 aneurysms) were 相似文献   

Diagnostic accuracy of 3D time-of-flight MR angiography compared with digital subtraction angiography for follow-up of coiled intracranial aneurysms: influence of aneurysm size

BACKGROUND AND PURPOSE: 3D time-of-flight MR angiography (3D TOF MRA) may be used as noninvasive alternative to digital subtraction angiography (DSA) for the follow-up of patients with intracranial aneurysms treated with Guglielmi detachable coils (GDCs). We aimed to determine the influence of aneurysm size and location on diagnostic accuracy of 3D TOF MRA for follow-up of intracranial aneurysms treated with GDCs. MATERIALS AND METHODS: Two hundred and one 3D TOF MRAs in 127 consecutive patients with 136 aneurysms were compared with DSA as standard of reference. Sensitivity and specificity of 3D TOF MRA for detection of residual or reperfusion of the aneurysms was calculated with regard to aneurysm size and location. RESULTS: Overall sensitivity and specificity of MRA was 88.5% and 92.9%, respectively. Sensitivity was lower for aneurysms 相似文献