Two new compounds from marine Streptomyces sp. FX-58

Two new compounds, 5-carboxymethyl-2-propylchromone (1) and 1,6-dihydroxy-8-propylanthraquinone (2), together with a known anthraquinone, 3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid (3), were isolated from the mycelium of an actinomycete, Streptomyces sp. FX-58, which was separated from a marine plant collected in Qingdao. Their structures were determined based on spectroscopic methods, especially 2D NMR spectral analysis.     

A new cerebroside,Asperiamide A,from the marine fungus Asperillus sp.

A new cerebroside, asperiamide A (1), and adenosine were produced from a marine fungus, identified as Asperillus sp., collected in the Mei Zhou Gulf, China. Two-dimensional NMR methods, FAB-MS, were used to established the structure of the new compound.     

A new spiro-sesquiterpene from the sponge Dysidea fragilis

A new spiro-sesquiterpene, spirofragilin (1), along with a known related sesquiterpene, dehydroherbadysidolide (2), have been isolated from the marine sponge Dysidea fragilis collected in the South China Sea. The structure of 1 was elucidated on the basis of detailed spectroscopic analysis.     

Fortisterol,a novel steroid with an unusual seven-membered lactone ring B from the Chinese marine sponge Biemna fortis Topsent

Fortisterol (1), a novel steroid with a rare seven-membered lactone ring B, has been isolated from the marine sponge Biemna fortis and its structure gas been elucidated on the basis of spectroscopic data.     

A new chloro-monoterpene from the mangrove endophytic fungus Tryblidiopycnis sp. (4275)

A new chloro-monoterpene (compound 1) and three known compounds, peroxyergosterol, uracil and methylisocoumarin, were isolated from the ethyl acetate extract of the fermentation broth of the mangrove endophytic fungus Tryblidiopycnis sp. (4275) obtained from Kandelia woody tissue from Mai Po, Hong Kong. Its structure was determined spectroscopically and by X-ray crystallographic analysis.     

Marine natural products sourced from marine-derived Penicillium fungi

Marine micro-organisms have been proven to be a major source of marine natural products (MNPs) in recent years, in which filamentous fungi are a vital source of bioactive natural products for their large metagenomes and more complex genetic backgrounds. This review highlights the 390 new MNPs from marine-derived Penicillium fungi during 1991 to 2014. These new MNPs are categorized based on the environment sources of the fungal hosts and their bioactivities are summarized.     

Two new compounds from a marine-derived Penicillium griseofulvum T21-03

A new phenolic acid compound, 46-dimethylcurvulinic acid (1) and a new citrinin monomer derivative penicitrinol P (2) were isolated from marine-derived Penicillium griseofulvum T21-03. The structures of 1 and 2 were elucidated on the basis of spectroscopic data.     

Studies on lectins from marine shells (III): Screening of lectin-like agglutinins from marine shells

Forty species of marine shells were collected from Korean coasts and studied extensively for their lectin activities by using erythrocytes of human blood A, AB, B, O group and rabbit blood. In total, 7 species contained lectins:Neptunea intersculpta, Omphalius nigerrimus andScapharca subcrenata, blood group nonspecific;Saxidomus purpuratus, human blood A and AB group specific;Lepidozona coreana, Tegillarca granosa andNeptunea polycosta, rabbit blood specific.     

A new antioxidant compound from Capparis spinosa

An activity-directed fractionation and purification process was used to isolate 1,1-diphenyl-2-picrylhydrazyl radical (DPPH?) scavenging components from fruits of Capparis spinosa L. (Capparaeae). Ethyl acetate and aqueous fractions showed greater DPPH? scavenging activities compared to the petroleum ether fractions. The ethyl acetate fraction was subjected to purification using column chromatography. A new antioxidant cappariside (4-hydroxy-5-methylfuran-3-carboxylic acid, 1), together with seven known organic acids (2–8) for the first time from plants of genus Capparis and four known organic acids (9–12) were isolated from C. spinosa. The structures were elucidated by extensive analysis of 1D- and 2D-NMR spectroscopic. In addition, compounds 1, 2, 4, 5, 9, 10 and 12 indicated strong scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with a SC₅₀ value of 0.204?±?0.002, 0.007?±?0.0, 0.011?±?0.0, 0.044?±?0.0016, 0.032?±?0.0, 0.090?±?0.001, and 0.350?±?0.017?mM, respectively.     

Seven new meroditerpenoids,from the marine sponge Strongylophora strongylata,that inhibited the maturation of starfish oocytes

Seven new meroditerpenoids, strongylophorines 13–19 (1–7), have been isolated together with the four known strongylophorines 2 (8), 3 (9), 4 (10), and 8 (11) by a screening method using oocytes of the starfish Asterina pectinifera from a marine sponge Strongylophora strongylata collected at Iriomote Island, Okinawa, Japan. The structures were assigned according to their spectral data. Ten strongylophorines inhibited the maturation of starfish oocytes in the range 1.1–37.6?μM (IC₅₀), while strongylophorine 4 (10) was not active at 250?μM.