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忧郁症是一种常见的精神病,女性发病率比男性高2-3倍.根据《精神障碍统计和诊断手册》第4版标准,其临床表现为持续2周以上情绪低落和兴趣缺失,同时伴随食欲减退或增加、失眠或嗜睡、敏感或运动迟钝、疲乏无力、无用感和负疚感、思维和注意力下降及反复出现的自杀等症状[1].周连华[2]等报道糖尿病患者中31.4%合并忧郁症,其中评分为60分及以上的重度忧郁症占14.3%,Thomas等[3]报道糖尿病人群中忧郁发生率36%,糖尿病患者易合并忧郁是肯定的,我院自2004年11月至今对住院糖尿病人200例患者用SDS量表进行忧郁症筛查,报告如下: 相似文献
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目的 研究牙隐裂的病因和发病规律.方法 对40例患者共47颗患牙的临床表现及牙颌情况进行了研究.结果 牙隐裂多发生于中老年人的磨牙40颗(85.11%),尤其是上磨牙,35颗(74.47%),其次是前磨牙7颗(14.89%).患牙颌面多有异常磨损和高陡牙尖,颌面隐裂与发育沟吻合并延伸至边缘嵴.患牙有咬在某一特定部位疼痛或曾有硬物硌伤的病史.结论 牙齿结构的薄弱环节及创伤性颌力可能是牙隐裂发生的重要条件. 相似文献
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白内障是由于各种原因如老化、遗传、局部营养障碍、免疫与代谢异常、外伤、中毒、辐射等,引起晶状体代谢紊乱,导致晶状体蛋白质变性而发生浑浊的一种老年人常见眼病,此时光线被混浊晶状体阴扰无法投射在视网膜上,就不能看清物体. 相似文献
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头孢哌酮/舒巴坦致过敏性休克1例 总被引:2,自引:0,他引:2
患者,女,70岁,因COPD合并感染入院,体格检查,T36.8℃,P 100次/分,R 26次/分,Bp 140/85 mmHg,神清,无紫绀,桶状胸,两肺叩呈高清音,两肺呼吸音低,满布哮鸣音,两肺低细湿罗音,心率100次/分,律齐,无病理性杂音,其他未见异常.追问病史,患者反复多次使用过多种抗生素,自述有时青霉素皮试阳性,1周前使用头孢哌酮/舒巴坦2.0加入0.9%氯化钠100 ml中静滴5 d.医嘱给予头孢哌酮/舒巴坦2.0加入0.9%氯化钠100 ml中静滴,未做皮试.静滴约10 min时,患者出现心慌、胸闷,继之紫绀、呼吸微弱,心音、脉搏消失,立即给予心、肺、脑复苏.复苏成功能,患者已康复出院. 相似文献
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1994年,Zhang等[1]成功克隆和测序了小鼠和人类的肥胖基因(obese gene,Ob),确定了其编码蛋白产物为瘦素(leptin).瘦素是分子量为16 000的蛋白质类激素,主要由白色脂肪细胞产生和分泌,在脂肪组织中表达最高,在胎盘,骨骼肌,胃,乳房和脑组织均有表达. 相似文献
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近年来,由于普遍开展了宫颈细胞学检查,使许多宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)得以早期发现;而宫颈电圈环切除术(loop electrosurgical excision procedure,LEEP)是近年来治疗CIN的一种新技术,LEEP治疗简便、经济,且对患者损害小.本文介绍,经过详细采集病史,遵循细胞学、阴道镜与组织学活检三阶梯式诊断程序,对于112例CINⅠ~Ⅱ级的门诊患者行LEEP术. 相似文献
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新闻描述: 4月27日,新华社向全国发布消息,称"阜阳市3月份以来已有789名儿童感染肠道病毒EV71,19人经全力抢救无效死亡".据悉,自今年3月上旬起,阜阳市几家医院陆续收治了以发热伴口腔,手足臀部皮疹为主的患儿,少数伴有脑、心、肺严重损害.经卫生部、安徽省和阜阳市专家的流行病学调查、临床诊断和实验室检测,确定该病为肠道病毒EV71感染. 相似文献
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20世纪,一个独特的生命个体以其勇敢的方式震撼了世界.海伦·凯勒,一个生活在黑暗中却又给人类带来光明的女性,一个度过了生命的88个春秋,却熬过了87年无光、无声、无语的孤独岁月的弱女子,竟然毕业于哈佛大学德克利夫学院,并用生命的全部力量处处奔走,建起了一家家慈善机构,为残疾人造福,被美国《时代周刊》评选为20世纪美国十大英雄偶像. 相似文献
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Meng Mao Lin Yang Zhuo Jin Ling-xu Li Yan-ru Wang Ting-ting Li Ya-jun Zhao Jing Ai 《Acta pharmacologica Sinica》2021,42(3):361-369
Intrauterine hypoxia(IUH)affects the growth and development of offspring.It remains unclear that how long the impact of IUH on cognitive function lasts and whether sexual differences exist.Spermidine(SPD)has shown to improve cognition,but its effect on the cognitive function of IUH offspring remains unknown.In the present study we investigated the influence of IUH on body weight and neurological,motor and cognitive function and the expression of APP,BACE1 and Tau5 proteins in brain tissues in 2-and 4-month-old IUH rat offspring,as well as the effects of SPD intervention on these parameters.IUH rat model was established by treating pregnant rats with intermittent hypoxia on gestational days 15-21,meanwhile pregnant rats were administered SPD(5 mg·kg?1·d?1;ip)for 7 days.Neurological deficits were assessed in the Longa scoring test;motor and cognitive functions were evaluated in coat hanger test and active avoidance test,respectively.We found that IUH decreased the body weight of rats in both sexes but merely impaired motor and cognitive function in female rats without changing neurological function in the rat offspring of either sex at 2 months of age.For 4-month-old offspring,IUH decreased body weight in males and impaired neurological function and increased cognitive function in both sexes.IUH did not affect APP,BACE1 or Tau5 protein expression in either the hippocampus or cortex of all offspring;however,it increased the cortical Tau5 level in 2-month-old female offspring.Surprisingly,SPD intervention prevented weight loss.SPD intervention reversed the motor and cognitive decline caused by IUH in 2-month-old female rat offspring.Taken together,IUH-induced cognitive decline in rat offspring is sex-dependent during puberty and can be recovered in adult rats.SPD intervention improves IUH-induced cognitive and neural function decline. 相似文献
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乙肝试纸条可以最大程度满足无偿献血现场快速筛查HBsAg,并使用在条件简陋的广大乡村、边远地区,并且便于在家庭中开展个人自查,这将有助于推动无偿献血运动的广泛开展以及无偿献血法的顺利实施[1].作者对乙肝试纸条快速筛查无偿献血者HBsAg结果进行分析,报告如下: 相似文献
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Yuan-yuan Qin Ping Xu Tong Wu Chao-qun Qian Yi-lin Fan Dong-hao Gen Liang Zhu Wei-min Kong Han-yu Yang Feng Xu Yi-ting Yang Li Liu Xiao-dong Liu 《Acta pharmacologica Sinica》2020,(2):181-191
Breast cancer resistance protein(BCRP)is one of ATP-binding cassette(ABC)transporters in brain microvessel endothelial cells that transport their substrates from brain to blood,thus limiting substrates to crossing into brain through blood–brain barrier.Our previous works show that bile duct ligation(BDL)impairs expression and function of brain BCRP in rats.Since zidovudine(AZT)is BCRP substrate,we investigated whether impaired expression and function of BCRP increased brain distribution and toxicity of AZT in BDL-D7 rats.After administration of AZT(10 mg/kg,i.v.),BDL markedly increased brain AZT concentrations,compared with sham-operated(SO)rats.The ratio of AZT brain-to-plasma area under concentration curve(AUC)in BDL rats was increased to 1.6-folds of SO rats.After treatment with AZT(100 mg/kg every day,i.v.)for 7 days,BDL significantly impaired cognitive functions compared with SO rats,evidenced by the significantly decreased percentage of alternation in Y-maze test and prolonged escaped latency in two-way passive avoidance trial.Furthermore,AZT treatment caused significant decrease in copies of mitochondrial DNA and mitochondrial membrane potential in hippocampus of BDL rats.Moreover,AZT treatment caused a significant decrease of cortex microtubule-associated protein 2 and hippocampus synaptophysin levels in BDL rats.AZT-induced CNS adverse alterations in BDL rats were not observed in SO rats treated with AZT.In conclusion,BDL decreases the function and expression of brain BCRP in rats,leading to increased brain distribution of AZT,which in turn enhances AZT CNS toxicity,leading to mitochondrial dysfunction,neuronal damage,and ultimately cognitive dysfunction. 相似文献
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我国医疗卫生界最高荣誉"白求恩奖章"获得者、防治艾滋病专家、武汉大学中南医院桂希恩教授说,王焕云只是一名乡村医生,但他勇敢地承担了一个人见人躲的社会责任,真了不起! 相似文献
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目的:加深对中药不良反应的认识.方法:对2001-2006年部分医药刊物报道的常见中药的不良反应进行汇总,分析.结果:中药不良反应涉及的器官、系统及临床表现较多,其中过敏反应发生率较高,尤其是注射剂.结论:对中药的应用应改变观念,加强合理应用,以降低不良反应的发生率. 相似文献