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1.
红厚壳属植物 C.caledonicum Vierll.心材具有抗真菌和抑制白蚁作用。作者从该植物茎皮的乙酸乙酯提取物中分离并鉴定了2种新的咕吨酮,拟名为 caledonixanthone E(1)和F(2),并评价了这2个化合物及从该植物二氯甲烷部位和乙酸乙酯部位中分得的其他已知多酚类的抗真菌活性。该植物茎皮干燥粉碎后依次用己烷、二氯甲烷、乙酸乙酯和甲醇提取。乙酸乙酯部位用硅胶柱层析,用二氯甲烷-乙酸乙酯梯度洗脱,得45个部位。这些部位经进一步层析得化合物1和2及一些已知成分。化合物1为  相似文献   

2.
李维亮  裘军  杨楠  阮金兰 《中国药师》2008,11(5):501-503
目的:探讨人工蛹虫草不同溶剂提取部位对大鼠肾小球系膜细胞增殖的影响.方法:系膜细胞与不同溶剂提取物共同培养或加入LPS刺激细胞增殖,培养68 h后,采用四甲基偶氮唑蓝(Mar)法观察人工蛹虫草不同溶剂提取物对培养的肾小球系膜细胞增殖的影响.结果:正丁醇提取物在2-250μg·ml-1浓度范围内呈浓度依赖性抑制系膜细胞增殖;乙酸乙酯提取物的抑制浓度为0.51~100μg·ml-1,甲醇提取物的抑制浓度为62.5~250.0μg·ml-1,而水提醇沉提取物在0.5~12.5μg·ml-1范围内具有促进系膜细胞增殖作用;乙醇提取物作用不明显.结论:人工蛹虫草子实体存在对肾小球系膜细胞增殖有抑制和促进作用的成分.  相似文献   

3.
黄花艾Artemisia princeps Pampan全草提取物在中医用于治疗炎症、腹泻及多种循环系统疾病。作者从该植物的甲醇提取物中分离出一活性成分,能抑制脂多糖(LPS)激活的RAW 264.7鼠巨噬细胞株产生NO。黄花艾的干植株室温下用甲醇提取,浓缩得糖浆状物质,悬浮于水中,依次以二氯甲烷和乙酸乙酯萃取,二氯甲烷部分经硅胶柱  相似文献   

4.
从莲Nelumbo nucifera Gaertn.的雄蕊中分离的提取物和黄酮类化合物可抑制活性氧(ROS)的形成,抑制DPPH和脂质过氧化离子的活性,防治氧化应激引起的疾病。莲的雄蕊用水、甲醇、丁醇等极性溶剂或醋酸乙酯、正己烷、二氯甲烷或氯仿等非极性溶剂提取得到具抗氧化作用的粗提物。莲雄蕊提取物和黄酮类化合物具抗氧化活性  相似文献   

5.
目的研究叶下珠的抗补体活性及活性成分。方法以活性筛选跟踪为向导,利用溶剂萃取和色谱方法对叶下珠提取物进行分离纯化,采用~(13)C-NMR波谱法结合文献数据鉴定化合物结构,测定其抑制补体的活性及可能的机制。结果筛选出叶下珠醇提取物的乙酸乙酯部位为抗补体活性部位,从中分离得到2个抗补体活性成分,经鉴定为柯里拉京和鞣花酸。乙酸乙酯部位和2个化合物均明显抑制补体经典途径的溶血活性,其IC50分别为53.77、176.54、102.23 mg·L~(-1),但对补体旁路途径溶血的抑制作用不明显。进一步研究表明,乙酸乙酯部位和2个化合物干扰了补体经典途径成分C1、C2、C4形成C3转化酶。结论叶下珠的多酚组分是其主要的抗补体活性成分,其机制与这些组分影响经典途径C3转化酶的形成有关。  相似文献   

6.
麻兵继  王佩佩 《中国药房》2008,19(10):740-742
目的:研究云南丽江地区产亮菌子实体中化学成分,寻找具有药用价值的活性化合物。方法:利用色谱技术对亮菌干燥子实体的甲醇提取物进行化学成分的分离。结果:共分离得到6个化合物,经鉴定分别为油酸甲酯(1)、硬脂酸(2)、3β-羟基-麦角甾-5,7,22-三烯(3)、亮菌乙素(4)、5-羟基尿嘧啶(5)和脑苷酯B(6)。结论:化合物1、2、3、5、6均为首次从亮菌子实体中分离鉴定。  相似文献   

7.
西班牙传统医学中广泛应用的小叶菊蒿Tanacetum microphyllum D C.具有抗炎、抗风湿和对消化道的保护作用。该植物的水提物对大鼠的抗炎和抑制溃疡活性曾有报道。本文研究其有机提取物在大鼠体内的药理作用。小叶菊蒿有机提取物(己烷,二氯甲烷,乙酸乙酯和甲醇)对大鼠由角叉菜诱导的水肿,在急性期(6d)和慢性期(8~22d)均有减轻作用。在急性期,其己烷、二氯甲烷、甲醇的提取物在早期(2h)、第2期(3h)和第3期(5h)都能抑制由角叉菜诱导的水肿。其中二氯甲烷提取物活性最强。尽管在最初其抑制率(39%)低于保泰松(60%),但在第3期二氯甲烷提取物仍起作用(34%),并与阳性对  相似文献   

8.
龙须菜的有机酸组成及其细胞毒活性   总被引:2,自引:0,他引:2  
目的研究红藻龙须菜有机酸提取物的组成及其细胞毒活性。方法用MTT法测定有机酸提取物对HeLa细胞的生长抑制活性,并将有机酸甲酯化后,以GC-MS测定其组成及含量。结果龙须菜有机酸提取物对HeLa细胞显示出细胞毒活性,其IC50=6.5μg.mL-1。鉴定了甲酯化有机酸中的13个化合物,其主要成分为棕榈酸甲酯(61.34%)。各组分对应的有机酸主要是C16或C18脂肪酸和邻苯二甲酸类等化合物,其中的棕榈酸、硬脂酸、棕榈油酸、油酸和亚油酸据文献报道具有抗肿瘤活性。结论上述脂肪酸成分可能是龙须菜抗肿瘤活性成分之一。  相似文献   

9.
云南红豆杉Taxus yunnanensis Chenget L.K.Fu木部被中国云南省几个少数民族用作传统药物。作者对该植物木部的化学成分及其抗癌活性进行了研究。该植物木部干粉依次用水、甲醇-水(1∶1)、甲醇提取,从水提取物的乙酸乙酯溶部位分得3个已知木脂素,即开环异落叶松树脂酚(5)、taxiresionol 和 isotaxiresinol。甲醇-水和甲醇提取物的二氯甲烷溶部位合并后多次经硅胶柱层析分得3个新的 C 14氧化紫杉烷类二萜 hongdoushans A~C(1~3),均为无色无定形固体。化合物1[a]_D~(25)+81.3°(c,  相似文献   

10.
作者将树舌Ganoderma applanatum(Leyss.ex Fr.)子实体磨碎后用甲醇回流提取,提取物悬浮于水,依次用正己烷、二氯甲烷、乙酸乙酯和正丁醇分配提取。将二氯甲烷部位进行硅胶柱色谱分离,用甲醇(不断增加浓度)-氯仿洗脱,得16个部位(MC01~MC16)。部位MC09经硅胶柱色谱分离,以己烷-丙酮梯度洗脱,得13个部位(MC09—01~MC09—13)。部位MC09—08用甲醇结晶得化合物3;部位MC09—07、MCl0和MC11进一步用硅胶柱层析,  相似文献   

11.
宋纯 《中国药业》2012,(22):31-32
目的观察杜虹花提取物的镇痛作用。方法运用热板法与扭体法,观察杜虹花不同提取部位小鼠扭体抑制率与痛阈提高百分率。结果杜虹花乙酸乙酯和正丁醇部位扭体抑制率与痛阈提高百分率与空白对照组比较有显著提高。结论杜虹花镇痛作用主要部位集中在乙酸乙酯和正丁醇部位。  相似文献   

12.
蒲公英有机萃取物的抗甲型H1N1流感病毒作用   总被引:2,自引:0,他引:2  
目的 通过检测蒲公英不同的萃取物体外抗甲型H1N1流感病毒作用,探讨其在甲型H1N1流感治疗上的应用。方法 首先用乙醇萃取而得到蒲公英的乙醇萃取物,然后依次采用乙酸乙酯、正丁醇、石油醚、水萃取蒲公英的乙醇萃取物,得到不同溶剂的萃取物;选用狗肾传代MDCK细胞作为病毒的宿主对病毒进行培养和扩增;通过血凝效价和Real time RT-PCR实验,间接或直接检测蒲公英不同萃取物对病毒的中和作用和增殖抑制作用。结果 4种不同溶剂的蒲公英萃取物作用病毒后,只有石油醚、乙酸乙酯组的血凝效价数值出现了一定程度的下降,其中乙酸乙酯萃取物组的值下降了2~4倍;而石油醚萃取物在96 h时,中和实验组和增殖抑制组的血凝效价值分别下降了256倍和128倍。Real time RT-PCR检测表明,石油醚和乙酸乙酯萃取物明显抑制病毒的扩增量。作用96 h时,无论是中和实验还是增殖抑制实验,石油醚萃取物的作用都是最显著的,病毒扩增率较阳性对照分别减少了92.4%和95.6%。结论 蒲公英乙酸乙酯萃取物和石油醚萃取物在体外有明显的抗甲型H1N1流感病毒的作用。  相似文献   

13.
Four extracts were prepared from the roots and leaves of Moricandia arvensis: root chloroform extract (ChlR), leaf chloroform extract (ChlL), root ethyl acetate extract (EAR) and leaf ethyl acetate extract (EAL). The genotoxic and antigenotoxic properties of these extracts were investigated by assessing the induction and inhibition of the genotoxicity induced by the direct-acting mutagen, hydrogen peroxide (H(2)O(2)), using the "Comet assay." It appears that none of the different extracts produces a genotoxic effect, except the highest tested concentrations of the leaf extracts which were capable to eliciting DNA damage. Human lymphoblast cells K562 were pretreated with different concentrations of each extracts and then treated by H(2)O(2), for the antigenotoxic study. The results showed that all extracts inhibited the genotoxicity induced by H(2)O(2) and particularly ChlR (42.5μg/ml) and ChlL (65μg/ml) extracts. In addition, antioxidant potential study of root and leaf extracts using different antioxidant tests indicated that root extracts possess a potent antioxidant activity through namely their capacity to transfer electrons.  相似文献   

14.
FK409, a novel vasodilator with anti-platelet aggregation activity, has been isolated from the acid-treated fermentation broth of Streptomyces griseosporeus No. 16917, which was cultured on a medium containing NaNO3 for 4 days. FK409 was purified from the culture-filtrate by extraction with ethyl acetate after adjusting the pH to 3.0 with HC1, followed by silica gel chromatography. The molecular formula of this compound was determined to be C8H13N3O4. In vitro, FK409 showed a potent relaxation activity on noradrenaline induced contraction of rat aorta. In addition to the vasodilating activity, this compound also showed potent anti-aggregation activities towards rabbit platelets. In vivo, intravenously administered FK409 resulted in marked blood pressure lowering in rats.  相似文献   

15.
目的比较研究刺玫果种子和果肉不同极性萃取物的体外抗氧化活性。方法以抗坏血酸为阳性对照,采用DPPH自由基清除法、邻苯三酚自氧化法和邻二氮菲亚铁法,测定种子和果肉不同极性萃取物对DPPH自由基(DPPH·)、超氧阴离子自由基(O-2·)和羟基自由基(·OH)的清除能力。结果种子和果肉不同极性萃取物均有一定的抗氧化能力,在一定质量浓度范围内,清除自由基的能力与其质量浓度呈正相关性。部分萃取物对DPPH·和·OH的清除能力较强,而对O-2·的清除能力较弱,其中果肉乙酸乙酯部分对DPPH·、O-2·和·OH的清除率最强,IC50分别为6.46,971.48和51.12μg·mL-1,总黄酮含量测定结果表明,该部分总黄酮含量为30.2%。结论果肉乙酸乙酯部分是一种很有潜力的天然抗氧化剂。  相似文献   

16.
在国产克拉霉素(6-O-甲基红霉素)的结晶母液中,有一个主要杂质,相对含量约占30%左右,采用一种简便有效的化学分离方法。经乙酸乙酯重结晶后,可得到纯度约94%的上述物质,经紫外、红外、质谱和核磁共振谱测试后,确证其结构为6,11-O-双甲基红霉素。  相似文献   

17.
目的研究石胆草(Corallodiscus flabellata)的化学成分。方法利用Diaion HP-20,Sephadex LH-20,硅胶柱等色谱技术分离,根据化合物的理化性质和光谱数据鉴定结构。结果从石胆草中分离并鉴定了7个化合物,分别为:5,3′,4′-三羟基-6,7-二甲氧基-8-C-[β-D-木糖-(1→2)]-β-D-葡糖黄酮碳苷(1);5,4′-二羟基-6,7-二甲氧基-8-C-[β-D-木糖-(1→2)]-β-D-葡糖黄酮碳苷(2);5,4′-二羟基-6,7-二甲氧基-8-C-β-D-葡糖黄酮碳苷(3);5,4′-二羟基-6,7-二甲氧基-8-C-[β-D-芹糖-(1→2)]-β-D-葡糖黄酮碳苷(4);3,4-二羟基-苯乙酸乙二醇酯(5);羟基酪醇(6);罗布麻宁(7)。结论化合物1和2为新化合物,其余化合物均系首次从该植物中分离得到。  相似文献   

18.
1H spin echo NMR spectra of intact hepatocytes, isolated from rat liver, showed resonances for glucose, mobile fatty acids, and +N(CH3)3 groups including choline headgroups of phosphoglycerides. Spectra from extracts of the same cells contained many more well resolved resonances due to low Mr metabolites. These included signals for free amino acids, ketone bodies, glucose, lactate, and acetate. 1H NMR spectra from suspensions of intact hepatocytes incubated with acetaminophen showed no resonances for drug metabolites, although changes in sugar resonances were observed. However, spectra of extracts from acetaminophen-treated hepatocytes contained resonances for both acetaminophen itself and its major metabolites, the glucuronide and sulfate conjugates. Results on the extent of acetaminophen metabolism as measured by 1H NMR compared well with previously reported chromatographic studies. The rate of metabolism of acetaminophen by hepatocytes was much slower in 2H2O buffer compared to H2O buffer and selective deuteration of several metabolites including the ketone bodies, glucose, and acetaminophen glucuronide was observed. The deuteration of glucose C2H appeared to be due to futile cycling of the glycolytic pathway to at least fructose 6-phosphate, and incorporation of deuterium by the enzyme phosphoglucoisomerase. This work demonstrates that 1H NMR studies of intact hepatocytes and cell extracts together can provide considerable insight into the metabolism of acetaminophen in vitro. Little pretreatment of samples is required, results can be obtained rapidly, and both normal and drug metabolites can be observed simultaneously. Similar studies should be applicable to a wide range of other drugs.  相似文献   

19.
由发酵液提取泰乐菌素C的初步研究   总被引:1,自引:0,他引:1  
研究了从发酵液中提取泰乐菌素C的工艺条件,确定了甲苯为萃取溶剂,在pH9.25~10.02萃取3次,继而用乙酸乙酯在pH9.44条件下进一步萃取,30%酒石酸溶液反萃取至水相(pH3.88),得到纯度84%的酒石酸泰乐菌素C溶液。  相似文献   

20.
Baccharis dracunculifolia D.C. (Asteraceae), a shrub which grows wild in Brazil, is the main botanical source of Brazilian green propolis. Since Brazilian propolis shows an immunomodulatory activity, the goal of this work was to evaluate the action of B. dracunculifolia extracts and some of its isolated compounds on reactive oxygen intermediate (H(2)O(2)) production by macrophages obtained from male BALB/c mice. The results showed that the leaf (Bd-L) (25, 50, and 100 microg mL(-1)), leaf rinse (Bd-LR) (25 microg mL(-1)), and the root (Bd-R) (25 microg mL(-1)) extracts enhanced H2O2 release by macrophages. A phytochemical study of the root and leaves of B. dracunculifolia was carried out. The chromatographic fractionation of Bd-R, using several techniques, afforded the isolation of baccharis oxide (1), friedelanol (2), viscidone (11), 11-hydroxy-10,11-dihydro-euparin (12), and 6hydroxy-tremetona (13), while Bd-LR gave the following isolated compounds: baccharis oxide (1), friedelanol (2), isosakuranetin (3), aromadendrin-4'-methyl ether (4), dihydrocumaric acid (5), baccharin (6), hautriwaic acid lactone (7), hautriwaic acid acetate (8), drupanin (9), and cumaric acid (10). Among the isolated compounds, baccharis oxide (1) and friedelanol (2) increased H2O2 production at a concentration of 100 microM. This is the first time that the presence of compounds 7, 8, 12, and 13 in B. dracunculifolia has been reported. Based on these results it is suggested that the crude extracts and some isolated compounds from B. dracunculifolia display an immunomodulatory action.  相似文献   

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