An overview of lefamulin for the treatment of community acquired bacterial pneumonia

ABSTRACT

Introduction

Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP).     

Postmenopausal hormone therapy in BRCA gene mutation carriers: to whom and which?

ABSTRACT

Introduction

Risk-reducing-salpingo-oophorectomy (RRSO) inevitably leads BRCA mutation carriers to premature menopause.     

Current and new pharmacotherapy options for non-alcoholic steatohepatitis

ABSTRACT

Introduction

There is an unmet medical need for an effective anti-fibrotic treatment for NASH with advanced fibrosis.     

Clinical effectiveness and radial artery remodeling assessment via very-high-frequency ultrasound/ultra biomicroscopy after applying slender 7Fr sheath for transradial approach in left main bifurcation disease

Abstract

Objective

To explore the clinical effect and radial remodeling of transradial slender 7?Fr sheath for left main bifurcation disease (LM bifurcation).     

A drug safety evaluation of atezolizumab in locally advanced or metastatic urothelial carcinoma

ABSTRACT

Introduction

Immune checkpoint inhibitors (ICIs) have rapidly changed the treatment landscape, demonstrating dramatic clinical efficacy in various cancers.     

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis

Abstract

Context

α-Hederin, a potent bioactive compound of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), has many pharmacological uses, but its effect on cancer cell metabolism is still unclear.     

Pharmacotherapeutic strategies for castrate-resistant prostate cancer

ABSTRACT

Introduction

Metastatic castration-resistant prostate cancer (CRPC) is a potentially symptomatic disease with an eventual lethal outcome. Novel pharmaceutical agents are continuously studied with encouraging results in CRPC.     

An evaluation of baricitinib as a therapeutic option for adult patients with moderate to severe atopic dermatitis

ABSTRACT

Introduction

Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease.     

Health-related quality of life and economic burden of chronic lymphocytic leukemia in the era of novel targeted agents

Abstract

Objective

To quantify the health-related quality of life (HRQoL) and economic burden of chronic lymphocytic leukemia (CLL).     

Potential drug interactions between targeted oral antineoplastic agents and concomitant medication in clinical practice

ABSTRACT

Objectives

Our objective was to analyze potential drug interactions (PDIs) between targeted OAAs and concomitant therapy in clinical practice.     

Pharmacologic management of Mycobacterium ulcerans infection

ABSTRACT

Introduction

Pharmacological treatment of Buruli ulcer (Mycobacterium ulcerans infection; BU) is highly effective, as shown in two randomized trials in Africa.     

User experiences with second-generation 32-gauge × 4 mm vs. thinner comparator pen needles: prospective randomized trial

Abstract

Objective

Two similarly designed studies compared user experiences with a second-generation extra-thin-wall, 5-bevel 32?G?×?4?mm pen needle (PN) with redesigned hub versus four thinner commercially available PNs.     

Current and emerging systemic treatments targeting the neural system for chronic pruritus

ABSTRACT

Introduction

Pruritus is a debilitating symptom that significantly affects the quality of life of patients who suffer from it. Many current and emerging systemic treatments targeting the neural system have been successful in treating itch of various underlying etiologies.     

An evaluation of rectal artesunate for the pre-hospital management of severe malaria

ABSTRACT

Introduction

Severe falciparum malaria stills accounts for around half a million childhood deaths per year in sub-Saharan Africa. Prompt treatment of sick children close to home starting with artesunate given rectally by appropriately trained people can be lifesaving.     

Pharmacotherapeutic strategies for critical asthma syndrome: a look at the state of the art

ABSTRACT

Introduction

‘Critical Asthma Syndrome’ (CAS) is an umbrella term proposed to include several forms of asthma, responsible for acute and life-threatening exacerbations. CAS requires urgent and adequate supportive and pharmacological treatments to prevent serious outcomes.     

Golimumab improves socio economic and health economic parameters in patients with rheumatoid arthritis,psoriatic arthritis,and ankylosing spondylitis

Abstract

Background

Golimumab (GLM) has shown its efficacy and safety in various clinical trials. We aimed to assess the effect of GLM on socio economic and health economic parameters in daily clinical practice.     

Spontaneous reports of hypersensitivity adverse drug reactions in Portugal: a retrospective analysis

ABSTRACT

Background

Hypersensitivity adverse drug reactions (ADRs) are usually serious, unpredictable, and associated with high morbidity and mortality. This study describes cases of hypersensitivity ADRs spontaneously reported in Central Portugal.     

Prognostic performance of proteomic testing in advanced non-small cell lung cancer: a systematic literature review and meta-analysis

Abstract

Objective

Timely assessment of patient-specific prognosis is critical to oncology care involving a shared decision-making approach, but clinical prognostic factors traditionally used in NSCLC have limitations. We examine a proteomic test to address these limitations.     

Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation,angiogenesis, and collagen biosynthesis

Abstract

Context

Zataria multiflora Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.     

Resource use and costs in patients with poorly controlled type 2 diabetes mellitus and obesity in routine clinical practice in Spain

Abstract

Objective

To compare healthcare resource use (HRU) and annual costs in type 2 diabetes mellitus (T2DM) patients with poor glycaemic control and obesity versus good glycaemic control without obesity.