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 共查询到10条相似文献,搜索用时 23 毫秒
1.
柴杰 《中国医药》2008,4(1):513-514
Objective To observe the effect of glargine for treatment of type 1 diabetes. Methods Sixteen type 1 diabetes patients were randomized in two groups. In the Glargine group, 10 patients were given injection Nov-olin R before every meal and injection Glargine at bedtime daily. Meanwhile 6 patients in the NPH group were given injection Novolin R before every meal and injection NPH at bedtime daily. The dosage of insulin was adjusted by blood glucose level, seeking a target of FBG ≤6.5 mmol/L and 2 h PBG≤10.0 mmoL/L. The blood glucose level and incidence of hypoglycemia were observed. Results Mean blood glucose level was similiar in the 2 groups(P > 0.10), but the incidence of hypoglycemia in the Glargine group was significantly lower than that in the NPH group (P < 0.05). Conclusion Glargine initiates the physiological secretion of insulin and controls the blood glucose lev-el more effectively.  相似文献   

2.
柴杰 《中国医药》2009,4(1):513-514
Objective To observe the effect of glargine for treatment of type 1 diabetes. Methods Sixteen type 1 diabetes patients were randomized in two groups. In the Glargine group, 10 patients were given injection Nov-olin R before every meal and injection Glargine at bedtime daily. Meanwhile 6 patients in the NPH group were given injection Novolin R before every meal and injection NPH at bedtime daily. The dosage of insulin was adjusted by blood glucose level, seeking a target of FBG ≤6.5 mmol/L and 2 h PBG≤10.0 mmoL/L. The blood glucose level and incidence of hypoglycemia were observed. Results Mean blood glucose level was similiar in the 2 groups(P > 0.10), but the incidence of hypoglycemia in the Glargine group was significantly lower than that in the NPH group (P < 0.05). Conclusion Glargine initiates the physiological secretion of insulin and controls the blood glucose lev-el more effectively.  相似文献   

3.
柴杰 《中国医药》2007,4(1):513-514
Objective To observe the effect of glargine for treatment of type 1 diabetes. Methods Sixteen type 1 diabetes patients were randomized in two groups. In the Glargine group, 10 patients were given injection Nov-olin R before every meal and injection Glargine at bedtime daily. Meanwhile 6 patients in the NPH group were given injection Novolin R before every meal and injection NPH at bedtime daily. The dosage of insulin was adjusted by blood glucose level, seeking a target of FBG ≤6.5 mmol/L and 2 h PBG≤10.0 mmoL/L. The blood glucose level and incidence of hypoglycemia were observed. Results Mean blood glucose level was similiar in the 2 groups(P > 0.10), but the incidence of hypoglycemia in the Glargine group was significantly lower than that in the NPH group (P < 0.05). Conclusion Glargine initiates the physiological secretion of insulin and controls the blood glucose lev-el more effectively.  相似文献   

4.
张伟  李晋平  杜滨 《中国基层医药》2009,16(7):1585-1586
Objective To discuss the clinical features and treatment of hepatogenous diabetes. Method Retrospective analysis was conducted in January 2002-April 2009 170 cases of clinical data in patients with liver cir-rhosis. Result 170 cases of liver cirrhosis 40 cases of diabetes, the incidence was 23.5% ,various types of cirrhosis may occur;typical "over three" obvious symptoms; 10 cases admitted tohospital when fasting blood glucose≥7.0 mmol/L, postprandial 2 hours blood glucose were ≥1.1 mmol/L;high level of total bilirubin,serum albumin,cholin-esterase,total cholesterol low. Given to diabetic diet and small doses of ct-glucosidase, short-acting insulin treatment; 26 cases of normal blood glucose, improvement in 8 cases (blood glucose 6. 1~11.1 mmol/L) ;6 deaths. Conclusion Prone to occur in patients with liver cirrhosis glucose metabolism disorders, its clinical features, treatment of liver damage and the need to take into account two aspects of diabetes, the use of insulin as the main.  相似文献   

5.
Reversal of hyperglycemia by protein transduction of NeuroD in vivo   总被引:2,自引:0,他引:2  
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6.
AIM:Effects on insulin sensitivity of Die-Huang-Wan,the herbal mixture widely used to treat diabetic disorder in Chinese traditional medicine,were investigated in vivo.METHODS:The obese Zucker rats were employed as insulin-resistant animal model.Also,insulin-resistance was induced by the repeatedintraperitoneal injections of long-acting human insulin at 0.5U/kg three times daily into adult male Wistar rats.Insulin resistance was identified using the loss of tolbutamide(10mg/kg) or electroacupuncture(EA)-induced plasma glucose lowering action.The plasma glucose concentration was examined by glucose oxidase assay.RESULTS:The plasma glucose-lowering action induced by tolbutamide was significantly enhanced in obese Zucker rats receiving the repeated administration of Die-Huang-Wan at dosage of 26mg/kg for 3d.Furthermore,administration of Die-Huang-Wan delayed the formation of insulin resistance in rats that were induced by the daily repeated injection of human long-acting insulin at 0.5U/kg three times daily and identified by the loss of tolbutamide-or EA-induced hypoglycemia.In streptozotocininduced diabetic rats,oral administration of metformain at 320mg/kg once daily made an increase of the response to exogenous short-acting human insulin 15d later.This is consistent with the view that metformin can increase insulin sensitivity.Similar treatment sith Die-Huang-Wan at an effective dose(26.0mg/kg) also increased the plasma glucose lowering action of exogenous insulin at 10d later.The effect of Die-Huang-Wang on insulin sensitivity seems to produce more rapidly than that of metformin.CONCLUSION;The present study found that oral administration of Die-Huang-Wan increased insulin sensitivity and delayed the development of insulin resistance in rats.  相似文献   

7.
许冰 《中国医药》2009,4(8):879-880
Objective To study on the changes of the IL-6、IL-8、TNF-α、CRP in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods (1) To assay the serum level of cytokines in 125 cases with type 2 diabetes mellitus(T2DM) and 40 normal controls. (2)To measure the level of fasting plasma glucose (FPG), hemoglobin A1c (HBA1c), fasting insulin (FINS), fasting C-peptide (FCP). (3)To analyze the relation of the level of FPG、HBA1c、FINS、FCP and cytokines. Results (1)The serum levels of cytokines in T2DM group were significantly higher than in control groups, IL-6、CRP、TNF-α in T2DM group with insulin resistance were significantly increase than in T2DM group without insulin resistance; (2)There was significantly positively correlation between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM, which is significantly correlated with insulin resistance. Cyto-kines plays an important role in the occurrence and development of T2DM and insulin resistance.  相似文献   

8.
Objective This study aimed to determine the change of plasma endothelin (ET) in patients with diabetes meUitus .Methods 42 diabetic patients and 50 normal people were included in our study.The diabetic patients were divided into 2 groups, one group with vascular complications, and the other one without. The plasma ET, blood pressure,fasting blood glucose and other intems were measured in these people. Result The plasma ET level was found to be greatly elevated in diabetic patients comparing with the normal people and ET level of diabetic patients with vascular complication was much higher than patients without complications. The plasma ET level had positive correlation with systolic pressure in diabetic patients. Conclusion The result indicated that the high level of plasma ET might play an improtant role in the occurrence and development of vascular complication. The level of plasma ET should be routinely measured in diabetic patients. The patients with high - level plamsa ET should take therapeutic measures to prevent the occurrence of vascular complication.  相似文献   

9.
沈洁  马娅梅  王晓华 《中国基层医药》2010,17(13):2775-2777
Objective To investigate the role of individualized psychological intervention in gastroscopy.Methods 286 patients first underwent gastroscopy were randomly divided into the intervention and control groups,143 patients in each group. Individualized psychological intervention were provided for intervention group,and the patients of control group were just given routine nursing care. All the patients were measured by self rating anxiety scale (SAS) ,which were as measuring standards before and after intervention. At the same time,the blood pressure and heart rate were compared before and after intervention. Visual analogue scale (VAS) was observed to investigate the satisfaction of patients after operation. Results Compared with control group,anxiety rate and degree,blood pressure and heart rate in intervention group were lower( P < 0. 05 ). The test of VAS revealed that the satisfaction of patients in intervention group was significantly higher than that in control group ( P < 0. 05). Conclusion Individualized psychological intervention could improve negative emotion and relieve anxiety and affliction of patients underwent gastroscopy, and the satisfaction degree for gastroscopy was improved.  相似文献   

10.
Aim: Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to elucidate the underlying mechanisms.
Methods: Diabetes mellitus was induced in male SD rats by a high-fat diet combined with a low-dose streptozotocin injection. The rats were orally administered paroxetine (10 mg/kg) and pravastatin (10 mg/d) or both the drugs daily for 28 d. The pharmacokinetics of paroxetine and pravastatin were examined on d 1 and d 28. Biochemical parameters including serum insulin, glucose and lipids were monitored during the treatments. An insulin-secreting cell line (INS-1) was used for measuring insulin secretion.
Results: In diabetic rats, co-administration of paroxetine and pravastatin markedly increased the concentrations of both the drugs compared with administration of each drug alone. Furthermore, co-administration severely impaired glucose homeostasis in diabetic rats, as demonstrated by significantly increased serum glucose level, decreased serum and pancreatic insulin levels, and decreased pancreatic Insulin-2 mRNA and tryptophan hydroxylase-1 (Tph-1) mRNA levels. Treatment of INS-1 cells with paroxetine (5 and 10 μmol/L) significantly inhibited insulin secretion, decreased the intracellular insulin, 5-HT, Insulin-2 mRNA and Tph-1 mRNA levels. Treatment of the cells with pravastatin (10 μmol/L) significantly stimulated insulin secretion, which was weakened by co-treatment with paroxetine.
Conclusion: Paroxetine inhibits insulin secretion at least via decreasing intracellular 5-HT and insulin biosynthesis. The deregulation of glucose homeostasis by co-administration of paroxetine and pravastatin in diabetic rats can be attributed to enhanced paroxetine exposure.  相似文献   

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