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1.
改善工艺提高头孢拉定精氨酸的混合均匀度   总被引:1,自引:0,他引:1  
张斌  涂勃曼 《黑龙江医药》2002,15(6):445-446
本课题通过正交试验研究,从头孢拉定和精氨酸原粉的松密度,混合时间,投料次序等几个方面加以改善,提高头孢拉定和精氨酸的混合均匀度。从而找出最佳工艺条件,提高了产品质量。  相似文献   

2.
急性肺损伤具有高发病率及高病死率,但目前临床尚无对于急性肺损伤的特效治疗措施,因此如何预防和治疗急性肺损伤仍是目前研究的重要课题。精氨酸是健康成年人中尿素、多胺、脯氨酸和其他蛋白质的合成所必要的氮载体,具有免疫调节活性且能够减轻炎性反应的作用,有研究表明,精氨酸通过产生大量一氧化氮等或产生免疫作用预防或治疗肺损伤,为深入了解应用精氨酸治疗肺损伤的研究现状,本文着重探讨精氨酸对肺损伤的保护效应,为临床治疗肺损伤提供新思路。  相似文献   

3.
用L-精氨酸及精氨酸-甘氦酸-天冬氨酸即RGD序列的短肽精氨酸-甘氨酸-天冬氨酸-苯乙酰胺对正常血压及原发性高血压大鼠离体动脉血管的舒张作用进行了研究。结果发现:L-精氨酸和精氨酸-甘氨酸-天冬氨酸-苯乙酰胺对于两种动物的血管平滑肌均有程度不等的舒张作用,且该舒张作用显示出剂量依赖性和内皮依赖性。药效动力学分析表明,L-精氨酸和精氨酸-甘氨酸-天冬氨酸-苯乙酰胺舒张血管的半数有效浓度分别为10-7和10-6mol/L,二者Ac-RGD-PEA最大舒张效应对于不同处置的不同动物约为4~20%左右。实验结果提示L-精氨酸及其衍生物对于血压的调节及高血压的治疗有一定的作用。  相似文献   

4.
目的建立精氨酸的细菌内毒素检查法。方法按照《中国药典》2005年版(二部)附录ⅪE中细菌内毒素检查法,使用两个厂家的鲎试剂对精氨酸进行干扰试验研究。结果精氨酸对采用鲎试剂进行细菌内毒素检查无干扰作用。结论精氨酸可以用细菌内毒素检查法(凝胶法)代替家兔热原检查法控制其产品质量。  相似文献   

5.
本研究观察离体状态下一氧化氮前体L—精氨酸及一氧化氮合成抑制剂N~G—硝基—L—精氨酸甲酯对犬十二指肠运动功能的影响。结果表明L—精氨酸能明显抑制十二指肠的收缩,而N~G—硝基—L—精氨酸甲酯能抵销其抑制作用。结果支持一氧化氮作为非肾上腺素能非胆硷能神经的主要介质,参与十二指肠运动功能的调节,表现为运动抑制。  相似文献   

6.
Copeptin与精氨酸加压素为加压素原分解产物,两者的病理生理意义基本相同。Copeptin比精氨酸加压素稳定、检测方便,目前已作为精氨酸加压素的替代指标。许多研究表明Copeptin可作为多种疾病的早期诊断和预后指标。本文对Copeptin的生物特性及与疾病的关系研究进展做一综述。  相似文献   

7.
随着对蛋白质磷酸化的深入研究,精氨酸甲基化备受人们关注。蛋白质精氨酸甲基转移酶(PRMTs)催化精氨酸残基甲基化。精氨酸是唯一含有胍基组的氨基酸,其包含5个潜在的氢键,有利于与生物氢键受体位置相互交换。精氨酸甲基化在细胞核和细胞质中是一种常见的翻译后修饰,2%左右的精氨酸甲基化是在小鼠肝细胞核中。其以S-腺苷-甲硫氨酸为甲基供体,将甲基转移到蛋白质精氨酸胍基的氮原子上。蛋白质精氨  相似文献   

8.
目的:研究腹部手术后使用精氨酸强化的全肠外营养(TPN)对患者营养及免疫状况的影响。方法:选择67例接受腹部手术和TPN的患者,随机分为对照组(常规TPN支持,24例)、试验Ⅰ组(TPN+15g精氨酸,25例)和试验Ⅱ组(TPN+30g精氨酸,18例),术后连续应用3d。结果:精氨酸强化的TPN提高了术后氮平衡的水平,促进血浆白蛋白、总蛋白的恢复,并使CD4+、CD4+/CD8+升高。在观察的周期内对免疫球蛋白和补体C3、C4的影响没有显著性意义。结论:精氨酸强化的TPN能提高术后患者的营养和免疫指标,提高TPN支持的效果。  相似文献   

9.
用L-精氨酸及精氨酸-甘氨酸-天冬氨酸即RGD序列的短肽表氨酸-甘氮酸-天冬氮酸-苯乙酰胺对正常血压及原发性高血压大鼠离体动脉血管的舒张作用进行了研究。结果发现:L-精氨酸和精氨酸-甘氮酸-天冬氮酸-苯乙酰胺对于两动物的血管平滑肌均有程度不等的作用,且该舒张作用显示出剂量依赖性和内皮依赖性。  相似文献   

10.
《中国处方药》2006,(2):64-65
L-精氨酸是-氧合酶作用的底物,越来越多的作为健康补充物使用。先前的研究表明L-精氨酸有降低血管硬化的潜能。但最近发表在JAMA(2006.295:58)杂志上的一项单中心随机双盲安慰剂对照试验研究显示,L-精氨酸对有ST段抬高的心肌梗死老年人无益,还可能增加死亡率。  相似文献   

11.
Post-translational modifications are well-known effectors in DNA damage signaling and epigenetic gene expression. Protein arginine methylation is a covalent modification that results in the addition of methyl groups to the nitrogen atoms of the arginine side chains and is catalyzed by a family of protein arginine methyltransferases (PRMTs). In the past, arginine methylation was mainly observed on abundant proteins such as RNA-binding proteins and histones, but recent advances have revealed a plethora of arginine-methylated proteins implicated in a variety of cellular processes including signal transduction, epigenetic regulation and DNA repair pathways. Herein, we discuss these recent advances, focusing on the role of PRMT1, the major asymmetric arginine methyltransferase, in cellular processes and its link to human diseases.  相似文献   

12.
陶文强  周雯  蒋光辉  万建国 《江西医药》2014,(12):1373-1375
目的:探讨精氨酸对外科重症患者营养和免疫的影响。方法收集32例外科重症患者,随机分为精氨酸组(n=16例)和对照组(n=16例),精氨酸组患者在常规营养支持基础上静脉给予精氨酸20g/d,连用7d。治疗第1d与第8d分别抽血检测营养指标(血清白蛋白、前白蛋白)、细胞免疫指标(CD3+、CD4+)、体液免疫指标(IgA、IgG、IgM)。结果精氨酸组患者第8d血清白蛋白、前白蛋白、CD3+、CD4+、IgG、IgM均较第1d明显升高(P〈0.05),对照组患者仅第8d血清前白蛋白均较第1d明显升高(P〈0.05)。两组患者白蛋白、IgA升高程度比较,差异无统计学意义(P〉0.05);前白蛋白、CD3+、CD4+、IgG、IgM升高程度比较,差异有统计学意义(P〈0.05)。结论添加精氨酸的营养支持能有效提高外科重症患者免疫应答水平,改善营养状况。  相似文献   

13.
Amino acids, for example L-arginine, are used in lyophilisation as crystalline bulking, buffering, viscosity reducing or stabilising excipients. In this study, arginine was formulated with different counter ions (hydrochloride, citrate, lactobionate, phosphate, and succinate). A monoclonal antibody was investigated in sugar-free arginine formulations and mixtures with sucrose regarding cake appearance and protein aggregation and fragmentation. Arginine hydrochloride formulations collapsed during lyophilisation due to its low Tg’ and partially crystallised during storage, but provided the best protein stability at low antibody concentration, followed by arginine succinate. Arginine citrate/phosphate/lactobionate formulations resulted in amorphous elegant cakes, but inferior protein stability. Addition of sucrose improved cake appearance and protein stability. Arginine phosphate with sucrose resulted in similar protein stability as the sucrose reference. Mixtures of sucrose with arginine hydrochloride/lactobionate/succinate provided better stability than sucrose alone. While 50 mg/mL antibody improved the cake appearance, only arginine lactobionate provided sufficient protein stability next to sucrose. Overall, sugar-free arginine hydrochloride and lactobionate lyophilisates stabilised the antibody comparably or better than sucrose depending on antibody concentration. The best protein stability was found for mixtures of arginine hydrochloride/lactobionate/succinate with sucrose.  相似文献   

14.
Successful development of marketable freeze-dried protein formulations requires adequate stabilization of the active biopharmaceutical ingredient. The choice of a stabilizer must therefore be based on sound knowledge of the physical and chemical properties of the excipients and specific needs of the protein component. Amino acids, such as arginine, have exhibit cryo- and lyoprotective effects similar to those of sugars and polymers and may therefore be considered to be an alternative approach to these established formulation strategies. The chemical structure and physicochemical characteristics of arginine are unique among amino acids and can provide additional benefits to freeze-dried protein formulations with regard to liquid and solid-state stability. This mini review provides a brief summary of research focused on the application of arginine in freeze-dried protein pharmaceuticals, including a discussion of its basic physical and chemical attributes as well as thermal behavior in the frozen and solid states. Mechanisms contributing to solid-state stabilization by arginine are discussed in the context of available stability studies on arginine-containing protein formulations. This mini review seeks to deepen the understanding of the opportunities and challenges associated with arginine-based preparations for freeze-dried protein pharmaceuticals.  相似文献   

15.
目的探讨门冬氨酸鸟氨酸联合精氨酸治疗肝性脑病的临床疗效。方法将我院收治的30例肝硬化肝性脑病患者随机分为观察组和对照组各15例,观察组给予门冬氨酸鸟氨酸联合精氨酸治疗,对照组仅给予精氨酸静脉滴注,比较两组患者的临床疗效。结果观察组的总有效率为93.33%,对照组的总有效率为66.67%,观察组显著高于对照组,两组比较,差异有统计学意义(P<0.05)。结论门冬氨酸鸟氨酸联合精氨酸能有效纠正肝性脑病,改善肝功能,疗效确切,优于单用精氨酸,且不良反应小,值得临床推荐使用。  相似文献   

16.
目的:探讨不同剂量精氨酸(Arg)强化的肠外营养(TPN)对胃肠癌患者术后免疫功能的影响.方法:选择90例胃肠癌患者,术后分别给予肠外营养支持,随机分为对照组(常规TPN,30例),试验Ⅰ组(TPN+Arg 15 g,30例)和试验Ⅱ组(TPN+Arg 30g,30例),分析术前术后不同时期白蛋白、总蛋白、C3、C4、CD4+ 、CD8+、CD4+/CD8+等免疫功能指标变化.结果:与对照组相比,Arg强化的TPN试验组患者免疫功能在术后第4天均有明显改善(P<0.05),随着精氨酸剂量的增加,总蛋白、CD4+ 、CD8+、CD4+/CD8+等指标改善更为显著(P<0.01).结论:精氨酸强化的TPN能提高胃肠癌患者术后免疫功能,添加精氨酸30 g优于15 g.  相似文献   

17.
Co-amorphous drug delivery systems based on amino acids as co-formers have shown promising potential to improve the solubility and bioavailability of poorly water-soluble drugs. Potential salt formation is assumed to be a key molecular interaction responsible for amorphous stability and increased solubility. However, little is known about the importance of the overall structure of the co-former. In this study, the structurally related amino acids arginine (basic) and citrulline (neutral) were chosen together with four model drugs (acidic furosemide and nitrofurantoin; basic cimetidine and mebendazole) to investigate the importance of salt formation versus structural similarity of co-formers. Drug-amino acid mixtures were ball milled at a molar ratio of 1:1. Generally, arginine showed a higher tendency to successfully form co-amorphous systems with the model drugs compared with citrulline, irrespective of assumed salt formation. Salt forming mixtures showed much higher Tgs, faster dissolution rates, higher solubility and physical stability compared to the corresponding non-salt forming mixtures. In conclusion, structural similarity of the co-formers does not lead to similar co-former performance for a given drug. Salt formation is not a prerequisite for the formation of a co-amorphous system, but if a co-amorphous salt system is formed, improved dissolution rate and physical stability are observed.  相似文献   

18.
目的:建立一种荷移分光光度法测定人纤维蛋白原中盐酸精氨酸含量的方法.方法:根据荷移分光光度法原理,利用盐酸精氨酸在硼砂缓冲液作用下与四氯苯醌发生荷移反应,在350nm波长下测定其吸光度,从而计算出人纤维蛋白原中盐酸精氨酸含量.结果:通过测定回收率和相对偏差来评价该方法准确度、线性范围和耐用性.平均值回收率为99.67%(RSD为1.27%),线性范围为99.92±0.696%(RSD为0.7%),耐用性为100.43%(RSD为1.47%);该方法适用于2.5%~6 5%浓度区间.与药典法测定结果相比无显著差异.结论:通过对本法的准确度、线性范围、耐用性方面的验证,该方法可适用于人纤维蛋白原中盐酸精氨酸含量的测定.  相似文献   

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