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1.
目的探讨采用UVB治疗和常规治疗银屑病疗效并进行对比性研究。方法选择2010年7月至2011年5月在我院进行治疗的银屑病112例患者作为演技对象,所有患者均签署知情同意书,愿意参加本研究。采用SPSS13.0统计软件进行统计描述与分析。结果对112例银屑病患者疗效分析研究显示,UVB组总显效为93.10%,常规组总显效率为66.67%,两组患者显效率比较存在统计意义(P<0.05),银屑病主要分为点滴型银屑病和斑块型银屑病,均为56例患者,两种类型银屑病有些病有效率比较存在统计学差异(P<0.05),银屑病治疗不良反应主要为轻度红斑、瘙痒和毛囊炎,无1例患者出现光毒反应,两组患者并发症发证没有统计学差异(P>0.05)。结论采用UVB治疗银屑病相对于常规治疗疗效较好,应加强临床推广。  相似文献   

2.
靳隽 《医药论坛杂志》2007,28(14):60-60,62
目的 评价雷公藤多甙和阿奇霉素治疗寻常型银屑病的疗效.方法 129例寻常型银屑病随机分为治疗组和对照组,分别应用雷公藤多甙和阿奇霉素与红霉素对照治疗观察.结果 治疗组治疗点滴状银屑病的疗效和总疗效间的差别有显著性意义(P<0.01).结论 雷公藤多甙和阿奇霉素联合治疗寻常型银屑病安全、有效.  相似文献   

3.
复方喜树碱涂膜剂的制备和疗效观察   总被引:1,自引:0,他引:1  
目的研制复方喜树碱涂膜剂,观察治疗银屑病的临床疗效.方法试制复方喜树碱涂膜剂,并以氯氟舒松涂膜剂、复方喜树碱酊剂和软膏剂作对照,观察临床应用效果.结果复方喜树碱涂膜剂的疗效优于复方喜树碱酊剂和软膏剂(P<0.01),同时也优氯氟舒松涂膜剂(P<0.05).结论复方喜树碱涂膜剂剂型优良,疗效可靠,是治疗银屑病的有效、低毒、安全制剂.  相似文献   

4.
目的调查银屑病患者的心理状态,探讨心理干预对治疗银屑病疗效的影响。方法将60例患者随机分为干预组和对照组各30例,对照组行常规治疗和护理,干预组在此基础上实施心理干预。治疗前采用症状自评量表(SCL-90)对60例银屑病患者进行心理测评和问卷调查。结果 SCL-90各项统计指标均高于我国正常人群,差异均有统计学意义;多数患者缺乏对银屑病知识的了解;两组痊愈率比较有明显差异(P<0.01)。结论银屑病患者存在明显的不良心理;在常规治疗的基础上,实施针对性的心理干预能有效提高治疗效果。  相似文献   

5.
银屑病的免疫治疗进展   总被引:1,自引:0,他引:1  
杨多 《天津药学》2007,19(3):72-74
银屑病的病因目前仍不明确,临床治疗困难。近年来,银屑病免疫治疗日益受到重视。本文介绍了治疗银屑病的一些新的免疫治疗药物(环孢素A、他克莫司、辣椒辣素、抗角蛋白抗体、转移因子、抗α-肿瘤坏死因子),临床应用中取得了一定的疗效,免疫治疗银屑病疗效肯定。  相似文献   

6.
钟均堂 《天津药学》2011,23(3):42-43
目的:观察雷公藤多苷片与复方丹参注射液联合应用治疗寻常型银屑病的疗效。方法:雷公藤多苷片与复方丹参注射液联合治疗寻常型银屑病41例,并与单用雷公藤多苷片或复方丹参注射液治疗组进行疗效比较。结果:雷公藤多苷片联合复方丹参注射液治疗寻常型银屑病的疗效明显优于单用雷公藤多苷片或复方丹参注射液。结论:雷公藤多苷片联合复方丹参注射液治疗寻常型银屑病的疗效确切,且不良反应少,值得临床推广。  相似文献   

7.
川芎嗪治疗银屑病的临床疗效及血液流变学研究   总被引:3,自引:0,他引:3  
为研究川芎嗪治疗寻常型银屑病的疗效 ,对川芎嗪静脉输液治疗 70例寻常型银屑病其中 30例患者进行了治疗前后的血液流变学观察。结果显示 ,川芎嗪治疗寻常型银屑病有良好疗效 ,治疗后患者的血液粘度、血浆粘度、血小板粘附率有明显下降  相似文献   

8.
目的:观察中医药治疗银屑病的临床疗效。方法:对118例寻常银屑病患者进行辨证分型,中草药治疗。结果:治疗后获临床痊愈63例,好转39例,总有效率86.4%。结论:中医辨证治疗血热风燥型的早期银屑病疗效较为满意。  相似文献   

9.
目的对比观察阿维A与常规药物治疗重症银屑病的临床疗效。方法 48例重症银屑病患者,随机分为甲组与乙组,每组24例。乙组予以常规药物进行治疗,甲组患者此基础之上予以阿维A进行治疗,并对两组患者的临床治疗效果进行观察。结果甲组患者的总有效率为95.8%,明显高于乙组患者的87.5%,差异有统计学意义(P<0.05);甲组患者的不良反应发生率为20.8%与乙组的45.8%相比,差异具有统计学意义(P<0.05)。结论在临床上应用阿维A药物,在重症银屑病疾病治疗中能够获得比较好的疗效。  相似文献   

10.
目的:研究治疗银屑病制剂克银1号片的制备及疗效观察。方法:建立克银1号片的制备方法和质控标准,对6B例银屑病患者进行疗效观察。结果:本制剂制备工艺简单,治疗银屑病总有效率为93.9%,明显优于对照组。结论:本制剂质量控制可靠,治疗银屑病有较好疗效,无明显不良反应。  相似文献   

11.
12.
Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.  相似文献   

13.
The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure–activity relationships within these compounds were discussed.  相似文献   

14.
Nestorov I 《Toxicology letters》2001,120(1-3):411-420
Two important methodological issues within the framework of the variability and uncertainty analysis of toxicokinetic and pharmacokinetic systems are discussed: (i) modelling and simulation of the existing physiologic variability in a population; and (ii) modelling and simulation of variability and uncertainty when there is insufficient or not well defined (e.g. small sample, semiquantitative, qualitative and vague) information available. Physiologically based pharmacokinetic models are especially suited for separating and characterising the physiologic variability from the overall variability and uncertainty in the system. Monte Carlo sampling should draw from multivariate distributions, which reflect all levels of existing dependencies in the intact organism. The population characteristics should be taken into account. A fuzzy simulation approach is proposed to model variability and uncertainty when there is semiquantitative, qualitative and vague information about the model parameters and their statistical distributions cannot be defined reliably.  相似文献   

15.
骨质疏松是一种全身性骨骼疾病,导致骨折风险增加。成人的骨量通过破骨细胞的骨吸收和成骨细胞的骨形成作用来维持动态平衡,治疗骨质疏松症的理想策略是抑制破骨细胞的骨吸收和/或增强成骨细胞的骨形成功能。目前针对保护成骨细胞及增强其功能的骨质疏松疗法相对较少。因此,本文针对成骨细胞相关功能蛋白、各种细胞损伤机制(内质网应激、氧化应激、机械过载、微小RNA和长链非编码RNA的影响等)及骨质疏松的治疗与预防作一综述,以期为针对增强成骨细胞功能的骨质疏松治疗策略提供新思路。  相似文献   

16.
益生菌广泛存在于自然界中,通过维持宿主体内菌群平衡、影响肠屏障功能和调节免疫应答等作用,提高宿主健康水平,被公认为"肠道健康卫士".一些益生菌可以增强机体的免疫功能,抑制致癌物质,影响肿瘤细胞的基因表达,对肿瘤具有拮抗作用.大量研究表明,益生菌在未来的肿瘤防治中有很好的应用和发展前景.  相似文献   

17.
[6,7-3H] Estrone (E) and [6,7-3H]estradiol-17 (E2) have been synthesized by reduction of 6-dehydroestrone and 6-dehydroestradiol with tritium gas. Tritiated E and E2 were administered by oral gavage to female rats and to male and female hamsters on a dose level of about 300 g/kg (54 mCi/kg). After 8 h, the liver was excised from the rats; liver and kidneys were taken from the hamsters. DNA was purified either directly from an organ homogenate or via chromatin. The radioactivity in the DNA was expressed in the units of the Covalent Binding Index, CBI = (mol chemical bound per mol DNA-P)/(mmol chemical administered per kg b.w.). Rat liver DNA isolated via chromatin exhibited the very low values of 0.08 and 0.09 for E and E2, respectively. The respective figures in hamster liver were 0.08 and 0.11 in females and 0.21 and 0.18 in the males. DNA isolated from the kidney revealed a detectable radioactivity only in the female, with values of 0.03 and 0.05 for E and E2, respectively. The values for male hamster kidney were < 0.01 for both hormones. The minute radioactivity detectable in the DNA samples does not represent covalent binding to DNA, however, as indicated by two sets of control experiments. (A) Analysis by HPLC of the nucleosides prepared by enzyme digest of liver DNA isolated directly or via chromatin did not reveal any consistent peak which could have been attributed to a nucleoside-steroid adduct. (B) All DNA radioactivity could be due to protein contaminations, because the specific activity of chromatin protein was determined to be more than 3,000 times higher than of DNA. The high affinity of the hormone to protein was also demonstrated by in vitro incubations, where it could be shown that the specific activity of DNA and protein was essentially proportional to the concentration of radiolabelled hormone in the organ homogenate, regardless of whether the animal was treated or whether the hormone was added in vitro to the homogenate.Carcinogens acting by covalent DNA binding can be classified according to potency on the basis of the Covalent Binding Index. Values of 103–104 have been found for potent, 102 for moderate, and 1–10 for weak carcinogens. Since estrone is moderately carcinogenic for the kidney of the male hamster, a CBI of about 100 would be expected. The actually measured limit of detection of 0.01 places covalent DNA binding among the highly unlikely mechanisms of action. Similar considerations can be made for the liver where any true covalent DNA binding must be below a level of 0.01. It is concluded that an observable tumor induction by estrone or estradiol is unlikely to be due to DNA binding.Paper presented at the Satellite Symposium of the European Society of Toxicology, Rome, March 29, 1983  相似文献   

18.
The effects of the d and l isomers of amphetamine on self-stimulation responding were tested following acute and chronic administration. Tolerance and post-drug depression of responding occurred in tests with both isomers, indicating no role for p-hydroxynorephedrine (PHN) which is one of the metabolites of d-amphetamine. In the second experiment, d-amphetamine, methylphenidate and cocaine all produced quantitatively and qualitatively similar effects on self-stimulation responding following acute administration. Following chronic administration of d-amphetamine, animals showed tolerance to all three drugs, indicating cross-tolerance among them. These data are consistent with an hypothesis that tolerance and post-drug depression following chronic amphetamine treatment are the result of decreases in postsynaptic receptor sensitivity, which would lead to a decreased effectiveness of all three drugs, regardless of their pre-synaptic mechanisms.  相似文献   

19.
Rationale  Two pharmacotherapies are approved for treating alcohol craving (acamprosate and naltrexone), but both have shown mixed findings in animals and humans. Objectives  The present experiments utilized a “reinforcer blocking” approach (i.e., rats were able to consume ethanol during treatment) to better understand the efficacy of these treatments for ethanol seeking and drinking using ethanol-dependent and nondependent rats. Materials and methods  In “nondependent” experiments, drugs (acamprosate 50, 100, and 200 mg/kg; naltrexone 0.1, 0.3, and 1.0 mg/kg) were administered over 3-week periods prior to operant sessions with a low response requirement to gain access to reinforcers for 20 min. For “dependent” experiments, rats were made dependent in vapor/inhalation chambers. Results  Acamprosate and naltrexone had similar effects on intake in nondependent and dependent rats; neither drug was selective for ethanol over sucrose drinking. In nondependent animals, naltrexone was more efficacious at more doses than acamprosate, and acamprosate’s effects were limited to a dose that also had adverse effects on body weight. Both pharmacotherapies showed more selectivity when examining reinforcer seeking. In nondependent rats, acamprosate and naltrexone had response-attenuating effects in ethanol, but not sucrose, groups. In dependent animals, acamprosate had selective effects limited to a decrease in sucrose seeking. Naltrexone, however, selectively decreased ethanol-seeking in nondependent rats. Conclusions  The naltrexone-induced decreases in seeking suggested a change in incentive motivation which was selective for ethanol in nondependent rats. The “nondependent” paradigm may model early stages of “problem drinking” in humans, and the findings suggest that naltrexone could be a good intervention for this level of alcohol abuse and relapse prevention.  相似文献   

20.
Catheters, urethral and ureteral stents and other urological implants are frequently affected by encrustration and infection due to their permanent contact with urine. Indwelling urinary catheters provide a haven for microorganisms and thus require extensive monitoring. Several surface modification techniques have been proposed to improve the performance of devices including the immobilization of biomolecules, the incorporation of hydrophilic grafts to reduce protein adsorption, the creation of hydrophobic surfaces, the creation of microdomains to regulate cellular and protein adhesion, new polymers and antimicrobial coatings. Physico-chemical explanation to elucidate the mechanism of such encrustation or infection inhibiting materials is still not available. Our series of experiments showed a marked decrease of silver-activity in biological fluids which corresponds with the controversial clinical results obtained with silver coated urinary catheters. Rifampicin/minocycline coated catheters had very low activity against Gram-negative rods, enterococci and Candida spp., the main causing organisms of urinary catheter infection. Surface engineered materials and antimicrobial drug delivery systems will be the next generation of sophisticated urinary catheters and stents, if both efficacy as well as efficiency has been proved clinically.  相似文献   

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