经导管封堵器介入治疗动脉导管未闭的临床研究

目的观察经导管封堵器治疗动脉导管未闭(PDA)的临床疗效.方法32例单纯PDA患者采用蘑菇伞动脉导管封堵器经皮经股静脉封堵治疗PDA,应用X线造影术观察即刻疗效,术后72 h、1个月、3个月分别行超声心动图评价治疗效果.结果X线主动脉造影测量PDA最窄处的直径平均6.8±1.1(3～12)mm,封堵器直径平均12.6±1.3(6～18)mm.全组技术成功率100%;术后10 min降主动脉造影显示29例无残余分流,3例存在极少量残余分流.术后肺动脉平均压较术前明显下降(P＜0.05).术中无任何严重并发症,3个月随访,未发现残余分流、封堵器移位、溶血、血栓或主、肺动脉狭窄.结论应用蘑菇伞动脉导管封堵器经导管介入治疗PDA安全有效,创伤小,成功率高,操作简单.     

Amplatzer封堵器治疗动脉导管未闭

动脉导管未闭（PDA）是常见的先天性心脏病,既往手术是惟一的治疗方法。随着介入医学的发展,已有若干种器械应用于PDA的介入治疗,Amplatzer封堵器是比较有代表性的一种。我院自2000年6月开始采用Amplatzer封堵器对PDA病人进行封堵治疗,共完成3例,现报道如下。1 资料与方法1.1 临床资料 例1:女,20岁。主因间断心悸,活动后气喘3年于2000年6月入院,查体于胸骨左缘第2肋间可闻及连续性机器样杂音。经胸超声心动图（TTE）示PDA直径11     

应用Amplatzer封堵器经皮穿刺治疗房间隔缺损及动脉导管未闭

目的：探讨应用Amplatzer封堵器治疗二孔型房间隔缺损(ASD)及动脉导管未闭(PDA)的效果。方法：术前均常规经胸超声心动图(TTE)确认ASD或PDA位置、大小及形态，分流情况及肺动脉压。在透视监视下经导管置入封堵器。成人ASD术中在经食道超声(TEE)监视下了解ASD的诸边缘及封堵结果。儿童使用经胸超声监视。PDA封堵前后分别行主动脉造影，确认PDA形态、大小及封堵结果。术后1个月及6个月分别经TTE评价治疗结果。结果：全组8例均手术成功，无任何并发症。术后24h TTE显示全部病例封堵成功，无残余分流。随访2～26个月，全部病例无再通，肺动脉压正常，增大的心脏房室恢复正常。结论：经皮穿刺应用Amplatzer封堵器治疗二孔型ASD及PDA疗效肯定，操作简便，成功率高，值得推广。     

国产封堵器治疗动脉导管未闭的疗效观察

我院自 2 0 0 3年 10月至 2 0 0 4年 2月应用国产动脉导管封堵器成功封堵动脉导管未闭 6例 ,随访 1～ 5个月 ,无并发症 ,现报告如下。1　资料与方法1.1　临床资料 :6例患者中 ,男性 1例 ,女性 5例 ,年龄 4～5 5岁 ,平均 2 5 .6岁。术前经临床体检 ,X线胸片 ,多普勒超声心动图检     

经导管AMPLATZER蘑菇伞堵闭动脉导管未闭的临床应用

经导管先天性心脏病动脉导管未闭 (ＰＤＡ)的堵闭治疗 ,近年来在器械装置的设置上有了很大的改进。 1998年 5月我们应用新推出的Ａｍｐｌａｔｚｅｒ蘑菇伞成功堵闭了 2例ＰＤＡ ,现报告如下。临床资料病例 1,男 ,17岁 ,体检发现心前区杂音 3个月 ,平时无任何自觉症状 ,能参加体育活动及各种劳动。体格检查 ,胸骨左缘 2～ 3肋间触及震颤 ,心浊音界明显向左下扩大 ,胸骨左缘 2～ 3肋间可及连续机器样杂音 ,向左上部放射 ,两肺呼吸音无异常 ,周围血管征阴性 ,全身未发现其它畸形。辅助检查 ,心电图 :左心室肥厚 ;超声心动图 :左心房 4 4ｍｍ ,…     

Amplatzer堵塞器堵闭动脉导管未闭2例

例 1:女 ,17岁。因发现动脉导管未闭 16a,劳力性气短5 a,于 2 0 0 2年 10月 2 5日入院。患者 1985年 11月发现心脏杂音并确诊为“先天性心脏病 ,动脉导管未闭”。查体 :体温 3 6.2℃、脉搏 92次 /min、呼吸 2 0次 /min、血压 110 /70m m Hg( 1m m Hg=0 .13 3 k Pa) ,发育中等 ,胸骨左缘第二肋间闻及连续的机器样杂音 ,肺动脉瓣区第二心音亢进。心电图示左室肥大。心脏超声在降主动脉与左肺动脉间可见直径 8m m ,长 11m m的动脉导管 ,并有双期正向血流。当天进行了 Am platzer蘑菇伞堵塞器堵闭动脉导管术。手术在 X光透视下进行。首先采用 …     

静脉入路Amplatzer伞治疗动脉导管未闭1例报道

动脉导管未闭(PDAAmplatzer)封堵术是近年来发展迅速的先心介入治疗手段,具有安全、有效,且创伤小,病人痛苦少,恢复快等特点.我科自1999年开展该项目以来,先后为十几位PDA患者施行该项手术治疗,取得良好疗效.现将我院采用静脉入路Amplatz伞治疗动脉导管未闭报道如下:     

动脉导管未闭介入治疗的护理

<正>动脉导管是位于主动脉与肺动脉之间的一根管道,是胎儿循环的重要通路。胎儿在母体内不能直接从外界取氧,肺无呼吸作用。肺动脉在入肺之前,大多通过动脉导管入降主动脉,循脐动脉到胎盘换氧;但出生后又必须及时阻断,使所     

应用蘑菇伞形封堵器经皮封堵婴儿及儿童动脉导管未闭

目的:评估蘑菇伞形导管封堵器经皮封堵婴儿及儿童动脉导管未闭的安全性和有效性,特别是选择封堵器尺寸的标准.方法:动脉导管未闭患儿96例,年龄4个月～12岁,中位年龄22个月,体质量5.5～37.5 kg,中位体质量11 kg.因心功能衰竭(心衰)、肺炎入院者58例,因生长迟缓、肺炎或反复呼吸道感染27例,仅因杂音入院者11例.动脉导管最窄处直径(3.4±1.9)mm,Qp/Qs为2.5±1.1,Rp/RB为0.2h±0.12.随访77例,随访时间为1～42个月.结果:封堵成功率94.8%.使用封堵器直径,动脉导管直径≥1.50的最小封堵器占73.6%.即刻、2 d、1个月及3个月累积完全封堵率分别为64.8%、86.8%、97.8%和100%.1例出现轻度主动脉狭窄,仍在随访中.无左肺动脉狭窄患儿.5例出现暂时性Ⅰ度或Ⅱ度Ⅰ型房室传导阻滞,2例出现暂时性Q-T延长.1例术后输血50mL.无封堵器脱落、移位、溶血、感染、周同血管破裂及血栓形成.封堵后心衰及肺炎迅速消失.结论:本法对大多数婴儿及儿童动脉导管未闭安全、有效.封堵器直径/动脉导管直径≥1.5的最小封堵器可以首选使用.当主动脉峡部直径小于6 mm或与动脉导管直径接近时,应十分谨慎.     

Amplatzer封堵伞经导管治疗继发孔型房间隔缺损及管型动脉导管未闭的临床应用

目的 评价Amplatzer封堵伞经导管治疗继发孔型房间隔缺损（ASD），管型动脉导管未闭（PDA）的治疗效果。方法 ASD7例及PDA3例，均在透视及食道超声心动图及经胸超声心动图监视下经导管置入Amplatzer封堵伞治疗。术后24小时、1月、3月分别行TTE、心电图及X线检测评价治疗效果。结果 7例ASD及3例PDA封堵伞置入全部成功。ASD病例术后24小时TTE显示4例存在微量残余分流，3例完全闭合；PDA病例术后即刻经逆行主动脉造影及24小时TTE显示3例存在微量残余分流。术后1月所有病例TTE显示完全闭合，无残余分流，术后随访3月，X线检查全部病例显示肺血减少，TTE示惦记主室缩小。结论 Amplatzer封堵伞是治疗继发孔型房缺及管型动脉导管未闭有效的非外科手术方法，操作简便、安全、并发症少、成功率高，近、中期疗效可靠。     

Percutaneous transcatheter closure of patent ductus arteriosus with an amplatzer duct occluder using retrograde guidewire-established femoral arteriovenous loop

1. The traditional antegrade wire-guided percutaneous transcatheter approach is not ideal in closing some types of patent ductus arteriosus (PDA) with abnormal morphology. The aim of the present study was to evaluate the efficacy of a retrograde wire-guided transcatheter approach for closure of some types of PDA using the Amplatzer duct occluder (ADO). 2. Nineteen patients with abnormal PDA morphology, including a smaller ostium of the side of the pulmonary artery compared with the side of the descending aorta, severe calcification or tortuosity, were included in the present study. In these patients, after the antegrade approach failed to cross a wire from the pulmonary artery via the PDA to the descending aorta, a retrograde guidewire was passed through the PDA in the opposite direction, from the descending aorta to the pulmonary artery, to establish a femoral arteriovenous loop that assisted the deployment of the ADO in all 19 patients. The size of the PDA, as determined by angiography, was 3.1 +/- 1.1 mm and the diameter of the ADO selected was 6.5 +/- 1.5 mm. 3. In 16 cases, systolic murmur disappeared after the procedure. Systolic murmur (less than Grade II) and angiographic residual shunt remained in three cases immediately after the procedure, but disappeared 1 month later. Mean pulmonary arterial pressure decreased from 33 +/- 8 to 22 +/- 4 mmHg in all 19 patients (P < 0.01). There were no complications during or after the procedure. 4. The retrograde wire-guided technique offers an alternative approach to facilitate closure of a PDA that cannot be achieved by traditional antegrade wire-guided methods due to morphological abnormalities in the PDA.     

经导管Amplatzer双面伞堵闭器关闭继发孔房间隔缺损

目的：观察Amplatzer双面伞堵顺关闭继发孔房间隔缺损（ASDⅡ）的临床疗效及安全性。方法：超声心图及临床诊断为ASDⅡ病人30例，选择经导管Amplazer双上房间隔缺损关闭治疗。结果：超声测定ASDII直径为13－25mm,ASDII最大伸展径及所选Amplatzer房间隔堵闭器为18－38mm，成功率为100％，超声心动图示术后即刻，24小时后及3个月后残余分流分别为40％，9．9％和3．3％，手术中除一过性房性心动过速和房室传导阻滞外，无其他并发症，3个月随访，所有病人临床症状及心脏大小改善，未发现并发症。结论：Amplatzer双面伞房间隔堵闭器关闭ASDⅡ临床疗效及安全性均好。     

钮扣装置关闭动脉导管未闭的临床应用

报告应用钮扣装置关闭先天性心脏动脉导管未闭４例。方法；手术在Ｘ线和彩色超声心动图联合监视下进行，从股静脉插入导管，经肺动脉，动脉导管到降主动脉。释放钮扣装置半闭ＰＤＡ。结果；４例关闭成功后连续性杂音均消失，肺动脉明显下降。影响无明显残余分流。     

国产动脉导管未闭封堵器的临床应用

目的评价应用国产动脉导管未闭(PDA)封堵器经导管治疗PDA的疗效。方法13例患者(男5例,女8例)成功采用国产动脉导管未闭封堵器进行了PDA封堵术。年龄10岁至24岁。PDA最窄处直径为2-8mm。输送长鞘为6-10F。术后即时、24小时、1个月、3个月、6个月、12个月随访心电图、彩色多普勒超声心动图检查、X线,观察疗效。结果13例患者均成功置入国产动脉导管未闭封堵器。12例即时心血管造影显示完全封堵,1例有微量残余分流。术后1个月、3个月、6个月、12个月彩色多普勒超声心动图检查13例显示完全封堵。全部病例均无严重并发症。结论应用国产动脉导管未闭封堵器对PDA进行介入治疗,疗效确切,远期效果满意。     

Pharmacologic management of patent ductus arteriosus

The incidence, pathophysiology, and clinical findings of symptomatic patent ductus arteriosus (PDA) are reviewed, and the pharmacologic management of symptomatic PDA is discussed. Spontaneous closure of the ductus arteriosus (DA) usually occurs within four days after birth in most premature and full-term infants. The incidence of PDA is related to birth weight in premature infants and has been shown to decrease with an increase in birth weight. Clinical findings are reviewed. Prophylactic treatment in the first few hours after birth may not be needed in most premature infants. Treatment should be considered only if the ductus becomes symptomatic. Medical management consists of respiratory support, fluid restriction, diuretics, digoxin, and indomethacin. Respiratory support, fluid restriction, and diuretics are used as first-line treatment of symptomatic PDA. Digoxin cannot be recommended as part of first-line therapy, since its risks seem to outweigh the benefits in preterm infants. Indomethacin should be used only if other standard measures including fluid restriction and diuretic treatment fail. The mechanism of action, pharmacokinetics, adverse effects, and drug interactions of indomethacin are discussed. Symptomatic PDA can increase morbidity and mortality, especially in very low birth weight infants. Treatment of symptomatic PDA may decrease the morbidity associated with this condition.     

Diameter of the ductus arteriosus as a predictor of patent ductus arteriosus (PDA)

Patent ductus arteriosus (PDA) is the most prevalent cardiovascular defect and is more often seen in females; premature babies are at increased risk. For both sexes, a relationship exists between the risk of this defect occurring and the higher dimensions of the ductus arteriosus. In this study, we examined the relationship between the dimensions of the ductus arteriosus (diameter, length, capacity) and sex. We analyzed a total of 223 fetuses, 108 males and 115 females, ranging in age from four to eight months of intrauterinal life. All fetuses of normal karyotype were obtained from spontaneous abortions. None of the analyzed specimens demonstrated any visible malformations. The increase in the length and diameters of the ductus is linearly related to gestational age. The volumetric growth of this vessel was dependent on fetal age, according to the exponential function. The large number of analyzed specimens allows reliable determination of the ductus arteriosus dimensions in consecutive months of fetal life. The data obtained could be of prognostic value during echocardiographic follow-up in the fetus. We found that the dimensions analyzed did not differ with regard to sex. It is a contradiction that, more frequently PDA in females is caused with the gender differences in the dimensions of ductus arteriosus.     

粗大型动脉导管未闭的外科治疗

目的：总结粗大型动脉导管未闭的外科治疗经验。方法：57例粗大动脉导管未闭病人，导管直径1cm-2.6cm，采用单纯结扎导管24例，加垫结扎4例，切断缝合22例，体外循环下经肺动脉直接缝闭导管7例，结果：56例治愈，1例死亡，结论：选择合理的术式及麻醉方法，采取必要的防治导管破裂出血的措施，粗大动脉导管的手术治疗可取得满意的疗效。