凯时注射液治疗突发性耳聋的Meta分析

目的利用Meta分析方法对凯时注射液治疗突发性耳聋的临床试验进行分析,评价其治疗效果。方法检索1994-2006年国内发表的凯时注射液治疗突发性耳聋临床试验的相关文献,采用Review Manag-er 4.2软件对符合条件的文献进行荟萃分析。结果与对照组比较,凯时注射液治疗突发性耳聋更有效,比值比为2.10,可信区间为1.44~3.05(P=0.000 1,即P<0.05)。结论临床可首选凯时治疗突发性耳聋。     

葛根素注射液治疗突发性耳聋的Meta分析

目的利用Meta分析方法对葛根素注射液治疗突发性耳聋的临床试验进行分析,评价其治疗效果。方法检索1994年~2004年国内发表的葛根素注射液治疗突发性耳聋临床试验的相关文献,采用Review Manager4.2软件对符合条件的文献进行荟萃分析。结果共有4个临床试验纳入本次研究,同质性检验X2=0.80,P>0.05,故采用固定效应模型进行分析。与对照组比较,葛根素注射液治疗突发性耳聋总有效率更高,比值比为2.05,95%可信区间为1.10~3.82(P<0.05)。结论临床可选用葛根素注射液治疗突发性耳聋。     

金纳多治疗突发性耳聋的疗效观察

金纳多治疗突发性耳聋的疗效观察袁玉梅樊黎明杨向华（河南省确山县人民医院耳鼻喉科确山县４６３２００）金纳多做为一种脑部和周围循环改善剂在治疗突发性耳聋取得满意疗效，１９９６年１２月～１９９７年４月我科对确诊突发性耳聋４０例患者，随机分成金纳多治疗组和脑...     

凯时及复方丹参注射液治疗突发性耳聋的疗效观察

目的:观察凯时及复方丹参注射液治疗突发性耳聋的临床疗效。方法:对57例突发性耳聋患者,分别采用凯时、高压氧(凯时组)及复方丹参注射液、高压氧(复方丹参组)两种方法治疗。结果:凯时组治疗突发性耳聋疗效明显优于复方丹参组。经统计学处理差异有显著性。结论:凯时是治疗突发性耳聋的有效药物。     

长春西汀联合舒血宁注射液治疗突发性耳聋的疗效

目的:对长春西汀联合舒血宁注射液治疗突发性耳聋的疗效进行观察,对其药理作用进行分析.方法:选取我院2014年7月~2016年6月收治并已确诊的突发性耳聋患者100例,根据就诊方式的不同进行随机分组,采取血塞通注射液联合低分子右旋糖酐治疗为参照组,采取长春西汀联合舒血宁注射液治疗为研究组,每组50例.治疗后分析对比两组疗效.结果:研究组治疗总有效率(96%)与参照组(78%)相比明显要高,P<0.05,两组差异有统计学意义.结论:突发性耳聋应用长春西汀联合舒血宁注射液治疗的临床效果确切,值得推广.     

巴曲酶联合金纳多治疗突发性耳聋的疗效及对血流动力学的影响

目的:探讨对于突发性耳聋的临床治疗中采取巴曲酶与金纳多联合用药治疗的效果.方法:选取本院2018年1月—2019年3月收治的104例突发性耳聋患者为研究对象,随机分成联合组与单药组各52例,单药组仅使用巴曲酶治疗,联合组用巴曲酶+金纳多的治疗方法,比较两组临床疗效、血流动力学改变以及不良反应情况,评估治疗效果.结果:联合组治疗总有效率为94.23％,明显高于对照组80.77％的总有效率(P<0.05);治疗后两组血清PV、HCT、BV-HS指标水平均较治疗前降低,联合组降低幅度明显比单药组更显著(P<0.05);联合组治疗期间不良反应总发生率为7.69％,与单药组9.52％的发生率无显著差异(P>0.05).结论:临床中对于突发性耳聋疾病,应用巴曲酶+金纳多的联合用药治疗方式,可取得满意效果及改善血流动力学指标,且治疗期间患者不良反应发生率也较低,安全有效.     

赛莱乐注射液和元活苏注射液治疗突发性耳聋的对比观察

目的；观察赛莱乐注射液和元活苏注射液治疗突发性耳聋的临床疗效。方法：随机选择突发性耳聋患，用赛莱乐注射液和元活苏注射液各1组，赛莱乐注射液联合元活苏注射液为1组，治疗突发性耳聋10－14d，每组各30例。治疗前后进行纯音听阈测定。2周后进行疗效评估。结果：赛莱乐注射液组有效率79％，元活苏注射液组有效率80％，赛莱乐注射液联合元活苏注射液组有效率89％。结论：赛莱乐注射液和元活苏注射液治疗突发性耳聋均有效，而且两药联合使用能提高疗效。     

前列地尔注射液治疗突发性耳聋的疗效观察

目的:观察前列地尔注射液治疗突发性耳聋的疗效。方法:将105例突发性耳聋患者随机分为治疗组和对照组。在常规治疗的基础上,治疗组55例再给予前列地尔注射液,对照组50例再给予传统的低分子右旋糖酐和复方丹参注射液。结果:治疗组和对照组在临床症状和听力上都有改善,但治疗组疗效更为显著;两组均无明显不良反应。结论:前列地尔注射液用于治疗突发性耳聋疗效显著,安全可靠。     

杏丁注射液治疗突发性耳聋的疗效观察

为探讨杏丁注射液治疗突发性耳聋的疗效,对应用两种方法治疗突发性耳聋的患者44例(47 耳)进行分析比较,现将结果报道如下.     

输血宁治疗突发性耳聋耳鸣的临床与护理

目的讨论输血宁注射液用于治疗突发性耳聋、耳鸣的临床效果。方法将突发性耳聋、耳鸣患者80例随机分成两组。治疗组用输血宁注射液,对照组用低分子右旋糖酐进行治疗,其他治疗两组相同,并给予相应的临床护理,观察两组患者耳聋、耳鸣的改善情况。结果治疗组有效率高于对照组(P<0.05)。结论输血宁注射液治疗突发性耳聋、耳鸣较低分子右旋糖酐治疗效果好。     

银杏叶标准提取物对H2O2诱导PC12细胞凋亡的保护作用

目的：探讨银杏叶标准提取物EGB761对过氧化氢（H2O2）诱导大鼠肾上腺髓质嗜铬瘤细胞（PC12细胞）凋亡的保护作用及可能的机制。方法：PC12细胞常规培养生长至对数期,进行如下分组试验：正常对照组（NS）,H2O2组（H2O2,200μmol/LH2O2）,低剂量EGB761组（GL,10μg/mlEGB761＋H2O2）,中剂量EGB761组（GM,20μg/mlEGB761＋H2O2）,高剂量EGB761组（GH,50μg/mlEGB761＋H2O2）。用四甲基偶氮唑盐（MTT）比色法测定PC12细胞活力;流式细胞仪测定PC12细胞凋亡率;分光光度计测定过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、总超氧化物岐化酶（T-SOD）活力和抗氧化能力（T-AOC）以及丙二醛（MDA）含量;Western blot法测定胞浆内Bcl-2、Bax以及Caspase-3的表达。结果：与正常对照组比较,H2O2组的PC12细胞的活力明显降低,细胞凋亡率显著增加（P〈0.05）。与H2O2组比较,EGB761低、中、高组的PC12细胞活力显著增强,且呈剂量依赖关系（P〈0.05）;GM组和GH组CAT,GSH-Px,T-SOD和活性和T-AOC均显著提高（P〈0.05）,MDA含量显著下降（P〈0.05）,GL组T-SOD活力和T-AOC水平升高以及MDA含量下降（P〈0.05）,而CAT和GSH-Px活力无显著变化（P〈0.05）。与H2O2组比较,EGB761低、中、高组PC12细胞的Bcl-2的表达量增加,Bax的表达量下降,Bcl-2/Bax的比值显著增加（P〈0.05）,Caspase-3的表达显著降低（P〈0.05）。结论：H2O2可诱导PC12细胞凋亡,EGB761能显著抑制H2O2诱导PC12细胞凋亡并对细胞有保护作用;EGB761有较强的抗氧化能力,通过其抗氧化作用改善H2O2诱导的氧化应激状态,并能显著提高Bcl-2/Bax的比值,抑制Caspase-3的活化,发挥保护作用。     

Effects of an extract of Ginkgo Biloba (EGB 761) on "learned helplessness" and other models of stress in rodents

The effects of repeated oral administration of an extract of Ginkgo Biloba (EGB 761) on various behavioral models of stress in rodents were investigated. The models in rats included "learned helplessness," shock-suppressed licking (Vogel conflict test) and forced swimming-induced immobility ("behavioral despair"). The models in mice included shock-suppressed exploration (four plates test), spontaneous exploration (staircase test) and food consumption in a novel situation (emotional hypophagia). Further tests in rats examined the effects of EGB 761 on memory (passive avoidance test) and responsiveness to shock to determine whether the preventive effects observed with EGB 761 in the learned helplessness procedure were due either to drug-induced impairment of memory or to reduced shock sensitivity. In all experiments EGB 761 was administered over 5 days at daily doses of 50 and 100 mg/kg PO. In some experiments (Vogel test, four plates test, staircase test, emotional hypophagia) the effects of acute administration were also investigated. The results showed that repeated administration of EGB 761 (50 and 100 mg/kg/day) before exposure to unavoidable shock (preventive treatment) clearly reduced the subsequent avoidance deficits in the learned helplessness procedure but was less effective when first administered after "helplessness" induction (curative treatment). EGB 761 did not affect performance in the passive avoidance task or alter the animals' response to electric shock, suggesting that the effects observed in the learned helplessness procedure were not due to impaired memory or reduced shock sensitivity. Anxiolytic-like activity was also seen in the emotional hypophagia test in mice where repeated administration of EGB 761 increased the amount of food consumed.(ABSTRACT TRUNCATED AT 250 WORDS)     

Ginkgo biloba normalizes stress- and corticosterone-induced impairment of recall in rats.

Exposure to chronic restraint stress in rats and psychosocial stress in humans has been shown to alter cognitive functions such as learning and memory and has been linked to the pathophysiology of mood and anxiety disorders. Antianxiety or sedative agents used in the management of stress have several disadvantages and side effects. Therefore, in this study, we investigated efficacy of a natural medicine, the extract of Ginkgo biloba (EGB 761), in prevention and treatment of the post-stress memory dysfunctions. The results showed that chronic restraint stress (2h for 21 days) or an 'equivalent' dose of exogenous corticosterone (5 mg kg(-1)) decreased re-entry latencies in the passive avoidance situation showing thus impairment of recall. Preventive doses of EGB 761 (100 mg kg(-1)), given 30 min before each restraint stress episode or corticosterone injection, abolished cognitive deficits seen in unprotected rats. There was no influence of stress, corticosterone, and EGB 761 on the acquisition of conditioned avoidance responses (CARs).     

天麻素注射液联合地塞米松磷酸钠治疗突发性耳聋的效果及安全性分析

目的:分析天麻素注射液联合地塞米松磷酸钠治疗突发性耳聋的效果及安全性。方法:回顾性分析2018年3月至2020年4月赣州市人民医院收治的80例突发性耳聋患者临床资料,根据治疗方案不同进行分组,将40例使用天麻素注射液联合地塞米松磷酸钠、甲钴胺注射液治疗的患者纳入观察组,将40例使用地塞米松磷酸钠联合甲钴胺注射液治疗的患者纳入对照组,两组均治疗12 d。比较两组症状改善时间、治疗前、治疗12 d后听力损伤评分、听力阈值及不良反应发生率。结果:观察组听力、眩晕、耳鸣、耳闷改善时间早于对照组,差异有统计学意义(P<0.05)。治疗前,两组听力损失评分及平均听力阈值对比,差异无统计学意义(P>0.05);治疗12 d后,两组听力情况均有改善,且观察组听力损失评分、平均听力阈值均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:突发性耳聋患者采用天麻素注射液联合地塞米松磷酸钠治疗可以改善患者听力损伤,促进患者听力恢复,且用药安全性高,值得推广。     

Protective effect of Ginkgo biloba extract (EGB 761) on free radical-induced changes in the electroretinogram of isolated rat retina.

The retina is a tissue particularly rich in polyunsaturated fatty acids and thus highly sensitive to lipid peroxidation initiated by oxygenated free radicals. By recording the electroretinogram (ERG) b wave amplitude on isolated rat retina, the authors have investigated the anti-oxidant properties of Ginkgo biloba extract (EGB 761). Two groups of rats were used: one group was treated with EGB 761 at a dose of 100 mg/kg/day per os for 10 days; the other one of untreated animals served as a control. At the end of the treatment (10 days), rats were sacrificed, one retina isolated and perfused in order to record ERG. Lipid peroxidation was induced by adding a mixture of (FeSO4 + Na ascorbate) to the perfusion solution. In the untreated rats a 50% decrease in ERG was observed after only 55 min. Such a delay in the decrease and subsequent maintenance of ERG b wave amplitude confirm that the anti-oxidant properties of EGB 761 can protect the retina against lipoperoxidation.     

Extract of Ginkgo biloba EGb761 facilitates extinction of conditioned fear measured by fear-potentiated startle.

A standard extract of Ginkgo biloba (EGb761) has been used in the treatment of various common geriatric complaints including vertigo, short-term memory loss, hearing loss, lack of attention, or vigilance. We demonstrated that acute systemic administration of EGb761 facilitated the acquisition of conditioned fear. Many studies suggest the neural mechanism underlies extinction is similar to the acquisition. This raises a possibility that EGb761 may modulate and accelerate the fear extinction process. We tested this possibility by using fear-potentiated startle (FPS) on laboratory rats. Acute systemic injection of EGb761 (10, 20, or 50 mg/kg) 30 min before extinction training facilitated extinction in a dose-dependent manner. Intra-amygdaloid infusion of EGb761 (28 ng/side, bilaterally) 10 min before extinction training also facilitated extinction. Control experiments showed that facilitation effect of EGb761 was not the result of impaired expression of conditioned fear or accelerated forgetting. Rats previously injected with EGb761 showed significant FPS after retraining. Extinction of conditioned fear appeared to result from acute drug effects rather than from toxic action. Systemic administration of EGb761 immediately after extinction training did not facilitate extinction, suggested the EGb761 facilitation effect is contributed to the acquisition phase of extinction learning. Western blot results showed that extinction induced amygdaloid extracellular signal-regulated kinase (ERK1/2) phosphorylation was significantly elevated by EGb761 treatment. Intra-amygdala injection of ERK1/2 inhibitor PD98059 completely blocked the EGb761 effect. Therefore, acute EGb761 administration modulated extinction of conditioned fear by activating ERK1/2.     

金纳多与复方丹参注射液治疗突发性耳聋的疗效对比分析

目的对比分析金纳多与复方丹参注射液治疗突发性耳聋的疗效差异。方法选取2008年2月至2011年5月来我院就诊治疗的突发性耳聋患者60例,随机分为两组,对照组30例患者采用静脉注射复方丹参,治疗组30例患者金纳多静脉给药。治疗10d后,比较2组患者的疗效差异,并分析治疗组患者的病程与最后疗效之间的关系。结果治疗组患者治疗总有效率为86.7%,对照组总有效率为63.3%,P<0.05,数据差异明显,具有统计学意义。结论金纳多治疗突发性耳聋较复方丹参注射液治疗效果更为明显。     

高压氧辅助治疗突发性聋疗效观察

目的:观察高压氧辅助治疗突发性聋的疗效,并进一步探讨突发性聋的综合治疗方法。方法72例突发性聋患者随机分为高压氧组和对照组,均用药物治疗,高压氧组在常规药物治疗基础上行高压氧治疗,结果与对照组进行比较。结果:高压氧辅助治疗组的临床恢复疗效,与对照组比较有显著性差异(P<0.05)。结论:高压氧可作为一种辅助手段治疗突发性聋,效果显著。