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1.
周双林  张立飞 《中国药师》2009,12(8):1018-1020
目的:研究雨生红球藻中虾青素酯的皂化工艺,优选雨生红球藻中虾青素酯皂化的最佳工艺条件。方法:采用HPLC测定皂化后虾青素的含量,以雨生红球藻中虾青素提取量为指标,应用正交试验设计进行筛选。结果:皂化的最佳工艺条件为10g·L^-1的KOH-CH30H皂化液在20℃争件下恒温振荡皂化60min。结论:优选得到的工艺稳定可行。  相似文献   

2.
正天然虾青素在食品添加剂、保健品、制药业、化妆品等方面都有广泛的应用。国内外关于虾青素致畸试验的报道较少,有研究发现虾青素未引起胎兔畸形率的增加[1]。红球藻富含虾青素,是商业虾青素产品的良好来源。但关于红球藻提取物尚缺乏系统的毒理学  相似文献   

3.
本文综述了近年来国内外在雨生红球藻(Haematococcus pluvialis)的虾青素生物合成途径、关键酶的性质及相关基因的克隆、表达与调控的分子机理等领域取得的最新研究进展,并提出了国内应开展的相关创新性研究的通报。  相似文献   

4.
虾青素-胶原蛋白耦合物改善小鼠皮肤光老化作用研究   总被引:1,自引:0,他引:1  
目的 在制备虾青素-胶原蛋白耦合物的基础上,探讨耦合物对小鼠皮肤光老化的改善作用。方法 将来源于雨生红球藻的虾青素单体和均一分子量胶原蛋白多肽在一定条件下反应后生成耦合物,将耦合物与适当基质混合后制成外用乳膏。采用UV灯照射Balb/c小鼠背部裸露皮肤,建立动物光老化模型,随机分为正常对照组、模型对照组、基质对照组、虾青素组、胶原蛋白多肽组、耦合物组和维生素E组,每天UV照射前进行药物涂抹。6周后观察小鼠皮肤形态、测定皮肤厚度变化及进行皮肤组织病理学检测等。结果 虾青素和胶原蛋白可结合生成具有特征吸收波长的水溶性耦合物,耦合物可有效缓解皮肤厚度增生,修复皮肤胶原纤维和弹性纤维网状结构。结论 虾青素-胶原蛋白多肽耦合物可有效改善UV引起的皮肤光老化损伤。  相似文献   

5.
HPLC测定皂化后雨生红球藻中虾青素的含量   总被引:1,自引:1,他引:0  
周双林  张立飞 《中国药师》2009,12(7):902-903
目的:建立雨生红球藻中皂化后虾青素的含量测定方法。方法:采用高效液相色谱法,Dionex Acclaim120 C18柱(150mm×4.6mm,5μm)。流动相:甲醇-水(95:5)。检测波长:475nm。结果:线性范围为0.5~10.0μg·ml^-1,r=0.9999(n=5)。平均回收率为97.00%,RSD为0.99%。结论:本方法简便快速、重复性好。  相似文献   

6.
天然虾青素的超级抗氧化活性及其应用   总被引:33,自引:1,他引:32  
本文综述了天然虾青素的来源、超级抗氧化活性和生物安全性 ,以及在医药、保健食品和饲料工业中的应用 ,并对国内虾青素的产业化前景进行了展望。  相似文献   

7.
天然虾青紫的超级抗氧化活性及其应用   总被引:5,自引:0,他引:5  
本文综述了天然虾青素的来源、超级抗氧化活性和生物安全性,以及在医药、保健食品和饲料工业中的应用,并对国内虾青素的产业化前景进行了展望。  相似文献   

8.
虾青素是一种天然的类胡萝卜素,国外对其抗氧化、抗高血压、抗炎症、抗癌、抗辐射和增强免疫等药理作用进行了广泛研究。本文对近年来虾青素在药理作用方面的研究进展进行综述。  相似文献   

9.
虾青素的毒理学安全性评价   总被引:3,自引:0,他引:3  
虾青素(Astaxanthin)是一种天然的类胡萝卜素,它的分子式为C40H52O4与β-胡萝卜素(Beta-carotene)相似,分子式为C40H52.在一些体外试验中,虾青素具有较β-胡萝卜素更强的抗氧化性,同时它也是一种天然色素,作为饲料添加剂应用于畜牧饲养业和水产养殖业[1-2].  相似文献   

10.
虾青素是1种海洋类胡萝卜素,它主要分布在海洋细菌,藻类,甲壳类和鱼类中。虾青素是自然界最强的抗氧化剂之一,有抗肿瘤发生、抗炎、抗糖尿病、抗肥胖等生物功能。目前国内外对虾青素在治疗糖尿病方面进行了大量研究,结果表明,虾青素对糖尿病及其并发症有预防和治疗作用。本文介绍了糖尿病的病因和发病机制,虾青素的生理功能,虾青素的概况,虾青素对Ⅱ型糖尿病的防治及相关作用机制的研究进展。  相似文献   

11.
The anti-ulcer properties of astaxanthin fractions such as total carotenoid and astaxanthin esters from Haematococcus pluvialis were evaluated in ethanol-induced gastric ulcers in rats. Since oxygen radical release is a pathogenic factor of ethanol-induced gastric damage, astaxanthin - a free radical scavenger, was investigated as a potential ulcer preventive agent. Astaxanthin fractions - total carotenoid and astaxanthin esters were orally administered to experimental rats at 100, 250 and 500 microg/kg b.w. prior to ulcer induction. Alcian blue binding assay indicates that, total carotenoid and astaxanthin esters at 500 microg/kg b.w could protect gastric mucin approximately 40% and 67% respectively. Pre-treatment with astaxanthin esters, also resulted in significant increase in antioxidant enzyme levels - catalase, superoxide dismutase, and glutathione peroxidase in stomach homogenate. Histopathological examination substantiated the protective effect of astaxanthin in pre-treated rats. The increased antioxidant potencies such as free radical scavenging activity with an IC(50) of approximately 8 microg/ml and reducing power abilities (59 x 10(3) U/g) in vitro, reveal that H. pluvialis astaxanthin may protect gastric mucosal injury by antioxidative mechanism. In addition, approximately 23 fold increased lipoxygenase-inhibitory property, in comparison with standard astaxanthin and significant H(+), K(+)-ATPase-inhibitory activity of astaxanthin esters, in comparison with known proton pump blocking anti-ulcer drug - omeprazole, may envisage the potential gastroprotective effect by regulating the gastric mucosal injury and gastric acid secretion by the gastric cell during ulcer disease.  相似文献   

12.
Astaxanthin, a natural nutritional component, is marketed as a dietary supplement around the world. The primary commercial source for astaxanthin is Haematococcus pluvialis (microalgae). The objective of the present study was to investigate the acute and subchronic toxicity of an astaxanthin-rich biomass of H. pluvialis (AstaCarox((R))). The oral LD(50) of the biomass in rats was greater than 12g/kg body weight. In the subchronic study, Wistar rats (10/sex/group) were fed diets containing 0%, 1%, 5% and 20% of the biomass (weight/weight) for 90 days. trans-Astaxanthin was quantifiable in the plasma of the high-dose treated group only. Compared to the control group, no treatment-related biologically significant effects of astaxanthin were noted on body weight or body weight gain. Biomass feeding did not affect hematological parameters. In the high-dose group, slightly elevated alkaline phosphatase and changes in some urine parameters and an increase in kidney weight in both sexes were noted. Histopathology examinations did not reveal adverse effects except for a marginal increase in pigment in the straight proximal tubule of the kidney in 5/10 female rats treated with the high-dose. These changes were not considered as toxicologically significant. Although the rats in high-dose group received about 9% more fat, it is unlikely that this confounding factor significantly altered the outcome. The no-observed adverse-effect-levels (NOAEL) of the astaxanthin-rich biomass for male and female rats were determined as 14,161 and 17,076mg/kg body weight/day, or 465 and 557mg astaxanthin/kg/day, respectively, the highest dose tested.  相似文献   

13.
The four species of microalgae (Dunaliella bardawil, Chlorella minutissima, Pavlova lutheri and Haematococcus pluvialis) were immobilized in Ca-alginate capsules as a basic study for the development of the economic cultivation process. Under the batch culture of aerobic conditions, the thickness of the capsule membrane and CO2 supply did not affect the growth of the immobilized microalgae, Dunaliella bardawil. Cell concentration of immobilized microalgae in the capsule was higher than those of immobilized microalgae in beads and free cells. The cell concentrations of microencapsulated Dunaliella bardawil and Haematococcus pluvialis were five times greater than that of free cells. Based on these results, microencapsulation for the culture of microalgae was an effective method for the high-density cultivation. In comparison to the immobilized cultivation on the bioreactor type, it was more effective for the cultivation in the bubble column bioreactor than that in the stirrer tank bioreactor.  相似文献   

14.
The effects of soft-shell turtle (Trionyx sinensis) powder (SST) on the proximal tibiae of ovariectomized (OVX) rats were investigated using peripheral quantitative computed tomography (pQCT) and examination of serum biochemical markers. Considering the relationship between the antioxidative property and antiosteoporotic activity, the synergistic effects of a mixture of SST and essential oil of the microalgae Haematococcus pluvialis (OHP) with strong antioxidant activity were also examined. Oral administration of SST (100, 200 mg/kg) or a mixture of SST (100, 200 mg/kg) and OHP (13, 26 mg/kg) three times weekly prevented the decrease in bone mineral content (BMC) in total bone, BMC and bone mineral density (BMD) in cortical bone, and bone strength indices induced by ovariectomy in a dose-dependent manner without uterine side effects. However, OHP alone showed no significant effects.  相似文献   

15.
Hypoglycemic effect of astaxanthin obtained from shrimp waste was assessed in alloxan-induced diabetic and normal mice. Animals received oral administration of astaxanthin in dose of 5 and 10?mg/kg. The plasma glucose levels were examined and compared with that of metformin and gliclazide. Administration of astaxanthin (5 and 10?mg/kg) produced significantly fall on plasma glucose in alloxan-induced diabetic mice, while a slight fall in normal mice. In normal mice, postprandial hyperglycemia was significantly suppressed by oral administration of astaxanthin, which significantly lowered the postprandial area under curve. These results demonstrate that astaxanthin is effective in controlling hypoglycemia in animal model of type 1 diabetes mellitus. Therefore, astaxanthin can be a useful natural oral agent to treat diabetes.  相似文献   

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