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目的 介绍褐藻多糖硫酸酯在药理学上的研究进展.方法 查阅国内外有关文献进行分析和综述.结果 褐藻多糖硫酸酯具有抗凝血作用、抑制平滑肌增殖、抗血管成形术后的再狭窄、对血管形成的影响、抗炎症反应、抗缺血、对肾脏胃黏膜的保护作用等.结论 褐藻多糖硫酸酯可能成为治疗人类许多疾病的重要药物. 相似文献
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多糖硫酸酯的药理作用研究进展 总被引:4,自引:0,他引:4
多糖硫酸酯(polysaccharide sulfate,Pss)或称硫酸酯化多糖(sulfated polysaccharides,SPS)是指含有硫酸基团的天然及其半合成的酸性多糖,为聚阴离子化合物。自1987年发现硫酸酯化葡聚糖具有抑制艾滋病病毒(HIV)活性以来,发现了许多具有抗多种病毒活性的多糖硫酸酯。此外,人们还发现其具有抗肿瘤、抗凝血、抗氧化、增强免疫等作用,本文就近年来多糖硫酸酯的药理作用研究作一综述。 相似文献
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褐藻多糖硫酸酯的药理活性及作用机制研究进展 总被引:4,自引:0,他引:4
目的介绍关于褐藻多糖硫酸酯的最新药理活性的研究状况及可能的机制,为进一步研究其各种生物学功能提供参考。方法对近几年来有代表性的中英文文献进行分析、归纳。结果褐藻多糖硫酸酯拥有许多有前景的药理活性。结论加强对褐藻多糖硫酸酯的药理活性和作用机制的进一步研究,对于有目的的进行应用开发方面的研究有重要指导意义。 相似文献
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乙酰化海带褐藻多糖硫酸酯的制备及其抗氧化活性研究 总被引:2,自引:0,他引:2
目的 优选乙酰化海带褐藻多糖硫酸酯的制备方法,并测定不同条件下制备得到的乙酰化衍生物的体外抗氧化活性.方法 以甲酰胺为溶剂;乙酸酐为酰化试荆,N-溴代琥珀酰亚胺(NBS)为催化剂,采用正交设计法,考察反应时间、反应温度及酰化剂用量对海带褐藻多糖硫酸酯酰化反应的影响,测定不同条件下乙酰化衍生物的清除超氧阴离子、羟自由基和有机自由基DPPH的能力,及还原能力.结果 酰化荆用量和反应温度对海带褐藻多糖硫酸酯乙酰化有显著影响(P<0.05).不同条件下制备的乙酰化衍生物的清除超氧阴离子、羟自由基和有机自由基DPPH的能力,及还原能力不同.结论 NBS作为催化荆对海带褐藻多糖硫酸酯进行乙酰化是可行的,可以代替传统毒性较强的吡啶对海带褐藻多糖硫酸酯的羟基进行乙酰化.乙酰化后多糖的抗氧化活性明显增强,对其进行深入研究有重要意义. 相似文献
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褐藻多糖硫酸酯抗PAF作用研究 总被引:5,自引:0,他引:5
目的:对从褐藻多糖硫酸酯分离的各组分进行抗PAF作用测定和化学分析,探讨其构效关系。方法:用碱提醇沉法获取褐藻中褐藻多糖硫酸酯的不同组分。用兔血小板聚集试验检测其抗PAF作用。用硫酸-咔唑法测定其葡萄糖醛酸含量,用氯化钡沉淀法测定其硫酸根含量,用硫酸-半胱氨酸法测定其岩藻糖含量。结果:研究结果表明,各组分均呈现出一定的抗PAF活性;各组分中岩藻糖含量变化不大,而SO4^2-和葡萄糖醛酸含量变化较大。葡萄糖醛酸含量愈低、硫酸根含量愈高,其抗PAF作用愈强。结论:褐藻多糖硫酸酯各组分均有一定的抗PAF活性,其作用随葡萄糖醛酸含量降低、硫酸根含量升高而增强。 相似文献
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褐藻多糖硫酸酯抗凝血活性的研究 总被引:8,自引:0,他引:8
本文对海带褐藻多糖硫酸酯的抗凝血作用进行了探讨。结果表明:小鼠一次灌胃给予褐藻多糖硫酸酯能明显延长CT,RT,PT,KPTT,TT的时间;小鼠连续灌胃3周能明显减少血浆Fib含量;大鼠连续灌胃1周,可明显减轻手术结扎静脉法及Chandler氏法体外血栓的形成,减轻血栓的湿重及干重,表明褐藻多糖硫酸酯具有抗凝血活性并对静脉血栓形成有明显的抑制作用。 相似文献
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褐藻多糖硫酸酯化学研究的进展 总被引:33,自引:3,他引:30
褐藻多糖硫酸酯是一类硫酸化多糖,存在于褐藻中,首先由Kylin在1913年用稀酸从掌状海带中提取出来。Kylin将提取物水解后分离出L-岩藻糖,他将这种多糖命名为fucoidin,现根据多糖的命名原则一般定名为fucoidan。中文名称以前一直称为墨角藻多糖、岩藻多糖或褐藻糖胶,但这一名称并不规范,本文称之为褐藻多糖硫酸酯。以后随着海藻化学和海藻工业的发展,陆续在褐藻多糖硫酸酯的分离纯化、组分、结构、理化性质、应用等方面进行了大量的工作。 相似文献
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Fucoidan, a sulfated polysaccharide extracted from various brown seaweeds, possesses a wide range of pharmacological properties. In this study, we investigated the protective effect of fucoidan on acetaminophen-induced acute liver injury in rats. Liver injury was induced by administration of acetaminophen (800 mg/kg, i.p.) and fucoidan was administered (100 mg kg, p.o.) 2 h before and after acetaminophen administration. After 24 h, co-treatment of fucoidan ameliorated liver damage and cell death induced by acetaminophen. Acetaminophen induced the overexpression of CYP2E1, one of the metabolizing enzymes of acetaminophen, but cotreatment with fucoidan suppressed its increased expression of CYP2E1. Fucoidan also reduced the hepatic apoptosis induced by acetaminophen exposure as shown in the protein expression of Bax, Bcl-2, and cleaved caspase-3. The anti-oxidative effect of fucoidan was observed from the increase of the production and expression of glutathione, superoxide dismutase, and glutathione peroxidase, both of which were decreased by acetaminophen. Also, fucoidan decreased the expression of inflammatory mediators, including tumor necrosis factoralpha, interleukin 1 beta, and inducible nitric oxide synthase. Taken together, the data demonstrate the hepato-protective effects of fucoidan against acetaminophen-induced liver injury via anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. 相似文献
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岩藻多糖具有抗氧化、抗炎、抗凝血等功效,已成为研究热点。慢性肾功能衰竭(CRF)近年来发病率逐年上升。肠-肾轴研究发现肠道菌群(GM)与CRF之间存在双向调节。GM能够通过平衡内稳态调控机体健康,已成为治疗CRF潜在新靶点。岩藻多糖被作为一种微生物调节剂能干预GM失调进而控制CRF进程,预防加速肾衰竭潜在的危险因素。因此,本文探讨岩藻多糖对GM和CRF作用及GM与CRF双向调节机制,为后续岩藻多糖的开发和利用提供研究方向与思路。 相似文献
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小檗碱亦称黄连素,是从中药黄连中分离的一种季铵生物碱,是中药黄连的主要成分。现代药理研究表明,小檗碱具有抗菌、抗氧化、消炎、降血糖、降脂、抗凋亡等多种生物活性。近年来随着研究的不断进展,作为一种多靶点治疗的药物,小檗碱对动脉粥样硬化、心血管疾病、糖尿病等均具有良好效果。鉴于其诸多的优点,其具有良好的应用前景。本研究就小檗碱药理作用及机制等研究进展作一简要综述,为其应用于临床治疗疾病提供进一步科学依据。 相似文献
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Omar EA Kam A Alqahtani A Li KM Razmovski-Naumovski V Nammi S Chan K Roufogalis BD Li GQ 《Current pharmaceutical design》2010,16(34):3776-3807
Diabetes is one of the most prevalent chronic diseases throughout the world. The majority of its complications arise from vascular-related inflammation apparently initiated by endothelial cell injury. One cause of this injury has been attributed to hyperglycaemia-induced reactive oxygen species. Consequently, current drug developmental strategy has targeted specific inflammatory and oxidative stress pathways for the prevention of diabetic vascular complications. Herbal medicines have traditionally been used for the treatment of diabetes and its complications. In fact, current pre-clinical and clinical studies have demonstrated that many of them exhibit potent anti-inflammatory and anti-oxidative properties, and have also identified the active phytochemicals responsible for their activities. The present review summarises the latest research on the molecular mechanisms of diabetic vascular complications, and evaluates the level of scientific evidence for common herbal medicines and their bioactive phytochemicals. These agents have been shown to be effective through various mechanisms, particularly the NF-κB signalling pathways. Overall, herbal medicines and nutraceuticals, as well as their bioactive components, which exhibit anti-inflammatory and anti-oxidative properties, provide a promising approach for the prevention and treatment of diabetic complications. 相似文献
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Park JM Kim SD Lee WM Cho JY Park HJ Kim TW Choe NH Kim SK Rhee MH 《Die Pharmazie》2007,62(6):453-458
Suaeda asparagoides Miq. (Chenopodiaceae: S. asparagoides) is a salt-marsh plant that has long been prescribed in traditional Oriental medicine for the treatment of hypertension and hepatitis. In order to elucidate the pharmacological mechanisms of the herb, we conducted an examination of the anti-oxidative and anti-inflammatory properties of solvent-extracts of S. asparagoides. All of the solvent fractions showed potent anti-oxidative effects, as assessed using a radical generation assay system (xanthine oxidase assay) and an electron-donating activity system (DPPH [2,2-diphenyl-l-picrylhydrazyl radical] assay), with IC50 values ranging from 9 to 42 microg/ml. In agreement with this pattern, the total phenolic contents were widely distributed in the various solvent fractions, and ranged from 36.5 to 50.3 mg/g of dry weight. All of the solvent fractions significantly suppressed NO production in RAW264.7 cells induced by lipopolysaccharide (LPS, 0.1 microg/ml) and of the fractions, only the chloroform (CHC) fraction completely blocked the expression of inducible NO synthase (iNOS). Additionally, the hexane (HEX) and CHC fractions suppressed the mRNA expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) and monocyte chemoattractant protein 1 (MCP-1), respectively, in the LPS-stimulated RAW264.7 cells. Therefore, these results suggest that the pharmacological action of S. asparagoides is due to its potent anti-oxidative effects and anti-inflammatory effects, and that therefore it can be applied to other diseases caused by oxidative stress and inflammation, such as cardiovascular diseases. 相似文献
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R. De La Puerta E. Martinez L. Bravo M. C. Ahumada 《The Journal of pharmacy and pharmacology》1996,48(9):968-970
In-vivo anti-inflammatory activity of silymarin was tested in different acute inflammation experimental models. In carrageenan-induced paw oedema in rats, silymarin given orally reduced in a dose-dependent manner the food-pad abscesses (ED50 = 62.42 mg kg?1). In xylene-induced ear mouse inflammation, silymarin applied topically was more effective than administered intraperitoneally, with effects comparable with those of indomethacin. Silymarin also produced a dose-dependent inhibition of leukocyte accumulation in inflammatory exudates following intraperitoneal injection of carrageenan in mice; silymarin significantly reduced the number of neutrophils. Silymarin was unable to inhibit phospholipase A2 in an in-vitro assay. Besides its known anti-oxidative properties and its ability to act as a radical scavenger, these results suggest that silymarin exerts an important anti-inflammatory action in-vivo by reducing oedema with the effect markedly influenced by the inhibition of neutrophil migration into the inflamed site. 相似文献
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Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effects. Trx 1 over-expression has been shown to be effective in a wide variety of animal models for oxidative and inflammatory disorders. An administration of recombinant Trx 1 protein is also effective in animal models especially for severe acute lung diseases where Trx 1 is likely to act with its anti-inflammatory properties. Trx 1 in circulation shows anti-chemotactic effects for neutrophils and inhibitory effects against macrophage migration inhibitory factor (MIF). Neovascularization is also suppressed by Trx 1 via inhibition of the complement activation. Here we discuss precise mechanisms of Trx 1 and potential therapeutic approach of this molecule. 相似文献