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1.
目前,癌症是全球第二大死亡人数最多的疾病。炎症反应是一个复杂的生理学过程,涉及到生物体中细胞以及分子层面的广泛变化。在组织修复,伤口愈合以及抵御外来病原体入侵的过程中,有序的炎症反应是机体免疫系统产生的正常防御反应,保证机体的健康。但当这种急性炎症持续较长时间且得不到有效控制时,就易发展成慢性炎症,从而促进许多疾病的发生,包括风湿性关节炎,心血管疾病,阿尔茨海默症和癌症等。越来越多的证据表明,炎症反应失调在癌症中起到关键作用,长期使用非甾体类抗炎药(Non-steroidal anti-inflammatory drugs,NSAIDs)可以降低多种癌症的发病率。文章重点综述了核因子-κB(Nuclear factor-kappa B,NF-κB)在炎癌中的复杂作用,包括NF-κB对炎症反应具有的正向和负向调节作用,以及它如何影响肿瘤的发生和发展。深度解析NF-κB在炎-癌转化中的作用对于现代肿瘤生物学来说是一个重要挑战。  相似文献   

2.
C-反应蛋白(CRP)是炎症反应中最敏感的急性时相蛋白.最近的研究发现,CRP基因多态性与疾病的发生、发展存在着一定的关系,同时对肿瘤的研究已发展到基因水平,发现癌症患者的血液中存在着肿瘤DNA,CRP基因就是其中一个.人们发现CRP基因序列或表达情况的变化,在一定程度上可以诊断肿瘤,这无疑是一种非侵入性诊断方法,并为后续肿瘤的诊疗提供依据.  相似文献   

3.
妊娠期糖尿病(GDM)的发生与胰岛素抵抗和胰岛素分泌受损有关,胰岛素抵抗是一个亚临床炎症过程,与C反应蛋白、肿瘤坏死因子、瘦素、脂联素、抵抗素、血浆纤溶酶原激活物抑制因子等关系甚密.收集近年来炎症因子与GDM发生发展相关的研究文献,对它们之间的相关性进行探讨,为临床的诊断、治疗和预防提供参考.  相似文献   

4.
彭文斌  张琍 《现代医药卫生》2012,28(23):3601-3603
核因子-κB(NF-κB)作为一种特异性转录因子结合在编码免疫球蛋白kappa轻链基因的启动子上,其作用与发育、损伤、炎症和肿瘤的发病机制有关。越来越多的证据表明,NF-κB与癌症密切相关,在癌症的发生、发展过程中发挥着关键作用[1-2]。  相似文献   

5.
IKKβ结构与功能及其抑制剂研究进展   总被引:1,自引:0,他引:1  
  相似文献   

6.
胡金萌  王健 《天津医药》2018,46(6):657-660
基质相互作用蛋白分子1(STIM1)与肿瘤的发生发展密切相关,其参与多种癌症细胞凋亡、增殖、迁移和侵袭的调节过程。阻断或敲除STIM1可以显著抑制癌细胞的增殖和迁移。阐明STIM1在癌症细胞中的调节机制,将有助于新的治疗靶点的确定。本文对STIM1分子在不同肿瘤中的作用机制及临床应用前景作一综述。  相似文献   

7.
潜在的炎症或炎症形成中微环境的恶性发展致使NF-κB通路激活,激活的NF-κB能够促进细胞因子(IL-6、IL-8、IL-12、IL-17、IL-22、TNF-α、i NOS、COX-2)表达,进而引发结肠癌、前列腺癌、肝癌、淋巴癌等肿瘤形成,表明NF-κB通路在炎症和癌症之间起到了重要的桥梁作用。为明确NF-κB通路在炎症和癌症之间的关系,笔者对相关文献进行综述。  相似文献   

8.
颜璐  张天宝 《毒理学杂志》2007,21(4):332-332
目前认为肿瘤的发生是一种宿主与环境之间复杂的、动态的相互作用过程。长期以来人们一直认为肺癌发病的主要原因之一是吸烟,然而调查研究发现,吸烟者中仅有10%~15%发生肺癌,而10%~15%的肺癌患者并不吸烟。显然,肿瘤的发生和发展并不单纯取决于致癌物,基因.环境致癌物的交互作用在癌症的发生和发展过程中无疑是非常重要的。  相似文献   

9.
核因子kB(NF-kB)转录因子在许多生理过程中,如固有及获得性免疫应答、细胞增殖、细胞死亡和炎症,都起重要作用。目前已很清楚,NF-kB和控制其活性的信号通路的调节异常与癌症的发生发展以及患者对化疗和放疗产生耐受性有关。本文综述了NF-kB与癌症的关系、以NF-kB为靶点的癌症治疗潜能和益处以及这种治疗可能引发的并发症和缺陷。  相似文献   

10.
白细胞介素-1受体相关激酶4 (interleukin-1 receptor associated kinase 4, IRAK-4)作为一种丝氨酸-苏氨酸激酶,是转导IL-1R家族和TLRs信号通路的关键信号节点。研究发现IRAK-4介导的炎症通路可以引起人体的关节、肠道、肝脏和神经系统的炎症反应及其他自身免疫疾病,也是一些癌症细胞的耐药性原因。因此, IRAK-4可以作为炎症疾病和癌症的有效治疗靶点。研发结构新颖的IRAK-4小分子抑制剂,考察其安全性和有效性,丰富对炎症和癌症疾病的临床治疗用药,是该通路药物发展的方向。本文按不同结构分类概述了关于IRAK-4信号通路小分子抑制剂的最新研究进展,旨在为相关药物的研发工作提供参考。  相似文献   

11.
目的观察和分析绝经前后阴道不规则出血的诊治方法以及出血的原因。方法选取门诊收治的绝经前后阴道不规则出血的患者278例,回顾性分析患者临床的诊治资料。结果患者绝经前后阴道不规则出血的原因主要为炎症、癌症、功能性子宫出血以及其它因素,其中最主要因素为炎症,和其它因素相比较有明显差异(P〈0.05),对于患者临床疗效癌症因素导致的治疗总有效率最低,和其它因素相比,差异有显著性(P〈0.05)。结论临床上建议绝经妇女定期检查和防癌筛查,早发现病变,及时治疗,具有十分深远的临床意义。  相似文献   

12.
Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer arises in the context of hepatic inflammation, such as hepatitis B virus and hepatitis C virus infection. Despite significant improvements in the therapeutic modalities for liver cancer, patient prognosis is not satisfactory due to the limited efficacy of current drug therapies in anti-metastatic activity. Therefore, developing new effective anti-cancer agents with anti-metastatic activity is important for the treatment of liver cancer. In this study, SP-8356, a verbenone derivative with anti-inflammatory activity, was investigated for its effect on the growth and migration of liver cancer cells. Our findings demonstrated that SP-8356 inhibits the proliferation of liver cancer cells by inducing apoptosis and suppressing the mobility and invasion ability of liver cancer cells. Functional studies revealed that SP-8356 inhibits the mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways, which are related to cell proliferation and metastasis, resulting in the downregulation of metastasis-related genes. Moreover, using an orthotopic liver cancer model, tumor growth was significantly decreased following treatment with SP-8356. Thus, this study suggests that SP-8356 may be a potential agent for the treatment of liver cancer with multimodal regulation.  相似文献   

13.
Store-operated calcium entry (SOCE) is an important pathway for calcium signaling that regulates calcium influx across the plasma membrane upon the depletion of calcium stores in the endoplasmic reticulum. SOCE participates in regulating a number of physiological processes including cell proliferation and migration while SOCE dysregulation has been linked with pathophysiological conditions such as inflammation and cancer. The crosslink between cancer and inflammation has been well-established where abundant evidence demonstrate that inflammation plays a role in cancer pathophysiology and the response of cancer cells to chemotherapeutic agents including cisplatin. Indeed, the efficacy of cisplatin against cancer cells is reduced by inflammation. Interestingly, it was shown that SOCE enhances inflammatory signaling in immune cells. Therefore, the main objectives of this study are to examine the impact of SOCE inhibition on the cisplatin sensitivity of breast cancer cells and to explore its related mechanism in modulating the inflammatory response in breast cancer cells. Our findings showed that SOCE inhibitor (BTP2) enhanced cisplatin cytotoxicity against resistant breast cancer cells via inhibition of cell proliferation and migration as well as induction of apoptosis. We also found an upregulation in the gene expression of two major components of SOCE, STIM1 and ORAI1, in cisplatin-resistant breast cancer cells compared to cisplatin-sensitive breast cancer cells. In addition, cisplatin treatment increased the gene expression of STIM1 and ORAI1 in cisplatin-resistant breast cancer cells. Finally, this study also demonstrated that cisplatin therapy caused an increase in the gene expression of inflammatory mediators COX2, IL-8, and TNF-α as well as COX2 protein and upon SOCE inhibition using BTP2, the effect of cisplatin on the inflammatory mediators was reversed. Altogether, this study has proven the pivotal role of SOCE in cisplatin resistance of breast cancer cells and showed the importance of targeting this pathway in improving breast cancer therapy.  相似文献   

14.
Osteopontin (OPN) is a highly modified integrin-binding extracellular matrix glycophosphoprotein produced by cells of the immune system, epithelial tissue, smooth muscle cells, osteoblasts, and tumor cells. Extensive research has elucidated the pivotal role of OPN in cell signaling that controls inflammation, tumor progression, and metastasis. OPN interaction with the integrin receptors expressed on inflammatory cells through its arginine-glycine-aspartate (RGD) and non-RGD motifs promote migration and adhesion of cells. In the liver, it has been reported that hepatic Kupffer cells secrete OPN facilitating macrophage infiltration into necrotic areas following carbon tetrachloride liver toxicity. Recent work has highlighted the role of OPN in inflammatory liver diseases such as alcoholic and nonalcoholic liver disease and T-cell-mediated hepatitis. The role of OPN in hepatocellular carcinoma (HCC) has also generated significant interest, especially with regards to its role as a prognostic factor. OPN therefore appears to play an important role during liver inflammation and cancer. In this review we will present data to demonstrate the key role played by OPN in mediating hepatic inflammation (neutrophils, monocytes/macrophages, and lymphocytes) and its role in HCC. Greater understanding of the pathophysiologic role of OPN in hepatic inflammation and cancer may enable development of novel inflammation and cancer treatment strategies.  相似文献   

15.
Cancer cachexia is a complex syndrome that describes the progressive muscle wasting and weakness in many cancer patients. Muscle wasting reduces the ability of affected patients to perform the tasks of daily living and causes severe fatigue, leading to a reduction in quality of life. Cancer cachexia reduces patient response to anti-neoplastic treatments, increases the risk of postoperative complications and accounts for > 20% of cancer-related deaths. The pathogenesis of cancer cachexia is multifactorial and includes anorexia, inflammation, metabolic disturbances and enhanced muscle proteolysis, and each of these presents as a potential therapeutic target for ameliorating cancer cachexia. Objective: This review provides an update on some of the emerging drugs for cancer cachexia. Methods: This is a review of the current status of emerging therapies for cancer cachexia. Results: An increasing number of studies are focused on the development of novel therapies for cancer cachexia. Initial studies concentrated on the treatment of anorexia, but now aim to attenuate inflammation or muscle proteolysis, or to use different drugs in combination so as to treat several aspects of cachexia simultaneously. Conclusions: There are several existing and emerging drugs with the potential to ameliorate cancer cachexia, but the most efficacious treatment will probably come from combined drug therapies.  相似文献   

16.
目的探讨肺不张形成原因及临床治疗方案。方法回顾性分析142例肺不张病例,分析形成原因,不同疾病对肺不张的好发部位、分布及治疗方法。结果肺不张形成的疾病以结核(47.2%)、肿瘤(32.4%)、炎症(14.8%)为多见。支气管镜对结核、炎症引起肺不张有较好治疗价值。结论 CT及支气管镜检查是了解肺不张病因的重要方法,应注意基础治疗,如鼓励患者咳嗽、翻身拍背、超声雾化、反复吸痰和纤维支气管镜检查等。  相似文献   

17.
BACKGROUND: The inability to accurately predict treatment outcomes for cancer patients in terms of tumour response and anticancer drug toxicity is a severe limitation inherent in current approaches to chemotherapy. Many anticancer drugs are metabolically cleared by cytochrome P450 3A4 (CYP3A4), the predominant CYP expressed in liver. CYP3A4 expression exhibits marked interindividual variation and is repressed in acute inflammatory states. OBJECTIVES: (1) To review the relevance of CYP3A4 variability to drug metabolism in the setting of cancer and to understand how inflammation associated with malignancy contributes to both this variability and to adverse treatment outcomes. (2) To examine the relationship between tumour-induced inflammation and repression of CYP3A4 and to explore methods of dosing of anticancer drugs in the setting of advanced cancer. METHODS: Review of relevant literature covering both human and animal studies as well as in vitro mechanistic studies. RESULTS/CONCLUSIONS: Interindividual variability in CYP3A4 expression is a major confounding factor for effective cancer treatment and methods to predict CYP3A4-mediated drug clearance may have clinical utility in this setting. Although acute inflammation has long been recognised to repress drug metabolism, it is now becoming apparent that cancer patients exhibiting clinical and laboratory features of an inflammatory response have reduced expression of CYP3A4 and possibly other genes relevant to anticancer drug disposition.  相似文献   

18.
卵巢癌是最常见的妇科恶性肿瘤之一,它的发生既与遗传有关,也会受到慢性炎症、雌激素、肥胖等的影响。近年来有研究发现,微生物与人类的健康与疾病状态息息相关。本文就微生物在卵巢癌发生发展中发挥的作用以及对卵巢癌治疗的影响作一综述。  相似文献   

19.
四君子汤是中医经典名方,具有益气健脾的功效,主治脾胃虚弱证,具有调节胃肠功能、增强机体免疫功能等作用。同时,四君子汤也具有防治肿瘤的作用,常用于癌症的辅助治疗。四君子汤对结直肠癌的抗癌作用主要体现在缓解肠道炎症、防治癌前病变、抑制癌症转移、调节机体免疫以及改善肿瘤恶病质等方面,主要综述四君子汤防治结直肠癌药理作用机制的研究进展,以期为四君子汤的应用开发以及抗肿瘤药物的研发提供参考。  相似文献   

20.
The host inflammatory response is activated in both cancer and infection. This includes enhanced production of acute phase reactants, involvement of coagulation and inflammation and the potential for systemic effects. This overview will identify the prothrombotic links between cancer and sepsis and suggest antithrombotic agents as an approach in the specific treatment of sepsis in cancer patients.  相似文献   

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