共查询到20条相似文献,搜索用时 31 毫秒
1.
Hua Guo Jing Si Zheng-Hui Li Tao Feng Ze-Jun Dong Yu-Cheng Dai 《Journal of Asian natural products research》2013,15(3):253-257
Two new triterpenoids, 3β-(2-methoxy-oxalyloxy)-24-methylene-lanost-8-en-21-oic acid (1) and 3β-(2-methoxy-oxalyloxy)-15α-hydroxy-24-methylene-lanost-8-en-21-oic acid (2), were isolated from cultures of the fungus Perenniporia maackiae, together with two previously known triterpenoids (3 and 4). Their structures were determined by spectroscopic methods, including 1D and 2D NMR, and MS analyses. All compounds were evaluated for their cytotoxic activities on five tumor cell lines. 相似文献
2.
Feng Wang Xiao Bian Yue-Hu Pei Yong-Kui Jing 《Journal of Asian natural products research》2013,15(1-2):137-141
Two new aromatic compounds, trans-(tetrahydro-2-(4-hydroxy-3-methoxyphenyl)-5-oxofuran-3-yl)methyl benzoate (1), 3-(4-hydroxy-3-methoxyphenyl)-2-oxopropyl benzoate (2) and one new natural product, 4-((E)-3-ethoxyprop-1-enyl)-2-methoxyphenol (3) together with five known aromatic compounds have been isolated from the resin of Styrax tonkinensis (Pier.) Craib. Their structures were determined by physical and spectroscopic methods. 相似文献
3.
Yu Luo Ling Qiu Yun Deng Xiao-Hong Yuan Ping Gao 《Journal of Asian natural products research》2013,15(9):883-888
AbstractA new chromone and a new aliphatic ester were isolated from the EtOAc extract of myceliums of Daldinia eschscholtzii. Their structures were elucidated as (R)-5-hydroxy-8-methoxy-2-methylchroman-4-one (1) and (E)-6-(non-3-en-1-yl) -2H-pyran-2-one (2) by interpretation of the spectroscopic evidence. 相似文献
4.
Lin Chen Xi-Xiang Tang Min Zheng Zhi-Wei Yi Xiang Xiao 《Journal of Asian natural products research》2013,15(5):444-448
To explore secondary metabolites in deep-sea sediment metagenomic clone-derived Escherichia coli fermentation broth, different kinds of chromatography methods were used in the isolation procedures, while the structures of the isolated compounds were assigned based on the MS analysis and their 1H and 13C NMR spectra including 2D NMR techniques such as COSY, HMQC, and HMBC experiments. As a result, a novel compound was isolated and characterized as N-{1-[4-(acetylamino)phenyl]-3-hydroxy-1-(1H-indol-3-yl)propan-2-yl}-2,2-dichloroacetamide (1). In addition, eight known compounds were also obtained. Fatty acid amide hydrolase and monoacylglycerol lipase were used to screen analgesic activity, and the new compound showed analgesic activity to some extent in pharmacological test. 相似文献
5.
Xiao Hu Xin Liu Li-xin Niu Hui Xu Chun-yue Huang Pei-ming Yang 《Journal of Asian natural products research》2016,18(7):643-647
Two new phenolic compounds, 2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-hydroxybenzofuran (1) and 1-methoxycarbonyl-2, 3-dihydroxydibenzo[b, f]oxepine (2), were isolated from the tuber of Sparganium stoloniferum. The structures of both new compounds were determined on basis of spectroscopic means including HR-ESI-MS, 1D and 2D NMR experiments. 相似文献
6.
A new steroid 24β-methylcholasta-1,8,14,22,25-penten-3-one-5α-ol (1) and a new alkaloid 1-(1H-indol-3-yl)-2,3-dihydroxy-5-methyl-hexane (2), together with four known compounds, were isolated from the EtOH extract of the South China Sea sponge Axinella sp. The structures of 1 and 2 were determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR spectral data. 相似文献
7.
Zhi-Bo Jiang Bing-Ya Jiang Cheng-Gen Zhu Qing-Lan Guo Ying Peng Xiao-Liang Wang 《Journal of Asian natural products research》2013,15(9):891-900
Seven new aromatic acid derivatives (1–7), together with five known analogs, were isolated from the lateral roots of Aconitum carmichaelii. Structures of the new compounds were determined by spectroscopic and chemical methods as 4-methyl ( ? )-(R)-hydroxyeucomate (1), 4-butyl ( ? )-(R)-hydroxyeucomate (2), 4-butyl-1-methyl (+)-(R)-2-O-(4′-hydroxy-3′-methoxybenzoyl)malate (3), 1-butyl-4-methyl (+)-(R)-2-O-(4′-hydroxy-3′-methoxybenzoyl)malate (4), dimethyl (+)-(R)-2-O-(4′-hydroxy-3′-methoxybenzoyl)malate (5), dimethyl (+)-(R)-2-O-(4′-hydroxybenzoyl)malate (6), and methyl ( ± )-3-(4′-hydroxy-3′-methoxyphenyl)-3-sulfopropionate (7), respectively. Compounds 1 and 2 are 2-benzylmalates (eucomate derivatives), 3–6 belong to 2-O-benzoylmalates, and 7 is a rare phenylpropionate containing a sulfonic acid group. The absolute configurations of eucomate derivatives were confirmed by X-ray crystallographic analysis of 4-methyl eucomate (11). 相似文献
8.
M. Eda Y. Hayashi K. Kinoshita K. Koyama K. Takahashi K. Akutu 《Pharmaceutical biology》2013,51(2):184-188
ABSTRACTWater extract of Brazilian propolis showed anti-emetic activity on copper sulfate–induced emesis in young chicks. Bioassay-guided fractionation of the extract was carried out, and dehydrohautriwaic acid (1), (E.)-3-(2,2-dimethyl-2H.-1-benzopyran-6-yl)-2-propenoic acid (2), dihydrocinnamic acid (3), (Z.)-3-(2,2-dimethyl-2H.-1-benzopyran-6-yl)-2-propenoic acid (4), aromadendrane-4β,10α-diol (5), and lupeol (6) were isolated as the active components. 相似文献
9.
A novel flavone, named 4′-methoxy-3′,5,7-trihydroxy-8-(1″-(3?,4?,5?-trihydroxyphenyl)ethyl)flavone (1), was isolated from Sarcopyramis nepalensis, along with two known compounds syringaresinol (2) and aralidioside (3). Their structures were established by the spectroscopic analysis, especially by 2D NMR. All of the three compounds were isolated from the plant for the first time. 相似文献
10.
Hong-Hua Wu Li Tian Gang Chen Nan Xu Ya-Nan Wang Sha Sun 《Journal of Asian natural products research》2013,15(8):748-751
Two new compounds, together with four known compounds, have been isolated from the ethyl acetate extract of the fermentation broth of the marine fungus Y26-02. Their structures were elucidated, respectively, as 5-(ethynyloxy)-3-hydroxy-3,6-dihydro-2H-pyran-2-one (1), 4-(butoxymethyl)benzene-1,2-diol (2), 4-(methoxymethyl)benzene-1,2-diol (3), 2-acetoxymethylphenol (4), N-(2-phenylethyl)acetamide (5), and 4-hydroxyphenethyl acetate (6) on the basis of their spectroscopic and physico-chemical properties. 相似文献
11.
Two new flavonoid alkaloids, 8-(2″-pyrrolidinone-5″-yl)-quercetin (1) and 8-(2″-pyrrolidinone-5″-yl)-isorhamnetin (2), were isolated from the herb of Senecio argunensis. Their structures were elucidated by spectral analysis. 相似文献
12.
A new compound, (2R)-4-phenyl-2-O-[β-d-xylopyranosyl(1→6)-β-d-glucopyranosyl]butane (1), has been isolated from the aerial parts of Rhododendren anthopogonoides, together with two known compounds, fraxin (2), and lyoniside (3). Their structures were determined by means of physico-chemical evidence and spectral analyses, including UV, IR, HR-FABMS, 1H and 13C NMR, and 2D NMR data. 相似文献
13.
Y. W. Kim Y. K. Kim J. Y. Lee K. T. Chang H. J. Lee D.-K. Kim 《Xenobiotica; the fate of foreign compounds in biological systems》2013,43(3):325-339
The authors investigated the pharmacokinetics and metabolism of 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide (IN-1130), a novel ALK5 inhibitor, which suppresses renal and hepatic fibrosis, and also exerts anti-metastatic effects on breast cancer-bearing MMTV-cNeu mice model. Plasma half-lives of orally administered IN-1130 were 62.6 min in mice, 76.6?±?10.6 min in dogs, 156.1?±?19.3 min in rats, and 159.9?±?59.9 min in monkeys. IN-1130 showed a high apparent permeability coefficient (Papp) of (45.0?±?2.3)?×?10?6 cm s?1 in in vitro permeability tests in a Caco-2 cell monolayer model. The bioavailability of orally administered IN-1130 was 84.9% in dogs and 34.4% in monkeys (oral dose, 5.5 mg kg?1), 11.4% in rats and 8.95% in mice (oral dose, 50.3 mg kg?1), respectively. Orally given IN-1130 was readily distributed into liver, kidneys and lungs. The major metabolite of IN-1130 (M1) was detected in the systemic circulation of rat and mouse and was purified and tentatively identified as 3-((4-(3-hydroxyquinoxaline-6-yl)-5-(6-methylpyridine-2-yl)-1H-imidazol-2-yl)methyl)benzamide or 3-((4-(2-hydroxyquinoxalin-6-yl)-5-(6-methylpyridine-2-yl)-1H-imidazol-2-yl)methyl)benzamide. The highest levels of M1 were found in liver. The results of this study suggest that IN-1130 has the potential to serve as an effective oral anti-fibrotic drug. 相似文献
14.
Xue-Mei Li Jin-Long Cai Le Wang Wen-Xiang Wang 《Journal of Asian natural products research》2017,19(2):164-171
Two new phenolic acid compounds, asparoffin C (1) and asparoffin D (2), together with four known compounds, asparenyol (3), gobicusin B (4), 1-methoxy-2-hydroxy-4-[5-(4-hydroxyphenoxy)-3-penten-1-ynyl] phenol (5), and asparinin A (6), have been isolated from the stems of Asparagus officinalis. The structures were established by extensive spectroscopic methods (MS and 1D and 2D NMR). Compound 6 has obvious antitumor activities both in vitro and in vivo. 相似文献
15.
K. Sun J.-M. Liu J.-H. Wang W. Li Y. Sha 《Journal of Asian natural products research》2013,15(6):853-856
A new sulphur glycoside, named descurainoside (1), and the known compound sinapic acid (2) have been isolated from the seeds of Descurainia sophia (L.) Webb ex Prantl. The structure of 1 has been identified as (1R,6S,8R,9S,10S)-9,10-dihydroxy-4-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-8-(hydroxymethyl)-2,7-dioxa-5-thiabicyclo[4.4.0]decan-3-one by means of physico-chemical properties and spectroscopic methods (1D and 2D NMR, HRMS, ESI-MS). 相似文献
16.
Wan-Hua Li Xiang-Ming Zhang Rong-Ren Tian Yong-Tang Zheng Wen-Ming Zhao Ming-Hua Qiu 《Journal of Asian natural products research》2007,9(6):551-555
A new lupane acid, 2β-carboxyl,3β-hydroxyl-norlupA (1)-20 (29)-en-28-oic acid (1), together with five known lupane acid derivatives (2-6), were isolated from the stings of Gleditsia sinensis Lam.. Their structures were elucidated on the basis of 1D and 2D NMR techniques. All these known compounds were isolated from this genus for the first time. The new compound 1 showed strong anti-HIV activity. 相似文献
17.
F.-H. Song X. Fan X.-L. Xu J.-L. Zhao L.-J. Han 《Journal of Asian natural products research》2013,15(6):777-781
A novel sesquiterpene-substituted benzoic acid, named dictyvaric acid (1), together with nine known compounds (2–10), have been isolated from the brown alga Dictyopteris divaricata Okam. The structure of 1 was elucidated as 3-[(decahydro-2-hydroxy-2,5,5,8a-tetramethyl-1-naphthalenyl)-methyl]-4-hydroxybenzoic acid by spectroscopic methods, including IR, FABMS, HR-FABMS, 1D and 2D NMR techniques. All compounds were obtained from this species for the first time. 相似文献
18.
The new sesquiterpenoid (6R)-2-chloro-6-[(1S)-1,5-dimethylhex-4-en-1-yl]-3-methylcyclohex-2-en-1-one (1), together with ten known compounds, (6R)-6-[(1S)-1,5-dimethylhex-4-en-1-yl]-3-methylcyclohex-2-en-1-one (2), bauerenol acetate (3), lupenone (4), α-amyrenone (5), β-sitosterol (6), stigmasterol (7), β-amyrin (8), ursolic acid (9), betulinic acid (10), scopolin (11), have been isolated from the roots of Euphorbia chrysocoma Lévl. et Vant. Their structures have been elucidated by spectroscopic data. 相似文献
19.
X.-W. Yang H. Zhang M. Li L.-J. Du Z. Yang S.-Y. Xiao 《Journal of Asian natural products research》2013,15(8):697-703
Six alkaloids (1–6) have been isolated from the fruits of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang, two of which are new compounds, identified as 2-undecyl-4(1H)-quinolone (4) and 1-methyl-2-undecanone-10′-4(1H)-quinolone (5); the known compounds were identified as rutaecarpine (1), evodiamine (2), 1-methyl-2-undecyl-4(1H)-quinoline (3) and 2-undecanone-10′-4(1H)-quinolone (6). Compounds 1–5 were evaluated for their acute toxicity. 相似文献
20.
K. Vinaya R. Kavitha C. S. Ananda Kumar S. B. Benaka Prasad S. Chandrappa S. A. Deepak S. Nanjunda Swamy S. Umesha K. S. Rangappa 《Archives of pharmacal research》2009,32(1):33-41
Several 1-benzhydryl-sulfonyl-4-(3-(piperidin-4-yl)propyl)piperidine derivatives 8(a–j) were prepared by the treatment of substituted benzhydryl chlorides with 4-(3-(piperidin-4-yl)propyl)piperidine followed by
N-sulfonation with sulfonyl chlorides in the presence of dry methylene dichloride and triethyl amine. The synthesized compounds
were characterized by 1H-NMR, IR, and elemental analysis. All the synthesized compounds were evaluated in vitro for their efficacy as antimicrobial agents by artificial inoculation technique against standard strains of two important
bacterial viz., Xanthomonas axonopodis pv. vesicatoria and Ralstonia solanacearum as well as and two fungal pathogens namely Alternaria solani and Fusarium solani of tomato plants. We have briefly investigated the structure-activity relation studies and reveal that the nature of substitutions
on benzhydryl ring and sulfonamide ring influences the antibacterial activity. Among the synthesized new compounds 8b, 8d, 8g, 8h, 8i, and 8j were showed significant potent antimicrobial activities compared to the standard drugs Chloramphenicol, Mancozeb. 相似文献