贝复舒与爱丽滴眼液治疗准分子激光手术后角膜上皮缺损的疗效对比

①目的评价贝复舒与爱丽治疗准分子激光屈光手术后角膜上皮缺损的疗效比较与安全性。②方法观察准分子激光对屈光不正行PRK手术后患100例，随机分成3组。贝复舒组30例，爱丽组30例，普通抗生素组40例。定期观察角膜上皮修复情况，以角膜染色作为观察指标，时间为1个月。③结果贝复舒与爱丽对屈光不正手术后角膜上皮修复均有显的促进作用(P＜0．01)。贝复舒治疗组的有效率高于爱丽组(P＜0.05)。贝复舒治疗组3天角膜上皮完全修复率为93％，爱丽组为89％，普通抗生素组为85％，但差异比较无统计学意义(P＞0．05)。④结论贝复舒与爱丽滴眼液治疗准分子激光矫正屈光不正手术后角膜上皮缺损安全有效，疗效确切。     

爱丽滴眼液治疗角膜上皮病34例

由多种原因引起的角膜上皮病是学校卫生所常见病，其中角膜点状上皮糜烂较为多见。我院于2003年3月-2005年5月，应用0．1％爱丽滴眼液对角膜点状上皮糜烂进行治疗，取得较好疗效，报道如下。     

贝复舒滴眼液治疗角膜溃疡临床疗效分析

目的：探讨和分析贝复舒滴眼液在角膜溃疡患者治疗中的使用方法和临床效果。方法整群选取该院自2014年3月-2015年2月期间收治的角膜溃疡患者共96例作为研究对象,按随机原则,分成对照组和观察组各48例,对照组给予常规的氧氟沙星滴眼液进行治疗,观察组则使用贝复舒滴眼液进行治疗,使用一个疗程后,将两组的治疗效果进行对比。结果在经过2个疗程治疗以后,观察组患者治疗总的有效率为93.8%(45/48﹚,明显高于对照组患者75%,(36/48﹚,观察组和对照组患者治疗总有效率对比,差异有统计学意义(χ2=6.272,P<0.05﹚;该两组患者治疗中,没有出现局部刺激或者其它的不良反应。结论对于角膜溃疡患者,通过使用贝复舒滴眼液进行治疗,能够明显改善患者的角膜溃疡病症,并且安全有效,非常值得临床推广和使用。     

聚乙烯醇滴眼液联合贝复舒滴眼液治疗干眼症的疗效观察

目的:探讨临床上应用聚乙烯醇滴眼液联合贝复舒滴眼液治疗干眼症患者的效果。方法:选取120例干眼症患者,将这120例患者随机分为治疗组和对照组,每组60例,治疗组给予聚乙烯醇滴眼液联合贝复舒滴眼液治疗,对照组单用聚乙烯醇滴眼液治疗,治疗4周后,将两组患者的治疗效果进行比较。结果:在给予聚乙烯醇滴眼液联合贝复舒滴眼液治疗的治疗组患者中,治疗的总有效率为93.34%;给予单纯聚乙烯醇滴眼液治疗的对照组患者中,治疗的总有效率为78.33%。治疗组优于对照组,组间差异有统计学意义(P<0.05)。结论:应用聚乙烯醇滴眼液联合贝复舒滴眼液治疗干眼症,效果明显,值得在临床推广应用。     

纤维连结蛋白治疗角膜上皮缺损

纤维连结蛋白治疗角膜上皮缺损广州市第一人民医院眼科（５１０１８０）金宏，杨为中，杨以嘉广州市红十字会医院眼科赵坤明广州市医药卫生研究所任国梅，高雄辉，黎婉玲纤维连结蛋白（Ｆｉｂｒｏｎｅｃｔｉｎ，ＦＮ）是一种存在于血浆与细胞表面的高分子糖蛋白，它是细胞...     

纤维连结蛋白滴眼液治疗角膜上皮病变的临床应用

目的：评价纤维连结蛋白滴眼液治疗角膜上皮病变的临床疗效。方法：用纤维加接蛋白滴 眼液治疗眼科门诊由各种原因所致的角膜上皮病变患者50例82眼，观察其治疗效果；结果：经4周的治疗及随诊，有67眼显效，占81．7％，15眼好转，占18．3％，总有效率100．0％ ；其中对角膜上皮缺损者疗效最佳，显效率为100．0％，其次是点状角膜炎，显效率为77．1％，对于无特效疗法的眼干燥症也取得了较好的临床疗效，显效率为71．4％；用药后症状体征多在（1－7）天内改善，观察中未出现与应用药物有关的不良反应。结论：纤维连结蛋白滴眼液治疗角膜上皮病变安全、有效。     

贝复舒与光安滴眼液治疗麻风性角膜溃疡

随着对重组牛碱性成纤维细胞生长因子(Recombinant Basic Fibroblast Growth Factor,bFGF)贝复舒滴眼液的不断深入研究,人们越来越认识到了其在角膜组织细胞分化功能维持和组织修复方面所具有的极为重要的生物学作用[1].与此同时,贝复舒在眼科的临床工作中也得到了更为广泛的使用.我院自2001年5月～2003年5月应用贝复舒治疗麻风性角膜溃疡(Leprotic Corneal Ulcer),与光安滴眼液(Acetylcysteine Oculogutta)治疗作疗效对比观察,现报道如下.     

三种角膜修复剂促角膜损伤修复的临床效果观察

目的:观察三种常用角膜修复剂治疗干眼症引起的角膜上皮损伤的临床效果。方法:160例(211只眼)具有角膜上皮损伤的干眼症患者随机分为四组,分别使用三种不同的角膜修复剂(重组牛碱性成纤维细胞生长因子滴眼液、小牛血去蛋白提取物眼用凝胶、0.3%玻璃酸钠滴眼液)及安慰剂(0.1%玻璃酸钠)治疗1周。在治疗前后均使用活体共聚焦显微镜检查,观察记录角膜表层上皮细胞形态,并对图像进行分析、记录。结果:治疗前四组之间角膜表层上皮细胞密度、角膜表层上皮细胞面积比较均无统计学差异(P>0.05);治疗后,治疗组较对照组单位面积的角膜表层上皮细胞数明显增多,角膜表层上皮细胞面积明显减少,差异有统计学意义(P<0.05);治疗组间,小牛血去蛋白提取物眼用凝胶组较其他两组单位面积的角膜表层上皮细胞数明显增多,角膜表层上皮细胞面积明显减少,差异均有统计学意义(P<0.05);其他两组之间比较差异无统计学意义(P>0.05)。结论:三种角膜修复剂在治疗角膜损伤时均有明显效果,其中以小牛血去蛋白提取物眼用凝胶疗效最优。     

Interleukin-1 receptor antagonist eye drops promoting high-risk corneal allografts survival in rats

Background Immune rejection is the main reason of grafts failure after corneal transplantation. This study was to determine whether interlerkin-1 receptor antagonist (IL-1ra) eye drops could prolong corneal allografts survival in high-risk corneal orthotopic allotransplantation in rat model and to study the effect of IL-1ra on the expression of CD1-positive cells in the grafts. Methods For all experiments, the Sprague-Dawley (SD) rats’ corneas were transplanted into Wistar rats’ eyes. High-risk transplants included those that had been sutured into Wistar recipient beds with corneal neovascularization induced by placement of three interrupted sutures in the host cornea 7 days earlier. All the animals were divided, in a masked fashion, into three treatment groups and one control group. Each treatment group received IL-1ra eye drops of different concentrations (1 mg/ml, 3 mg/ml, or 5 mg/ml, respectively) four times a day for 30 days. The control group received 0.9% normal saline (NS) eye drops in the same way as the treatment groups. All allografts were evaluated for signs of rejection from the first day after surgery. Ten days later, corneal specimens were processed to examine the expression of CD1-positive cells and histopathological changes. Results The survival time of the transplants was 5.80±0.79, 5.89±1.05, 6.78±0.83, and 9.00±2.36 days respectively in the control or three treatment groups. Compared with the control group, 1 mg/ml IL-1ra eye drop did not prolong the survival time of the allografts (t=0.210, P&gt;0.05). However, 3 mg/ml and 5 mg/ml IL-1ra eye drop did prolong the survival time of the grafts (t≥2.627, P&lt;0.05), with the latter showing more obvious effect. Immunohistochemical examinations showed a significant decrease in inflammatory cell and CD1-positive cell infiltration in IL-1ra treated groups compared with the control group. Conclusions IL-1ra can promote corneal allograft survival in a dose-dependant manner by reducing the infiltration of CD1-positive cells in high-risk corneal transplantation.     

易贝滴眼液治疗栗刺角膜异物临床观察

目的观察易贝滴眼液（重组人表皮生长因子滴眼液）治疗栗刺角膜异物的疗效。方法选择108例栗刺角膜异物患者,随机分成两组：对照组52例（52眼）,取出栗刺后,氧氟沙星滴眼液每日4次,每次1滴,氧氟沙星眼膏每晚1次;实验组56例（56眼）,取出栗刺后,在对照组基础上加用易贝滴眼液每日6次。对用药后1周进行患者主观症状（疼痛、怕光、异物感等）、裂隙灯检查、角膜荧光素染色检查进行疗效评价。结果实验组的有效率明显高于对照组（P〈0．01）。结论经易贝滴眼液治疗栗刺异物术后的角膜恢复快,效果显著,可优先选用。     

Prescription of eye drops

The aim of this study was to assess whether patients have their ocular drops correctly prescribed during non-ophthalmic admissions to hospital. A retrospective review of notes of patients who were admitted to hospital for general medical or surgical care, while on regular eye drops at the time of admission was performed. Twenty two patients were on regular ocular medication when admitted. Only seven out of 22 patients had their eye drops correctly prescribed. Furthermore, six patients had been prescribed topical beta-blockers, yet suffered from medical conditions that may have been aggravated by these drops. These findings demonstrate that the majority of patients on drops do not have their medication correctly prescribed during non-ophthalmic admissions to hospital. Also topical beta-blockers continue to be inappropriately prescribed.     

Clinical trial of diclofenac sodium (Naclof) eye drops on Nigerians

Twenty-eight eyes of 26 age-matched patients who had planned extracapsular cataract extraction with or without intraocular lens implantation were enrolled into a double blind randomised actively controlled study of 2 groups. Each group of 14 eyes was assigned to receive 0.1% diclofenac sodium (Naclof) eye drops or 1% prednisolone acetate eye suspension. The patients received either 0.1% Diclofenac sodium eye drops or 1.0% prednisolone acetate eye suspension four times a day as their post operative anti-inflammatory medication for a period of four weeks. No significant difference was noticed in the subjective assessment of pain and conjunctival injection in the 28 days follow-up period except day 1 in the diclofenac sodium group (0.05> p >0.01). Other measured objective variables of inflammation such as anterior chamber cells and flare showed no significant difference from the 3rd-28th postoperative days (0.05< p > 0.20). The result demonstrated that 0.1% diclofenac sodium eye drops was as effective as 1% prednisolone acetate eye suspension in the control of postoperative inflammation after cataract surgery, and could serve as a viable alternative to topical steroids in Nigerians who are steroid responders.     

腭托与口外弓在方丝弓增强支抗的临床效果研究

目的介绍腭托用于正畸支抗的临床经验,对腭托和口外弓在方丝弓增强支抗方面进行临床评价.方法在40例需要强支抗的临床病例中,采用随机方法分为2组,每组20例.实验组选用腭托加强支抗;对照组选用口外弓加强支抗.比较治疗前后头颅X线侧位片,测量前牙内收和磨牙支抗的变化.结果实验组切牙切缘平均内收6.0mm,支抗磨牙平均前移0.5mm;对照组除3例因配合较差改用其它方法外,其余病例切牙切缘平均内收6.2mm,支抗磨牙平均前移0.4mm.均获得磨牙强支抗的效果.结论腭托能作为稳定的正畸支抗,代替口外力的作用,起到磨牙强支抗的作用.该型腭托具有操作简单,不依赖患者合作的优点.     

腭托与口外弓在方丝弓增强支抗的临床效果研究

目的：介绍腭托用于正畸支抗的临床经验，对腭托和口外弓在方丝弓增强支抗方面进行临床评价。方法：在加例需要强支抗的临床病例中，采用随机方法分为2组，每组20例。实验组：选用腭托加强支抗；对照组：选用口外弓加强支抗。比较治疗前后头颅X线侧位片，测量前牙内收和磨牙支抗的变化。结果：实验组：切牙切缘平均内收6．0mm，支抗磨牙平均前移0．5mml对照组：除3例因配合较差改用其它方法外，其余病例切牙切缘平均内收6．2mm，支抗磨牙平均前移0．4mm。均获得磨牙强支抗的效果。结论：腭托能作为稳定的正畸支抗，代替口外力的作用，起到磨牙强支抗的作用。该型腭托具有操作简单，不依赖患者合作的优点。     

加替沙星滴眼液与诺氟沙星滴眼液治疗细菌性角膜炎临床疗效分析

目的:观察加替沙星滴眼液与诺氟沙星滴眼液治疗细菌性角膜炎的疗效及不良反应。方法:将62例细菌性角膜炎患者随机分为两组,治疗组采用加替沙星滴眼液,2~3滴/次,4~6次/d;对照组诺氟沙星滴眼液,2~3滴/次,4~6次/d。比较两组间的临床疗效及不良反应。结果:加替沙星组总有效率为93.75%(30/32),明显高于诺氟沙星组80%(24/30),差异有统计学意义(P<0.05);两组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加替沙星滴眼液治疗细菌性结膜炎有较好的疗效及安全性。     

蜂地麻滴眼液的制备及质量控制

目的制备蜂地麻滴眼液，并建立其质量标准。方法根据制备工艺制备滴眼液，用薄层色谱法进行鉴别，用高效液相色谱法进行含量测定。结果受试品和对照品的薄层特征性斑点一致，盐酸丁卡因的平均回收率为100．25％，RSD=0．75％，盐酸麻黄碱的平均回收率为99．57％，RSD=0．91％。结论蜂地麻滴眼液的制备方法简便，质量可控。