顺食汤防治急性放射性食管炎的临床研究

目的：观察中药组方顺食汤对急性放射性食管炎的防治效果。方法：将267例确诊为食管癌并行放射治疗的患者随机分为研究组和对照组。研究组自放疗开始前1周服用顺食汤剂（25ml／次，3次，d），出现急性放射性食管炎后加量（50ml／次，3次／d）。对照组只在出现急性放射性食管炎时使用抗生素、激素治疗。两组病例均采用60Co-γ射线或6MV—X射线加速器照射，放疗剂量〉50Gy。结果：研究组急性放射性食管炎发生时间为放疗后（20．7±0．4）d，较对照组（17.3±0．3）d明显推迟（P〈0．05）；研究组和对照组急性放射性食管炎发生率分为23．4％和44．6％（P〈0．05）；研究组和对照组发生急性放射性食管炎后的治疗总有效率分别分为90．6％和70．7％（P〈0．05）；研究组和对照组放疗后近期有效率（CR＋PR）分别为90.5％和76．2％（P〈0．05）。结论：顺食汤能推迟放射性食管炎的发生时间，明显降低发生率，提高了近期疗效，改善了病人生存质量，对急性放射性食管炎有一定防治作用。     

多西他赛和顺铂配合放疗同步治疗期非小细胞肺癌54例

目的:观察同步放化疗治疗局部晚期非小细胞肺癌的近期疗效和急性毒副作用。方法:54例期非小细胞肺癌患者放疗前1周开始化疗,采用每4周方案,多西他赛30mg/m2溶于生理盐水200ml中,第1、8天给药;顺铂20mg/m2,第1～5天;常规放疗2Gy/次,1次/d,5d/周,肿瘤灶总剂量66～70Gy/7周。结果:近期完全缓解(CR)率为27.8%,部分缓解(PR)率为59.2%,总有效率87.0%。主要毒副作用是急性放射性食管炎和肺炎,放射性食管炎的发生率为57.4%,放射性肺炎为42.6%,但大多数患者经过对症支持治疗均能耐受。结论:多西他赛和顺铂配合放疗同步治疗局部晚期非小细胞肺癌,近期疗效肯定,远期疗效和晚期并发症有待进一步观察。     

三维适形放疗联合高-低氧治疗老年非小细胞肺癌的疗效观察

目的:探讨氧疗对老年非小细胞肺癌放疗增敏作用的治疗价值。方法:56例经病理证实的老年非小细胞肺癌患者,分为高-低氧疗+放疗组(研究组)28例,单纯放疗组(对照组)28例,两组均给予三维适形放疗(3DCRT),总剂量50～66 Gy/25～33次,其中,研究组放疗前给予5升/分的高流量吸氧2小时,吸氧结束后即给予放疗,放疗结束后给予持续3升/分低流量吸氧至次日放疗前2小时,对照组不予吸氧。结果:研究组近期总有效率为96.4%,对照组近期总有效率为71.4%,两组比较差异有统计学意义(P<0.05);治疗中急性放射性肺炎的发生率低于单纯放疗组(P<0.05)。结论:与单纯放疗相比,高-低氧放疗能提高老年非小细胞肺癌近期疗效,同时能降低急性放射性肺炎不良反应。     

鸦胆子油乳增强宫颈癌放疗疗效的临床研究

目的:观察中药鸦胆子油乳联合调强放疗(IMRT)及192Ir腔内后装治疗宫颈癌的临床疗效。方法:68例宫颈癌患者随机分为2组,对照组34例,采用6 MV X线调强放疗,平均剂量54.5 Gy,1.8².2 Gy/次,每周5次,放疗30 Gy后开始作腔内后装治疗,后装照射共给5次,每周1次,每次6 Gy,治疗当日不进行外照射。研究组34例,在对照组治疗基础上另加用鸦胆子油乳注射液30 mL加入0.9%氯化钠注射液250 mL中静脉滴注,每天1次,连续使用21 d。结果:研究组治疗后KPS评分较治疗前升高(P<0.05),对照组治疗后KPS评分较治疗前降低(P<0.05)。研究组和对照组治疗前KPS评分比较无差异(P>0.05),治疗后研究组KPS评分高于对照组(P<0.05);2组近期有效率为91.2%和88.2%(P>0.05);1年控制率为70.6%和79.4%(P<0.05),2年控制率为64.7%和76.5%(P<0.05);1年生存率为82.4%和94.1%(P<0.05),2年生存率为79.4%和91.2%(P<0.05);研究组治疗后血液流变学中的8项指标均较治疗前明显下降(P<0.05),对照组治疗前后8项指标无明显变化(P>0.05)。研究组治疗后血液流变学中的8项指标均明显低于对照组治疗后水平(P<0.05)。结论:鸦胆子油乳可通过改善患者血液系统微环境,增加氧的供给来提高宫颈癌细胞对IMRT和腔内后装放疗的敏感性,增强宫颈癌放疗疗效,并进一步提高了生存期和生存质量。     

中药制剂直肠外用防治宫颈癌放疗所致放射性直肠炎的临床研究

目的探讨中药制剂直肠外用防治宫颈癌放疗引起的放射性直肠炎的临床价值。方法将90例Ⅰ～Ⅲ期宫颈癌患者随机分为研究组和对照组,每组45例,两组放疗方法相同,研究组在放疗开始给予中药制剂直肠外用至放疗结束,对照组直肠局部不用药物干预。放疗期间和放疗后观察放射性直肠炎发生情况及严重程度。结果研究组和对照组急性放射性直肠炎的发生率分别为37.8%(17/45)、64.4%(29/45),慢性放射性直肠炎的发生率分别为2%(1/45)、11%(5/45),(P均<0.05);两组Ⅱ级以上急性放射性直肠炎发生率分别为15.6%(7/45)、44.4%(20/45),(P<0.05);两组患者急性放射性直肠炎持续时间分别为(0.9±1.3)周和(5.2±8.1)周(P<0.05)。对照组和研究组放疗开始后前3周内急性放射性直肠炎发生率分别为58.6%(12/29)和29.4%(5/17)(P>0.05)。结论采用中药制剂直肠外用可降低宫颈癌放疗所致的放射性直肠炎的发生率,并能缓解其症状,从而减轻患者的痛苦并提高患者生活质量。     

非小细胞肺癌超分割放疗疗效分析

目的:探讨超分割放疗治疗非小细胞肺癌的疗效分析。方法:选取非小细胞肺癌患者74例,随机分为两组,研究组实施超分割放疗方案,常规组实施常规放疗方案;6～7周后比较两组患者的近期有效率和急性放射反应发生率。结果:研究组治疗有效率(CR+PR)为83.8%显著高于常规组的64.9%;差异有统计学意义(P<0.05),急性放射损伤中除放射性食管炎发生率差异有统计学意义(P<0.05),其余差异均无统计学意义(P>0.05)。结论:超分割放疗治疗非小细胞肺癌的近期疗效显著优于常规放疗,且放射性食管炎发生率显著低于常规放疗,值得临床推广应用。     

立体定位放疗联合化疗对局部晚期非小细胞肺癌患者生存率的影响

目的:观察立体定位放疗联合化疗对局部晚期非小细胞肺癌(LA-NSCLC)患者生存率的影响。方法:选取64例LANSCLC患者作为研究对象,按照随机数字表法将其分为对照组30例和研究组34例,对照组行常规放射治疗联合化疗,研究组行立体定位放射治疗联合化疗,比较两组临床疗效、血清肿瘤标志物水平的变化情况、不良反应发生情况及生存情况。结果:研究组的治疗有效率为82.4%(28/34),明显高于对照组的60.0%(18/30),差异有统计学意义(P<0.05);治疗后研究组糖类抗原125(CA125)、癌胚抗原(CEA)、转化生长因子β1(TGF-β1)水平均明显低于对照组,差异有统计学意义(P<0.05);研究组放射性肺炎发生率为8.8%(3/34),低于对照组的33.3%(10/30),差异有统计学意义(P<0.05);两组血液系统毒性、胃肠道反应及放射性食管炎发生率比较,差异无统计学意义(P>0.05);两组半年生存率比较,差异无统计学意义(P>0.05);研究组1年生存率、2年生存率均明显高于对照组,差异有统计学意义(P<0.05)。结论:立体定位放疗联合化疗应用在局部晚期非小细胞肺癌患者中,效果显著,可下调血清肿瘤标志物水平,提高患者1年、2年生存率,且可明显降低放射性肺炎发生率。     

艾迪注射液联合放疗治疗老年非小细胞肺癌的临床观察

目的:观察艾迪注射液联合放疗治疗老年非小细胞肺癌(NSCLC)的疗效。方法:将60例老年非小细胞肺癌患者随机分两组,对照组30例,单纯放疗;观察组30例,应用艾迪注射液联合放疗。两组均采用三维适形放疗,2GY/次,1次/d,5次/周,达到40～50GY时,根据病灶变化,对原发灶缩野照射,总剂量达60～70GY,疗程6周。观察组同时给予艾迪注射液100ml加入0.9%NS或5%GS 400ml中静脉滴注,1次/d,连用14d,休息7d,连用2个周期。两组放疗结束后均判断疗效及不良反应。结果:观察组有效率(66.7%)高于对照组(33.3%),差异有统计学意义(P<0.05)。观察组临床症状改善21例(70.0%)优于对照组8例(26.7%)(P<0.05)。观察组骨髓抑制、消化道反应、放射性食管炎、放射性肺炎的发生率明显低于对照组(P<0.05)。结论:艾迪注射液联合放疗可提高放疗效果,减轻放疗引起的胃肠道反应,减少骨髓抑制、放射性食管炎、放射性肺炎的发生率,改善患者的生活质量。     

阿米福汀在局部晚期非小细胞肺癌放疗中的作用研究

目的 探讨阿米福汀在局部晚期非小细胞肺癌(NSCLC)放疗中对近期疗效的影响及降低放射性食管炎和放射性肺炎的作用.方法 2008年1月-2010年2月我院放疗科收治62例局部晚期NSCLC患者,采用随机数字表法分为单纯三维适形放疗组(对照组)和阿米福汀+三维适形放疗组(试验组).试验组每次放疗前15～30 min给予阿米福汀300 mg/m2,静脉滴注.每周放疗5次,持续6周.放疗结束后6周评价两组患者的近期疗效.放疗期间每周记录1次放射性食管炎、放射性肺炎的发生率.结果 两组共44例患者完成了预定试验,对照组23例,试验组21例.对照组完全缓解(CR)1例,部分缓解(PR)11例,客观有效率为52%;试验组CR 2例,PR 12例,客观有效率为67%,两组客观有效率比较差异无统计学意义(χ2=0.95,P＞0.05).对照组累计发生放射性食管炎15例(65%),放射性肺炎16例(70%);试验组累计发生放射性食管炎和放射性肺炎各5例(24%),两组放射性食管炎和放射性肺炎累计发生率比较,差异均有统计学意义(P值分别为0.017和0.003).结论 阿米福汀可以降低 NSCLC放疗中放射性食管炎和放射性肺炎的发生率,但不降低放疗的近期疗效.     

图像引导调强放疗联合替吉奥治疗老年食管癌临床研究

目的:研究图像引导调强放疗联合替吉奥治疗老年食管癌患者近期疗效、急性不良反应。方法:选择2010年6月至2013年8月郑州大学附属肿瘤医院放疗科收治的63例老年食管癌患者,随机分为单纯放疗组32例(对照组)和放疗同步替吉奥组31例(试验组)。试验组给予替吉奥口服,两组均给予6MV-X图像引导下调强放疗。比较两组近期疗效、急性不良反应发生率。结果:试验组及对照组患者的总有效率分别为81.25%及54.55%,差异有统计学意义(P<0.05),试验组和对照组患者的消化道反应和放射性食管炎差异有统计学意义(P<0.05),两组血液学毒性及放射性肺炎差异无统计学意义(P>0.05)。结论:图像引导调强放疗联合替吉奥治疗老年食管癌近期疗效确切,毒副反应可耐受,患者的长期生存结局需进一步研究证实。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.