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1.
原瑞芳  董丽 《中原医刊》2011,(20):98-99
目的观察干扰素治疗病毒性肺炎的临床疗效。方法将86例病毒性肺炎患儿随机分为治疗组50例和对照组36例,治疗组应用干扰素,对照组应用病毒唑。比较两组临床疗效。结果治疗组病毒性肺炎总有效率显著提高,平均住院天数明显缩短,差异有统计学意义(P〈0.05)。结论干扰素对病毒性肺炎疗效显著,可缩短病程。  相似文献   

2.
目的观察干扰素联合炎琥宁治疗婴幼儿病毒性肺炎的临床效果.方法将96例婴幼儿病毒肺炎随机分成对照组(51例)和治疗组(45例),两组均给予抗生素防治感染及对症、支持等综合治疗,对照组在此基础上给予炎琥宁静滴,治疗组在对照组基础上给予重组人干扰素α1b肌肉注射,对比分析两组患者治疗情况.结果治疗组有效率88.9%,高于对照组的74.4%,组间差异有统计学意义(P<0.05).治疗组症状、体征的消失时间较对照组缩短,差异有统计学意义(P<0.05).结论应用重组人干扰素α1b联合炎琥宁治疗婴幼儿病毒性肺炎效果显著,值得临床推广应用.  相似文献   

3.
目的:观察重组人干扰素α-2b治疗婴幼儿病毒性肺炎疗效。方法:98例确诊为病毒性肺炎患儿随机分为治疗组50例,对照组48例,两组基础治疗相同,治疗组加用干扰素肌肉注射,分别比较两组咳嗽、喘憋、肺部啰音消失时间。结果:治疗组肺炎症状消失时间明显少于对照组,治疗组总有效率(100%)明显高于对照组总有效率(85.4%),差异具有统计学意义(P<0.01)。结论:肌肉注射干扰素治疗婴幼儿病毒性肺炎有临床应用价值,值得推广。  相似文献   

4.
苏颖 《黑龙江医学》2010,34(4):285-286
目的观察重组人干扰素α-2b治疗婴幼儿病毒性肺炎疗效。方法49例确诊为病毒性肺炎患儿随机分为治疗组25例,对照组24例,两组基础治疗相同,治疗组加用干扰素肌肉注射,分别比较两组咳嗽、喘弊、肺部啰音消失时间。结果治疗组肺炎症状消失时间明显少于对照组,治疗组总有效率(100%)明显高于对照组总有效率(85.4%),差异具有统计学意义(P<0.01)。结论肌肉注射干扰素治疗婴幼儿病毒性肺炎,具有临床应用价值,值得推广。  相似文献   

5.
目的 探讨α-2b干扰素与静脉丙球(IVIG)联合治疗新生儿病毒性肺炎的疗效及其安全性.方法 将95例病毒性肺炎患儿分为治疗组45例和对照组50例,除常规治疗外,治疗组加用α-2b干扰素与静脉丙球,对照组加用病毒唑治疗.结果 两组退热时间、咳嗽、气促及啰音消失时间比较差异均有统计学意义(P<0.05).治疗组治愈率为55.6%,对照组为34.0%,两组比较差异有统计学意义(P<0.05).治疗组总有效率为93.3%,对照组为62.0%,两组比较差异有统计学意义(P<0.01).结论 α-2b干扰素与静脉丙球联合治疗新生儿病毒性肺炎疗效优于病毒唑,未见明显不良反应,值得临床推广.  相似文献   

6.
干扰素治疗小儿病毒性肺炎126例疗效观察   总被引:1,自引:0,他引:1  
邓惠玲  龙金海  邓建峰 《海南医学》2005,16(8):54-54,27
目的观察干扰素治疗小儿病毒性肺炎的临床疗效。方法将252例病毒性肺炎的患儿随机分成两组。两组均给予综合治疗,治疗组126例加用干扰素肌注,100万u/次,1次/d,5d为一疗程。结果治疗组发热、咳嗽、气喘、肺部啰音消失时间及住院天数均较对照组明显缩短(p<0.01),总有效率治疗组94.44%,对照组72.22%,两组比较差别有显著意义(x2=4.253,p<0.05)。结论干扰素治疗病毒性肺炎有显著疗效。  相似文献   

7.
目的:探讨重组人干扰素α-1b雾化吸入治疗病毒性肺炎的疗效。方法选取病毒性肺炎患者300例,随机均分为2组(n=150)。C1组选择重组人干扰素α-1b实施雾化治疗,C2组选择利巴韦林雾化治疗,对比C1组与C2组病毒性肺炎患者在退热时间、临床咳嗽症状缓解时间、患者肺部体征消除的时间、临床治愈率及治疗后产生的不良反应等。结果 C1组治疗总有效率明显高于C2组,差异有统计学意义(P<0.05);C1组与C2组患者完成治疗后,临床均未出现严重不良反应的情况。结论针对病毒性肺炎患者,在选择重组人干扰素α-1b进行治疗的过程中,采用雾化吸入的方式,在缩短患者的治疗时间等方面表现了重要的意义。  相似文献   

8.
目的探讨基因重组干扰素(INF-α1b)治疗婴幼儿病毒性肺炎的疗效及安全性。方法运用基因重组干扰素治疗52例婴幼儿病毒性肺炎,并以43例患儿作为对照组给予利巴韦林(病毒唑)治疗。结果治疗组治愈率为88.46%,总有效率为100%;对照组治愈率为62.79%,总有效率为83.72%,两组治愈率和总效率比较差异有统计学意义(P0.01);治疗组咳嗽、喘息、肺部罗音以及退热时间均明显短于利巴韦林对照组(P0.01)。结论基因重组干扰素用于治疗婴幼儿病毒性肺炎疗效显著,优于利巴韦林,值得临床推广应用。  相似文献   

9.
应用α-干扰素注射液肌注加抗生素治疗30例小儿病毒性肺炎,并与常规抗生素治疗30例对照,结果表明a-干扰素注射液具有较强的抗病毒作用,在退热、止咳、平喘,肺部啰音消失及缩短病程方面均明显优于对照组(P<0.05).  相似文献   

10.
郭瑜 《海南医学》2010,21(11):35-36
目的观察基因重组干扰素α-2b(IFNα-2b)联合利巴韦林(三氮唑核苷病毒唑)治疗呼吸道合胞病毒肺炎的疗效。方法将确诊为呼吸道合胞病毒性肺炎的173例患儿随机分为普通治疗组(83例)和联合治疗组(90例),联合治疗组在常规治疗组基础上加用干扰素α-2b注射,观察两组症状、体征改善情况。结果联合治疗组喘憋缓解、哮鸣音消失及总住院时间等均短于普通治疗组,差异均有统计学意义(P均〈0.05)。结论干扰素α-2b联合利巴韦林治疗呼吸道合胞病毒性肺炎疗效明显。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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