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1.
目的 研究小叶石楠茎的化学成分。方法 采用硅胶色谱法分离纯化,薄层色谱及波谱法进行结构鉴定。结果 从其乙醇提取物的氯仿、醋酸乙酯部分分得7个化合物,其结构鉴定为羽扇豆醇(Ⅰ),β-谷甾醇(Ⅱ),白桦酸(Ⅲ),pyracrenic acid(Ⅳ),表儿茶素(V),胡萝卜苷(Ⅵ),野樱苷(Ⅶ)。结论 化合物Ⅰ,Ⅲ~Ⅵ为首次从该属植物中分离得到,化合物Ⅲ和Ⅶ为首次从该植物中分离得到。化合物Ⅳ具有抗肿瘤活性。  相似文献   

2.
薄叶鸢尾的化学成分研究   总被引:13,自引:2,他引:11  
目的:从鸢尾属植物薄叶鸢尾(lris leptophylla Lingel.)根茎中分离出黄酮类化合物。方法:采用80%乙醇提取,硅胶往层析及重结晶等方法从鸢尾属植物薄叶鸢尾中分离其化学成分。通过波谱及化学方法进行结构鉴定。结果:分离得到8个化合物,其中5个为异黄酮类成分,分别为:次野鸢尾黄素irisflorentin(I)、德鸢尾苷元irilone(Ⅱ)、野鸢尾苷iridin(Ⅲ)、鸢尾苷tectoridin(Ⅳ)、德鸢尾苷irilone-4′-glucoside(Ⅴ),其余3个化合物分别为胡萝卜苷(Ⅵ)、β—谷甾醇(Ⅶ)、十八烷基酸(Ⅷ)。这些化合物都为在该植物中首次发现。  相似文献   

3.
中药女贞子化学成分的研究(Ⅰ)   总被引:21,自引:0,他引:21  
目的:分析中药女贞子的化学成分。方法:采用溶剂法和层析法分离、纯化女贞子的化学成分,并通过理化性质与光谱分析,鉴定所得化合物的分子结构。结果:从女贞子的乙醇提取物中分离得到7个单体化合物,分别鉴定为齐墩果酸(I)、木犀草素—7—O—β—D—葡萄糖苷(Ⅱ)、槲皮苷(Ⅲ)、β—胡萝卜苷(Ⅳ)、对羟基苯乙醇—β—D—葡萄糖苷(V)、甘露醇(Ⅵ)及己六醇(Ⅶ)。其中化合物Ⅱ、Ⅲ和Ⅶ为首次从该植物中分离得到。结论:分离并鉴定了女贞子的7个水溶性化学成分,为进一步开发利用女贞子提供了实验依据。  相似文献   

4.
目的 研究地骨皮(枸杞Lycium cinense根皮)的化学成分。方法 利用各种色谱技术进行分离纯化,根据化合物的理化性质和光谱数据进行结构鉴定。结果分离得到5个化合物,分别为:香草酸(vanillic acid,I)、芹菜紊(apigenin,Ⅱ)、蒙花苷(1inarin,Ⅲ)、紫丁香酸葡萄糖苷(glucosyringic acid,Ⅳ)及地骨皮苷甲(digupigan A,V)。结论 化合物V为新化合物,化合物I~Ⅳ均为首次从地骨皮中分得。  相似文献   

5.
目的 研究落花生枝叶的化学成分。方法 采用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20柱色谱等方法分离纯化,根据化合物的波谱数据鉴定结构。结果 从落花生枝叶水提取物中分离鉴定了17个化合物,本实验主要研究从正丁醇萃取部分分离得到的4个降倍半萜类化合物:落花生苷A(arachiside A,Ⅰ)、狗筋蔓内酯(cucubalactone,Ⅱ)、长春花苷(roseoside,Ⅲ)、柑橘苷A(citroside A,Ⅳ)。结论 化合物Ⅰ为新的化合物,命名为落花生苷A(arachiside A),化合物Ⅱ~Ⅳ为首次从该属植物中分离得到。  相似文献   

6.
宋丽娜  陈光  喻长远 《医学教育探索》2009,40(10):1525-1528
目的 对四川淫羊藿Epimedium sutchuenense的化学成分进行研究。方法 利用硅胶、聚酰胺、Sephadex LH-20、ODS等柱色谱进行分离和纯化,根据化合物的光谱学数据和理化方法鉴定其结构。结果 从四川淫羊藿70%乙醇提取物中分离得到了10个化合物,鉴定其结构为川藿苷A(sutchuenoside A,Ⅰ)、川藿苷B(sutchuenoside B,Ⅱ)、大豆苷元(daidzein,Ⅲ)、宝藿苷-Ⅰ(baohuoside-Ⅰ,Ⅳ)、kaempferide 3-rhamnoside(Ⅴ)、淫羊藿苷(icariin,Ⅵ)、anhydroicaritin-3-O-α-L-rhamnopyranosyl (1→2)-α-L-rhamnopyranoside(Ⅶ)、对羟基苯甲酸(p-hydroxybenzoic acid,Ⅷ)、胡萝卜苷(daucosterol,Ⅸ)、β-谷甾醇(βsitosterol,Ⅹ)。结论 化合物Ⅰ和Ⅱ为新化合物,分别命名为sutchuenoside A和B,俗名为川藿苷A和B,化合物Ⅲ、Ⅴ、Ⅶ、Ⅷ~Ⅹ系首次从该植物中分离得到。  相似文献   

7.
目的研究蜀葵Althaea rosea花中的黄酮类化学成分。方法用各种柱色谱方法进行分离纯化,根据理化性质和波谱解析鉴定其化学结构。结果分离得到9个黄酮类化合物,分别鉴定为紫云英苷(astragalin,Ⅰ)、山柰酚(kaempferol,Ⅱ)、洋芹素(apigenin,Ⅲ)、香橙素(aromadendrin,Ⅳ)、异甘草苷(isoliquiritin,Ⅴ)、南酸枣苷(cho-erospondin,Ⅵ)、虎耳草苷(saxifragin,Ⅶ)、4′,5,7,8-tetrahydroxy-3-methoxyflavone(Ⅷ)、芦丁(rutin,Ⅸ)。结论其中化合物Ⅲ~Ⅷ为首次从蜀葵属中得到,化合物为首次从该植物中得到。  相似文献   

8.
目的:对苦苣菜的化学成分进行研究。方法:利用多种柱色谱方法进行分离纯化,根据光谱数据和理化性质进行结构鉴定。结果:共分离得到六个单体化合物,分别结构鉴定为:20-taraxasten-3β-ol(Ⅰ)、豆甾醇(Ⅱ)、胡萝卜苷(Ⅲ)、槲皮素(Ⅳ)、槲皮素-3-O-β-D-葡萄糖苷(Ⅴ)、山莴苣素(Ⅵ)。结论:其中化合物Ⅰ,Ⅱ,Ⅲ为首次从该植物中分离得到;化合物Ⅵ为首次从该属植物中分离得到。  相似文献   

9.
穿心莲的化学成分   总被引:16,自引:0,他引:16  
目的:研究穿心莲(Andrographis paniculata)叶中的活性成分.方法:用各种色谱方法进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构.结果:从穿心莲叶中分离得到6个化合物,分别鉴定为:8-甲基新穿心莲内酯苷元(8-methylandrograpanin,Ⅰ)、3-脱氢脱氧穿心莲内酯(3-dehydrodeoxyandrographolide,Ⅱ)、新穿心莲内酯苷元(andrograpanin,Ⅲ)、8(17),13-ent-labdadien-15→16-lactone -19-oic acid(Ⅳ)、β-谷甾醇(Ⅴ)和胡萝卜苷(Ⅵ).结论:化合物Ⅱ和Ⅲ为新天然产物,化合物Ⅳ和Ⅴ为首次从该植物中分离得到.  相似文献   

10.
目的 对卫矛Euonymus alatus抗心肌缺血有效部位的化学成分进行研究.方法 利用各种色谱法分离化学成分,通过理化性质和波谱法鉴定化合物的结构.结果 从卫矛中分离得到5个化合物,分别为1-[3-(α-D-吡哺葡萄糖氧基)-4,5-二羟基苯基]-乙酮(Ⅰ)、8-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基苯乙醇(Ⅱ)、丁香酚苷(Ⅲ)、金丝桃苷(Ⅳ)、橙皮苷(Ⅴ).结论 化合物Ⅰ为新化合物,命名为鬼箭羽苷(guijianyuside),化合物Ⅱ、Ⅲ为首次从卫矛中分离得到.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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