胃淋巴瘤的CT诊断

目的探讨胃淋巴瘤的CT表现特征,提高CT对其的诊断价值。方法对32例经病理证实的胃淋巴瘤的CT表现,包括胃受累的部位、病灶大体形态、侵犯范围、胃壁厚度、浆膜及胃周脂肪间隙受累情况、增强后病灶与周围肌肉的比较、有无坏死、有无其他器官受累、胃周及其他腹部淋巴结情况进行分析。结果本组32例病例大多数发生在胃窦和胃体,胃壁累及范围均大于胃周径的75%,胃壁厚度不均,胃壁最大厚度〉10 mm的有25例（78%）。27例（85%）有一处或一处以上胃周、腹膜后、肝门区、肠系膜淋巴结肿大。20例（61%）病人有腹膜后肾门水平下淋巴结的肿大。24例（75%）病例合并脾肿大。结论胃淋巴瘤的CT表现有一定特征性,有助于其诊断。     

多排螺旋CT对原发性胃淋巴瘤的CT征象分析

目的：分析原发性胃淋巴瘤（primary gastric lymphoma,PGL）的CT表现。方法回顾性分析经胃镜活检或手术切除病理证实的51例PGL患者的CT表现,分析肿瘤的部位、形态、密度、强化程度、淋巴结情况等。结果该组51例PGL病例均为非霍奇金淋巴瘤,以同时累及胃体、胃窦部多见（占45.1%）;全部病例均出现胃壁增厚,以弥漫性增厚多见（占49.2%）;CT显示增厚胃壁密度均匀,未见坏死区,增强扫描轻中度均匀强化;68.6％的病例可见溃疡样改变,41.2%的病例伴有胃周淋巴结肿大。结论 PGL的CT表现具有一定特征性,在PGL的诊断与鉴别方面起重要作用。     

64排螺旋CT对胃淋巴瘤的CT征象分析

目的 分析64排螺旋CT对胃淋巴瘤的CT征象特点,并探讨其对该病的诊断价值.方法 回顾性分析21例经胃镜活检或手术切除病理证实淋巴瘤的64层螺旋CT表现.结果 本组21例患者均为非霍奇金氏淋巴瘤.病变部位:3例胃窦,5例胃体,9例累及两个及以上部位,4例为弥漫浸润,同时累及两个及以上部位的占61.90%;胃壁呈不均匀增厚,厚度范围为1.3～5.4 cm,均数3.4 cm,其中9.52%呈局限性增厚,4.29%呈节段性增厚, 76.19%呈弥漫性增厚,2例显示深溃疡形成,1例胃黏膜呈"梳齿征".增强扫描病灶呈中度强化.95.24%病灶显示胃腔形态可改变.80.95%病灶胃周围脂肪间隙清晰.结论 胃淋巴瘤的CT表现具有一定的特征性,多个部位或弥漫性胃壁不均匀增厚,黏膜皱襞结节样增厚,胃周脂肪间隙清晰,胃壁有一定扩张度和柔软度时高度提示胃淋巴瘤可能.     

原发性胃淋巴瘤的CT和MR影像表现对比

目的对比分析原发性胃淋巴瘤CT和MR影像学表表现,为临床诊断提供参考。方法回顾性分析我院收治原发性胃淋巴瘤患者临床资料,整理CT和MR影像学表现。结果 CT和MRI诊断均能够清晰显示原发性胃淋巴瘤病变范围、部位以及周围淋巴结情况,3例近累及胃体,7例累及胃体和胃窦,6例累及胃底,3例同时累及胃体、胃底和胃窦,3例累及贲门和胃底,所有患者均出现胃壁增厚情况,CT诊断3例患者浆膜面模糊,MRI诊断6例患者浆膜面模糊。CT扫描20例患者均匀轻度强化,2例患者重度不均匀强化,MRI诊断11例患者增强,其中9例均匀轻度强化,2例中度不均匀强化,所有患者DWI信号出现高信号,突出显示肿瘤及转移淋巴结高信号,对比明显。结论原发性胃淋巴瘤CT和MR影像学表现存在一定特点,联合使用对诊断有更高的价值。     

胃弥漫大B细胞淋巴瘤与黏膜相关淋巴组织淋巴瘤CT比较研究

目的探讨胃淋巴瘤两种主要类型：弥漫性大B细胞淋巴瘤（Diffuse large B—ceil lymphoma,DLBCL）和黏膜相关淋巴组织淋巴瘤（Mucosa-gssociated lymphoid tissue Iymphoma,MALToma）CT征象的异同,为胃淋巴瘤的生物学行为评价和影像学鉴别诊断提供依据。方法回顾分析我院规范CT检查胃淋巴瘤病例42例,均经胃镜或手术病理证实。根据病理结果将全部病例分为DLBCL和MALToma。分析两种类型淋巴瘤CT影像学征象特征,包括病变所处胃的分部、范围、形态、厚度、强化、黏膜及浆膜面情况、淋巴结转移、腹腔大血管及脏器侵犯情况、腹腔转移及有无腹水等。统计学分析比较两种类型淋巴瘤的CT征象差异。结果DLBCL多累及胃的多个部分,且以近端胃受累为主,MALToma以胃的单一部分受累更为多见,且以胃远端分布为主,差异有显著性。DLBCL癌肿平均厚度（275±152）cm,大于MALToma癌肿平均厚度（123±064）cm,差异存在显著性（P〈0．01）。DLBCL胃壁以弥漫性、不均匀增厚为主,MALToma以局限性、均匀增厚为主;DLBCL较MALToma更易侵犯浆膜,淋巴结转移率较MALToma高,转移淋巴结体积大、分布更为广泛,侵犯腹腔干分支大血管及腹腔脏器的比例均高于MALToma。DLBCL静脉期强化0T值（6909±1349）HU．低于MALToma静脉期强化CT值（81．79±25．82）Hu。MALToma黏膜面“白线征”显示率高于DLBCL;DLBCL浆膜侧“血管穿行征”显示率高于MALToma。结论GT影像学征象可反映DLBCL和MALToma的生物学行为,显示两种胃淋巴瘤侵袭性的差异,可作为两者鉴别的重要手段。MALToma黏膜面“白线征”、DLBCL浆膜侧“血管穿行征”丰富了胃淋巴瘤的CT征象,为鉴别诊断及生物学行为评价提供了新的指标。     

原发性胃淋巴瘤的多排螺旋CT表现及病理对照分析

目的 分析胃淋巴瘤病理特点及多排螺旋CT表现,旨在提高对该病的认识及诊断水平。方法 回顾性分析安徽医科大学第一附属医院2017年1月至2019年12月经活检或手术病理证实的11例原发性胃淋巴瘤患者的CT图像,其中男性7例、女性4例,年龄40~75岁,分析CT图像上病变部位、形态及强化特点。结果 11例均为非霍奇金淋巴瘤,其中9例为弥漫大B淋巴瘤,1例为套细胞淋巴瘤,1例为黏膜相关淋巴组织结外边缘区淋巴瘤。CT均表现为胃壁较广泛增厚,呈均匀软组织密度,无明显钙化及低密度坏死区,增强扫描呈轻中度均匀强化,黏膜破坏较轻,病变多发生于胃体、胃窦部,伴胃腔扩张4例,3例伴有胃周淋巴结肿大。结论 胃淋巴瘤CT表现具有一定的特异性,可以全面反映胃壁受累范围及病灶与邻近组织关系、腹腔及腹膜后淋巴结肿大情况,对临床诊断及治疗具有重要意义。     

原发性胃淋巴瘤的多排螺旋CT诊断

目的 分析原发性胃淋巴瘤的CT表现,探讨CT诊断原发性胃淋巴瘤的价值.方法 回顾性分析经手术病理免疫组织化学证实的16例原发性胃淋巴瘤的临床及影像学资料.结果 16例原发性胃淋巴瘤患者均为非霍奇金淋巴瘤;CT表现为胃壁不均匀增厚,其中弥漫性增厚9例,节段性增厚4例,局限性增厚3例;14例呈均匀强化,2例内见片状低密度坏死;12例胃壁黏膜完整,4例黏膜破坏;胃壁浆膜面模糊1例,浆膜面清晰15例; 5例胃周淋巴结肿大.结论 CT检查对原发性胃淋巴瘤诊断有较高价值,并有助于肿瘤的定位、定性诊断.     

胸部结节病的CT诊断与分析

【目的】分析结节病的CT表现，以提高对本病的认识和诊断水平。【方法】回顾性分析经活检证实52例胸部结节病的CT表现。【结果】52例结节病中，肺门、纵隔淋巴结肿大46例（88．5％），其中仅见肺门或／和纵隔淋巴结肿大16例（30．7％），肺门或／和纵隔淋巴结肿大伴有肺内改变30例（57．5％），仅见肺部侵润性改变而无淋巴结肿大2例（3．8％），肺纤维性改变4例（7．7％）。肺内主要表现为结节影（30例），支气管血管束增粗（14例），小叶间隔增厚（8例），实变影（2例），磨玻璃影（2例）。【结论】双侧肺门对称性淋巴结肿大和／或纵隔淋巴结肿大以及沿支气管血管束分布的结节影是胸部结节病的特征性表现；不典型者需密切结合临床检查及治疗后随访。     

胃壁增厚的CT研究及应用价值

目的 提高CT对于引起胃壁增厚的胃部病变的诊断及应用价值重要性的认识.方法 回顾性分析经手术病理及胃镜病理证实的82例胃壁增厚患者CT表现,并与正常胃壁厚度相比较,从胃壁增厚的程度、形态等来诊断及鉴别胃壁增厚的病变.结果 82例胃部疾病,其中胃癌45例、胃淋巴瘤17例、间质瘤12例、胃炎8例,累及范围共122处;其中胃窦部56处,平均厚度(19.3+11.8)mm;胃体部45处,平均厚度(32.6+12.3)mm;胃底贲门部21处,平均厚度(39.1+7.5)mm;与正常各区胃壁厚度有显著性差异.本组82例病例胃壁增厚的CT类型:条形或梭形增厚(30)、肿块形增厚(14)、结节形增厚(5)、溃疡型增厚(10)、不规则形增厚(8)、混合型增厚(15)等.结论 CT对于胃壁增厚的厚度、形态等的观察有很大的价值,能够较好地准确诊断胃壁增厚的相关疾病及鉴别诊断.     

恶性淋巴瘤累及腹腔、腹膜后淋巴结的多层螺旋CT表现特征

目的：总结分析恶性淋巴瘤累及腹腔、腹膜后淋巴结的多层螺旋CT表现特征。方法选择2013年10月至2014年3月期间医院收治的40例恶性淋巴瘤累及腹腔、腹膜后淋巴结患者为研究对象,其中10例霍奇金病,30例非霍奇金淋巴瘤,分析40例患者多层螺旋CT表现中受累淋巴结大小、形态以及密度等特征。结果 HL中受累淋巴结部位数为62个,其中均匀强化密度55个,均匀强化合并坏死7个。 NHL中受累淋巴结部位数为180个,其中均匀强化密度165个,均匀强化合并坏死15个;主要累及肝十二指肠韧带、胰周与腹主动脉周边上下、肝胃韧带淋巴结等。结论多层螺旋CT能清楚显示恶性淋巴瘤累及腹腔、腹膜后淋巴结的特异性病理变化。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…