红景天对兔烫伤后多器官功能障碍综合征的治疗作用

目的　研究兔烫伤早期多器官功能障碍综合征(MODS)及红景天的防治作用 ,并分析其作用机制 .方法　制备兔烫伤后早期 MODS模型 .检测假烫 (SB)组、烫伤 (B)组、口服红景天对照 (R)组、烫伤红景天治疗 (BR)组的平均动脉压、中心静脉压、心输出量 ,计算总外周阻力、心指数 ;测定肺泡灌洗液蛋白及血浆总蛋白 ,计算肺通透指数 ;测定动脉血氧分压、氧饱和度 ,测定血中肌酸磷酸激酶、谷丙转氨酶、尿素、肌酐、血小板等反映心、肺、肝、肾、血液功能的一系列指标 .用 Griess法测定血中、肺泡灌洗液中一氧化氮 (NO)含量 .结果　烫伤后 4 8h反映动物心、肝、肾功能的血清学指标肌酸磷酸激酶、谷丙转氨酶、尿素均明显上升 ,与 SB组比 ,分别由 (781± 14 9) ,(46± 2 0 ) ,(5 .91± 0 .97)升高到 (15 5 36 3±6 6 5 78) ,(16 0± 115 ) ,(2 0 .6 7± 13.0 8) ,(P<0 .0 5 ) ,达到多器官功能障碍标准 ,肺功能下降 ,总外周阻力上升 ,动物发生MODS.血中及支气管肺泡灌洗液 NO含量均明显增多 ,与SB组比 ,分别由 (49.80± 2 8.35 ) ,(2 .37± 0 . 4 2 )增加到(76 .12± 2 5 .16 ) ,(4.0 3± 1.34) ,(P<0 .0 5 ) .烫伤红景天治疗组动物的心、肾功能明显改善 ,与 B组比 ,肌酸磷酸激酶 :(75 16 4± 35 0 4 3) ,尿素 :(9.6 9±     

前列腺增生症尿视黄醇结合蛋白测定的临床意义

目的了解良性前列腺增生症(BPH)产生的下尿路梗阻对肾功能损害.方法新鲜随意尿10ml测定视黄醇结合蛋白(retinol-binding protein RBP)测定,同时测定血尿素氮(BUN)和肌酐(Cr)水平;B超测定残余尿.结果残余尿量50～100ml,尿RBP24.30±5.9μg/mmol,BUN6.2±7.21mmol/l,Cr112.21±31.86μmol/l;残余尿量100～300ml,尿RBP29.30±4.87μg/mmol,BUN6.9±6.18mmol/l,Cr94±1.02μmol/l;尿潴留,尿RBP33.33±5.0μg/mmol,,BUN7.04±4.32mmol/l,Cr127±6.31μmol/l.结论 RBP与残余尿量呈正相关.     

围术期多巴酚丁胺联用去甲肾上腺素对感染性休克患者肾功能的影响

目的：比较围术期联合使用多巴酚丁胺加去甲肾上腺素与多巴胺加去甲肾上腺素对感染性休克患者肾功能的影响。方法：20例感染性休克患者经过液体复苏后,随机分为Ⅰ组(多巴酚丁胺加去甲肾上腺素)和 Ⅱ组(多巴胺加去甲肾上腺素),观察尿量、尿肌酐（UCr）、肌酐清除率(CCr)及钠排泄分数(FeNa)的变化。结果：Ⅰ组3 h时UCr、CCr明显高于基础值和Ⅱ组,差异有显著性（P＜0.05)。结论：围术期感染性休克患者联合使用多巴酚丁胺加去甲肾上腺素,不但提升血压,而且能保护肾功能,是治疗感染性休克较理想的血管活性药。     

液体复苏量与急性重症胰腺炎患者腹内高压及肾脏损害的关系

目的：探讨大量液体复苏对急性重症胰腺炎（SAP）腹内高压及肾脏损害的关联性。方法：以60例SAP患者为研究对象,以AbViser法测量腹内压,将研究对象分为正常组、IAH组和ACS组,统计分析各组的一般情况、死亡率、液体复苏量及肾功能损害情况。结果：①本研究中IAH发病率为31.67%,ACS发病率为11.67%,ACS组死亡率显著高于正常组,分别为57.14% vs 5.88%,p=0.007;② 正常组、IAH组和ACS组3日液体平衡量组间比较具有差异,分别为4350±892ml VS 5512±1246ml VS 5974±1765ml,p＜0.001;总液体累积量同样具有组间差异,分别为8530±2384ml、9403±2064ml、13172±2409ml,p＜0.001;其中ACS组3日液体平衡量及液体累积量均为最高;③正常组、IAH组和ACS组肾功能生化指标血肌酐、尿素氮均具有组间差异,p均＜0.001,ACS组血肌酐、尿素氮水平均显著高于正常组及IAH组,p＜0.05。结论：SAP患者前3日液体累积量与腹腔内压增高、甚至ACS发生密切相关,而腹内压增高将进而导致SAP患者肾功能损伤。     

尿流量动态监测仪对ICU休克早期患者的观察及临床意义

目的评价尿流量动态监测仪对ICU休克早期患者实现液体复苏的影响以及临床意义。方法选择2016年4月至2017年7月在我院重症监护室住院的84例休克患者,其中对照组42例患者采用尿袋或量杯监测尿量,观察组42例患者接受尿流量动态监测仪监测尿量。比较两组复苏前、复苏后6h的中心静脉压(CVP)、平均动脉压(MAP)、中心静脉血氧饱和度(SCVO_2)、尿量变化情况、患者实现液体复苏所需时间以及实现6h复苏的成功率。结果观察组患者实现液体复苏所需要的平均时间为(3.29±1.15)h,短于对照组(P0.05);观察组40例患者实现6h液体复苏,复苏率为95.24%,高于对照组(P0.05)。患者苏醒后6h,观察组患者CVP、MAP、SCVO2、尿量均高于对照组以及苏醒前数值(P0.05)。结论尿流量动态监测能及时、全面、动态、准确地反映患者的尿流量情况。     

腹膜透析患者残余肾功能保护的观察

目的 :探讨腹膜透析患者残余肾功能的保护措施。方法 :观察 6例腹膜透析患者的残余肾功能和尿量变化 ,为期 1年。男 2例 ,女 4例 ,年龄 2 5～ 6 2岁。原发病为慢性肾小球肾炎、糖尿病和高血压病。均采用 Baxter双联透析液CAPD治疗 ,每天 4次。同时配合注射 EPO、降血压和营养治疗等。透析前血尿素氮 (BUN)(38.2± 1 1 .7) mmol/ L,肌酐 (Scr) (830± 2 5 4)μmol/ L,2 4h尿量 (6 40± 1 80 ) ml。透析 1个月后 BUN(1 7.6± 8.5 ) mmol/ L ,Scr(4 91± 1 2 0 )μmol/ L,2 4h尿量 (4 6 0± 1 1 0 ) ml。透析 1 2月后 BUN(1 9.7± 9.…     

尿毒症腹膜透析患者同型半胱氨酸清除机制的临床研究

目的:探讨持续不卧床腹膜透析(CAPD)及残余肾功能(RRF)对尿毒症患者血同型半胱氨酸(Hcy)的清除的影响.方法:留取22例CAPD患者24 h的透出液及尿液,同日取血标本,用高压液相色谱技术(HPLC)测定血清、透出液的总同型半胱氨酸(tHcy)浓度;常规检测血、透出液和尿液的尿素氮、肌酐值;计算总尿素清除指数(Kt/V)、RRF、腹膜tHcy清除率和每日腹透液tHcy清除量.结果:CAPD患者的血tHcy平均浓度高于正常人[(15.95±3.77) vs (8.87±2.43) μmol/L,P＜0.05],平均每日tHcy清除量为(15.24±4.52) μmol.RRF与血tHcy浓度无关,与每日腹透液tHcy清除量呈负相关;Kt/V与每日腹透液tHcy清除量呈正相关,与血tHcy浓度无关.结论:CAPD患者血tHcy水平较正常人升高;RRF及Kt/V对CAPD患者血tHcy浓度的降低影响较小.     

分钟尿流量监测在脓毒症早期液体复苏中的应用研究

目的探讨分钟尿流量监测在脓毒症早期液体复苏中的应用价值。方法选取2014年5月~2016年2月收住重症监护室(ICU)的脓毒症早期液体复苏患者60例,随机分为研究组和对照组;两组患者均按照中华医学会重症医学分会制定的《中国严重脓毒症/脓毒性休克治疗指南(2014)》进行规范化治疗及液体复苏治疗、护理,在此基础上,对照组留置导尿管采用传统的尿量监测法(量杯测量尿量)监测记录尿量,研究组留置导尿管采用分钟尿流量监测仪监测记录尿量,根据测量结果分析、调整液体入量及性质;观察比较两组复苏前、复苏后6 h的中心静脉压(CVP)、平均动脉压(MAP)、中心静脉血氧饱和度(SCVO2)、尿量变化情况,实现液体复苏目标所需时间及6 h内液体复苏目标实现率。结果复苏前两组CVP、MAP、SCVO2、尿量比较差异无统计学意义(P>0.05);复苏后6 h两组CVP、MAP、SCVO2、尿量均较复苏前显著改善(P<0.01),但研究组改善程度优于对照组(P<0.01);研究组实现液体复苏目标所需时间为(3.83±0.83)h,对照组为(5.17±0.92)h,两组比较差异有统计学意义(P<0.001);6 h内实现液体复苏目标研究组为29例,实现率为96.67%,对照组为22例,实现率为73.33%,两组比较差异有统计学意义(P=0.030)。结论与传统尿量监测方法相比,分钟尿流量监测能更及时、动态、真实反映患者尿量的实际情况,有利于发现患者的血容量变化,及时分析调整恢复有效血容量,更快更有效地实现6 h内早期液体复苏目标,值得临床推广使用。     

解聚复肾宁对糖尿病鼠尿TGF-β1的影响及肾保护作用研究

目的:探讨解聚复肾宁(JJFSN)对糖尿病(DM)大鼠尿转化生长因子-β1(TGF-β1)的影响及肾脏保护作用。方法:建立链脲佐菌素(STZ)诱导的SD大鼠DM模型,将成模DM大鼠随机分为2组:DM模型(B组)、JJFSN组(C组),另设正常对照组(A组)。采用相应干预措施处理12周。常规方法测定12周末各组大鼠肾功能、24h尿量、24h尿蛋白定量(24hPro)、尿肌酐;ELISA法测定尿TGF-β1的水平;光镜观察肾脏形态。结果:与DM模型比较,JJFSN组大鼠尿素氮(BUN)、血肌酐(Scr)、24hPro、24h尿量、尿TGF-β1水平明显降低(P﹤0.05),尿肌酐排泄增高(P﹤0.05)。结论:JJFSN对DM大鼠肾脏具有保护作用,其机制可能与降低尿TGF-β1有关。     

泌尿系统常见症状的护理

一、尿量异常的护理 尿量异常分为少尿、无尿、多尿. 1.少尿或无尿护理 (1)加强监测:少尿或无尿病人因肾功能减退,常伴有血尿素氮及血清肌酐增高,电解质紊乱和酸碱平衡失调等现象.临床对于少尿或无尿病人要严密监测血尿素氮和血肌酐水平;密切关注电解质变化和有无代谢性酸中毒的表现,必要时予以纠正.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.