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1.
广州管圆线虫病(Angiostrongyliasis)是由广州管圆线虫(Angiostrongylus cantonensis)幼虫侵入人体中枢神经系统,继而导致嗜酸粒细胞增多性脑膜脑炎。同时幼虫也可侵犯身体其他器官,导致相应脏器功能异常。由于广州管圆线虫病在我国多发生于南方地区,北方发病率较低,因而容易导致误诊误治的发生。我院最近收治4例广州管圆线虫病致嗜酸粒细胞增多性脑膜脑炎患者,为提高临床医师的诊断意识,现报道如下。  相似文献   

2.
广州管圆线虫病临床诊治与预防   总被引:8,自引:1,他引:8  
广州管圆线虫病(angiostrongyliasis cantonensis)又名嗜酸性粒细胞增多性脑脊髓膜炎,为食源性寄生虫病。因进食了含有广州管圆线虫幼虫的生或不熟的螺肉而感染,病变主要侵犯中枢神经系统,表现为脑膜炎、脑膜脑炎、脑脊髓膜炎,脑脊液内出现大量嗜酸性粒细胞。2006年6月中旬至8月底,北京市小范围局部广州管圆线虫病暴发。截至8月25日,临床诊断97例,住院治疗56例,治愈出院9例。  相似文献   

3.
广州管圆线虫病又称嗜酸性粒细胞增多性脑膜脑炎.因食入生的或不熟的含有广州管圆线虫幼虫的螺肉,幼虫寄生在中枢神经系统而致病.其主要临床表现为脑膜炎、脊髓膜炎、脑炎或脊髓炎,脑脊液内有大量嗜酸粒细胞.本例实验室检查与结核性脑膜炎十分相似,造成误诊,报告如下.  相似文献   

4.
正广州管圆线虫病(Angiostrongyliasis)是由广州管圆线虫(Angiostrongylus cantonensis)引起的一种人兽共患病。人是广州管圆线虫的非正常属主,其幼虫侵入人体后,进入中枢神经系统,可引起嗜酸粒细胞增多性脑膜炎或脑炎,对人体危害很大。我院最近收治1例广州管圆线虫病致嗜酸粒细胞增多性脑膜脑炎患儿,现报道如下。1资料病例:男,9岁2月。因"头痛、反复呕吐12天,伴神萎6天、发热2  相似文献   

5.
广州管圆线虫病是因为人被其幼虫感染后致使中枢神经损伤而出现的相关病症,又称嗜酸性粒细胞增多性脑膜脑炎或嗜酸性粒细胞增多性脑脊髓膜炎(Angiostrongy luscanto—nensis)。广州管圆线虫成虫首先由我国陈心陶教授于1935年在广州家鼠及褐家鼠的肺部检出。1945年Normura和Lin首次报道在我国台湾省一患者脑脊液(CSF)中找到广州管圆线虫幼龄成虫。  相似文献   

6.
曾炘  吴忠道 《热带医学杂志》2011,11(9):1091-1093
广州管圆线虫是一种鼠源性寄生虫,其幼虫侵入人体后,可引起嗜酸性粒细胞增多性脑膜炎或嗜酸性粒细胞增多性脑膜脑炎。本文综述了近年来有关广州管圆线虫生活史的实验研究进展,以加深对广州管圆线虫病的认识。  相似文献   

7.
广州管圆线虫病是重要的人兽共患病。广州管圆线虫三期幼虫侵犯人体神经系统,损伤神经细胞,引起嗜酸性粒细胞增多性脑膜炎或脑膜脑炎。本文主要讨论从人体感染广州管圆线虫后,虫体抗原激活小胶质细胞释放大量NO以及IL-4、IL-5、TNF-a、IFN-γ等炎性因子,分析这些炎性因子致神经细胞损伤的发病机制,从而寻找预防和治疗广州管圆线虫病的有效措施。  相似文献   

8.
冯英  吴忠道 《热带医学杂志》2012,12(7):911-912,916
正广州管圆线虫病(angiostrongyliasis cantonensis)又称嗜酸粒细胞增多性脑膜脑炎或脑脊髓膜炎,主要是食生或半生的感染广州管圆线虫Ⅲ期幼虫的福寿螺螺肉而感染,幼虫寄生在中枢神经系统,引起脑膜炎、脊髓膜炎、脑炎、脊髓炎等。幼虫可以侵犯眼  相似文献   

9.
一例严重广州管圆线虫病病例报道   总被引:4,自引:0,他引:4  
广州管圆线虫[Angiostrongylus cantonensis(Chen,1935)Dougherty,1946]由我国陈心陶教授于1933年在广州的鼠体内首次发现,首例病人1945年报告于台湾。广州管圆线虫病又名嗜酸粒细胞增多性脑膜脑炎,是一种食物源性寄生虫病。全球已报道确诊和疑似病例达3000余例,其中我国台湾省  相似文献   

10.
目的探讨广州管圆线虫病的临床特点,诊治方法、疗效以及感染源。方法回顾性分析42例广州管圃线虫病患者的临床表现、实验室检查资料、诊治情况以及开展流行病学调查。结果广州管圆线虫病的临床表现复杂多样,但以头痛为主征;血白细胞可正常(28例,66.67%)或升高(14例,33.33%),大部分病例血嗜酸性细胞升高(31例。73.81%);全部病例脑脊液白细胞数、嗜酸性细胞均升高,但少部分病例脑脊液嗜酸性细胞早期并不升高;早期误诊率高(42.8%);用阿苯哒唑治愈率100%,药物主要不良反应是肝脏损伤;流行病学调查证实是一起输入性暴发事件。结论大理地区广州管圆线虫病全部为输入性病例,头痛为其主要临床表现。早期易误诊,血液、脑脊液中嗜酸性细胞升高为特征性改变,是诊断的主要依据,阿苯哒唑治疗安全有效。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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