精氨酸联合瑞甘治疗亚临床肝性脑病的疗效及安全性分析

目的:探讨精氨酸联合瑞甘(门冬氨酸鸟氨酸)治疗亚临床肝性脑病(SHE)的疗效及安全性.方法:选取2015年4月～2019年4月我院收治的SHE患者80例,用随机数字表法分为观察组和对照组各40例.观察组患者予以精氨酸+瑞甘治疗,对照组患者予以精氨酸治疗.治疗前后检测患者血氨及血清丙氨酸转氨酶(ALT)、总胆红素(TBIL)、内毒素(ET)水平,使用数字连接试验A(NCT-A)、数字连接试验B(NCT-B)、线追踪试验(LTT)、数字符号试验(DST)对患者进行智力测试,用特异性亚临床肝性脑病患者生命质量量表评估患者生命质量,记录患者肝性脑病发生率和不良反应发生情况.结果:治疗2周后,两组患者血氨及血清ALT、ET水平均较治疗前降低,NCT-A、NCT-B、LTT、DST以及生理功能、心理功能、躯体症状及治疗副作用等生命质量评分均较治疗前降低,且观察组上述指标低于对照组;随访3个月,观察组患者肝性脑病发生率(10.0％)低于对照组(27.5％);观察组患者5例(12.5％)出现恶心、呕吐,余下患者未见不良反应.结论:精氨酸联合瑞甘治疗SHE可有效降低血氨,减轻肝脏损伤,提高智力水平,改善生命质量,降低肝性脑病发生率,且具有较高的安全性.     

慢性乙型肝炎血液生化指标与肝脏纤维化相关性研究

目的：探讨慢性乙型肝炎病人常见血液生化指标与肝组织纤维化相关性。方法：回顾性调查120例肝活检慢性乙型肝炎病人资料，对病人血液常规、生化指标、HBV DNA定量、血清甲胎蛋白进行等级相关、等级回归及Logistic回归等统计学分析。结果：1-氨酰转肽酶（GGT）、甲胎蛋白（AFP）、天冬氨酸转氨酶（AST）、凝血酶原时间（PT）、白蛋白（ALB）、血小板（PLT）、总胆红素（TB）、血清丙氨酸转氨酶（ALT）与炎症程度相关；PLT、ALB、PT、GGT水平显著影响炎症分级，预测准确率60％；AFP、PT、GGT、PLT、ALB、TB、AST与肝纤维化相关，其中PLT、ALB、AST及GGT显著影响肝纤维化分期，预测准确率62．0％。PLT、GGT参与代偿性肝硬化诊断敏感度27％，特异度96．7％，准确率83．2％，阳性预告值66．7％，阴性预告值84．6％；PLT100×10^9／L单一指标诊断代偿性肝硬化ROC下面积0．793，特异度98．4％，敏感度23．1％，准确率85．6％，阳性预告值75％、阴性预告值86．2％。结论：在慢性乙型肝炎常见血液生化指标中，血清GGT、AFP、AST、PT、ALB、PLT、TB与肝脏炎症、纤维化有相关性，PLT、ALB、AST及GGT显著影响肝纤维化分期，PLT、GGT预测肝硬化准确率83．2％。     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP） 血红蛋白（Hb） 白细胞（WBC） 红细胞（RBC） 血小板（PLT） 动脉血氧分压（PaO2） 动脉血二氧化碳分压（PaCO2） 丙氨酸氨基转移酶（ALT） 天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

本刊可以直接用的缩写词

血压（BP）血红蛋白（Hb）白细胞（WBC）红细胞（RBC）血小板（PLT）动脉血氧分压（PaO2）动脉血二氧化碳分压（PaCO2）丙氨酸氨基转移酶（ALT）天冬氨酸氨基转移酶（AST）     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.