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1.
溶致液晶是由两亲性分子溶解在极性溶剂中形成的具有特殊几何结构的体系,根据结构的不同,可分为层状液晶、立方相液晶及六角相液晶。近年来,溶致液晶已应用于药物传递领域,尤其是在经皮和黏膜给药系统上表现出独特的优势,如高生物黏附性、高透皮渗透性、低流动性、缓慢释药等。笔者结合所在课题组对溶致液晶在鼻腔给药、经皮给药的研究和相关文献,探讨并分析溶致液晶用于经皮及黏膜给药的技术策略,着重探讨了在鼻腔黏膜给药领域的研究策略,最终为溶致液晶在经皮及黏膜给药制剂的进一步研究提供理论基础和研究方向。  相似文献   

2.
60Co辐射对肝脏类脂滴液晶态织构的改变安虎雁古丽努尔·木哈买提马明珍(新疆医学院物理学教研室)(新疆医学院附属肿瘤医院放疗科)(新疆石油学院)电离辐射具有广泛的生物学作用,放射分子生物学的研究逐渐趋向于各种辐射效应的分子机制。由于液晶态对温度、光线...  相似文献   

3.
液晶是一种介于液体和晶体之间的物质状态,按其形成方式不同可分为两大类:一类是因加热而产生的液晶态,称为热致性液晶;另一类是将某种物质溶于特定/的溶剂而形成的液晶态,称为溶致性液晶。若按照其结构不同可分为三种类型:向列型、近晶型和胆甾型[1]。液晶的独...  相似文献   

4.
鼠伤寒杆菌类脂A的制备及其生物学活性   总被引:1,自引:0,他引:1  
类脂A(Lipid A)是细菌内毒素的重要组成成分,与O特异性链、核心多糖3者共同组成高分子的脂多糖(LPS),类脂A是其中活性成分,在脂多糖介导的各种生物学反应中起关键性作用。肠杆菌科细菌的类脂A结构基本相同。从脂多糖中提取类脂A,研究其理化特性和生物学活性有其重要意义,可  相似文献   

5.
本文是对革兰氏阴性菌沙门氏菌脂多糖、化学合成的大肠杆菌型类脂A,以及类脂A部分结构如406成份和脂X诱导人单核细胞产生白细胞介素1(IL-1)的功能的研究报道.类脂A部分结构对脂多糖或类脂A的协同刺激实验表明,无活性的406成份和类脂X具有抑制脂多糖或类脂A介导的IL-释放功能.其抑制效应与类脂A部分结构的剂量明显相关.时相效应和胞浆内IL-1β合成的研究表明,类脂A部分结构介导的抑制作用涉及细胞浆内IL-1蛋白分  相似文献   

6.
作者研究了脂多糖、类脂A以及类脂A部分结构(406成份和类脂X)诱导正常人单个核细胞产生白细胞介素6的免疫调节功能.结果表明,脂多糖的诱导活性大于类脂A:类脂A部分结构缺乏诱导活性,但具有抑制脂多糖和类脂A介导的白细胞介素6释放功能,其抑  相似文献   

7.
根据痤疮的发病机理和桉叶油及中草药的药理作用而形成的天然桉叶油复合配方,经临床试用疗效观察表明,天然桉叶油复合配方对痤疮的治疗和修复的总有效率为95%,且无毒副作用。  相似文献   

8.
促渗剂对水合胼胝类脂热转变影响的差示扫描热分析研究   总被引:8,自引:0,他引:8  
从人胼胝组织提取出类脂经水合后代替人皮肤角质层用作差示扫描热分析研究促渗剂作用的简单模型。研究了1,8-桉油精,月桂氮酮和丙二醇等促渗剂对水合胼胝类脂热转变特征的影响。三种促渗剂均不同程度地降低水合胼胝类脂的热变温度,作用强弱依次为1,8-桉油精>月桂氮酮>丙二醇。丙二醇与1,8-桉油精或月桂氮酮混合应用时对热转变的影响具有协同作用。结果提示促渗剂可能改变脂质分子的排列和增加其流动性。同时,水的存在对脂质分子物理结构的形成具有重要作用。  相似文献   

9.
用偏光显微镜研究了一种新的液晶高分子-丁酸壳聚糖液晶的织构。丁酸壳聚糖能溶于十多种溶剂中形成胆甾型液晶相。指纹状织构是主要织构,此外还观察到鲜偏振场织构、滴状织构、平面织构和条带织构等,与纤维素衍生物的液晶态结构很相似。  相似文献   

10.
桉叶油体外抗菌作用的初步实验研究   总被引:12,自引:0,他引:12  
本文对桉叶油溶液抗菌作用进行了实验研究,当金黄色葡萄球菌为10~8个/ml时,65%桉叶油溶液的最小抑菌浓度(MIC)为1.3mg/ml,桉叶油丹参溶液MIC为0.163mg/ml,其最小杀菌浓度(MBC)分别为2.63mg/ml和0.326mg/ml。桉叶油对革兰阳性菌有抑菌作用,而桉叶油丹参复合液对革兰阳性、阴性菌均有较强抑菌作用,结果表明桉叶油及其与丹参的复合液都具有抗菌作用。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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