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1.
目的:探讨用左氧氟沙星联合甲硝唑治疗急性化脓性阑尾炎的疗效观察。方法:选取2011年3月-2013年10月在我院进行急性化脓性阑尾炎治疗的患者80例,随机将其分为Lev组(左氧氟沙星联合甲硝唑治疗)和Cef组(头孢曲松钠联合甲硝唑治疗)各40例,手术后进行抗菌治疗,1周后分别观察患者的切口感染率、不良反应发生率和腹腔感染率。结果:采用左氧氟沙星联合甲硝唑观察组的切口感染发生率、不良反应发生率和腹腔感染发生率分别为11.8%、18.2%、4.9%,Cef组治疗后的切口感染率、不良反应率和腹腔感染率分别为11.0%、16.2%、4.8%,2者疗效差异无统计学意义(P﹥0.05)。结论:采用左氧氟沙星联合甲硝唑治疗急性化脓性阑尾炎的疗效与头孢曲松钠联合甲硝唑疗效相当,不良反应相同。  相似文献   

2.
目的分析莫西沙星用左氧氟沙星+甲硝唑治疗盆腔炎性疾病临床疗效及安全比较。方法将48例盆腔炎性疾病患者随机分成治疗组26例和对照组22例,两组分别给予莫西沙星空腹喝左氧氟沙星+甲硝唑静脉滴注治疗。结果治疗组合对照组的总有效率分别为84.6%和77.3%,痊愈率分别为65.4%和45.5%,两组比较,总有效率差异无显著性(P〉0.05),治疗组的痊愈率显著高于对照组(P〈0.05)。治疗组不良反应发生率为3.8%,对照组为4.5%,两组差异无显著性((P〉0.05)。结论莫西沙星可以作为盆腔炎性疾病的治疗用药。  相似文献   

3.
零交导数光谱法测定栓剂中氧氟沙星和甲硝唑的含量   总被引:2,自引:0,他引:2  
采用零交导数光谱法测定栓剂中氧氟沙星和甲硝唑的含量。在一定浓度范围内氧氟沙星一阶导数光谱的零交点(293.8nm)不随其浓度的变化而变化,亦即在293.8nm处甲硝唑的一阶导数光谱振幅值不随氧氟沙星浓度的变化而改变,反之亦然,由此不必进行分离即可消除测定中两主药之间的相互干扰。氧氟沙星和甲硝唑的标准曲线的相关系数都为0.9999,样品平均回收率分别为103.1%及100.8%,方法简便、快速、准确  相似文献   

4.
目的:研究通过两种四联方案对Hp阳性胃病患者的疗效观察,比较雷贝拉唑、左氧氟沙星、阿莫西林和果胶铋四药联用与雷贝拉唑、克拉霉素、甲硝唑、果胶铋四药联用的治疗效果。方法:将胃镜检查确认消化性溃疡的188例患者随机分为治疗组和对照组,治疗组服用雷贝拉唑、左氧氟沙星、阿莫西林和果胶铋,对照组将实验组方案中的左氧氟沙星和阿莫西林替换为克拉霉素和甲硝唑。结果:实验组和对照组根除率分别为88.54%和77.17%,不良反应率分别为10.42%和14.13%。结论:雷贝拉唑、左氧氟沙星、阿莫西林和果胶铋四药联用,在缓解消化性溃疡症状的临床方面远较其他药物配伍具有更佳的价效比,可以显著提高Hp的根除率和溃疡的治愈率。  相似文献   

5.
阳帆 《西部医学》2009,21(2):251-252
目的观察潘托拉唑,阿莫西林和左氧氟沙星三联疗法对幽门螺旋茵(Hp)阳性消化性溃疡的疗效。方法将80例消化性溃疡患者随机分为两组。观察组40例,潘托拉唑40mg,每日1次,早餐前口服;阿莫西林胶囊1.0g,每日2次;左氧氟沙星0.2g,每日2次。对照组40例,奥美拉唑20mg,每日2次,早晚空腹各1次;阿莫西林1.0g,每日2次;甲硝唑0.4g,每日2次。2周为1个疗程。治疗结束后4周复查胃镜。结果观察组与对照组的总有效率分别为85%和65%,HP根除率分别为90%和67.5%,均有显著性差异(P〈0.05)。结论潘托拉唑,阿莫西林和左氧氟沙星三联疗法治疗HP相关消化性溃疡有较好的溃疡愈合率和HP根除率。  相似文献   

6.
目的:探讨甲硝唑联合左氧氟沙星治疗慢性盆腔炎的临床疗效。方法:选取2012年6月~2014年6月我院收治的80例慢性盆腔炎患者为研究对象,随机平均分成两组,观察组与对照组,每组各40例。对照组患者仅给予甲硝唑治疗,观察组患者给予甲硝唑联合左氧氟沙星治疗,比较两组患者的临床疗效和不良反应发生情况。结果:观察组患者治愈18例(45.0%),显效11例(27.5%),有效9例(22.5%),总有效率为95.0%,较对照组患者总有效率72.5%有显著性提高,而观察组患者的不良反应总发生率仅为7.5%,远低于对照组患者37.5%,两组比较差异有统计学意义(P<0.05)。结论:慢性盆腔炎患者应用甲硝唑联合左氧氟沙星治疗可有效消除炎症,显著改善临床症状和体征,临床疗效显著且不良反应发生率低,安全、可靠,是临床治疗慢性盆腔炎的有效方法,值得推广使用。  相似文献   

7.
目的:了解幽门螺旋杆菌(H.pylori)对不同种抗菌药物的耐药情况。方法:采用Kirby—Bauer法(以下简称K-B法)对92例H.pylori菌进行抗菌药物敏感实验。结果:H.pylori对甲硝唑敏感率达91.3%,对克扛霉素达92.3%,对阿莫西林达99.0%,对呋喃唑酮达99.0%,对阿奇霉素达95.6%,对左氧氟沙星达100%。结论:甲硝唑、克扭霉素、阿莫西林仍是治疗H.pylori的首选药物,当以上药物耐药时,可以选用左氧氟沙星、呋喃唑酮、阿奇霉素来代替。  相似文献   

8.
目的:比较奥硝唑和替硝唑、甲硝唑治疗滴虫性阴道炎的临床效果和不良反应。方法:将120例滴虫性阴道炎病人,随机分为3组。奥硝唑组40例,口服奥硝唑0.5g,每日2次,疗程5天;替硝唑组40例,口服替硝唑0.5g,每日2次,疗程5天;甲硝唑组40例,口服甲硝唑0.2g,每日3次,疗程7天。结果:奥硝唑、替硝唑、甲硝唑的有效率分别为100%、94.8%、82.1%(P〈0.05)。不良反应发生率分别为12.8%、23.1%、74.4%。结论:奥硝唑治疗滴虫性阴道炎疗程短,不良反应小。  相似文献   

9.
幽门螺杆菌耐药性分析   总被引:1,自引:0,他引:1  
目的 分析幽门螺杆菌对6种临床使用抗生素的耐药率,为临床选用抗生素治疗幽门螺杆菌提供依据。方法 2006年3月~2007年2月期间共采集3304例患者胃镜检查后活检组织做幽门螺杆菌培养,采用Kiby—bauer法对幽门螺杆菌阳性分离菌株进行甲硝唑、阿莫仙、庆大霉素、左氧氟沙星、呋喃唑酮和克拉霉素6种抗生素药敏试验。结果 3304例临床标本中幽门螺杆菌培养阳性为1171例,占35.4%;药敏试验结果显示甲硝唑耐药率最高,达99.32%;左氧氟沙星耐药率最低,仅0.51%,在12个月时间内的两种抗生素耐药率无明显变化;阿莫仙、庆大霉素、呋喃唑酮和克拉霉素均存在不同程度的耐药.耐药率分别为61.06%、4.78%、21.35%和39.45%,且在12个月内的耐药趋势均有明显变化。结论随着根治幽门螺杆菌时抗生素的应用,幽门螺杆菌的抗生素耐药率逐年上升,甲硝唑的耐药率最高;药敏试验对临床幽门螺杆菌菌株的根治具有一定参考作用。  相似文献   

10.
采用紫外差示分光光度法测定复方制剂“耳安”滴耳液中氧氟沙星、甲硝唑的含量。浓度线性范围:氧氟沙星4.801 ̄14.404μg/ml,RDS0.788%;甲硝唑4.817 ̄11.24μg/ml,RSD0.647%。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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