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1.
Objective To evaluate the different influences of anterior and posterior correction and fusion approaches upon disc wedging in adolescent idiopathic thoracolumbar/lumbar scoliosis. Methods The retrospective study was conducted with the medical records and radiographs of adolescent idiopathic thoracolumbar/lumbar scoliosis patients that underwent anterior (group A) or posterior (group B) correction and fusion surgery from December 1998 to May 2008. The correction of the main curve and changes of the disc wedging were analyzed. Results Fifty-three patients were included, 26 in group A and 27 in group B. The mean coronal Cobb angles of the main curve in group A and group B were significantly corrected after surgery (P〈0.05), with an average correction rate of 75.2% and 88.2%, respectively. Upon final follow-up, the coronal Cobb angles of the two groups were 18.9°± 11.1 ° and 7.7°±5.6°, respectively, with an average correction loss of 6.8°±6.5° and 2.7°±3.3°, respectively. The coronal Cobb angle after operation and at final follow-up, and the correction rate were significantly better in group B than those in group A (P〈0.05), while the coronal Cobb angle loss in group A was greater than that in group B (P〈0.05). The disc wedging before operation, after operation, and at final follow-up were 3.2°±3.0° 5.7°±3.0% and 8.6°±4.4° in group A, and 2.4°±3.2° , 3.3°± 3.4°, and 3.7°± 3.6° in group B, respectively. Postoperative disc wedging was significantly larger compared with preoperative measurements in group A (P〈0.05), but not in group B (P〉0.05). The difference between disc wedging at final follow-up and that after surgery was significant in group A (P〈0.05), but not in group B (P〉0.05). Between the two groups, group A had larger disc angles after operation and at final follow-up (P〈0.05), and a greater loss of disc angle (P〈0.05). Conclusion For adolescent idiopathic thoracolumbar/lumbar scoliosis, posterior approach using all pedicle screws might produce a better result in terms of disc wedging compared with anterior approach.  相似文献   

2.
Evaluation of oxidative stress in colorectal cancer patients   总被引:1,自引:0,他引:1  
Objective To evaluate the oxidative stress in patients with colorectal cancer and to investigate the relationship between oxidative stress and colorectal cancer. Methods Seventy-six subjects were divided into two groups (36 colorectal cancer patients as the study group and 40 normal healthy individuals as the control group). Their protein oxidation, DNA damage, lipid peroxidation and antioxidants, vitamin C, vitamin E, glutathione (GSH), and antioxidative enzymes in serum were detected. Results The levels of protein carbonyl and advanced oxidation protein products (AOPP) were significantly higher in the study group than in the control group (P〈0.01). Serum 8-OHdG was significantly increased in the study group compared to the control group (P〈0.01). However, the mean serum level of MDA and conjugated diene was lower in the study group than in the control group (P〈0.01). The activity of antioxidative enzymes was significantly decreased in the study group compared to the control group (P〈0.01). Serum vitamins C and E concentrations were significantly reduced in the study group compared to the control group (P〈0.01). Conclusion Colorectal cancer is associated with oxidative stress, and assessment of oxidative stress and given antioxidants is important for the treatment and prevention of colorectal cancer.  相似文献   

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Objective To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase (MTHFR) gene and methionine synthase (MS) gene. Methods A total of 192 hyperlipidemia patients were selected and divided into hypercholesterolemia group, hypertriglyceridemia group, and combined hyperlipidemia group. Another 208 normal individuals were selected as control. Total plasma homocysteine (tHcy) concentration was measured by high-performance liquid chromatography (HPLC). Lipid profiles were measured for all subjects The polymorphisms of MTHFR gene C677T and MS gene A2756G were analyzed by PCR-RFLP. Results The tHcy concentration in the combined hyperlipidemia patients was significantly higher than that in the control (15.95μmol/L vs 13.43 μmol/L, P〈0.05). The prevalence of hyperhomocysteinemia (HHcy) in the combined hyperlipidemia group was significantly higher than that in the control (42.2% vs 23.0%, P=0.015), with the odds ratio (OR) of 3.339 (95%CI: 1.260-8.849). The hyperlipidemia patients with HHcy had a higher concentration of total cholesterol (TC) than that in the normal tHcy patients (5.67±0.95 mmol/L vs 5.47±0.92 retool/L, P=0.034). There was no significant difference in genotype or allele frequencies of MTHFR C677T between the hyperlipidemic and control groups. The hyperlipidemia patients with MTHFR CT/TT genotype had a higher concentration of triglyceride (TG) than those with CC genotype (2.24±1.75 mmol/L vs 1.87±0.95 mmol/L, P〈0.05). Individuals with CT/TT genotype had a higher concentration of tHcy than those with 677CC genotype both in the hyperlipidemia group (12.61±1.24μmol/L vs 11.20±1.37 μmol/L, P〈0.05) and in the control group (14.04±1.48 μmol/L vs 12.61±1.24 μmol/L, P〈0.05). The percentage of MS 2756 GG/AG genotype in the combined hyperlipidemia group was significantly higher than that in the control (26.7% vs 13.0%, P=0.012), with the OR of 3.  相似文献   

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Background Adjacent segment disease (ASD) is common after cervical fusion.The aim of this study was to evaluate the risk factors for ASD on X-ray and magnetic resonance imaging (MRI).Methods Patients included in this study had received revision surgeries after developing symptomatic ASD following anterior decompression and fusion.A control group that had not developed ASD was matched 1:1 by follow-up time and fusion segments.Plate-to-disc distances (PDDs),developmental cervical canal stenosis on X-ray,cervical disc degeneration grading,and cervical disc bulge impingements on preoperative MRI were measured and compared between the ASD group and the control group.Results Thirty-four patients with complete radiographic data were included in the ASD group.The causative segments of ASD included nine cases of C3-4,18 cases of C4-5,three cases of C5-6,and four cases of C6-7.The ASD occurred at the upper adjacent segments in 26 patients and at the lower adjacent segments in eight patients.PDD distributions were similar between the ASD group and the control group.Developmental cervical canal stenosis was a risk factor for ASD,with an odd ratio value of 2.88.Preoperative cervical disc degenerations on MRI were similar between the ASD group and the control group.In the upper-level ASD group,the disc bulge impingement was (19.7±9.7)%,which was significantly higher than that of the control group of (11.8±4.8)%.Conclusions ASD was more likely to develop above the index level of fusion.Developmental cervical canal stenosis and greater disc bulge impingement may be risk factors for the development of ASD.  相似文献   

7.
Background Patients with sliding hiatus hernia (HH) and reflux esophagitis (RE) usually suffer from esophageal dysmotility. The aim of the present study was to investigate the role of acid reflux and duodenal gastroesophageal reflux (DGER), esophageal manometry, and esophageal dysmotility by applying the barium meal examination.
Methods RE with HH was initially diagnosed using the reflux disease questionnaire, and was further confirmed by a barium meal examination and an endoscopy. The radiographic technique was used to test for spasms, strictures, and the coarseness of the mucosa, also was to study the types of reflux and clearance. Then, the esophageal manometry, the esophageal 24-hour pH, and the bilirubin monitoring were observed.
Results Fifty-five patients were diagnosed as HH combined with RE and divided into two groups according to the severity of their esophagitis: group HH1 (grades A and B) and group HH2 (grades C and D). The barium meal examination revealed that the mucosa was either granular or nodular in all cases. The dump reflux and delayed clearance were more significant in patients in the HH2 group than those in the HH1 group (P 〈0.05). The percentages of total, supine, and upright acid exposure time were greater in patients with HH than those in the control group (P 〈0.01), but the differences between the HH1 and the HH2 groups were not significant. Lower esophageal sphictor pressure (LESP) was lower in the HH group than in the control group (P 〈0.05). Three DGER parameters: the percentage of time with absorbance greater than 0.14, the number of bile reflux episodes, the number of bile refluxes lasting longer than 5 minutes were (28.43±23.34), (40.57±31.30), and (15.15±8.72), respectively in the HH2 group; these statistics were significantly higher than those for the HH1 (P 〈0.05). The frequency and amplitude of peristalsis were all lower in HH patients than in the control (P 〈0.05). Of all the patients, 54.3% (30 of  相似文献   

8.
Background Estrogen deficiency contributes to postmenopausal osteoporosis. Periosteum might be a potential target of estrogen, but the underlying mechanism at gene level is far from being elucidated. The objective of this study was to investigate the correlation between estrogen and fatty acid synthase (FAS) expression in periosteum. Methods Human periosteum cells were cultured in vitro. Expressed genes in the substrated cDNA library were verified using semi-quantitative PCR and real-time PCR. The expression of FAS in periosteum of ovarectomized (OVX) SD rats was investigated. Results FAS gene was most significantly expressed in the subtracted cDNA library of periosteal cells screened by semi-quantitative PCR. Low FAS expression was verified by real-time PCR in the estrogen exposed human periosteum rather than in the control. The estradiol levels were (20.81±12.62) pg/ml, (19.64±4.35) pg/ml and (13.47±1.84) pg/ml in the sham group, the control, and the OVX group, respectively. The estradiol levels in the OVX group was significantly lower (P=-0.0386). The FAS gene expression in periosteum in the OVX group, sham group, and control group was 3.09±1.97, 1.33±0.47 and 1.51±1.32, respectively. The gene expression in the OVX group was significantly higher (P=0.0372). Conclusion Estrogen modulates FAS gene expression in in vitro human perisoteum as well as in in vivo rat periosteum.  相似文献   

9.
Objective: To study the efficacy and safety of autologous transplantation of bone marrow mesenchymal stem cells on diabetic patients with lower limb ischemia. Methods: Fifty Type 2 diabetic patients with lower limb ischemia were enrolled and randomized to either transplanted group or control group. Patients in both group received the same conventional treatment. Meanwhile, 20 ml bone marrow from each transplanted patient were collected, and the mesenchymal stem cells were separated by density gradient centrifugation and cultured in the medium with autologous serum. After three-weeks adherent culture in vitro, 7.32×10^8-5.61×10^9 mesenchymal stem cells were harvested and transplanted by multiple intramuscular and hypodermic injections into the impaired lower limbs. Results: At the end of 12-week follow-up, 5 patients were excluded from this study because of clinical worsening or failure of cell culture. Main ischemic symptoms, including rest pain and intermittent claudication, were improved significantly in transplanted patients. The ulcer healing rate of the transplanted group (1 5 of 18, 83.33%) was significantly higher than that of the control group (9 of 20, 45.00%, P=0.012).The mean of resting ankle-brachial index (ABI) in transplanted group significantly was increased from 0.61±0.09 to 0.74±0.11 (P〈0.001). Magnetic resonance angiography (MRA) demonstrated that there were more patients whose score of new vessels exceeded or equaled to 2 in the transplant patients (11 of 15) than in control patients (2 of 14, P=0.001). Lower limb amputation rate was significantly lower in transplanted group than in the control group (P=0.040). No adverse effects was observed in transplanted group. Conclusion: These results indicate that the autologous transplantation of bone marrow mesenchymal stem cells relieves critical lower limb ischemia and promotes ulcers healing in Type 2 diabetic patients.  相似文献   

10.
Background Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was to compare concentrations of soluble forms of adhesion molecules in patients with different clinical presentations of coronary artery disease (CAD).Methods One hundred and twenty-eight patients with CAD were divided into three groups; the first group was acute myocardial infarction group (AMI group, n=45), the second group was unstable angina pectoris group (UAP group, n=48),the third group was stable angina pectoris group (SAP group, n=35). We compared them with patients with normal coronary arteries (control group, n=31). The serum levels of vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin and P-selectin were measured in all subjects.Results The serum level of VCAM-1 in the AMI group was significantly higher than in the UAP, SAP and control groups (P 〈0.01). The level in the UAP group was significantly higher than the SAP group and control group (P 〈0.01) and the level in the SAP group was significantly higher than in the control group (P 〈0.01). The serum ICAM-1 level was significantly elevated in the AMI, UAP and SAP groups as compared to the control group (P 〈0.01). The levels of serum E-selectin and P-selectin in the AMI and UAP groups were significantly higher than in the SAP and control groups (P〈0.01).Conclusions Increased levels of VCAM-1 and ICAM-1, E-selectin and P-selectin, as markers of inflammation, showed the importance of inflammatory processes in the development of atherosclerosis and clinical expression of CAD. Soluble ICAM-1, VCAM-1, E-selectin and P-selectin concentrations are useful indicators of the presence of atherosclerosis and the severity of CAD clinical presentation.  相似文献   

11.
Background Anterior cruciate ligament reconstruction (ACLR) has developed dramatically in the last century.Now,ACLR has become a reliable and productive procedure.Patients feel satisfied in 〉90% cases.The aim of this study was to evaluate the feasibility of allogenetic cortical bone cross-pin (ACBCP) used as a clinical fixation method in anterior cruciate ligament reconstruction on the femoral side based on biomechanical tests in vitro.Methods The specimens were provided by the bone banks of the First Affiliated Hospital of People's Liberation Army of General Hospital from September 2011 to June 2012.Fresh deep frozen human allogenetic cortical bone was machined into cross-pins which is 4.0 mm in diameter and 75.0 mm in length.Biomechanical parameters compared with Rigidfix were collected while cross-pins were tested in double-shear test.The load-to-failure test and cycling test were carried out in a goat model to reconstruct anterior cruciate ligament with Achilles tendon autograft on the femoral side fixed by human 4.0 mm ACBCP and 3.3 mm Rigidfix served as control.Maximum failure load,yield load,and stiffness of fixation in single load-to-failure test were compared between the two groups.Cycle-specific stiffness and displacement at cycles 1,30,200,400,and 1 000 were also compared in between.Results In double-shear test both maximum failed load and yield load of 4.0 mm humanACBCP were (1 236.998±201.940) N.Maximum failed load and yield load of Rigidfix were (807.929±110.511) N and (592.483±58.821) N.The differences of maximum failed load and yield load were significant between ACBCP and Rigidfix,P 〈0.05.The shear strength of ACBCP and Rigidfix were (49.243±8.039) MPa and (34.637±3.439) MPa,respectively,P 〈0.05.In the load-to-failure test ex vivo,yield load and maximum failed load of ACBCP fixation complexity ((867.104±132.856)N,(1 032.243±196.281) N) were higher than those of Rigidfix ((640.935±42.836) N,(800.568±64.890) N,P 〈0.05).However,s  相似文献   

12.
Background The treatment strategies for multilevel thoracic ossification of the posterior longitudinal ligaments (T-OPLL) were rarely reported. The aim of this study was to investigate the clinical outcomes and complications of circumferential decompression for multilevel T-OPLL and compare two different methods in the management of the OPLL (resection or floating). Methods Data of sequentially treated patients who received surgical treatment for thoracic spinal stenosis caused by multilevel T-OPLL from January 2005 to February 2012 were retrospectively reviewed. Based on the surgical approaches applied, the patients were divided into two groups. Group A consisted the patients who received posterior decompression and group B consisted the patients who received circumferential decompression via the posterior approach. Group B was further divided into two subgroups: subgroup 1 (the resection group) where the OPLL was completely resected and subgroup 2 (the floating group) where the OPLL was floated. Results A total of 49 patients were included in the study. Fourteen patients with single posterior decompression were included in group A and 35 patients who received circumferential decompression were included in group B. In group B, 29 patients had complete resection of the ossified posterior longitudinal ligaments, while the other six underwent a flotation procedure. The follow-up data were available in 39 patients. Mean JOA scores improved from 5.4 ± 1.8 to 7.5 ± 2.8 in group A and from 3.7 ± 1.8 to 7.9 ± 2.4 in group B. The main complications included cerebrospinal fluid (CSF) leakage and postoperative neurelogic deterioration (ND). Twenty-three of the 25 cases with postoperative CSF leakage achieved a complete recovery at the last follow-up and 12 of the 15 cases with ND achieved some neurological improvement at the last follow-up. Conclusions Circumferential decompression via the posterior approach is an effective surgical method for thoracic spinal stenosis caused by multilevel OPLL  相似文献   

13.
目的 探讨窦性心律震荡现象对急性心肌梗死的影响.方法 分析急性心肌梗死(98例)与对照组(30例),急性心肌梗死存活组(75例)与死亡组(23例)的24 h动态心电图,比较各组间的心律震荡(HRT)的震荡初始(TO)和震荡斜率(TS).结果 ①与对照组TO、TS比较,急性心肌梗死组TO值高、TS值低,差异均有统计学意义(P<0.05);②与急性心肌梗死存活组TO、TS比较,死亡组TO值高、TS值低,差异均有统计学意义(P<0.05).结论 窦性心律震荡现象可作为急性心肌梗死死亡率的预测指标. Abstract: Objective To investigate the clinical value of heart rate turbulence(HRT) in acute myocardial infarction ( AMI). Methods HRT onset (TO) and HRT slope (TS) were calculat ed based on holter recorded in 75 survivors of AMI,23 cases died of AMI and 30 normal subjects.Results ①TO was higher and TS was lower in AMI patients than in normal subjects. ②TO was higher and TS was lower in cases died of AMI than in survivors of AMI. Conclusions HRT is relative to death and prognosis of with AMI.  相似文献   

14.
Background The tibial plateau is asymmetric with a larger medial plateau.We observed from clinical practice that the shape of the tibial plateau does not always present a larger medial plateau.Tibial plateau also showed other shapes.The purpose of this study was to analyze the anthropometric data of the proximal tibia in a large group of Chinese patients undergoing total knee arthroplasty and to investigate the morphology of the resected proximal tibial surface and its gender differences.Methods A total of 822 knees (164 males,658 females) from the Chinese population were measured intraoperatively for medial anteroposterior (MAP) and lateral anteroposterior (LAP) dimensions of the resected proximal tibial surface.The difference of MAP and LAP (DML) was also calculated as MAP minus LAP.We then classified the data into three groups based on the DML (<-2,-2 to 2,and >2 mm) to analyze the morphology of the proximal tibia and its distribution between male and female.Results The shape of proximal tibial plateau was of three types:larger medial plateau type,symmetric type,and larger lateral plateau type.There were significant differences between males and females in relation to the shape distribution of the proximal tibial plateau (P <0.05).Most of the proximal tibial plateau was asymmetric,with 517 of 822 (62.9%) tibia having a DML >2 mm and 120 of 822 (14.6%) tibia having a DML<-2 mm.Only 185 of 822 (22.5%) tibia had a DML between-2 and 2 mm.Conclusion The results of this study can be used as a guideline to design tibial components with different DMLs to better match the different anthropometry of the resected tibial surface.  相似文献   

15.
精、神、气、血、津、液是中医理论中6个非常重要的概念,有关术语在《WHO西太区传统医学国际标准名词术语》中一共收录了59条,“世界中医药学会联合会”(以下简称世中联)《中医基本名词术语中英对照国际标准》中收录了58条。血、津、液的内涵较为具体,有一定的物质基础,理解并不困难。翻译上虽有差异,但亦不难统一。精、神、  相似文献   

16.
目的观察益智健脑颗粒联合针灸对阿尔茨海默病(Alzheimers disease,AD)大鼠学习记忆的影响。方法将大鼠随机分为假手术组(A组)、模型组(B组)、针灸组(C组)、益智+针灸组(D组)各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35(Aβ25-35)造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义(P〈0.05);与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义(P〈0.05,P〈0.01);与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义(P〈0.05)。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。  相似文献   

17.
钟文昭  吴一龙 《循证医学》2008,8(4):193-197
以表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI)分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,  相似文献   

18.
The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus (Trg) based on Cytochrome P450 isozymes (CYPs) in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.  相似文献   

19.
程丑夫教授运用六君子汤加减治疗疑难杂症验案举隅   总被引:1,自引:0,他引:1  
程丑夫教授出身中医世家,是全国第五批名老中医学术继承指导老师,主任医师,博士研究生导师,享受国务院特殊津贴。从医40余年来,善于治疗心脑血管疾病、呼吸系统疾病、脾胃病等,在治疗疑难杂症方面尤为突出。笔者有幸跟师门诊,观程师运用六君子汤加减治疗疑难杂症效果显著,现举验案4则来阐述程丑夫教授从脾胃入手治疗疑难杂病的经验。  相似文献   

20.
Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome (MetS) and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio (RR):1.06,95% confidence interval (C/):0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia (RR:0.50,95% CI:0.39-0.64,P <0.01).Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension (RR:0.91,95% CI:0.83-1.00,P=0.06) after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation (RR:1.79,95% CI:0.98-3.27,P=0.06) compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.  相似文献   

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