桥小脑角区肿瘤的MRI诊断和鉴别诊断

目的 探讨桥小脑角区肿瘤MRI的特征、诊断和鉴别诊断。方法 回顾性分析34例经手术和病理证实的桥小脑角区肿瘤的MRI资料，采用T1-SE序列，T2-FSE序列，所有患者均常规行横断面T1WI、T2WI及冠状面T1WI，必要时矢状面T2WI，其中28例加做Gd-DTPA增强扫描。结果 23例听神经瘤中16例听神经增粗并向内耳道延伸，为听神经瘤的典型征象：4例三叉神经瘤均跨中、后颅窝生长呈哑铃状：3例脑膜瘤中1例增强后出现“脑膜尾征”；1例室管膜瘤呈类圆形，与第四脑室出口关系密切；1例蛛网膜囊肿边缘光滑，信号类似脑脊液；1例胆脂瘤边缘光滑，信号均匀，沿桥脑池生长；1例海绵状血管瘤无典型征象。34例桥小脑角区肿瘤术前定位、定性诊断准确率分别为100％、91．2％。结论 MRI是桥小角区肿瘤检查的首选方法，对桥小脑角区肿瘤的诊断和鉴别诊断有重要价值。     

桥小脑角区肿块性病变的MRI表现及其分析

目的MRI的应用对桥小脑角区肿块性病变的诊断具有重要作用。文中分析桥小脑角区肿块性病变的MRI表现,以提高桥小脑角区病变的诊断准确率,为临床治疗方案的制定提供有价值的影像信息。方法选取42例桥小脑角区肿块性病变,行MRI检查和手术病理证实,对该组病变的MRI表现和病理结果进行回顾性对照分析。结果42例桥小脑角区肿瘤中,听神经瘤22例,其中16例表现为实性肿块,6例为囊实性病变,瘤体在T1WI等或稍低信号,在T2WI呈等高混杂信号,囊性部分不强化,实性部分强化;脑膜瘤7例,其中6例表现典型,瘤体在T1WI和T2WI均呈等信号,肿瘤明显均匀强化,5例可见脑膜尾征;蛛网膜囊肿2例,表现为水样信号,病变不强化;表皮样囊肿5例也表现为水样信号,但在DWI上呈高信号,增强扫描无强化。其他病变如髓母细胞瘤2例,海绵状血管瘤、星形细胞瘤、室管膜瘤、内淋巴囊乳头状肿瘤各1例,MRI表现各有特点。MRI的定位准确率95.2%,正确诊断率为88%。结论MRI对桥小脑角区肿块性病变定位、诊断准确率高,但对该部位不典型病变存在误诊现象,应注意鉴别。     

桥脑小脑角区常见肿瘤的MR诊断及鉴别诊断

目的探讨桥脑小脑角区常见肿瘤的特征性MR表现以达到鉴别诊断的目的。方法分析59例经手术和病理证实的桥脑小脑角区肿瘤,其中听神经瘤30例,三叉神经瘤12例,脑膜瘤8例,胆质瘤9例。结果发生于桥脑小脑角区的肿瘤听神经瘤占首位,其次为三叉神经瘤、脑膜瘤、胆质瘤等,该区肿瘤大多具有较特征性的MR表现,术前定位定性诊断准确率较高。结论MR是检查桥脑小脑角区肿瘤的首选方法,对桥脑小脑角区肿瘤的诊断和鉴别诊断有重要价值。     

听神经瘤的CT及MRI表现与病理学对照研究

目的提高听神经瘤的CT及MRI诊断水平。方法对24例经手术及病理证实的听神经瘤的CT及MRI表现与病理学结果进行对照性研究。结果CT表现为桥小脑角部低密度或等密度病灶,薄层扫描可见同侧内听道口扩大;MRI表现为桥小脑角区圆形或类圆形肿块,T1WI呈低信号或等信号,T2WI呈高信号或混杂信号;增强扫描显示病灶实质部分及增粗的听神经明显强化。结论CT对骨质破坏和内听道口的扩大的显示优于MRI,但常规扫描易漏诊。而MRI多轴位成像对显示肿瘤大小范围及周围临界组织的解剖关系较CT有明显优势,同时无骨伪影对显示听神经瘤瘤体及病侧听神经增粗很有价值。进行听神经瘤的CT及MRI表现与病理对照研究,有助于其术前正确诊断。     

桥小脑角区肿瘤56例CT及MRI分析

目的提高桥小脑角区占位性病变的影像学诊断准确率。方法搜集经手术及病理证实的桥小脑角区肿瘤患者56例,全部行CT和MRI平扫及增强检查。结果本组56例中听神经瘤38例,脑膜瘤7例,三叉神经瘤5例,胆脂瘤4例,血管母细胞瘤2例。肿瘤在CT上多呈等密度或略低密度;在MRI中T1WI上多呈低信号,T2WI上多呈高信号,增强后呈明显均匀强化。结论CT、MRI对桥小脑角区占位性病变的诊断与鉴别诊断有重要价值。     

桥脑小脑角区占位性病变的影像学分析

目的通过对桥脑小脑角区占位性病变的CT表现及MRI表现进行分析,进一步提高对该区占位性病变的诊断及鉴别诊断水平。方法对经手术病理证实的52例桥脑小脑区占位性病变的CT及MRI表现进行分析。结果听神经瘤CT平扫为等密度或等、低混杂密度,内见囊变区,囊变部分无强化,增强扫描实质部分明显均匀强化;MR平扫T1WI为等或等、低混杂信号,T2WI为高信号,实性部分明显强化,囊变区无强化。脑膜瘤CT平扫为等或高密度,部分见沙砾状钙化,明显均匀强化;MRI平扫T1WI呈等或稍低信号,T2WI呈等或稍高信号,部分见细血管流空信号,明显均匀强化。胆脂瘤的CT平扫低于脑脊液密度,均无明显强化;MRI平扫T1WI呈不均匀低信号,内见比脑脊液高的信号,无强化。三叉神经瘤跨越后、中颅窝生长,呈哑铃状,为等密度,有明显强化;MRI平扫T1WI为稍低信号,T2WI为高信号,明显强化。结论 CT及MRI检查对桥脑小脑角区占位性病变的定位及定性有重要价值。     

桥小脑角区神经鞘瘤的影像学诊断价值

目的：分析桥小脑角区神经鞘瘤的CT、MRI表现，旨在提高诊断正确率。方法：41例听神经瘤和5例三叉神经瘤均经手术病理证实。18例经CT检查（16例增强扫描），28例MRI检查（增强扫描25例），2例DSA检查。结果：听神经瘤以内听道为中心生长，患者内听道和脑池增宽，Ⅶ、Ⅷ神经束经束较对侧增粗，三叉神经瘤表现为特征性哑铃形伴岩骨尖骨质破坏，CT显示肿瘤呈等密度，低密度或以低密度为主的混杂密度，MRI示T1WI呈低，稍低或混杂信号，T2WI为均匀或不均匀高信号，增强扫描肿瘤呈均匀或不均匀网格状或环形强化，DSA见肿瘤血供丰富，染色明显，CT、MRI正确诊断分别为81％和92％，结论：CT和MRI对神经鞘瘤均有重要诊断价值，而MRI优于CT，疑难者和DSA检查可有助于诊断。     

MRI对听神经瘤的诊断意义

目的总结MRI对听神经瘤的诊断意义。方法搜集经手术和病理证实的24例听神经瘤患者的MRI平扫及钆显影葡胺（Gd-DTPA）增强扫描，对其影像学资料进行分析。结果24例中22例为单侧，2例为双侧，2例为微小听神经瘤；圆形或类圆形19例，不规则形5例，实质性6例，T，WI呈略低或等信号，T2WI呈高或稍高信号；囊实性14例，T1WI呈稍低或低混杂信号，T2WI呈高及稍高混杂信号，4例完全囊变，T1WI呈低信号，T2WI呈高信号；注射Gd-DTPA后，肿瘤瘤体实性成分明显强化，囊变区不强化；2例微小听神经瘤T1WI呈等信号，增强后瘤体呈小结节状均匀强化。结论MRI是听神经瘤最敏感和有效的检查方法。     

听神经瘤的MRI诊断

目的 探讨听神经瘤的MRI特征.方法 回顾性分析12例经手术病理证实的听神经瘤的MRI表现.结果 肿瘤位于桥小脑角区10例,均以内听道为中心生长,其中呈囊实性改变者8例,T1WI呈混杂低信号,T2WI呈混杂高信号,增强扫描呈不均匀强化,实性者2例,T1WI呈等低信号,T2WI呈等高信号增强扫描均匀强化;位于内听道内2例均呈实性,与听神经相比呈等信号,增强扫描肿瘤亦呈均匀强化.12例肿瘤术前均明确诊断.结论 MRI对听神经瘤诊断具有重要价值,结合临床资料在术前可做出正确诊断.     

桥小脑角区肿瘤MRI诊断分析

目的:探讨桥小脑角区(CPA)肿瘤MRI诊断价值.方法:收集经手术和病理证实的单侧桥小脑角区肿瘤30例,回顾性分析其MRI表现.结果:听神经瘤17例,三叉神经瘤7例,脑膜瘤3例,表皮样囊肿3例.根据解剖部位、肿瘤病变特征和MRI信号特点,能对大多数桥小脑角区肿瘤进行定性诊断.结论:桥小脑角区肿瘤中以听神经瘤最多见,MRI能对CPA区肿瘤作出较好的诊断.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.