CT引导下射频消融治疗不能切除的原发性肺癌22例

目的:探讨CT引导下射频消融治疗不能切除的原发性肺癌的临床效果和安全性.方法:对不能切除的原发性肺癌22例27个肿瘤进行多电极高温射频治疗,观察患者术前及术中无创血压、脉搏和周围血氧饱和度,治疗后肝肾肺功能,CT扫描肿瘤组织低密度影和肿瘤体积的变化以及术后5a生存率.结果:射频消融治疗中患者血压、脉搏和周围血氧饱和度无统计学改变;治疗后肝肾肺功能无统计学改变;治疗后1 mo内肿瘤体积增大,治疗后3 mo CT扫描显示在27个肿瘤中,肿瘤完全消失(CR)14个(衰退100%);肿瘤缩小(Pra)8个(衰退80%～100%);肿瘤缩小(PRb)4个(衰退50%～80%),肿瘤缩小(NR)1个(衰退小于50%).肿瘤内低密度影3 mo Ⅰ型1个;Ⅱ型12个;Ⅲ型14个.5 a生存率为40.91%(9/22).结论:射频消融治疗不能切除的原发性肺癌效果良好、创伤小,是对不能切除的原发性肺癌潜在补充治疗.     

高温射频消融治疗肺部肿瘤的安全性探讨

目的 探讨球形多极针高温射频消融治疗肺部恶性肿瘤对生命体征的影响和安全性。方法 CT引导下采用双定位法经皮肺穿刺高温射频消融治疗肺部恶性肿瘤62例，包括原发性肺癌56例，转移性肺癌6例，观察无创血压、脉搏和周围血氧饱和度的变化。结果 一次定位率达94％，62例患者治疗中血压、脉搏和周围血氧饱和度无明显变化，术后并发症包括创伤性气胸10例，皮肤烧灼伤3例，高热并呼吸性碱中毒1例。结论 球形多极针高温射频消融治疗肺部肿瘤对生命体征无明显影响，严重并发症少，能扩大手术适应证，是一种较为安全的姑息治疗新方法。     

CT引导经皮肺穿刺锚状电极高温射频消融治疗肺部肿瘤105例

目的 观察ＣＴ引导经皮肺穿刺高温射频消融治疗１０５例肺部恶性肿瘤的近期效果。方法 ＣＴ引导经皮肺穿刺,可扩展锚状电极配合ＲＦ－２０００仪高温射频消融治疗原发性肺癌８１例,肺部转移瘤２４例,共计２４２个肿瘤,每个肿瘤治疗３～８次,持续时间３～３３７ｍｉｎ。结果 完全缓解（ＣＲ）率１１．１％,部分缓解（ＰＲ）率７１．１％,轻微疗效（ＭＲ）率１３．２％,无改变（ＮＣ）率４．５％,其中ＣＲ＋ＰＲ率为８２．     

介入法热疗肺部恶性肿瘤62例临床总结

目的：探讨球形多极针高温射频消融治疗肺部恶性肿瘤对生命体征的影响和安全性。方法：CT引导下采用双定位法经皮肺穿刺高温射频消融治疗肺部恶性肿瘤62例，包括原发性肺癌56例，转移性肺癌6例，并观察无创血压、脉搏和周围血氟饱和度的变化。结果：一次性定位率达93．5％，62例患者治疗中血压、脉搏和周围血氟饱和度无明显变化，术后并发症包括创伤性气胸10例，皮肤烧灼伤3例，高热并呼吸性碱中毒1例。结论：球形多极针高温射频消融治疗肺部肿瘤对生命体征无明显影响，严重并发症少，能扩大手术适应征，是一种较为安全的姑息治疗新方法。     

CT引导下射频消融术在实体肿瘤治疗中的临床应用

目的 探讨CT引导下射频消融术（RFA）在实体肿瘤治疗中的临床效果.方法 选择2009年1月～2012年12月盐城市第二人民医院收治的21例实体肿瘤患者的临床资料进行分析,其中,周围型肺癌3例,原发性肝癌13例,肝癌切除术后复发2例,肝癌介入术后复发2例,肝癌介入术后腹膜后转移癌1例,所有患者均给予CT引导下RFA治疗,观察患者术前、术中血压、脉搏及血氧饱和度的变化,临床疗效以及并发症.结果 21例患者术中血压、脉搏及血氧饱和度无明显变化,与术前比较,差异无统计学意义（P＞0.05）;总有效率为90.5％;1例出现呕吐,3例局部疼痛,1例术后出现胸腔积液,1例肝周有少量渗血,经对症治疗后好转;术后10个月复查CT,15例患者肿瘤完全坏死,4例患者肿瘤部分坏死.结论 CT引导下经皮穿刺RFA治疗实体肿瘤是一种安全、有效的微创治疗方法.     

CT引导下锚状电极高温射频治疗肺部肿瘤

0　引言　锚状电极配合 RF- 2 0 0 0 (集束聚能刀 )高温射频治疗肺部肿瘤的临床应用未见报道 ,唐都医院胸外科于 1999-10起在 Dr.P.Sewell的帮助下使用美国 Radiotherapeutic公司生产的集束聚能刀治疗肺部肿瘤 42例 .1　临床资料　男性 2 9例 ,女性 13例 ,年龄 43～ 74岁 .原发性肺癌 35例 ,肺转移癌 7例 . 35例肺癌中合并骨转移 2例 ;肺功能差 10例 ;心肌广泛供血不足 12例 .单发病灶 35例 ,多发病灶 7例 .肝癌双肺转移 3例 ,肾透明细胞癌双肺转移 1例 ,乳腺癌肺转移 1例 ,原发性肺癌双肺转移 2例 .1.1　治疗方法　 1麻醉 :35例全麻 ,1…     

CT介导下射频原位灭活疗法治疗肺肿瘤

目的分析CT介导经皮肺穿刺多极射频原位灭活治疗肺肿瘤的疗效。方法对92例不同病理类型的肺肿瘤综合治疗的同时行多极射频原位灭活治疗。分析治疗前后影像学、组织学变化,观察肿瘤灭活率和远期生存率。结果患者治疗中生理监测指标无明显改变,治疗后肺功能无明显影响;治疗后CT扫描肿瘤密度降低,治疗区域增强无强化。肿瘤代谢监测显示,肿瘤代谢消失,肿瘤灭活率为93.5%,远期生存率明显提高。结论多极射频原位灭活治疗肺肿瘤创伤小、效果好,安全可靠,为临床提供了一种新的安全有效的治疗方法。     

CT介导下射频原位灭活疗法治疗肺肿瘤

目的分析CT介导经皮肺穿刺多极射频原位灭活治疗肺肿瘤的疗效。方法对92例不同病理类型的肺肿瘤综合治疗的同时行多极射频原位灭活治疗。分析治疗前后影像学、组织学变化,观察肿瘤灭活率和远期生存率。结果患者治疗中生理监测指标无明显改变,治疗后肺功能无明显影响;治疗后CT扫描肿瘤密度降低,治疗区域增强无强化。肿瘤代谢监测显示,肿瘤代谢消失,肿瘤灭活率为93.5%,远期生存率明显提高。结论多极射频原位灭活治疗肺肿瘤创伤小、效果好,安全可靠,为临床提供了一种新的安全有效的治疗方法。     

CT引导下集束电极射频治疗肺癌

目的 探讨集束电极射频治疗肺癌的临床应用和疗效。方法 在全麻或局麻下经CT引导定位，经皮肤穿刺插入多极电针至瘤体。经一次或多次对肿瘤进行射频治疗，重叠加热使肿瘤细胞凝固坏死。术中直视肿瘤经射频治疗后的图象和CT值变化，术后观察瘤体大小和CT值。结果 33例肺部肿瘤术后早期肿瘤影像增大，CT值降低至20—30Hu以下和出现空泡现象。术后1-48个月复查CT片示：2例肿块消失，30例肿块缩小，1例无变化。本组无手术死亡病例。结论 CT引导下经皮肺穿刺集束电极射频治疗肺癌，定位准确，微创痛苦小，安全有效，病人易于接受，为肺癌病人提供了一种可供选择的治疗新方法。但远期疗效尚待进一步观察。     

螺旋CT对射频治疗肝癌的效果观察

目的：应用螺旋CT扫描评价集束电极射频治疗肝癌的近期疗效。方法：对65例肝癌患者集束电极射频治疗前及治疗后一个月行螺旋CT增强扫描，观察治疗前后肿瘤的大小、密度、血供情况及治疗后凝固性坏死的程度；结果：射频治疗后一个月，65例肝癌患者78个肿块CT复查≤5cm的 病灶体积缩小，密度减低，与治疗前相比有统计学差异，＞5cm的病灶体积无明显变化，而密度减低较明显，70％（55／78）的病灶呈完全凝固性坏死，增强扫描坏死区域无强化；结论：螺旋CT扫描可观察肝癌射频治疗前后肿瘤的大小、密度、血供消失情况以及术后凝固性坏死程度，为临床治疗效果及预后提供重要参考价值。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.