中国北方强直性脊柱炎患者中HLA-B27阳性频率的联合观测

目的；综合分析中国北方居民强直性脊柱炎患的ＨＬＡ－Ｂ２７阳性率。方法；用统一的血清学方法分别在４省市的５家医院共检测５２１例ＡＳ患的ＨＬＡ－Ｂ２７。结果；ＨＬＡ－Ｂ２７阳性率平均为９３．１％；ＡＳ患中，男女之比为４：１，男女患中的ＨＬＡ－Ｂ２７阳性率相近，但男性ＡＳ患的平均年龄，均低于女性ＡＳ患的平均年龄。     

4例性畸形病例的遗传学分析

在细胞遗传学核型分析的基础上，利用ＳＲＹ探针对４例性畸形病例进行了Ｓｏｕｔｈｅｒｎ杂交分析，同时运用ＳＲＹ编码区的特异性引物对其基因组ＤＮＡ进行了ＰＣＲ扩增检测，结果显示：１例４６，ＸＹ女性（Ｓｗｙｅｒ综合征）和１例４５，ＸＯ／４６，ＸＹ女性（Ｔｕｒｎｅｒ综合征）未检出ＳＲＹ特异性杂交带及ＰＣＲ扩增带；１例４６，ＸＸ男性伴性腺发育不良症检测出与正常男性相同的杂交带及ＰＣＲ扩增带；另１例核型为４６，ＸＸ／４７，ＸＸＹ的真两性畸形患者有ＰＣＲ扩增带而ＳＲＹ特异性杂交带未能检出。根据上述结果，本文对４例患者的发病机理进行了分析和讨论，同时对两种检测手段进行了比较。     

输严X同型鲜血致成人型呼吸窘迫综合征4例

输严Ｘ同型鲜血致成人型呼吸窘迫综合征４例苏学高，王霞成人型呼吸窘迫综合征（ＡＲＤＳ），可并发于多种疾病，本文报道４例因输同型新鲜血后出现过敏反应而发展为ＡＲＤＳ。１临床资料４例均为我院１９９０年２～７月份妇产科住院病人。年龄２２～４７岁，例１、例２、...     

抗生素激素联合治疗金葡菌烫伤样皮肤综合征的体会

抗生素激素联合治疗金葡菌烫伤样皮肤综合征的体会李凌杭州市一院皮肤科３１０００６我科自１９９２～１９ｇ４年采用抗生素加激素联合治疗５例金葡菌烫伤样皮肤综合征（ＳＳＳＳ），疗效满意，报告如下。１临床资料１．１病例５例均为我科住院患儿，男３例，女２例。年龄...     

膀胱镜检在女性尿道综合征诊断中的意义（附59例临床分析）

目前女性尿道综合征概念尚未完全统一，对其病因亦有不少争论。我院自１９９２年１０月～１９９８年８月共收治女性尿道综合征患者１６８例，其中５９例进行膀胱镜检查，４７例直接或间接发现了病因，现报告如下。１临床资料１．１检查对象本组女性尿道综合征诊断标准：患...     

胸廓出口综合征4例

胸廓出口综合征４例郑来顺，孟庆海，朱庆如胸廓出口综合征（ＴＯＳ）在临床上较为少见。作者自１９８２～１９９２年共收治４例，经手术治愈，随访观察１～３年无复发。现报道如下。１临床资料４例均为男性，年龄２７～４４岁，平均３８．５岁。体检发现三头肌力减弱、二...     

肾综合征出血热并发腹水52例临床分析

肾综合征出血热并发腹水５２例临床分析刘洋海朱翠英河南省正阳县人民医院（４６３６００）１９９４年１１月～１９９６年１０月，我院共收治肾综合征出血热（ＨＦＲＳ）患者１０２例，其中并发腹水５２例，现报告分析如下：１临床资料１．１一般资料５２例ＨＦＲＳ住院患...     

唇痈并发海绵窦综合征4例

唇痈并发海绵窦综合征４例江凤英（广东省茂名市人民医院，茂名市，５１５０００）１临床资料我院于１９８８年３月至１９９４年８月收住４例唇痈并发海绵窦综合征，其中男３例，女１例，年龄７～１６岁。４例唇痈患者，３例自诉用手挤压患灶，这是炎症迅速扩散的诱因，另...     

侵袭性血管粘液瘤——附4例临床病理分析

目的;分析侵袭性血管粘液瘤的临床和病理学特点。方法：对１９８８年３月￣１９９８年６月我院收治的４例侵袭性血管粘液瘤患的临床资料进行回顾性分析。并对其病理切片行免疫组化染色。结果：４例均为女性,年龄３９￣５０岁,３例发生在外阴,１例在盆腔底部。肿瘤最大径４￣１５ｃｍ。免疫组化染色肿瘤细胞阳性反应分别为ｖｉｍｅｎｔｉｎ（４／４）,ｄｅｓｍｉｎ（４／４）,ａｃｔｉｎ（１／４）、ＳＭＡ（１／４）、ＣＤ３     

益气活血法治疗病窦综合征36例临床观察

益气活血法治疗病窦综合征３６例临床观察孙建民（浙江省杭州中西医结合医院邮编３１０００４）从１９８７年以来，我们采用中医益气活血法治疗３６例病窦综合征（ＳＳＳ）患者，取得较好疗效，报导如下。１临床资料本组病例均为住院病人，男性２４例，女性１２例。年龄３...     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…