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1.
目的 通过分析儿童哮喘缓解期治疗依从性,探讨改善依从性差的对策,从而提高儿童哮喘的治愈水平.方法 选择2006年12月~2009年12月期间因哮喘再次发作来院复诊的398例患儿,分析其哮喘规范化治疗依从性及糖皮质激素吸入治疗依从性,明确哮喘复发患儿治疗依从性差的主要原因.结果 通过问卷调查发现,复诊患儿中共360例患儿哮喘规范化治疗依从性差,还发现糖皮质激素吸入依从性差患儿未按时来院随访,哮喘相关疾病知识欠缺是规范化治疗依从性差的主要原因.进一步分析糖皮质激素吸入治疗依从性差而复发哮喘的176例患儿,担心药物副作用而停药,没有掌握正确用法和用量认为哮喘痊愈而停药,患儿治疗不配合是导致糖皮质激素吸入治疗依从性差的主要因素.结论 治疗依从性差是患儿复发哮喘的重要因素,针对患儿家长开展哮喘知识讲座,指导家长合理用药,定期来院随访是提高患儿哮喘治愈水平的重要手段.  相似文献   

2.
刘国群  朱波 《西部医学》2012,24(5):901-902,905
目的了解哮喘儿童使用吸入型糖皮质激素的依从性及其影响因素,探讨相应干预措施。方法对98例哮喘儿童家长进行问卷调查,并对调查结果进行统计分析。结果 98例患者中有21例患者依从性好,依从率为21.43%,其余77例均有不同程度不遵医嘱的现象。依从性差的影响因素有对糖皮质激素恐惧、对儿童哮喘知识了解不够、使用药物方法不当、经济困难、人员流动性较大及医生交流指导不一致等。结论加强儿童哮喘知识的宣传,对患儿家长进行长期系统的教育和管理,加强糖皮质激素的正确应用宣教,医务人员严格执行统一规范的治疗方案,从而提高哮喘儿童吸入糖皮质激素治疗的依从性。  相似文献   

3.
舒利迭吸入治疗儿童哮喘疗效观察   总被引:4,自引:1,他引:3  
目的观察舒利迭吸入治疗儿童哮喘的临床疗效。方法对40例哮喘患儿按病情轻、中、重度分别予以不同剂量的舒利迭治疗,观察12周。治疗期间记录哮喘日记,沙丁胺醇气雾剂使用情况。治疗前后PEF值,不良反应。结果40例患儿临床症状评分减少,使用沙丁胺醇气雾剂次数明显减少,PEFR值占预计值的百分比增加,肺功能改善,总有效率95%。结论应用舒利迭治疗哮喘具有显著疗效,临床应用安全,副作用少,依从性好,适用于儿童哮喘的长期治疗。  相似文献   

4.
《陕西医学杂志》2014,(7):916-917
目的:调查和分析儿童哮喘糖皮质激素吸入治疗依从性及其影响因素,探讨干预措施。方法:对137例吸入糖皮质激素治疗的哮喘患儿或其家长进行问卷调查和电话访谈,针对调查结果分析其依从性的影响因素。结果:137例哮喘患儿中哮喘治疗依从性好的人数第13个月、第43个月、第46个月、第76个月、第712个月分别为86.9%、65.0%、52.5%;影响其依从性因素依次为担心药物副作用(33.33%),怀疑医师诊断(17.95%),嫌治疗烦琐和漫长(13.67%);未正确掌握手控气雾剂吸入方法82.76%,使用布地奈德粉吸入剂吸入力度不够23.81%。结论:哮喘患儿吸入治疗依从性随着时间延长,依从性逐渐降低。儿童哮喘吸入治疗依从性受多方面因素的影响。应大力加强儿童哮喘知识宣传,对患儿及家长进行长期系统的教育和科学管理,从而提高吸入糖皮质激素治疗的依从性。  相似文献   

5.
舒利迭治疗儿童哮喘40例疗效分析   总被引:1,自引:0,他引:1  
目的 观察舒利迭治疗儿童哮喘的疗效.方法 对门诊及住院40例4~14岁,中、重度哮喘患儿予舒利迭干粉吸入剂治疗,每次50μg,每日2次,共用12周.观察哮喘评分变化,速效β2激动剂使用次数及肺功能(呼吸峰流速值的变化).结果 观察组患儿哮喘症状评分降低(P<0.001),速效β2激动剂使用次数较治疗前明显减少(P<0.05),肺功能呼吸峰流速(PEFR)值较治疗前明显改善(P<0.01).显效36例,占90%,有效4例,占10%,总有效率100%.结论 舒利迭干粉吸入剂治疗儿童中、重度哮喘起率快、疗效佳,可明显减少皮质激素用量,患儿用药依从性好.可以使更多的患儿达到哮喘的完全控制.  相似文献   

6.
目的:探讨舒利迭治疗支气管哮喘的临床疗效.方法:支气管哮喘患者90例,其中治疗组45例,分别吸入糖皮质激素和长效β2受体激动剂的复方制剂舒利迭(沙美特罗/氟替卡松);对照组45例,分别吸入单纯的糖皮质激素必可酮,每次1吸,1吸该药内含倍氯米松250μg,2次/日.结果:舒利迭治疗组用药后临床疗效明显优于对照组.结论:应用舒利迭治疗支气管哮喘,能有效改善临床症状和降低复发率,比单纯吸入糖皮质激素效果更明显.  相似文献   

7.
目的观察舒利迭治疗儿童哮喘的临床疗效。方法76例中度哮喘患儿随机分为观察组和对照组,分别应用舒利迭和辅舒酮吸入治疗1年,观察两组患儿哮喘急性发作次数及治疗前后肺功能(FEV1预计值%)的变化。结果舒利迭组哮喘急性发作次数明显少于辅舒酮组;两组均可提高FEV1预计值%,改善肺功能,但舒利迭组明显优于辅舒酮组。结论舒利迭治疗儿童哮喘的临床疗效较好。  相似文献   

8.
舒利迭治疗支气管哮喘的68例临床观察   总被引:1,自引:0,他引:1  
目的 观察并探讨舒利迭治疗支气管哮喘的临床疗效.方法 2006年1月~2009年1月对入住笔者所在医院的68例支气管哮喘患者,按照入院的先后顺序随机分为对照组34例和治疗组34例,治疗组以糖皮质激素和长效β受体激动剂吸入,使用的舒利迭用量为每次1吸,每天2次.对照组采用单纯的糖皮质激素吸入,使用必可酮用量为每次1吸,每天2次.结果 舒利迭治疗组用药后临床疗效明显优于对照组.结论 应用舒利迭治疗支气管哮喘,能够明显改善患者的症状和体征,提高临床疗效,值得在临床推广应用.  相似文献   

9.
联合治疗防治儿童哮喘临床观察   总被引:3,自引:0,他引:3  
袁大华 《华夏医学》2006,19(3):414-416
目的:观察联合制剂长期吸入防治儿童哮喘的疗效。方法:对70例中重度哮喘患儿予沙美特罗替卡松粉吸入剂(舒利迭)治疗。所有患儿每日早晚各吸50/100μg。观察记录患儿治疗前后PEF值以及哮喘症状记分等。结果:有66例坚持吸入治疗,PEF值与治疗前相比有极显著差异(P<0.01),均无加重恶化病例。结论:β2受体激动剂与糖皮质激素有互补作用模式及机制,对中重度儿童哮喘有显著疗效。  相似文献   

10.
目的 观察舒利迭吸入治疗儿童哮喘的疗效.方法 收集2006年3月~9月我院诊断为哮喘的患儿125例进行随机分组,治疗组吸入舒利迭,对照组吸入激素(辅舒酮),进行疗效分析.结果 两组临床疗效指标比较差异经非参数检验具有统计学意义.结论 舒利迭治疗儿童哮喘疗效好,副作用少,值得推广.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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