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1.
目的探讨2型糖尿病中医辨证分型特点,分析各临床常规指标与证型的关系,为2型糖尿病中医辨证提供客观依据。方法收集147例合格2型糖尿病病例,按阴虚热盛、湿热困脾、气阴两虚、阴阳两虚辨证分型,同时配以30例同期健康体检者做对照。分析不同证型与年龄、病程、体质指数(BMI)、胰岛素敏感指数(ISI)、糖代谢、脂代谢等的关系。结果气阴两虚最多见;阴阳两虚型女性比例大于男性;年龄与病程变化趋势相同:阴虚热盛型<湿热困脾型<气阴两虚型<阴阳两虚型。各证型的BMI、空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖基化血红蛋白(HbA1c)、ISI、高密度脂蛋白(HDL)、载脂蛋白AⅠ(ApoAⅠ)、甘油三酯(TG)、载脂蛋白B(ApoB)与对照组比较差异均有统计学意义(P<0.05);其中气阴两虚、阴阳两虚型HDL、ApoAⅠ与阴虚热盛、湿热困脾型比较差异有统计学意义(P<0.05);气阴两虚型的低密度脂蛋白(LDL)与对照组、阴阳两虚型差异有统计学意义(P<0.05)。结论 2型糖尿病辨证分型以气阴两虚型最多,证型变化有从阴虚热盛、湿热困脾、气阴两虚到阴阳两虚的趋势;2型糖尿病中医辨证分型与多项临床常规检查指标间存在相关性,对中医辨证客观化具有参考价值。  相似文献   

2.
[目的]观察老年糖尿病不同中医证型间T淋巴细胞亚群的变化。[方法]将84例老年糖尿病患者分为阴虚热盛(20例)、气阴两虚(21例)、阴阳两虚(18例)、气阴两虚兼血瘀(25例)4组,另设20例健康志愿者为对照组,观察各组CD3、CD4、CD8、CD4/CD8及FPG、FIns、HOMAIR、HBCI等变化情况。[结果]不同中医证型中阴虚热盛型CD3、CD4、CD8、CD4/CD8与健康对照组相比其差异无统计学意义(P〉0.05);而气阴两虚型、气阴两虚兼血瘀型、阴阳两虚型的CD3、CD4值分别与健康对照组、阴虚热盛型比较明显下降其差异均有统计学意义(P〈0.05),且三组患者FIns、HOMA—IR值较阴虚热盛型相比其差异有统计学意义(P〈0.05);阴阳两虚型FPG、HOMA—IR及HBCI与阴虚热盛型、气阴两虚型、气阴两虚兼血瘀型比较,其差异均有统计学意义(P〈0.05),阴阳两虚型CD8值与其他四组相比明显升高,且CD4/CD8比值与健康对照组、阴虚热盛型比较其差异有统计学意义(P〈0.05)。[结论]老年糖尿病患者不同中医证型组胰岛素抵抗程度不同,T淋巴细胞亚群变化亦有差异。胰岛素抵抗、B细胞功能及细胞免疫状态三者之间可能相互影响。  相似文献   

3.
目的:探讨老年2型糖尿病(T2DM)合并颈动脉粥样硬化斑块(CAS)中医证型分布特点。方法将150例老年2型糖尿病合并颈动脉粥样硬化斑块患者辨证分为湿热困脾、气阴两虚、血瘀阻络3型,观察一般情况及相关指标,研究其与中医证型的关系。结果老年 T2DM 合 CAS 的中医证型以气阴两虚型发生率最高,湿热困脾型最低,证型构成比差异有统计学意义(P <0.05)。3种证型在不同年龄段的分布差异无统计学意义(P >0.05);气阴两虚型、湿热困脾型、血瘀阻络型3种证型两两比较,在年龄、病程方面差异有统计学意义(P <0.05),气阴两虚型与其他2种证型腰臀比差异有统计学意义(P <0.05),各证型体质指数两两比较差异无统计学意义(P >0.05);气阴两虚型纤维蛋白原水平(Fg)最低,血瘀阻络型最高,3种证型两两比较差异有统计学意义(P <0.05);气阴两虚型血清同型半胱氨酸(Hcy)、胆固醇(TC)、甘油三酯(TG)水平最低,与其他2种证型比较差异有统计学意义(P <0.05),其他2种证型间无明显差异;3种证型低密度脂蛋白(LDL)和高密度脂蛋白(HDL)差异无统计学意义(P >0.05);老年 T2DM 合并 CAS 时 Fg 水平与 TG、TC、LDL 呈正相关,与 HDL 呈负相关,与糖化血红蛋白(HBALC)、空腹血糖(FPG)无相关性。结论2型糖尿病合并颈动脉粥样硬化斑块中医证型分布差异明显,与年龄、病程以及相关理化指标关系密切,掌握其特点可帮助临床诊疗。  相似文献   

4.
目的探讨中医证型与ACE基因多态性分布间的相关性。方法选择糖尿病微血管病变患者186例,中医辩证分为阴虚热盛型、气阴两虚型及阴阳两虚型。并采用PCR方法检测血管紧张素Ⅰ转化酶(ACE)基因多态性。结果ACE基因型及等位基因频率在阴虚热盛型与气阴两虚型间无显著性差异(p〉0.05),而在阴虚热盛型与阴阳两虚型以及气阴两虚型与阴阳两虚型间均有显著性差异(p〈0.05)。结论中医证型与ACE基因多态性有关联。ACE基因多态性可作为糖尿病微血管病变中医辩证分型的客观化指标依据。  相似文献   

5.
糖尿病患者T3核受体各亚型mRNA与中医辩证关系   总被引:2,自引:0,他引:2  
李晓苗  李源  谢永红  拓步雄 《医学争鸣》2002,23(13):1239-1241
目的 了解糖尿病患者外周血白细胞T3核受体与糖尿病(无/有慢性并发症)中医辩证的关系。方法 根据是否并发慢性并发症将20例糖尿病患者分为无慢性并发症组(A组、气阴两虚型)、慢性并发症组(B组、阴阳两虚型),应用半定量RT-PCR法,观察T3核受体各亚型mRNA变化。结果 B组比A组糖尿病患者外周血白细胞中T3Rα1,T3Rα2表达增强(P<0.05),T3Rβ1,T3Rβ2 mRNA变化不大(P>0.05)。结论 在外周血白细胞中,T3R mRNA各亚型表达有助于临床对中医气阴两虚、阴阳两虚型的确立。  相似文献   

6.
糖尿病患者血液生化、血细胞分析与中医辨证关系   总被引:2,自引:0,他引:2  
目的:探讨108例糖尿病及其并发症患血清生化、血细胞分析及血压、胰肾大小与中医辨证关系。方法:对糖尿病患进行中医辨证分型,采用全自动生化分析仪、电解质分析仪和血细胞分析仪测定生化、电解质、血细胞等指标。结果:气阴两虚型和阴阳两虚型糖尿病患,血浆总蛋白、白蛋白较正常对照组显性降低(P<0.01),而胆固醇无显性差异(P>0.05),血糖明显升高(P<0.01);血清钙离子较对照组显性下降(P<0.01)。阴阳两虚型糖尿病患血压、胰头、肾脏较正常对照组有明显差异(P<0.01或P<0.05);红细胞、红细胞比容、平均红细胞体积均较正常对照组显性下降(P<0.01),平均血红蛋白含量及平均血红蛋白浓度较正常对照组增高(P<0.01)。结论:阴阳两虚型糖尿病患存在糖、脂肪和蛋白质三大物质代谢紊乱,钙离子代谢紊乱,及其血压、胰头、肾脏大小及血细胞明显变化,有助于中医辨证客观化。  相似文献   

7.
目的:探讨南阳市2型糖尿病患者的体质特点,并分析与中医证候之间的关系。方法:选择2型糖尿病患者300例为调查对象,同时选择300例健康人群为对照组,运用中医体质量表进行中医体质调查、结果:普通人群常见的中医体质类型为平和质及8种偏颇体质,8种偏颇体质中居于前3位的体质类型是气虚质、湿热质、阳虚质,2型糖尿病常见中医体质类型有痰湿质、阴虚质、气虚质、血瘀质、湿热质等5种体质类型。与普通人群比较,痰湿质、阴虚质、瘀血质三种偏颇体质差异均具有统计学意义(P〈0.05),2型糖尿病患者中,气阴两虚证133例(44.33%),阴阳两虚证92例(30.67%),阴虚热盛证75例(25%)气虚质、阴虚质、气郁质、湿热质与气阴两虚型关系密切;阴虚质、湿热痰、痰湿质与阴虚热盛型关系密切;瘀血质、痰湿质、阳虚质与阴阳两虚型关系密切;各中医证候的糖尿病病程比较,差异有统计学意义(P〈001)结论:对2型糖尿病患者体质特点及其与中医证候关系进行总结分析,有利于更好的指导糖尿病的临床治疗。  相似文献   

8.
糖尿病视网膜病变中医证候与西医分期的关系研究   总被引:7,自引:0,他引:7  
【目的】研究糖尿病视网膜病变患者中医证候演变特征。【方法】对245例糖尿病视网膜病变患者不同分期的中医证候进行分析。【结果】经计数资料的相关分析表明,糖尿病视网膜病变的中医证候及其合并证候与病变的分期和病程均存在相关性(均P=0.0000)。①气阴两虚证、阴虚内热证、脾虚湿热证在亚临床期、单纯期分别占33.85%、33.00%、32.30%、25.00%、21.54%、26.00%;与同期脾虚痰湿证、阴阳两虚证相比较,差异有统计学意义(P〈0.05或P〈0.01);在增殖期,气阴两虚证、脾虚痰湿证、阴阳两虚证分别占39.74%、26.92%、19.23%,与阴虚内热证、脾虚湿热证相比较,差异均有统计学意义(P〈0.05),阴阳两虚证在增殖期所占比例与单纯期、亚临床期比较,差异均有统计学意义(P〈0.05);②病程在5年以下者,气虚证占85.48%为最多见,其次是阴虚证;病程在15年以上者,血瘀证型、痰湿证型达100%。【结论】糖尿病视网膜病变的中医证候在各期、各病程阶段是动态变化的。  相似文献   

9.
目的:探讨糖尿病患者血清IL-6,IL-8和TNF-α与中医辨证分型的关系。方法:采用放射免疫法检到82例糖尿病(DM)患者和正常人对照组30例血清中IL-6,IL-8和TNF-α的水平。结果:阴阳两虚组糖尿病患者IL-6,IL-8和TNF-α显著高于正常组、阴虚热盛组及气阴两虚组(P<0.01或P<0、05)。结论:DM患者中医征型间存在着不同程度的细胞免疫功能失调,IL-6,IL-8和TNF-α可作为DM患者中医辨证的客观指标之一。  相似文献   

10.
慢性肾衰的中医证型与血浆内皮素、血清一氧化氮的关系   总被引:1,自引:0,他引:1  
目的:研究慢性肾衰的不同中医证型与血浆内皮素(ET)、血清一氧化氮(NO)的关系。方法:150例慢性肾衰患者按照《中药新药临床研究指导原则》分为脾肾气虚型、气阴两虚型、脾肾阳虚型、阴阳两虚型及肝肾阴虚型组,并以30例健康体检者为对照组。测定并比较血浆ET与血清NO含量。结果:各组慢性肾衰患者血浆ET差异均有统计学意义(P〈0.01)。中医各证型血浆ET含量依次为对照组〈脾肾气虚组〈气阴两虚组〈肝肾阴虚组〈脾肾阳虚组〈阴阳两虚组。中医各证型血清NO含量依次为脾肾阳虚组〉阴阳两虚组〉肝肾阴虚组〉气阴两虚组〉脾肾气虚组〉对照组。在各病例组中ET和NO呈显著正相关(P〈0.01)。结论:慢性肾衰患者血浆ET、血清NO含量的变化可作为判断肾衰严重程度的客观指标。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

16.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

17.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

18.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

19.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

20.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

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