首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 78 毫秒
1.
目的 探讨血浆同型半胱氨酸 (Hcy)水平与冠状动脉病变支数的关系 ,以及其与急性心肌梗死 (AMI)、不稳定性心绞痛 (UA)之间的关系。方法 采用全自动酶化学发光法对 82例行选择性冠状动脉造影术的患者进行血浆Hcy测定。根据冠状动脉造影结果分组 :正常对照组 2 5例 (包括 3例临床诊断为AMI的患者 ) ,单支血管病变组 2 3例 ,双支血管病变组 18例 ,3支血管病变组 16例 ;根据临床诊断分组 :AMI组 36例、UA组 2 4例 (两组冠状动脉病变支数无差异 )和非冠心病组 2 2例。结果 ① 3支病变组的Hcy为 (2 5 .14± 11.78) μmol/L ,2支病变组为 (19.6 2± 7.0 4) μmol/L ,单支病变组为 (18.43± 7.16 ) μmol/L ,3组均显著高于正常对照组的 (14.0 6± 2 .5 4) μmol/L(P值均 <0 .0 1)。②AMI组的Hcy为(2 0 .0 7± 7.72 ) μmol/L ,UA组为 (2 0 .6 2± 10 .6 3) μmol/L ,均显著高于非冠心病组的 (14.2 3± 2 .6 3) μmol/L(P值均 <0 .0 1) ;UA组的Hcy略高于AMI组 ,但差异无显著性 (P =0 .41)。 结论 血浆Hcy升高是冠心病的危险因素。其增高不仅与冠状动脉病变支数呈正相关 ,而且与冠状动脉病变的活动显著相关 ,进一步提示增高的血浆Hcy与冠心病心肌缺血事件的发生密切相关。  相似文献   

2.
刘小艳 《西部医学》2017,29(3):347-350
【摘要】 目的 探讨川东北地区汉族人群血浆同型半胱氨酸(Hcy)水平与冠心病的相关性。方法 选取2013年3月~2014年8月在南充市中心医院心内科住院且生活在川东北地区的汉族人群431例为研究对象,根据临床症状、心电图表现、心肌酶学及其冠状动脉造影结果分为冠心病组221例和对照组210例,比较两组之间Hcy水平差异。结果 冠心病组平均血浆Hcy水平为(1539±689) μmol/L,对照组为(1290±644) μmol/L,冠心病组显著高于对照组(P<005),Hcy在两组之间比较OR值为1060 (95%CI 1021~1100,P<005)。冠状动脉不同病变血管支数之间比较 ,1支血管病变患者平均血浆Hcy水平为(1387±499) μmol/L,2支血管病变患者平均血浆Hcy水平(1581±814) μmol/L,3支血管病变患者平均血浆Hcy水平为(1774±715) μmol/L,血浆 Hcy 水平在 1、2、3 支血管病变患者中呈逐渐增高趋势,其中1支血管病变患者与3支血管病变患者差异有统计学意义(P<005)。冠心病不同临床类型之间比较,稳定型心绞痛患者平均血浆Hcy水平为(1236±45) μmol/L,不稳定型心绞痛患者为(1490±629) μmol/L,缺血性心肌病患者为(1539±680) μmol/L,急性心肌梗死患者为(1649±766) μmol/L,其中急性心肌梗死与稳定型心绞痛比较,差异有统计学意义(P<005),其余患者间比较差异无统计学意义(P>005)。结论 同型半胱氨酸(Hcy)是川东北地区汉族人群冠心病发病的独立危险因素。  相似文献   

3.
冠状动脉粥样硬化患者血浆同型半胱氨酸测定的临床意义   总被引:1,自引:1,他引:0  
目的 :探讨血浆同型半胱氨酸水平测定在冠状动脉粥样硬化患者中的临床意义。方法 :应用荧光偏振免疫分析技术 ,测定 6 8例健康人和 85例冠状动脉粥样硬化患者血浆同型半胱氨酸 (Hcy)水平。结果 :血浆 Hcy水平正常对照组为 (9.31± 3.80 )μmol/L ,其中男性 (10 .5 0± 4 .0 7)μmol/L ,女性 (7.80± 2 .85 )μmol/L,男性明显高于女性 (P<0 .0 0 1) ;冠状动脉粥样硬化患者 (13.39± 6 .0 6 ) μmol/L,其中男性 (13.77± 6 .6 8) μmol/L,显著高于健康男性 (P<0 .0 0 1) ;女性 (11.5 0± 3.5 8) μmol/L,显著高于健康女性 (P<0 .0 0 1)。血浆 Hcy水平随冠脉病变严重程度呈上升趋势 ,冠脉不典型狭窄组 (11.36± 3.86 ) μmol/L,1支病变组 (13.32± 6 .0 9) μmol/L,2支病变组 (13.39±4 .92 ) μmol/L,3支病变组 (18.2 3± 8.98) μmol/L。结论 :冠状动脉粥样硬化患者存在高同型半胱氨酸血症 ,对于冠心病的诊断和治疗有重要价值。  相似文献   

4.
目的 探讨血浆同型半胱氨酸 (Hcy)水平与急性心肌梗死 (AMI)之间的关系。方法 应用高效液相色谱仪测定血浆Hcy水平 ,对 50例确诊急性心肌梗死患者与 50例正常对照者进行比较分析。结果 AMI组和对照组血浆Hcy水平分别为 (1 6 73± 4 0 1 ) μmol/L和 (1 0 87± 2 95) μmol/L ,两者差异有显著性 (P <0 0 5)。在 37例行冠状动脉造影的AMI患者中 ,多支病变组 (≥ 2支血管病变 )的血浆Hcy水平显著高于单支病变组 [(1 7 2 5± 4 .86) μmol/Lvs (1 2 .2 3±5 1 7) μmol/L ,P <0 0 5]。 结论 高Hcy血症可能是AMI的一种独立危险因素 ,且冠脉病变越严重 ,血浆Hcy水平越高。  相似文献   

5.
查滨  周殷  张莉 《黑龙江医学》2005,29(2):102-104
目的 探讨血尿酸浓度与原发性高血压 (EH) ,冠心病 (CHD)病情程度的相关性。方法 采用酶学法 ,用全自动生化分析仪AU 4 0 0测定血尿酸浓度。结果  10 8例EH患者血尿酸浓度为 (4 2 2 .83± 15 0 .6 6 )μmol/L ,高血尿酸症 (HUA)总发生率为 4 2 .6 %。其中 :Ⅲ级EH患者血尿酸水平较Ⅰ级EH患者尿酸水平显著升高 (P <0 .0 5 ) ,Ⅲ级EH患者较Ⅱ级EH患者血尿酸水平、Ⅱ级EH患者血尿酸水平较Ⅰ级EH患者血尿酸水平显著升高 (P <0 .0 5 ) ,冠心病 (CHD)患者血尿酸浓度为 (4 31.83± 15 1.36 ) μmol/L ,高血尿酸症 (HUA)总发生率为 4 3.1%。冠状动脉 2支或 2支以上病变与高血尿酸检出率成正相关 (P <0 .0 5 )。结论 HUA与EH、CHD的发生率及病情程度关系密切  相似文献   

6.
目的 :探讨冠状动脉病变程度与血C反应蛋白 (C -reactiveprotein ,CRP)和血尿酸 (Uridacid ,UA)的关系。方法 :测定 186例初诊为“冠心病、不稳定心绞痛”患者的血清CRP和UA水平 ,并根据冠状动脉造影的结果分组 ,观察血清CRP和UA与冠脉病变的关系 ,进行统计学分析。结果 :各组间血CRP水平 :冠脉正常组 (1.5 6± 1.3 2 )mg/mL ;冠脉轻度狭窄组 (2 .45± 1.87)mg/mL ;冠脉中度狭窄组 (3 .0 2± 2 .5 3 )mg/mL ;冠脉重度狭窄组 (4.2 8± 3 .15 )mg/mL ;冠脉完全闭塞组 (5 .3 6± 4.11)mg/mL。冠脉重度狭窄组和冠脉完全闭塞组与冠脉正常组比较。统计学处理差异有显著性意义 (P <0 .0 5 ) ,余组间比较差异无显著性意义 (P >0 .0 5 )。不稳定病变组CRP水平显著高于稳定病变组 (7.83± 4.66)mg/mLvs.(3 .3 8± 2 .2 7)mg/mL ,(P <0 .0 0 1)。各组间血UA值分别为 :冠脉正常组(2 81.7± 5 1.86) μmol/L ;冠脉轻度狭窄组 (3 0 9.2± 5 0 .11) μmol/L ;冠脉中度狭窄组 (3 3 4.6± 49.69) μmol/L ;冠脉重度狭窄组 (3 62 .7± 48.3 2 ) μmol/L ;冠脉完全闭塞组 (3 93 .4± 47.5 5 ) μmol/L。 5组间比较统计学处理差异均有显著性意义 (P <0 .0 5或P <0 .0 1)。不稳定病变组UA水平与稳定病变组相比 (3 42 .7± 5 4  相似文献   

7.
冠状动脉病变与血尿酸水平的关系探讨   总被引:2,自引:0,他引:2  
目的了解不同程度冠状动脉病变患者血尿酸水平的变化。方法64例患者行冠状动脉造影,以冠脉病变程度分组,同时检测空腹血尿酸水平。结果血尿酸水平:冠状动脉正常组(0支组)为(0.30±0.06)mmol/L,冠状动脉1支病变组(1支组)为(0.35±0.05)mmol/L,冠状动脉双支病变组(2支组)为(0.46±0.07)mmol/L,冠状动脉3支病变组(3支组)为(0.48±0.04)mmol/L,随着病变支数的增加,血尿酸水平也逐渐增加,1支、2支、3支组血尿酸水平与0支组比较差异有显著意义(P<0.05),2支、3支组与1支组比较,血尿酸水平差异有非常显著意义(P<0.01)。结论随着冠状动脉病变程度的增加,血尿酸水平也逐渐增高。  相似文献   

8.
血尿酸水平与高脂血症的关系   总被引:2,自引:0,他引:2  
目的 :研究血尿酸水平与高脂血症的关系。方法 :比较高脂血症病人 (10 3例 )和正常血脂对照者 (10 9例 )间血尿酸水平的差别 ;简单相关和多元逐步回归分析血尿酸水平和血脂间的线性相关关系 ;Logistic回归分析血尿酸对高脂血症发病的影响程度。结果 :高脂血症组血尿酸水平 [(382 .4± 10 0 .3) μmol/L]高于正常血脂对照组 [(35 1.7± 88.9) μmol/L](P <0 .0 5 ) ;血尿酸水平与TG、ApoB间呈正相关 (P <0 .0 5 ,P <0 .0 5 ) ,与HDL间呈负相关 (P <0 .0 5 ) ;调整年龄、性别、BMI、SBP、DBP、PP、MAP、Glu后 ,血尿酸水平与高脂血症的发病间无相关性 (P >0 .0 5 )。结论 :血尿酸水平在高脂血症病人增加 ,与血脂密切相关 ,但不是高脂血症发病的独立危险因素。  相似文献   

9.
目的:探讨老年冠状动脉造影患者血清尿酸水平与冠状动脉病变严重程度之间的关系。方法:入选2008年1月~2011年12月在我科住院并行冠脉造影检查的老年患者255例,根据冠状动脉造影结果分为冠心病组(n=183)和非冠心病组(n=72),根据冠脉病变血管支数分为单支病变组、双支病变组和3支病变组,测定患者空腹血清尿酸水平并进行比较,分析血尿酸与冠状动脉病变严重程度的关系。结果:冠心病组患者的血清尿酸水平(321.825±113.483μmol/L)显著高于非冠心病组(260.948±76.438μmol/L,P<0.01)。单支病变组、双支病变组、3支病变组血尿酸分别为314.03±112.313、317.08±108.739和338.43±107.762μmol/L,各组间无统计学差异(均P>0.05)。经logistic回归校正相关因素后,血尿酸水平与冠心病的发病风险显著相关(P=0.014,OR=1.005,95%CI:1.001~1.008)。结论:血尿酸水平与冠状动脉病变的严重程度密切相关,是预测冠心病发病风险的独立危险因素之一。对其早期干预可能降低急性心血管事件的发生。  相似文献   

10.
目的 探讨冠心病患者血浆C反应蛋白(CRP)和载脂蛋白A-I(ApoA-I)水平与冠状动脉病变的相关性.方法 91例经冠状动脉造影确诊的冠心病患者(冠心病组).根据冠状动脉病变支数分为单支病变亚组(35例)、双支病变亚组(36例)和多支病变亚组(20例);另选43例正常健康者作为对照组.分别检测入选人群的血浆CRP和ApoA-I水平.结果 ①与对照组比较,冠心病组CRP[单支病变组:(8±5)mg/L;双支病变组:(10±5)mg/L;多支病变组:(10±5)mg/L];水平明显升高,差异有统计学意义(P<0.05);血浆ApoA-I[单支病变组:(1.33±0.33)g/L;双支病变组:(1.26±0.32)g/L;多支病变组:1.20±0.31g/L];水平明显低于对照组,差异有统计学意义(P<0.05).②冠心病组各亚组间比较,血浆CRP水平随冠状动脉病变支数的增加而升高,血浆ApoA-I水平在冠状动脉病变支数少的较低.各亚组间比较差异有统计学意义(P<0.05).结论 血浆CRP和ApoA-I水平在冠心病患者中明显区别,并与冠状动脉病变程度密切相关,提示上述指标可能共同参与或介导了动脉粥样硬化的形成,并可用于预测动脉粥样硬化的严重程度.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号