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1.
Background: Understanding the changing profiles of cardiovascular disease (CVD) and modifiable risk factors is essential for CVD prevention and control. We aimed to report the comprehensive trends in CVD and risk factors in China from 1990 to 2019.Methods: Data on the incidence, death, and disability-adjusted life years (DALYs) of total CVD and its 11 subtypes for China were obtained from the Global Burden of Disease Study 2019. The CVD burden attributable to 12 risk factors was also retrieved. ...  相似文献   

2.
《中华医学杂志(英文版)》2012,125(24):4361-4367
Background  Despite considerable improvements in the care of patients with cardiovascular disease in various populations over the last few decades, there are still limited data about long-term treatment patterns among patients with various atherosclerotic vascular conditions in China, especially the use of statin therapy.
Methods  Between June 2007 and October 2009, 16 860 patients aged 50–80 years with established history of atherosclerotic vascular disease (coronary heart disease (CHD), atherosclerotic cerebrovascular disease (CVD), or peripheral arterial disease (PAD)) from 51 hospitals in 14 cities of China were screened for a large randomized trial. Detailed information about current use of statins and various other treatments was recorded and analyzed by prior disease history, adjusting for various baseline characteristics.
Results  Among the 16 860 patients, the mean age was 63 years and 74% were male. Overall, 78% of the patients had documented CHD, 40% had CVD, 5% had PAD and 21% reported more than one condition. The median time from initial diagnosis of vascular disease to screening was 18 months. At screening, the proportions who took various treatments were 83% for antiplatelet agents, 49% for beta-blockers, 47% for statins and 28% for angiotensin-converting enzyme inhibitors. The proportion treated with statin was much higher in CHD than in CVD or PAD patients (61% vs. 10% vs. 22% respectively) and decreased significantly with time from initial diagnosis. Simvastatin (mainly 20 mg) and atorvastatin (mainly 10 mg) each accounted for about 40% of total statin use.
Conclusions  In urban China, there is still significant underuse of various proven secondary preventive therapies, with particularly low use of statins in patients with ischaemic stroke.
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3.
Objective This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index(BMI)or fat mass percentage and metabolic health status with the tenyear risk of cardiovascular disease(CVD)among Chinese adults.Methods Data were obtained from a cross-sectional study.BMI and body fat mass percentage(FMP)combined with the metabolic status were used to define metabolic phenotypes.Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk.Results A total of 13,239 adults aged 34-75 years were included in this study.Compared with the metabolically healthy non-obese(MHNO)phenotype,the metabolically unhealthy non-obese(MUNO)and metabolically unhealthy obese(MUO)phenotypes defined by BMI showed a higher CVD risk[odds ratio,OR(95% confidence interval,CI):2.34(1.89-2.89),3.45(2.50-4.75),respectively],after adjusting for the covariates.The MUNO and MUO phenotypes defined by FMP showed a higher CVD risk[OR(95%CI):2.31(1.85-2.88),2.63(1.98-3.48),respectively]than the MHNO phenotype.The metabolically healthy obese phenotype,regardless of being defined by BMI or FMP,showed no CVD risk compared with the MHNO phenotype.Conclusion General obesity without central obesity does not increase CVD risk in metabolically healthy individuals.FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk.Obesity and metabolic status have a synergistic effect on CVD risk.  相似文献   

4.
正In this study,we aimed to assess the relationship of socioeconomic status and acculturation with cardiovascular disease(CVD)risk profiles and CVD and examine the CVD risk factors associated with CVD.We used data from the 2010China Chronic Disease and Risk Factor Surveillance surveys,which consisted of a nationally  相似文献   

5.
Background Interleukin-23 (IL-23) is a pro-inflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not the serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA), and to determine the relationship between the IL-23 level and disease activity in RA patients. Methods Serum samples were obtained from 59 patients with RA and 30 healthy controls, and determined the clinical parameters of disease activity, including the 28-joint disease activity score (DAS28), C-reactive protein (CRP) and rheumatoid factor (RF) levels, and degree of bony erosions based on X-rays. The levels of IL-23 and IL-17 were determined by enzyme—linked immunosorbent assay (ELISA). The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined. Results The serum IL-23 level was significantly elevated in patients with RA compared to healthy controls. The serum IL-23 levels in patients with RA were correlated with IL-17 and CRP levels, and the DAS28.The levels of IL-23 based on X-ray classification phase I、II、III, and IV were gradually elevated in RA patients. Conclusion The levels of serum IL-23 in RA patients were higher than in healthy controls. Thus, elevated serum IL-23 levels may be the useful markers for active RA. In addition, IL-23 is involved in disease progression and bony erosions in patients with RA.  相似文献   

6.
Cardiovascular disease(CVD)is the leading cause of death in China.Even adequate treatment of these risk factors,including hypertension,diabetes mellitus,and smoking,does not completely reduce the risk of CVD.It  相似文献   

7.
Objective To review the main neuropsychiatric disorders and cognitive deficits in patients with Cushing's disease (CD) and the associated pathophysiological mechanisms underlying CD.These mechanistic d...  相似文献   

8.
正Cardiovascular disease(CVD)is a leading lifethreatening chronic disease in China.In the primary and secondary prevention,remarkable achievements have been made during past decades.In treating coronary artery disease(CAD),for example,the advanced treatment approaches,such  相似文献   

9.
Objective This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease(CVD) burden from 1990 to 2019.Methods Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study 2019. Deaths and disability-adjusted life years(DALYs) were used to quantify heat-induced CVD burden. We calculated the age-standardized mortality rate(ASMR) and DALY rate(ASDR) per 100,000population to compare this burden across regions. Generalized linear m...  相似文献   

10.
Parkinson' s disease(PD) is one of the com-mon neurodegenerative disorders in the aged popu-lation,which is thought to be for the environmen-tal factors acting on predisposed individuals ingene. The typical pathologic manifestation of PDis the presence of Lewy body (LB) in substantianigra dopaminergic neurons. As the major compo-nent of LB is protein, those genes involved in pro-tein aggregation may also be the candidate genes ofPD. Biochemical studies showed that α2-macroglobulin (A2M) …  相似文献   

11.
目的 观察慢性肾脏病(CKD)患者血清超敏C反应蛋白(hs-CRP)及胱抑素C(CysC)水平变化,分析hs-CRP对CKD的诊断价值.方法 从2016年6~11月到武汉大学人民医院就诊的患者中纳入CKD患者128例作为CKD组,以101例同期体检健康者作为对照(对照组).分别检测两组受检者的血肌酐(SCr)、hsCRP和Cys C,并计算肾小球滤过率(GFR).独立样本t检验比较CKD组和对照组SCr、hs-CRP、CysC水平的差异;绘制ROC曲线,评价SCr、hs-CRP、CysC对CKD的诊断价值;并通过Pearson相关检验分析CKD患者hs-CRP与GFR的相关性.结果 CKD组患者SCr[(476±273.5)μmol/L]、hs-CRP[(14.54±26.43)]mg/L和CysC[(4.13±2.05)mg/L]水平均高于对照组[(60.9±14.5)μmol/L、(0.58±0.69)mg/L、(1.06±0.28)mg/L],差异均有统计学意义(P<0.05);CKD患者hs-CRP与GFR水平呈负相关(r=-0.356,P<0.01);SCr、hs-CRP、CysC三指标诊断CKD的ROC曲线下面积分别为0.997、0.846、0.970.结论 CKD患者超敏C反应蛋白含量明显增加,且与肾损伤程度呈正相关,对诊断慢性肾脏病有一定的辅助价值,可用来评估病情的严重程度.  相似文献   

12.
目的:通过对非透析性慢性肾病患者(CKD)血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(I。DL)和高密度脂蛋白(HDL)]及肾功能[血肌酐(Cr)、肾小球滤过率(GFR)]进行检测分析,探讨非透析性慢性肾脏病患者的血脂水平和肾功能之间的相关性。方法:采用全自动生化仪测定血脂水平和Cr浓度;采用肾动态显像做肾图检查,运用Gares法计算GFR。比较非透析性CKD患者和健康对照组的血脂和肾功能,运用线性回归分析TC、TG、LDL和HDL水平与Cr和GFR的相关性。结果:非透析性CKD患者的TC、TG、LDL水平及Cr、GFR和对照组差异均有统计学意义(P均〈0.01)。线性回归显示,非透析性CKD患者的Cr水平与TC、TG、LDL水平呈正相关(P〈0.01),GFR与TC、TG、LDL水平呈负相关(P〈0.01)。结论:非透析性CKD患者肾脏功能的恶化与血脂紊乱密切相关,是CKD进行性恶化的重要危险因素。  相似文献   

13.
目的 探讨全段甲状旁腺激素(iPTH)联合钙磷测定在慢性肾脏病(CKD)患者中的应用价值.方法 选择2015年1月至2016年6月期间我院肾内科收治的CKD3~5期患者92例为研究对象,将52例CKD3~4期患者纳入慢性肾功能衰竭(CRF)早期组,40例CKD5期患者纳入终末期肾病组,并选择40例健康体检者纳入对照组,检测并比较三组受检者的血清钙磷及iPTH水平.结果 CRF早期组与对照组比较,血钙、血磷水平差异均无统计学意义(P>0.05),但CRF早期组患者血清iPTH为(105.54±31.45)pg/mL,明显高于对照组的(30.23±11.62)pg/mL,差异有统计学意义(P<0.05);终末期肾病组患者血钙为(2.02±0.24)mmol/L,明显低于CRF早期组的(2.23±0.48)mmol/L及对照组的(2.34±0.32)mmol/L,血磷及iPTH水平分别为(1.91±0.77)mmol/L、(413.53±114.75)pg/mL,均明显高于CRF早期组[(1.34±0.46)mmol/L、(105.54±31.45)pg/mL]及对照组[(1.17±0.43)mmol/L、(30.23±11.62)pg/mL],差异均有统计学意义(P<0.05).结论 血清iPTH测定可用于反映CKD患者的肾功能进展程度,进一步联合钙磷测定对CKD的早期诊断和治疗具有的指导意义.  相似文献   

14.
目的:检测血清和肽素(Copeptin)和降钙素原(procalcitonin,PCT)含量的变化,探讨其在慢性阻塞性肺疾病急性加重期(acute exacerbations of chronic obstructive pulmonary disease,AECOPD)中的临床意义。方法:选取62例AECOPD入院患者为观察组,同时选取30例健康体检者作为对照组,动态监测AECOPD患者血清中Copeptin和PCT治疗前后的水平变化。结果:⑴COPD患者急性加重期和稳定期患者血清中Copeptin浓度分别为(28.7±7.1)pmol/L和(12.8±4.2)pmol/L,高于健康对照组的(7.2±1.8)pmol/L(P<0.05);⑵COPD患者急性加重期和稳定期患者血清中PCT浓度分别为(1.80±0.36)g/L和(0.55±0.12)g/L,高于健康对照组的(0.08±0.05)g/L(P<0.05)。结论:⑴血清PCT和Copeptin是COPD急性加重期较好的监测指标,其参与了COPD患者急性期的发病过程;⑵动态检测AECOPD患者血清PCT水平更有助于疾病预后的判断。  相似文献   

15.
目的 探讨血浆脑钠肽(BNP)与肿瘤坏死因子(TNF-α)水平变化对早期诊断心力衰竭伴肺部感染的特异性及敏感性.方法 根据诊治记录选取2013年4月至2016年2月在我院接受住院治疗的65例早期心力衰竭伴肺部感染患者为观察组,依照NYHA分级将患者分为Ⅰ级20例、Ⅱ级18例、Ⅲ级15例和Ⅳ级12例,并采取常规的心力衰竭伴肺部感染治疗方式进行治疗;另选择同期65例我院健康的体检者作为对照组,比较两组受检者以及观察组不同NYHA患者的BNP、TNF-α水平变化.结果 观察组患者治疗后的BNP和TNF-α水平分别为(38.67±7.28)ng/L和(16.44±4.06)ng/L,与治疗前的(416.39±34.62)ng/L和(36.94±10.86)ng/L比较下降明显,差异具有统计学意义(P<0.05);不同NYHA级别的两两比较中,级数越高的患者BNP和TNF-α的指数就越高,且差异具有统计学意义(P<0.05);经过Spearman相关性分析得出BNP和TNF-α均与NYHA的功能分级呈正相关,相关系数为0.601和0.434,且差异具有统计学意义(P<0.05).结论 BNP和TNF-α可反映出患者心血管及肺功能的受损特点,在早期诊断心理衰竭伴肺部感染中具有重要的指标性意义.  相似文献   

16.
目的 探讨缺血缺氧脑病(HIE)患儿脑中央动脉血流动力学变化,并分析患儿脐血脑钠肽(BNP)、神经生长因子(NGF)、神经特异性烯醇化酶(NSE)水平和神经评定(NBNA)评分的相关性.方法 选取2015年6月至2016年5月宜宾市第二人民医院儿科收治的45例HIE新生儿(观察组)和33例健康新生儿(对照组)为研究对象,采用彩色多普勒检测脑中央动脉血流动力学指标,采用酶联免疫吸附实验(ELISA)法检测脐血BNP、NGF、NSE水平,分析HIE新生儿脐血BNP、NGF、NSE水平与NBNA评分的相关性.结果 观察组患儿脑动脉中央支平均峰流速(Vm)为(9.28±2.57)cm/s,阻力指数(RI)为(0.62±0.11),对照组脑动脉中央支Vm为(13.74±2.38)cm/s,RI为(0.48±0.09),两组比较差异均具有统计学意义(P<0.05);观察组患儿脐血BNP、NGF及NSE水平分别为(268.51±67.11)ng/L、(174.72±18.34)ng/L和(87.78±23.56)μmol/L,观察组患儿NBNA评分为(34.81±5.86)分;对照组患儿脐血BNP、NGF及NSE水平分别为(139.73±44.86)ng/L、(218.48±19.89)ng/L和(20.03±5.43)μmol/L,NBNA评分为(38.43±2.61)分,两组比较差异均具有统计学意义(P<0.05);观察组患儿脐血BNP、NSE水平与NBNA评分呈显著负相关(r=-0.416,-0.381,P<0.05),而NGF水平与NBNA评分呈显著正相关(r=0.321,P<0.05);对照组新生儿脐血BNP、NSE及NGF水平与NBNA评分均无明显相关性(r=-0.336、0.236、-0.162,P>0.05).结论 脑中央动脉血流动力学和脐血BNP、NGF、NSE水平对HIE的诊断和病情判断具有重要价值,临床上可根据具体情况进行监测随访.  相似文献   

17.
目的观察急性脑出血(acute cerebral hemorrhage)患者心脏左心室功能(left ventricu lar function,LVF)的变化及其与血浆脑钠素(brain natriuretic peptide,BNP)的关系并探讨其机制,为防治急性脑出血所致心脏损伤提供依据。方法选择发病24 h内经临床和头颅CT检查确诊的急性脑出血患者30例作为研究对象,所有患者既往无心脏病史,并除外心功能不全、心律失常等并发症。选择性别和年龄匹配的20例高血压患者及21例正常人作为对照组。以上各组受试者均行超声心动图检查,同时用ELISA法检测血浆BNP,并对结果进行分析。结果1)急性脑出血组左心室射血分数(left ventricu lar ejection fraction,LVEF)均值明显低于高血压组及正常对照组〔分别为(41.33±15.03)%vs(59.20±15.03)%,P<0.01;(41.33±15.03)%vs(67.71±8.02)%,P<0.01〕;高血压组LVEF均值与正常对照组比较差异无统计学意义(P>0.05)。急性脑出血组舒张早期最大血流速度/舒张晚期最大血流速度(E/A)均值低于高血压组及正常对照组,与高血压组比较差异无统计学意义(P>0.05),与正常对照组比较差异有统计学意义(1.00±0.46vs1.47±0.23,P<0.01),高血压组E/A均值低于正常对照组,二者比较差异有统计学意义(1.09±0.37vs1.47±0.23,P<0.01)。2)急性脑出血组血浆BNP浓度高于正常对照组〔(49.62 ng/L(17.18~85.25)ng/Lvs1.90 ng/L(0.15~21.50)ng/L,P<0.01)〕。3)急性脑出血组脑出血量与血浆BNP浓度的相关系数r=0.13(P>0.05);急性脑出血组脑出血量与各心功能参数间无相关性(P>0.05)。急性脑出血组血浆BNP浓度与左心室各结构与功能参数间无相关性(P>0.05)。结论急性脑出血可引起左心室收缩功能和舒张功能下降;脑出血量与心功能参数之间无相关性;急性脑出血发病后血浆BNP浓度升高,但与心脏结构和功能参数间无相关性,可能与急性脑出血本身的病理生理机制有关。  相似文献   

18.
封红灵 《海南医学》2012,23(7):22-23
目的探讨冠心病患者冠状病变程度与脑钠肽、和肽素水平之间的关系。方法选择我院2008年8月到2011年9月收治的冠心病患者100例(冠心病组)和我院同期体检的100例健康对照者(对照组)行血浆脑钠肽、和肽素水平检测,比较两组BNP、Copeptin水平及冠心病组内冠状动脉病变支数、左主干病变程度、冠脉Gensini评分。结果对照组BNP、Copeptin水平、Gensini积分均明显低于各冠心病组(SAP、UAP、AMI),冠心病组内各组与对照组比较,差异均具有统计学意义(P<0.05),冠心病组组内比较差异也具有统计学意义(P<0.05);3支病变、左主干病变与1、2支病变比较,BNP和Copeptin水平均明显增高,且差异均具有统计学意义(P<0.05);左主干病变与3支病变比较,BNP和Copeptin水平均明显增高,差异均具有统计学意义(P<0.05)。结论脑钠肽、和肽素水平和冠状动脉病变关系密切,且与冠状动脉病变程度、冠状动脉病变支数呈正相关,能准确的反应冠状动脉病变程度,具有重要的临床意义。  相似文献   

19.
目的探讨血浆脑钠肽(BNP)水平在非糖尿病急性心肌梗死(AMI)合并应激性高血糖患者病情评估中的作用。方法将我院2010年1月至11月收治的AMI患者60例患者根据空腹血糖值分为两组,非糖尿病AMI合并应激性高血糖组(试验组)36例(血糖≥7.0 mmol/L),AMI未合并应激性高血糖组(对照组)24例(血糖<7.0 mmol/L),在发病后24 h行血浆BNP浓度检测。结果发病后24 h血浆BNP水平在非糖尿病AMI合并应激性高血糖组明显高于AMI未合并应激性高血糖组[(671.87±631.71)ng/L vs(299.53±455.67)ng/L,P<0.01]。结论血浆BNP水平可以判断非糖尿病AMI合并应激性高血糖患者病情危重程度。  相似文献   

20.
目的初步探讨慢性阻塞性肺疾病(COPD)患者血浆食欲素A(orexinA)水平变化及其意义。方法选择伴有肥胖的COPD患者15例(肥胖COPD组)、不伴有肥胖的COPD患者20例(非肥胖COPD组)、单纯肥胖者20例(单纯肥胖组)和健康成人20例(正常对照组)。所有受试者均接受肺功能检查及血气分析,采用层析方法将血浆去蛋白处理,然后采用放射免疫分析法测定4组血浆食欲素A的水平。结果肥胖COPD组(8.82ngL±1.90ngL)与非肥胖COPD组(8.69ngL±1.84ngL)血浆食欲素A水平显著高于单纯肥胖组(7.18ngL±1.45ngL)及正常对照组(6.72ngL±1.58ngL)(P<0.01)。肥胖COPD组与非肥胖COPD组血浆食欲素A水平无显著差异(P>0.05)。肥胖与非肥胖COPD组检测指标相关分析显示:血浆食欲素A水平与氧分压(PO2)(r=-0.527,P<0.01)、血氧饱和度(SaO2)(r=-0.529,P<0.01)呈负相关,而与二氧化碳分压(PCO2)、FEV1占预计值的百分比以及体重指数(BMI)、脂肪百分比(%fat)无相关性。结论COPD患者血浆食欲素A水平升高,其原因可能与COPD患者气道阻塞所致低氧血症及其病理生理变化有关。  相似文献   

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