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1.
目的 研究卵巢肿瘤良恶性病变者行超声与MRI进行筛查和鉴别诊断的价值.方法 选取通过手术病理确诊的56例卵巢肿瘤病变患者资料进行分析,均行超声与MRI检查,对比两种方式的诊断价值.结果 超声影像学表现为:良性肿瘤的边界较清楚,恶性肿瘤的边界较模糊;MRI影像学表现为:良性肿瘤为单发,恶性肿瘤好发于双侧卵巢.超声与MRI术前定性诊断准确概率77.50%与90.00%和良恶性诊断准确概率对比差异无统计学意义;超声与MRI诊断疾病的特异度95.12%与97.00%、灵敏度82.93%与88.20%对比差异均无统计学意义.结论卵巢肿瘤良恶性病变者行超声与MRI进行筛查和鉴别诊断的价值相当,临床可将此两种方法相结合,以提高肿瘤病变诊断准确概率,为疾病尽早采取有效防治措施提供重要参考.  相似文献   

2.
杨晓惠 《蚌埠医学院学报》2019,44(6):771-773, 777
目的评价基于甲状腺影像报告和数据系统(TI-RADS)的超声细化计分法和血清促甲状腺素(TSH)值联合对甲状腺结节良恶性进行鉴别诊断的意义。方法选取进行甲状腺结节手术的病人,基于TI-RADS分级系统,根据超声图像中结节边界、纵横比、回声、钙化及颈部淋巴结对甲状腺结节进行细化计分,联合病人入院血清TSH值,绘制受试者工作特征曲线(ROC),计算ROC曲线下面积(AUC),评价超声细化计分法、血清TSH值和两者联合区分甲状腺良恶性结节的诊断价值。结果ROC分析显示,超声细化计分法区分甲状腺良恶性结节的敏感度88.6%,特异度83.9%,AUC为0.779(95%CI:0.718~0.839),约登指数最大时,超声细化计计分法最佳临界值为9分,≥ 9分判定结节为恶性, < 9分判定结节为良性;血清TSH值区分甲状腺良恶性结节的敏感度71.1%,特异度50.9%,AUC为0.703(95%CI:0.624~0.782),约登指数最大时取最佳临界值2.31 mIU/L;超声细化计分法与血清TSH值联合区分甲状腺良恶性结节的敏感度90.1%,准确度84.5%,特异度84.3%。结论基于TI-RADS的超声细化计分法和血清TSH值联合鉴别甲状腺结节良恶性可使诊断符合率进一步提高,降低甲状腺结节的穿刺活检或手术率。  相似文献   

3.
目的对超声弹性成像(UE)硬度评分法在乳腺肿瘤良恶性鉴别中的应用价值进行探讨。方法将中国人民解放军联勤保障部队第988医院开封院区2018年3月至2019年3月进行检查的78例乳腺肿瘤患者作为此次研究对象,对其施行UE检查,以手术病理结果为诊断金标准。分析UE硬度评分法在乳腺肿瘤良恶性病变鉴别中的诊断价值。结果经病理学检查诊断,78例患者中共发现良性肿瘤60个,恶性肿瘤36个;其中,UE评分法共检出良性肿瘤56个,其中2个恶性肿瘤误诊为良性,检出恶性肿瘤40个,其中6个良性肿瘤误诊为恶性;UE评分法诊断乳腺肿瘤良恶性病变的特异度、灵敏度、准确率分别为94.44%、90.00%、91.67%。结论 UE硬度评分法在乳腺肿瘤良恶性的鉴别中可取得较高的诊断准确率及敏感度,综合评价病灶的良恶性病变,从而为临床医师提供准确的乳腺肿瘤病变信息。  相似文献   

4.
超声弹性成像技术鉴别乳腺肿块良恶性应用价值探讨   总被引:1,自引:0,他引:1  
目的 探讨超声弹性成像技术在鉴别乳腺肿块良恶性中的应用价值.方法 对121例患者130个乳腺肿块进行超声弹性成像检查,对肿块弹性硬度采用5分法进行半定量分析,记录肿块弹性硬度,测量弹性模式下与灰阶模式下面积比值,通过对肿块2种成像模式下面积比值的分析,找出良恶性诊断截点,进一步计算其在诊断乳腺恶性肿瘤方面的灵敏度、特异度、准确率.结果 弹性硬度半定量分析诊断乳腺恶性肿瘤的灵敏度为80.0%、特异度为85.5%、准确率为83.8%.2种成像模式下面积比值鉴别乳腺肿块良恶性的截点为1.8,若以面积比≥1.8为恶性、〈1.8为良性作为诊断肿瘤良恶性的标准,则本组2种成像模式下面积比值诊断乳腺恶性肿瘤的灵敏度为77.5%、特异度为91.1%、准确率为86.9%.结论 超声弹性成像能客观地评价乳腺肿块的相对弹性硬度,有助于提高超声对乳腺肿块良恶性的定性诊断.  相似文献   

5.
目的:研究超声弹性应变率与常规超声对甲状腺结节的鉴别诊断价值。方法纳入研究共126例择期手术甲状腺结节患者,共有146个结节。行术前常规超声及超声弹性成像扫描。根据常规超声结果及Stacul半定量评分法判断结节良恶性。根据超声弹性成像结果构建ROC曲线,确定诊断最佳临界点。以术后病理结果作为标准,比较超声弹性应变率、常规超声及联合诊断在甲状腺结节鉴别诊断价值。结果超声弹性应变率ROC曲线下面积(AUC)为0.827,最佳诊断界值为2.53;弹性应变率诊断灵敏度、特异度及诊断准确率分别为78.38%、72.48%及73.97%;常规超声诊断灵敏度、特异度及诊断准确率分别为75.68%、74.31%及74.68%;联合诊断灵敏度、特异度及诊断准确率分别为86.49%、88.07%及87.67%;超声弹性应变率与常规超声在灵敏度及特异度上差异无统计学意义;联合诊断特异度及诊断准确率明显高于超声弹性应变率及常规超声(P<0.05)。结论超声弹性应变率在鉴别诊断甲状腺结节具有中等价值。超声弹性应变率与常规超声联合诊断可提高甲状腺结节特异度及诊断准确率。  相似文献   

6.
《陕西医学杂志》2019,(5):628-631
目的:探讨超声造影与常规彩色多普勒超声检查在卵巢肿瘤良恶性鉴别诊断中的应用价值。方法:回顾性分析76例经病理学诊断确诊良恶性的卵巢肿瘤患者的常规彩色多普勒超声及超声造影检查资料。分析两种检查方式在鉴别卵巢肿瘤良恶性方面的准确率及影像学特点。结果:76例卵巢肿瘤患者在超声造影检查中良、恶性结果与术后病理学符合率显著高于经常规彩色多普勒超声检查(90.24%与65.85%,88.57%与48.57%)(P<0.05)。常规彩色多普勒超声检查显示,良性卵巢肿瘤血流特点以Ⅰ型为主,恶性以Ⅲ型为主,且良性肿瘤Finkler评分显著低于恶性肿瘤,RI值显著高于恶性肿瘤(P<0.01);超声造影检查显示:良性卵巢肿瘤灌注水平以低增强为主,恶性则以高增强为主,良性卵巢肿瘤灌注低增强例数显著多于恶性肿瘤,高增强例数显著少数恶性肿瘤(P<0.01);恶性卵巢肿瘤造影剂的Imax显著强于良性肿瘤,TTP、mTT显著短于良性肿瘤(P<0.05);而两者RT间差异无统计学意义(P>0.05)。结论:与常规彩色多普勒超声检查相比,超声造影可更好的显示良恶性卵巢肿瘤组织及血管分布、灌注特点,且后续图像处理结果可进一步提高良恶性鉴别诊断的准确性。  相似文献   

7.
目的:探讨超声弹性成像技术在良恶性乳腺病变检查中的价值,为临床应用提供理论指导。方法:对该院选取的100例患者首先进行超声弹性成像检查,并按照5分法进行评分,以1~3分为良性肿瘤,4~5分为恶性肿瘤。然后对患者进行手术病理检查,利用统计学软件对两种方法的检查结果进行对比分析。结果:两方法的结果对比P>0.05差异不具有统计学意义。超声弹性成像检查的准确率为94%,灵敏度94.2%,特异度93.5%。结论:超声弹性成像技术对良恶性乳腺病变的检查结果准确可靠。  相似文献   

8.
吴芳芳  何丹青  王玲 《安徽医学》2022,43(6):699-702
目的 探讨超声弹性成像应变率比值法(SR法)联合二维灰阶超声评估腮腺肿块良恶性的临床价值。方法 选取2020年1月至2021年10月于安徽医科大学第一附属医院就诊并进行手术的单侧腮腺占位患者(共164个病灶),均于术前先行常规超声检查,再行超声弹性成像检查,测量并记录弹性模式下病灶周围正常软组织与病灶区的弹性成像应变率比值,术后送检病理。以病理结果为金标准,评价单独二维灰阶超声、单独SR法及两者联合鉴别诊断腮腺肿块良恶性的诊断效能。结果 164例患者中,良性病变结节118例,恶性病变结节46例。二维灰阶超声检查诊断腮腺良恶性结节的灵敏度为88.13%,特异度为69.56%、准确度为82.90%;弹性成像SR法诊断腮腺恶性结节的灵敏度为84.75%,特异度为73.90%,准确度为81.71%;二维灰阶超声联合SR法诊断的灵敏度、特异度、准确度(93.22%、80.43%、89.63%)均高于单一成像检查。腮腺肿瘤恶性组应变率比值(SR值)为(2.70±0.68),良性组为(1.42±0.43),SR法在鉴别腮腺良恶性肿瘤中差异有统计学意义(P<0.05)。对照病理结果,SR法判断肿块良恶性的受试者工作特征(ROC)曲线下面积为0.924。结论 二维灰阶超声联合SR法能提高对腮腺良恶性肿瘤的鉴别能力,有一定的临床应用价值。  相似文献   

9.
目的:检测超声弹性成像在甲状腺结节患者抗体功能正常及合并桥本甲状腺炎两者结节良恶性的鉴别中的应用,探讨弹性成像在两者良恶性结节鉴别中的不同影响力。方法:分别选取92例合并桥本甲状腺炎患者甲状腺结节(共123个);100例甲状腺抗体功能正常患者甲状腺结节(共134个),采用超声弹性成像检查,将其结果与病理结果对比,得出相应的灵敏度、特异度和准确率;并对两者进行比较。结果:合并桥本甲状腺炎患者的123个结节中,超声弹性成像对结节良恶性诊断的灵敏度为39.02%,特异度为85.37%,准确率为69.92%;而甲状腺抗体功能正常患者的134个结节中,超声弹性成像对结节良恶性诊断的灵敏度为83.33%,特异度为96.25%,准确率为91.04%。两者差异具有统计学意义(P<0.05)。结论:合并桥本甲状腺炎患者由于纤维化程度增高,甲状腺组织硬度增高,结节弹性评分减低,从而导致超声弹性成像诊断价值降低。  相似文献   

10.
李靖华 《中外医疗》2016,(10):170-172
目的 探讨超声弹性成像(UE)与二维超声在乳腺良恶性病变中的应用价值.方法2013年6月—2015年6月整群选取84例经病理组织确诊为乳腺良恶性病变的患者为研究对象,术前对患者行超声弹性成像及常规超声检查,并将影像学诊断结果与病理手术结果进行对比.结果84例乳腺良恶性病变患者中良性病变38例(68个病灶),恶性肿瘤46例(82个病灶).二维超声诊断乳腺良、恶性病变准确率为76.47%、82.93%,灵敏度分别为70.25%、68.23%,特异度分别为62.45%、72.32%.超声弹性成像诊断良、 恶性肿瘤准确率为91.17%、95.12%,灵敏度分别为93.65%、90.25%,特异度分别为80.25%、88.92%,差异有统计学意义(P<0.05).与良性病变相比,恶性病变组弹性成像3~5分所占的比例较高,差异有统计学意义(P<0.05).结论超声弹性成像技术为乳腺病变诊断及鉴别提供了全新的方法,提高了乳腺良恶性病变的诊断准确性及灵敏性.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

13.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

14.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

15.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

16.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

17.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

18.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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