男性酒精依赖患者戒酒前后注意偏向对比研究

目的研究酒精依赖(AD)患者戒酒治疗前后注意偏向的变化。方法选取2016年1月至2017年5月合肥市第四人民医院收治的54例男性接受戒酒治疗且符合入组标准的AD患者作为AD组,采用中文情绪词stroop范式在系统戒酒治疗前和戒酒治疗42 d后的1周内进行注意偏向的测试,同期选择合肥市第四人民医院周围社区49例男性健康志愿者作为健康对照(HC)组,同样采用中文情绪词stroop范式进行注意偏向的测试,比较两组研究对象中文情绪词stroop范式中负性词、中性词、线索词的反应时间及错误数。结果 AD组患者治疗后和治疗前在中文情绪词stroop范式的(负性词、中性词、线索词)的反应时间的差值大于HC组2次测验反应时间的差值,差异有统计学意义(P <0. 05)。AD组患者治疗后和治疗前在中文情绪词stroop范式的(负性词、线索词、中性词)错误数的差值大于HC组2次测验错误数的差值,在中性词方面差异有统计学意义(P <0. 05),而在负性词及线索词方面差异无统计学意义(P> 0. 05)。结论 AD患者系统的戒酒治疗可以改善患者注意偏向反应时间和中性词错误数。     

首发抑郁症患者对情绪词注意偏向相关研究

目的探讨首发型抑郁症患者注意偏向特点。方法选取34例未经治疗的首发型抑郁症患者以及与其人口学资料相匹配的40例健康对照组（HC）作为研究对象,采用中文情绪词stroop实验进行注意偏向的测试。结果患者组在负性词、中性词、正性词的反应时[分别为（1185．71±410．60）ms,（1127．92±344．89）ms,（1166．17±395．72）ms],高于HC组[分别为（754．68±215．36）ms,（755．37±213．49）ms,（761．70±194．66）ms],差异有统计学意义（t=5．775,P〈O．01;t=5．675,P〈0．01;t=5．708,P〈0．01）;方差分析显示患者组在负性词、中性词、正性词的错误数[（3．41±2．11）次,（2．24±1．65）次,（2．97±1．17）次]方面差异有统计学意义（F=4．197,P=0．018）,LSD（Leastsignificantdifference）进一步两两比较发现,负性词与中性词差异有统计学意义（P〈0．01）。结论抑郁症患者在治疗前对负性词具有显著的注意偏向,对负性相关刺激的注意偏向可能是抑郁症患者认知特质之一。     

进展期胃癌患者注意偏向相关研究

目的探讨进展期胃癌患者情绪及注意偏向的变化。方法选取40例治疗初期的进展期胃癌患者以及与其人口学资料相匹配的40例健康对照组(HC)作为研究对象,采用中文情绪词进行注意偏向的测试。所有被试者试验前分别予焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)对两组患者进行评定。结果胃癌患者组在SAS,SDS得分[(51.51±6.38)分,(55.23±5.51)分]高于对照组[(41.05±8.66)分,(42.18±10.02)分],差异有统计学意义(t=6.710,P=0.000;t=8.018,P=0.000);患者组在情绪词Stroop任务中负性词的正确率[(78.57±16.70)%]低于对照组[(85.05±10.82)%],差异有统计学意义(t=-2.148,P=0.034)。SDS量表得分与负性词正确率呈负相关(r=-0.529,P=0.000)。结论进展期胃癌患者对负性相关信息具有显著的注意偏向,需加强胃癌患者注意偏向的训练。     

加压疼痛对健康人群疼痛相关字词注意偏向的影响及其性别差异

目的 考察肢体加压疼痛对疼痛相关字词的注意偏向的影响与性别差异.方法 于被试者左臂肘横纹上方1～2 cm处捆绑止血带,采用dot-probe任务对32名健康大学生在有或无加压条件下进行五类疼痛相关字词(情感性疼痛词、感觉性疼痛词、社会威胁性词、积极词与中性词)的注意研究,加压压力为200 mm Hg.记录被试者认知反应的反应时与错误率,同时记录被试者的疼痛强度与疼痛不适度.结果 (1)与无加压相比,疼痛条件下女性反应时显著缩短(F(1,4)=19.157,P＜0.01),表现为对情感性疼痛词及社会威胁性词的反应速度加快[加压疼痛时两者反应时分别为[(464±79)ms,(465±72)ms];无加压时分别为[(507±78)ms,(504±89) ms].(2)无加压实验中男性的反应时[(456±59)ms]短于女性的反应时[(504±79)ms](F(1.4)=18.779,P＜0.01),而加压疼痛实验中男女反应时差异消失[分别为(454±63)ms,(474 ±77)ms].结论 实验性中重度疼痛会引起女性被试者对字词的反应速度加快,表现出对情感性疼痛词和社会威胁性字词的注意偏向.     

高强迫症状个体的注意偏好研究

目的 研究不同类型高强迫症状(HOC)个体的注意偏好特点及与症状的相关性,初步探讨强迫障碍的神经机制.方法 选取帕多瓦量表-华盛顿州立大学修订版(PI-WSUR)中文版量表总分在前7%的高强迫症状个体(HOC组)22人与PI-WSUR量表总分在后7%的低强迫症状个体(LOC组)38人,采用中文情绪词Stroop任务比较2组注意偏好有无差异;采用PI-WSUR的子量表把强迫症状分为5种亚型,HOC组各子量表得分的前50%(11人)为子量表高分组,比较不同亚型子量表高分组的注意偏好有无区别.结果 HOC组和LOC组对中性词、负性词、厌恶词的反应时[(638.63±125.76)ms/(665.74±145.59)ms;(637.82±118.84)ms/(666.51±139.82)ms;(635.57±100.61)ms/(665.49±133.42)ms]差异无显著性(t=0.729,P=0.469;t=0.808,P=0.423;t=0.911,P=0.366);不同亚型子量表高分组的注意偏好分析表明,污染/清洗强迫子量表高分组对负性词和厌恶词的反应时[(680.83±172.62)ms;(668.48±138.24)ms]显著低于中性词(696.39±174.66ms)(t=2.224,P=0.025;t=1.834,P=0.049),并且厌恶词注意偏好与症状分数存在显著相关(r=-0.648,P=0.031).结论 污染/清洗强迫的注意偏好与其他类型强迫不同,可能具有与其他强迫类型不同的神经机制.     

不同特质焦虑个体对负性汉语的注意偏向

目的 探讨正常人群中不同特质焦虑个体对负性汉语刺激的注意偏向特点.方法 采用点探测任务,使用汉语材料,比较不同特质焦虑个体(高焦虑组21、正常组20、低焦虑组21)在不同条件(负中词对、负正词对)下,对探测目标的反应时和注意偏向值差异.结果 当刺激为负中词对时,3组被试的注意偏向值与0差异有显著性[D1=(14.44±26.22)ms,t =2.401;D2=(12.05±19.89)ms,t =2.571;D3=(-13.14±24.07)ms,t =2.379;P <0.05];当刺激为负正词对时,只有低焦虑组和高焦虑组被试的注意偏向值与0差异有显著性[D4=(21.07±32.91)ms,t =2.791;D6=(-8.98±18.04)ms,t =2.170;P <0.05].结论 高焦虑被试对负性汉语存在注意偏向,低焦虑被试对负性汉语存在回避现象.     

难治性抑郁症与首发抑郁症注意偏向的相关研究

目的：比较和分析首发抑郁症（FED）与难治性抑郁症（TRD）患者的注意偏向特点。方法以26例FED患者（FED组）和27例TRD患者（TRD组）作为研究对象,以41例健康志愿者作为正常对照（Heathy controls,HC）。采用汉密尔顿抑郁量表（HAMD）、抑郁自评量表（SDS）评估临床严重程度,采用中文情绪词Stroop任务进行注意偏向测试,并进行3组组间比较和分析。结果①TRD组与FED组在 HAMD、SDS 量表得分方面差异均无统计学意义;②注意偏向测试显示 FED 组[（1213．07±391．28）ms,（1128．73±318．39）ms,（1184．90±386．40）ms]与TRD组[（1403．28±345．34）ms,（1333．71±331．38）ms,（1325．92±300．16）ms]在负性词、中性词、正性词的反应时均高于HC组[（754．08±212．88）ms,（763．43±209．01）ms,（763．45±192．69）ms],差异有统计学意义（F＝39．679,P＝0．000;F＝36．065,P＝0．000;F＝35．440,P＝0．000）;③TRD组在负性词错误数方面高于HC组,差异有统计学意义（F＝5．596,P＝0．021）;④TRD组在负性词、中性词、正性词的反应时均高于FED组,差异有统计学意义（F＝39．679,P＝0．000;F＝36．065,P＝0．000;F＝35．440,P＝0．023）。结论 TRD与FED均存在明显的注意偏向方面和执行功能方面的损伤,与FED患者相比,TRD症患者的执行功能损害更为严重。SDS、HAMD量表评估并不能反映TRD的临床严重程度,对消极词汇的注意偏向可能是TRD的特征性表现。     

内观认知疗法治疗酒依赖患者临床疗效研究

目的 探讨内观认知疗法对酒依赖患者的临床疗效.方法 将64例酒依赖患者应用随机数字表法分为研究组(32例)和对照组(32例).两组患者仍服用原有药物治疗,其中研究组给予连续7d集中内观认知疗法(NaiKan cognitive therapy,NCT).在治疗前和治疗后应用强制性饮酒问卷(OCDS)、症状自评量表(SCL-90)、护士观察量表(NOSIE)进行评定.结果 ①治疗后研究组OCDS评分[(49.51±1.63)分],低于对照组[(53.92±1.82)分],差异有统计学意义(P＜0.01).②治疗后研究组SCL-90总分、人际关系、抑郁、焦虑因子分低于对照组,均差异有统计学意义(t=-2.413,P=0.019;t=-2.033,P=0.047;t=-2.065,P=0.044;t=-2.038,P=0.046).③治疗后研究组NOSIE量表病情总估计、总积极因素评分[分别为(187.10±18.80)分,(78.51±12.22)分],高于对照组[分别为(175.51±11.71)分,(68.22±11.87)分],总消极因素评分(15.55±9.46)分低于对照组(20.51±9.33)分,均差异有统计学意义(P＜0.05).结论 内观认知疗法能有效降低酒依赖患者的饮酒渴求,减少饮酒相关问题.     

冰毒所致精神障碍患者的注意网络功能研究

目的 探讨冰毒所致精神障碍患者注意网络认知功能缺损的特征.方法 对100例冰毒所致精神障碍者入院第1周和入院第4周进行注意网络功能测试(ANT).结果 (1)与对照组相比,冰毒所致精神障碍组第1次ANT的平均反应时明显延长,正确率、定向作用和执行控制功能明显下降[如:平均反应时(867.37±272.24)ms,(668.56±136.20)ms;正确率(0.88±0.06)ms,(0.88±0.06)ms;定向作用(-217.86±198.0)ms,(-59.67±85.07)ms;执行控制功能(184.74±66.61)ms,(74.71±50.77)ms,P＜0.01],而警觉网络功能则明显提高[如(151.17±198.27)ms,(50.60±67.47)ms];(2)第2次ANT成绩与健康对照组差别无显著性意义(P＞0.05).(3)与第1次ANT成绩相比冰毒所致精神障碍组的第2次ANT成绩的平均反应时明显缩短,正确率,定向作用,执行控制功能明显提高(P＜0.01),而警觉网络功能则明显下降(P＞0.05).结论 冰毒所致精神障碍者的注意网络认知功能存在缺陷,此缺陷可在1月内痊愈.     

高师贫困生自尊与主观幸福感的特点及关系

目的 探讨高师贫困生自尊、主观幸福感的特点及关系.方法 采用自尊量表、生活满意度量表、快乐感量表对218名贫困生和216名非贫困生进行测查.结果 (1)高师贫困生的自尊、生活满意度、正性情感显著低于非贫困生[(27.56±4.13)分,(29.53±4.17)分,t =4.940,P ＜0.01;(15.53±5.10)分,(17.92±5.24)分,t =4.811,P ＜0.01;(23.96±5.97)分,(25.14±6.01)分, t =2.043,P ＜0.05],负性情感差异无显著性.(2)高师贫困生自尊、主观幸福感不存在性别差异,生活满意度年级差异有显著性,大一学生的生活满意度[(16.64±5.37)分]显著高于大二[(14.81±4.55)分]和大三学生[(14.76±5.09)分](F =3.547,P ＜0.05).(3)高师贫困生自尊与生活满意度、正性情感均呈显著正相关(r =0.448,r =0.449,P ＜0.01),自尊与负性情感呈显著负相关(r =-0.514,P ＜0.01).自尊水平越高,幸福感越强.结论 贫困生自尊和主观幸福感相对较低,自尊和主观幸福感显著相关.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.